{"id":"https://openalex.org/W2272922490","doi":null,"title":"Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.","display_name":"Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W2272922490","mag":"2272922490","pmid":"https://pubmed.ncbi.nlm.nih.gov/15073265"},"language":"en","primary_location":{"id":"pmid:15073265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15073265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013491696","display_name":"Kun\u2010Ju Lin","orcid":"https://orcid.org/0000-0003-1933-4564","observed_orcids":["https://orcid.org/0000-0003-1933-4564"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kun-Ju Lin","raw_affiliation_strings":["Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Tao-Yuan, Taiwan","chang gung university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Tao-Yuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"chang gung university","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113518516","display_name":"Tzu Chen Yen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Chen Yen","raw_affiliation_strings":["chang gung university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"chang gung university","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026217046","display_name":"Shiaw\u2010Pyng Wey","orcid":"https://orcid.org/0000-0002-7222-2601","observed_orcids":["https://orcid.org/0000-0002-7222-2601"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shiaw-Pyng Wey","raw_affiliation_strings":["chang gung university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"chang gung university","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054687824","display_name":"Jeng\u2010Jong Hwang","orcid":"https://orcid.org/0000-0002-3847-4426","observed_orcids":["https://orcid.org/0000-0002-3847-4426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeng-Jong Hwang","raw_affiliation_strings":["Department of Biomedical Imaging and Radiological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Imaging and Radiological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109087809","display_name":"Xin-Xian Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-Xian Ye","raw_affiliation_strings":["Brain Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044141560","display_name":"Kai\u2010Yuan Tzen","orcid":"https://orcid.org/0000-0002-5657-8579","observed_orcids":["https://orcid.org/0000-0002-5657-8579"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Yuan Tzen","raw_affiliation_strings":["chang gung university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"chang gung university","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100738024","display_name":"Ying Fu","orcid":"https://orcid.org/0000-0002-0242-1605","observed_orcids":["https://orcid.org/0000-0002-0242-1605"]},"institutions":[{"id":"https://openalex.org/I4210140015","display_name":"Institute of Nuclear Energy Research","ror":"https://ror.org/052jx3443","country_code":"TW","type":"government","lineage":["https://openalex.org/I2802216821","https://openalex.org/I4210140015"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Kai Fu","raw_affiliation_strings":["Institute of Nuclear Energy Research Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Nuclear Energy Research Taiwan","institution_ids":["https://openalex.org/I4210140015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027466098","display_name":"Jin\u2010Chung Chen","orcid":"https://orcid.org/0000-0003-2996-5781","observed_orcids":["https://orcid.org/0000-0003-2996-5781"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jin-Chung Chen","raw_affiliation_strings":["chang gung university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"chang gung university","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0856,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.70471711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"673","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.4088999927043915,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6340000033378601},{"id":"https://openalex.org/keywords/p-chloroamphetamine","display_name":"p-chloroamphetamine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.8999999761581421},{"id":"https://openalex.org/keywords/biogenic-amines","display_name":"biogenic amines","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dorsal-raphe-nucleus","display_name":"dorsal raphe nucleus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/serotonergic-neurons","display_name":"serotonergic neurons","score":0.7639999985694885},{"id":"https://openalex.org/keywords/quantitative-autoradiography","display_name":"quantitative autoradiography","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.842475414276123},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6903171539306641},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.6889857053756714},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6881735920906067},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.61403489112854},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5921178460121155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5880341529846191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4800871014595032},{"id":"https://openalex.org/C44107871","wikidata":"https://www.wikidata.org/wiki/Q17148165","display_name":"Interpeduncular nucleus","level":4,"score":0.4788782000541687},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.47015950083732605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4543142318725586},{"id":"https://openalex.org/C2776570665","wikidata":"https://www.wikidata.org/wiki/Q6806127","display_name":"Median raphe nucleus","level":5,"score":0.4488910138607025},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4329584836959839},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.36335718631744385},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3438318967819214},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33535534143447876},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.30281394720077515},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.2751173675060272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26305997371673584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14053875207901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1342107057571411},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001679","descriptor_name":"Biogenic Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002928","descriptor_name":"Cinanserin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002928","descriptor_name":"Cinanserin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010133","descriptor_name":"p-Chloroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:15073265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15073265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.313.8221","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.313.8221","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/45/4/673.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ae755c9d-dbde-4b41-96a0-55f50d981746","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ae755c9d-dbde-4b41-96a0-55f50d981746","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lin, KJ, Yen, TC, Wey, SP, Hwang, JJ, Ye, XX, Tzen, K Y, Fu, Y K & Chen, JC 2004, 'Characterization of the binding sites of [123I]ADAM and the relationship to serotonin transporter in rat and mouse brains using quantitative autoradiography', J Nucl Med, vol. 45, pp. 673-681.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2272922490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15073265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W196240282","https://openalex.org/W1965694122","https://openalex.org/W2000904449","https://openalex.org/W2007102622","https://openalex.org/W2008700794","https://openalex.org/W2011010617","https://openalex.org/W2030633339","https://openalex.org/W2046295391","https://openalex.org/W2046575058","https://openalex.org/W2081701126","https://openalex.org/W2082657969","https://openalex.org/W2088150709","https://openalex.org/W2089387504","https://openalex.org/W2110020124","https://openalex.org/W2110958252","https://openalex.org/W2118035595","https://openalex.org/W2163815564","https://openalex.org/W2188455049","https://openalex.org/W2313957375"],"related_works":["https://openalex.org/W7100870130","https://openalex.org/W2007102622","https://openalex.org/W2169312768","https://openalex.org/W2080031283","https://openalex.org/W2363675965","https://openalex.org/W2070160503","https://openalex.org/W2011060386","https://openalex.org/W2131477034","https://openalex.org/W1978313278","https://openalex.org/W2030633339"],"abstract_inverted_index":{"UNLABELLED:":[0],"Imaging":[1],"of":[2,40,50,91,100,106,208,219,235,265,286],"serotonin":[3,86,220,287],"transporter":[4],"(SERT)":[5],"in":[6,57,77,118,132,182,195,200,212,217,224,244,267,276,289],"the":[7,46,71,78,98,140,158,183,215,225,241,263],"central":[8,256],"nervous":[9],"system":[10],"may":[11],"provide":[12],"an":[13,280],"important":[14],"tool":[15],"to":[16,44,52,73,96,102,240,274],"evaluate":[17,97],"some":[18],"psychiatric":[19],"disorders.":[20],"Recently,":[21],"a":[22,33,163],"novel":[23],"(123)I-labeled":[24],"radiotracer,":[25],"2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine":[26],"((123)I-ADAM),":[27],"has":[28],"been":[29],"developed":[30],"that":[31,129,232,253],"exhibited":[32],"high":[34],"selectivity":[35],"for":[36,283],"SERT.":[37,103],"The":[38,104,125,153,198],"aim":[39],"this":[41],"study":[42,230],"was":[43,67,179,202,211],"characterize":[45],"biodistribution":[47,76],"and":[48,60,112,120,150,192,210,221,247],"specificity":[49,99],"(123)I-ADAM":[51,64,101,116,130,177,236,266,279],"SERT":[53,242,275],"using":[54],"quantitative":[55,81,115],"autoradiography":[56],"both":[58,245],"control":[59,119],"neurotoxin-treated":[61],"animals.":[62],"METHODS:":[63],"(74":[65],"MBq)":[66],"injected":[68],"intravenously":[69],"into":[70],"mice":[72],"access":[74],"its":[75],"brain":[79,134,269],"via":[80],"autoradiography.":[82],"Further,":[83],"rats":[84],"with":[85,114,162,214],"depleted":[87],"by":[88],"intraperitoneal":[89],"injection":[90],"p-chloroamphetamine":[92],"(PCA)":[93],"were":[94,109],"used":[95],"levels":[105],"biogenic":[107],"amines":[108],"then":[110],"measured":[111],"correlated":[113],"labeling":[117],"PCA-treated":[121],"rat":[122,246],"brains.":[123,249],"RESULTS:":[124],"autoradiographic":[126],"results":[127],"showed":[128],"accumulated":[131],"SERT-rich":[133],"areas":[135],"after":[136,175,259],"systemic":[137],"injection,":[138],"including":[139],"globus":[141],"pallidus,":[142],"thalamus,":[143,185],"hypothalamus,":[144,189],"substantia":[145,193],"nigra,":[146],"interpeduncular":[147],"nucleus,":[148,191],"amygdala,":[149,186],"raphe":[151,155,190],"nucleus.":[152],"dorsal":[154],"nucleus":[156],"had":[157],"highest":[159],"initial":[160],"uptake":[161,178,264],"peak":[164],"specific":[165,272],"binding":[166,273],"ratio":[167],"(i.e.,":[168],"[target":[169],"-":[170],"cerebellum]/cerebellum)":[171],"at":[172,205],"120":[173],"min":[174],"injection.":[176],"dramatically":[180],"decreased":[181],"hippocampus,":[184],"geniculate":[187],"nuclei,":[188],"nigra":[194],"PCA-lesioned":[196],"rats.":[197],"decrement":[199],"radioactivity":[201,237],"more":[203],"prominent":[204],"higher":[206],"dosages":[207],"PCA":[209,260],"parallel":[213],"changes":[216],"amounts":[218],"5-hydroxyindoleacetic":[222],"acid":[223],"prefrontal":[226],"cortex.":[227],"CONCLUSION:":[228],"This":[229],"demonstrates":[231],"regional":[233],"distribution":[234],"is":[238],"similar":[239],"localization":[243],"mouse":[248],"We":[250],"also":[251],"validated":[252],"destruction":[254],"on":[255],"serotonergic":[257],"neurons":[258],"treatment":[261],"inhibits":[262],"serotonin-rich":[268],"regions.":[270],"High":[271],"vivo":[277],"makes":[278],"appropriate":[281],"radiotracer":[282],"solitary":[284],"studies":[285],"functions":[288],"living":[290],"humans.":[291]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
