{"id":"https://openalex.org/W2273394499","doi":null,"title":"Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes","display_name":"Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2273394499","mag":"2273394499"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-273709","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273709","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113326655","display_name":"Steve Choy","orcid":"https://orcid.org/0009-0002-5385-4096","observed_orcids":["https://orcid.org/0009-0002-5385-4096"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steve Choy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113326655"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.47269999980926514,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.47269999980926514,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glucose-insulin-homeostasis","display_name":"glucose-insulin homeostasis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/semi-mechanistic-model","display_name":"semi-mechanistic model","score":0.953000009059906},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/beta-cell-insulin-secretion","display_name":"beta-cell insulin secretion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8759999871253967},{"id":"https://openalex.org/keywords/weight-change","display_name":"weight change","score":0.5519999861717224},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nonlinear-mixed-effects-modelling","display_name":"nonlinear mixed-effects modelling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pharmacometrics","display_name":"pharmacometrics","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6401957273483276},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5880112648010254},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5193985104560852},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5121583938598633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5008542537689209},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.44416847825050354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3917558491230011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38753029704093933},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.20929664373397827}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-273709","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2273394499","doi":null,"is_oa":false,"landing_page_url":"https://uu.diva-portal.org/smash/get/diva2:894953/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-273709","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1492642476","https://openalex.org/W1507448733","https://openalex.org/W1772107894","https://openalex.org/W1959795696","https://openalex.org/W1964777468","https://openalex.org/W1967553472","https://openalex.org/W1969535782","https://openalex.org/W1970297447","https://openalex.org/W1970607508","https://openalex.org/W1973125894","https://openalex.org/W1974323908","https://openalex.org/W1975007709","https://openalex.org/W1975510385","https://openalex.org/W1976320676","https://openalex.org/W1986804446","https://openalex.org/W1990804906","https://openalex.org/W1992335016","https://openalex.org/W1995504484","https://openalex.org/W2000741779","https://openalex.org/W2002062638","https://openalex.org/W2003758101","https://openalex.org/W2005180009","https://openalex.org/W2007241004","https://openalex.org/W2010818019","https://openalex.org/W2011922661","https://openalex.org/W2014825234","https://openalex.org/W2015300033","https://openalex.org/W2016620487","https://openalex.org/W2018417382","https://openalex.org/W2018559734","https://openalex.org/W2023327445","https://openalex.org/W2027547437","https://openalex.org/W2027648353","https://openalex.org/W2027651218","https://openalex.org/W2037871554","https://openalex.org/W2038187728","https://openalex.org/W2038961236","https://openalex.org/W2040633181","https://openalex.org/W2040770427","https://openalex.org/W2042553471","https://openalex.org/W2043473227","https://openalex.org/W2044160793","https://openalex.org/W2046459032","https://openalex.org/W2046666469","https://openalex.org/W2046913994","https://openalex.org/W2054666475","https://openalex.org/W2061099706","https://openalex.org/W2061144730","https://openalex.org/W2062496314","https://openalex.org/W2066898102","https://openalex.org/W2068946398","https://openalex.org/W2074671694","https://openalex.org/W2077458212","https://openalex.org/W2084496283","https://openalex.org/W2086667228","https://openalex.org/W2091528744","https://openalex.org/W2092362155","https://openalex.org/W2098966326","https://openalex.org/W2100784798","https://openalex.org/W2103014115","https://openalex.org/W2104978215","https://openalex.org/W2105912552","https://openalex.org/W2108816189","https://openalex.org/W2109270094","https://openalex.org/W2109652815","https://openalex.org/W2110590807","https://openalex.org/W2113544353","https://openalex.org/W2117343153","https://openalex.org/W2124095103","https://openalex.org/W2124620553","https://openalex.org/W2125624587","https://openalex.org/W2125724477","https://openalex.org/W2127187614","https://openalex.org/W2129154775","https://openalex.org/W2132411825","https://openalex.org/W2133222023","https://openalex.org/W2134293572","https://openalex.org/W2135868229","https://openalex.org/W2137616878","https://openalex.org/W2143045288","https://openalex.org/W2145434855","https://openalex.org/W2151729293","https://openalex.org/W2152397610","https://openalex.org/W2157739430","https://openalex.org/W2158216355","https://openalex.org/W2159205789","https://openalex.org/W2160234571","https://openalex.org/W2162729310","https://openalex.org/W2170972828","https://openalex.org/W2174569309","https://openalex.org/W2260845617","https://openalex.org/W2306733921","https://openalex.org/W2318143411","https://openalex.org/W2335970603"],"related_works":["https://openalex.org/W2535205638","https://openalex.org/W4391431710","https://openalex.org/W2237023489","https://openalex.org/W2078124649","https://openalex.org/W2414985918","https://openalex.org/W4322490332","https://openalex.org/W4391533471","https://openalex.org/W2791937499","https://openalex.org/W7078745874","https://openalex.org/W4394063426"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"mellitus":[3],"(T2DM)":[4],"is":[5,36,40],"a":[6,17,44,103,110,162,222,239,249,274,306],"metabolic":[7],"disorder":[8],"characterized":[9],"by":[10,139],"consistently":[11],"high":[12],"blood":[13],"glucose,":[14,232],"resulting":[15],"from":[16,264],"combination":[18],"of":[19,25,34,58,119,125,134,176,181,189,191,208,259,300,311],"insulin":[20,228,233],"resistance":[21],"and":[22,67,81,91,108,148,155,157,173,227,234,252,287,292],"reduced":[23],"capacity":[24],"\u03b2-cells":[26],"to":[27,42,61,75,84,98,145,166,169,230,255,266,280],"secret":[28],"insulin.":[29,92],"While":[30],"the":[31,55,63,86,131,151,170,179,186,200,205,257,298,312],"exact":[32],"causes":[33],"T2DM":[35,68,77,138,156,260,303],"yet":[37],"unknown,":[38],"obesity":[39,59,66,154,301],"known":[41],"be":[43,281],"major":[45],"risk":[46],"factor":[47],"as":[48,50],"well":[49],"co-morbidity":[51],"for":[52,297],"T2DM.":[53,177,212],"As":[54],"global":[56],"prevalence":[57],"continues":[60],"increase,":[62],"association":[64],"between":[65,89,153,224],"warrants":[69],"further":[70],"study.":[71],"Traditionally,":[72],"mathematical":[73],"models":[74,97,116,136,210,295],"study":[76],"were":[78,106],"mostly":[79],"empirical":[80,115],"thus":[82],"fail":[83],"capture":[85],"dynamic":[87],"relationship":[88,152,223],"glucose":[90,285],"More":[93],"recently,":[94],"mechanism-based":[95],"population":[96,143],"describe":[99,158,231,256],"glucose-insulin":[100,171,202],"homeostasis":[101,172,286],"with":[102],"physiological":[104,309],"basis":[105],"proposed":[107],"offered":[109],"substantial":[111],"improvement":[112],"over":[113],"existing":[114,142],"in":[117,137,161,211,238,248,261,283,290,302],"terms":[118],"predictive":[120,132,206],"ability.":[121],"The":[122],"primary":[123,187],"objectives":[124],"this":[126],"thesis":[127],"are":[128],"(i)":[129],"examining":[130],"usefulness":[133],"semi-mechanistic":[135,164,209,215],"applying":[140],"an":[141,192],"model":[144,165,216,243],"clinical":[146,240],"data,":[147],"(ii)":[149],"exploring":[150],"it":[159],"mathematically":[160],"novel":[163,214],"explain":[167],"changes":[168],"disease":[174,288],"progression":[175,289],"Through":[178],"use":[180],"non-linear":[182],"mixed":[183],"effects":[184,299],"modelling,":[185],"mechanism":[188],"action":[190],"antidiabetic":[193],"drug":[194],"has":[195,217,271],"been":[196,218],"correctly":[197],"identified":[198],"using":[199],"integrated":[201],"model,":[203],"reinforcing":[204],"potential":[207],"A":[213],"developed":[219],"that":[220,273,293],"incorporated":[221],"weight":[225],"change":[226],"sensitivity":[229],"glycated":[235],"hemoglobin":[236],"simultaneously":[237],"setting.":[241],"This":[242,269],"was":[244,253,278],"also":[245],"successfully":[246],"adapted":[247],"pre-clinical":[250],"setting":[251],"able":[254],"pathogenesis":[258],"rats,":[262],"transitioning":[263],"healthy":[265],"severely":[267],"diabetic.":[268],"work":[270],"shown":[272],"previously":[275],"unutilized":[276],"biomarker":[277],"found":[279],"significant":[282],"affecting":[284],"T2DM,":[291],"pharmacometric":[294],"accounting":[296],"would":[304],"offer":[305],"more":[307],"complete":[308],"understanding":[310],"disease.":[313]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}
