{"id":"https://openalex.org/W2273151965","doi":null,"title":"Molecular Pathogenesis of Fibulin-4 Associated Aortic Aneurysms","display_name":"Molecular Pathogenesis of Fibulin-4 Associated Aortic Aneurysms","publication_year":2014,"publication_date":"2014-02-05","ids":{"openalex":"https://openalex.org/W2273151965","mag":"2273151965"},"language":"en","primary_location":{"id":"pmh:eur:oai:repub.eur.nl:51292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/51292","pdf_url":"http://hdl.handle.net/1765/51292","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1765/51292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087027567","display_name":"Natasja W. M. Ramnath","orcid":"https://orcid.org/0000-0002-4215-138X","observed_orcids":["https://orcid.org/0000-0002-4215-138X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natasja W. M. Ramnath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087027567"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.1859000027179718,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibulin-4","display_name":"fibulin-4","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aortic-aneurysm","display_name":"aortic aneurysm","score":0.9700000286102295},{"id":"https://openalex.org/keywords/aortic-dissection","display_name":"aortic dissection","score":0.9269999861717224},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aortic-disease","display_name":"aortic disease","score":0.6600000262260437},{"id":"https://openalex.org/keywords/aortic-rupture","display_name":"aortic rupture","score":0.6940000057220459},{"id":"https://openalex.org/keywords/type-a-aortic-dissection","display_name":"type A aortic dissection","score":0.6549999713897705},{"id":"https://openalex.org/keywords/type-b-aortic-dissection","display_name":"type B aortic dissection","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.883603572845459},{"id":"https://openalex.org/C2778249958","wikidata":"https://www.wikidata.org/wiki/Q2349469","display_name":"Ascending aorta","level":3,"score":0.749123215675354},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.7010793089866638},{"id":"https://openalex.org/C2779993142","wikidata":"https://www.wikidata.org/wiki/Q594660","display_name":"Aortic dissection","level":3,"score":0.6372825503349304},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6206386685371399},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.5888642072677612},{"id":"https://openalex.org/C2780663194","wikidata":"https://www.wikidata.org/wiki/Q3270170","display_name":"Descending aorta","level":3,"score":0.5849900245666504},{"id":"https://openalex.org/C2781285907","wikidata":"https://www.wikidata.org/wiki/Q616032","display_name":"Aortic arch","level":3,"score":0.5764188170433044},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.5066035985946655},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4829789698123932},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4735868573188782},{"id":"https://openalex.org/C2776864027","wikidata":"https://www.wikidata.org/wiki/Q615993","display_name":"Thoracic aorta","level":3,"score":0.47292405366897583},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.4584912359714508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4168001413345337},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.38424426317214966}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:repub.eur.nl:51292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/51292","pdf_url":"http://hdl.handle.net/1765/51292","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:51292","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/51292","pdf_url":"http://repub.eur.nl/pub/51292","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:eur:oai:pure.eur.nl:publications/f09a4323-feeb-4246-b706-4d27388ec247","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/f09a4323-feeb-4246-b706-4d27388ec247","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2273151965","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/51292/140205_Ramnath-Natasja-Wanita-Monisha.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:repub.eur.nl:51292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/51292","pdf_url":"http://hdl.handle.net/1765/51292","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2273151965.pdf","grobid_xml":"https://content.openalex.org/works/W2273151965.grobid-xml"},"referenced_works_count":208,"referenced_works":["https://openalex.org/W1887463","https://openalex.org/W119322828","https://openalex.org/W1033793070","https://openalex.org/W1487581481","https://openalex.org/W1493707677","https://openalex.org/W1527313350","https://openalex.org/W1546430010","https://openalex.org/W1572736799","https://openalex.org/W1575754639","https://openalex.org/W1584346353","https://openalex.org/W1586552615","https://openalex.org/W1775749144","https://openalex.org/W1882983705","https://openalex.org/W1897269170","https://openalex.org/W1963855416","https://openalex.org/W1964513396","https://openalex.org/W1968181166","https://openalex.org/W1968304646","https://openalex.org/W1973423073","https://openalex.org/W1975142493","https://openalex.org/W1975500952","https://openalex.org/W1975785366","https://openalex.org/W1977756163","https://openalex.org/W1978146894","https://openalex.org/W1979651778","https://openalex.org/W1981801855","https://openalex.org/W1982229143","https://openalex.org/W1982531769","https://openalex.org/W1982862878","https://openalex.org/W1985929046","https://openalex.org/W1991456443","https://openalex.org/W1993531220","https://openalex.org/W1993744211","https://openalex.org/W1994560336","https://openalex.org/W1995713731","https://openalex.org/W1996427377","https://openalex.org/W1997243264","https://openalex.org/W1997814885","https://openalex.org/W1997993390","https://openalex.org/W2001277825","https://openalex.org/W2002093513","https://openalex.org/W2002621910","https://openalex.org/W2003062464","https://openalex.org/W2003129541","https://openalex.org/W2006036905","https://openalex.org/W2006264351","https://openalex.org/W2007094943","https://openalex.org/W2008586203","https://openalex.org/W2009358874","https://openalex.org/W2012409690","https://openalex.org/W2012690683","https://openalex.org/W2014725746","https://openalex.org/W2017217412","https://openalex.org/W2017409538","https://openalex.org/W2018492695","https://openalex.org/W2020492706","https://openalex.org/W2021145842","https://openalex.org/W2022849203","https://openalex.org/W2024010572","https://openalex.org/W2024460904","https://openalex.org/W2025073474","https://openalex.org/W2025244200","https://openalex.org/W2025808191","https://openalex.org/W2026428548","https://openalex.org/W2026939798","https://openalex.org/W2028116663","https://openalex.org/W2031575410","https://openalex.org/W2031674791","https://openalex.org/W2031924958","https://openalex.org/W2032061196","https://openalex.org/W2033190960","https://openalex.org/W2033317461","https://openalex.org/W2035252462","https://openalex.org/W2035876629","https://openalex.org/W2037115738","https://openalex.org/W2037394705","https://openalex.org/W2038136158","https://openalex.org/W2039026859","https://openalex.org/W2039661957","https://openalex.org/W2041191931","https://openalex.org/W2041764051","https://openalex.org/W2041938961","https://openalex.org/W2042451126","https://openalex.org/W2044069347","https://openalex.org/W2045371528","https://openalex.org/W2047152078","https://openalex.org/W2048400509","https://openalex.org/W2048890665","https://openalex.org/W2049862220","https://openalex.org/W2051020341","https://openalex.org/W2052402508","https://openalex.org/W2052620256","https://openalex.org/W2053146170","https://openalex.org/W2054248890","https://openalex.org/W2054292017","https://openalex.org/W2054781132","https://openalex.org/W2055373515","https://openalex.org/W2055447043","https://openalex.org/W2057157925","https://openalex.org/W2058734183","https://openalex.org/W2059139768","https://openalex.org/W2059530215","https://openalex.org/W2059599014","https://openalex.org/W2062395208","https://openalex.org/W2063255660","https://openalex.org/W2063485448","https://openalex.org/W2063671667","https://openalex.org/W2067202687","https://openalex.org/W2070040271","https://openalex.org/W2072648109","https://openalex.org/W2072703892","https://openalex.org/W2073224583","https://openalex.org/W2074619878","https://openalex.org/W2076737381","https://openalex.org/W2077701521","https://openalex.org/W2078836898","https://openalex.org/W2080170732","https://openalex.org/W2080373577","https://openalex.org/W2081209638","https://openalex.org/W2082016730","https://openalex.org/W2084311974","https://openalex.org/W2085828264","https://openalex.org/W2087450115","https://openalex.org/W2090518780","https://openalex.org/W2090540214","https://openalex.org/W2093938367","https://openalex.org/W2094165314","https://openalex.org/W2096488529","https://openalex.org/W2097178761","https://openalex.org/W2100379825","https://openalex.org/W2100392330","https://openalex.org/W2100678115","https://openalex.org/W2101314011","https://openalex.org/W2102318515","https://openalex.org/W2102799750","https://openalex.org/W2104028187","https://openalex.org/W2104921070","https://openalex.org/W2106181496","https://openalex.org/W2106203321","https://openalex.org/W2106319588","https://openalex.org/W2107122524","https://openalex.org/W2109108939","https://openalex.org/W2110034172","https://openalex.org/W2111563692","https://openalex.org/W2113317598","https://openalex.org/W2114232003","https://openalex.org/W2115328944","https://openalex.org/W2116293168","https://openalex.org/W2118898660","https://openalex.org/W2120001000","https://openalex.org/W2122588714","https://openalex.org/W2123035994","https://openalex.org/W2123236989","https://openalex.org/W2123869309","https://openalex.org/W2124588568","https://openalex.org/W2125633197","https://openalex.org/W2126300366","https://openalex.org/W2127951128","https://openalex.org/W2128168840","https://openalex.org/W2128843953","https://openalex.org/W2130239422","https://openalex.org/W2131141015","https://openalex.org/W2131202416","https://openalex.org/W2132831536","https://openalex.org/W2133512186","https://openalex.org/W2134014146","https://openalex.org/W2136335783","https://openalex.org/W2136358097","https://openalex.org/W2136841466","https://openalex.org/W2137009239","https://openalex.org/W2138946261","https://openalex.org/W2139197862","https://openalex.org/W2140404441","https://openalex.org/W2141399302","https://openalex.org/W2142614652","https://openalex.org/W2144228138","https://openalex.org/W2144541431","https://openalex.org/W2144820037","https://openalex.org/W2145897785","https://openalex.org/W2146051938","https://openalex.org/W2146071785","https://openalex.org/W2149069408","https://openalex.org/W2150504557","https://openalex.org/W2152096888","https://openalex.org/W2152350731","https://openalex.org/W2152745568","https://openalex.org/W2153231621","https://openalex.org/W2153593336","https://openalex.org/W2154001085","https://openalex.org/W2154572715","https://openalex.org/W2158196528","https://openalex.org/W2158287992","https://openalex.org/W2159148316","https://openalex.org/W2159323339","https://openalex.org/W2159379031","https://openalex.org/W2160514176","https://openalex.org/W2162377106","https://openalex.org/W2164615751","https://openalex.org/W2164936466","https://openalex.org/W2165340553","https://openalex.org/W2167135785","https://openalex.org/W2168947486","https://openalex.org/W2169927995","https://openalex.org/W2172114097","https://openalex.org/W2318019475","https://openalex.org/W2320426359","https://openalex.org/W2955504961","https://openalex.org/W3146264547"],"related_works":["https://openalex.org/W3199935512","https://openalex.org/W6977740491","https://openalex.org/W119648059","https://openalex.org/W4307328259","https://openalex.org/W7100338076","https://openalex.org/W4238882601","https://openalex.org/W3014542271","https://openalex.org/W935416757","https://openalex.org/W230886634","https://openalex.org/W7131095143"],"abstract_inverted_index":{"__Abstract__":[0],"\\n":[1],"\\nAortic":[2],"disease":[3],"represents":[4],"one":[5],"of":[6,10,20,38,46,72,83,105,132],"the":[7,15,39,47,70,73,81,84,88,94,120],"major":[8],"causes":[9,76],"morbidity":[11],"and":[12,28,86,109,127],"mortality":[13,103,131],"in":[14,55,69,119],"\\nindustrialized":[16],"society.":[17],"Approximately":[18],"2%":[19],"all":[21],"deaths":[22],"are":[23,32,123],"caused":[24],"by":[25],"aortic":[26,58,63,139],"aneurysm":[27,52],"\\ndissections":[29],"[1].":[30],"Aneurysms":[31],"defined":[33],"as":[34],"a":[35,56,67,102],"local":[36],"widening":[37],"artery":[40,74],"with":[41],"more":[42],"than":[43],"\\n50":[44],"percent":[45],"normal":[48],"diameter":[49],"[2].":[50],"An":[51],"can":[53],"result":[54],"fatal":[57],"rupture":[59],"or":[60],"\\nin":[61],"an":[62,129,137],"dissection,":[64],"which":[65],"is":[66],"tear":[68],"wall":[71,85],"that":[75],"blood":[77],"to":[78],"flow":[79],"\\nbetween":[80],"layers":[82,89],"forces":[87],"apart":[90],"[3].":[91],"Dissections":[92],"involving":[93],"\\nascending":[95],"aorta,":[96],"Stanford":[97],"type":[98],"A":[99],"dissections,":[100],"have":[101,128],"rate":[104],"1-2%":[106],"per":[107],"hour":[108],"\\nshould":[110],"be":[111],"immediately":[112],"treated":[113,125],"surgically":[114],"[4],":[115],"while":[116],"dissections":[117],"occurring":[118],"descending":[121],"\\naorta":[122],"usually":[124],"medically":[126],"in-hospital":[130],"about":[133],"10%":[134],"[5].":[135],"\\nHowever,":[136],"acute":[138],"dissecti":[140]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}