{"id":"https://openalex.org/W2272575121","doi":"https://doi.org/10.1017/s0007114599000306","title":"Effects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (fa/fa) Zucker rats","display_name":"Effects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (fa/fa) Zucker rats","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2272575121","doi":"https://doi.org/10.1017/s0007114599000306","mag":"2272575121","pmid":"https://pubmed.ncbi.nlm.nih.gov/10450335"},"language":"en","primary_location":{"id":"doi:10.1017/s0007114599000306","doi":"https://doi.org/10.1017/s0007114599000306","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114599000306","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/69049066E9ED55553EAAF145096F6330/S0007114599000306a.pdf/div-class-title-effects-of-simmondsin-on-food-intake-growth-and-metabolic-variables-in-lean-and-obese-span-class-italic-fa-fa-span-zucker-rats-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/69049066E9ED55553EAAF145096F6330/S0007114599000306a.pdf/div-class-title-effects-of-simmondsin-on-food-intake-growth-and-metabolic-variables-in-lean-and-obese-span-class-italic-fa-fa-span-zucker-rats-div.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012671450","display_name":"Gerda Flo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Flo","raw_affiliation_strings":["Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068703024","display_name":"Sabien Vermaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. Vermaut","raw_affiliation_strings":["Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048475867","display_name":"Veerle Darras","orcid":"https://orcid.org/0000-0003-4429-8868","observed_orcids":["https://orcid.org/0000-0003-4429-8868"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V. M. Darras","raw_affiliation_strings":["Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016292378","display_name":"Maurits Van Boven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Van Boven","raw_affiliation_strings":["Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087556846","display_name":"Eddy M. P. Decuypere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Decuypere","raw_affiliation_strings":["Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071396382","display_name":"Ralf K\u00fchn","orcid":"https://orcid.org/0000-0003-1694-9803","observed_orcids":["https://orcid.org/0000-0003-1694-9803"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R. K\u00fchn","raw_affiliation_strings":["Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085776117","display_name":"Paul Daenens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. Daenens","raw_affiliation_strings":["Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015522884","display_name":"Marnix M. Cokelaere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"M. Cokelaere","raw_affiliation_strings":["Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015522884"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.2528,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5118583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"2","first_page":"159","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simmondsin","display_name":"simmondsin","score":1.0},{"id":"https://openalex.org/keywords/anorexigenic-agents","display_name":"anorexigenic agents","score":0.6740000247955322},{"id":"https://openalex.org/keywords/food-intake-reduction","display_name":"hypophagia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.652999997138977},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.6729999780654907},{"id":"https://openalex.org/keywords/growth","display_name":"growth","score":0.44600000977516174},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pair-feeding","display_name":"pair feeding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fat-deposition","display_name":"fat deposition","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8144370317459106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8039056062698364},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7613519430160522},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6052833199501038},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.5562531352043152},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45723021030426025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41686341166496277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34588637948036194}],"mesh":[{"descriptor_ui":"D000097","descriptor_name":"Acetonitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001067","descriptor_name":"Appetite Depressants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006128","descriptor_name":"Growth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1017/s0007114599000306","doi":"https://doi.org/10.1017/s0007114599000306","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114599000306","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/69049066E9ED55553EAAF145096F6330/S0007114599000306a.pdf/div-class-title-effects-of-simmondsin-on-food-intake-growth-and-metabolic-variables-in-lean-and-obese-span-class-italic-fa-fa-span-zucker-rats-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},{"id":"pmid:10450335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10450335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/20032","doi":null,"is_oa":false,"landing_page_url":"http://openurl.ingenta.com/content/nlm?genre=article&issn=0007-1145&volume=81&issue=2&spage=159&aulast=Flo","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Nutrition, vol. 81 (2), (159-67)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1017/s0007114599000306","doi":"https://doi.org/10.1017/s0007114599000306","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114599000306","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/69049066E9ED55553EAAF145096F6330/S0007114599000306a.pdf/div-class-title-effects-of-simmondsin-on-food-intake-growth-and-metabolic-variables-in-lean-and-obese-span-class-italic-fa-fa-span-zucker-rats-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4359000027179718}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2272575121.pdf","grobid_xml":"https://content.openalex.org/works/W2272575121.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W244591058","https://openalex.org/W612997969","https://openalex.org/W613029614","https://openalex.org/W1966180039","https://openalex.org/W1976629385","https://openalex.org/W1988263024","https://openalex.org/W1992077067","https://openalex.org/W1995913192","https://openalex.org/W1996634799","https://openalex.org/W1999068243","https://openalex.org/W2008546480","https://openalex.org/W2020472190","https://openalex.org/W2028654736","https://openalex.org/W2029707431","https://openalex.org/W2049723996","https://openalex.org/W2054526510","https://openalex.org/W2068761967","https://openalex.org/W2071346592","https://openalex.org/W2092595434","https://openalex.org/W2095308289","https://openalex.org/W2102611868","https://openalex.org/W2125510262","https://openalex.org/W2168871248","https://openalex.org/W2180503927","https://openalex.org/W2256203853","https://openalex.org/W2278908280","https://openalex.org/W2409944325","https://openalex.org/W2443246591","https://openalex.org/W2460531272","https://openalex.org/W6694752970"],"related_works":["https://openalex.org/W2531161231","https://openalex.org/W2008546480","https://openalex.org/W2027973164","https://openalex.org/W1988263024","https://openalex.org/W2057066892","https://openalex.org/W2523813015","https://openalex.org/W2075731754","https://openalex.org/W1975582761","https://openalex.org/W2025833039","https://openalex.org/W1974436013"],"abstract_inverted_index":{"Incorporation":[0],"of":[1,4,36,90,117,191,222],"2.5":[2],"g/kg":[3],"the":[5,9,24,32,55,114,187,208,220],"anorexigen,":[6],"simmondsin,":[7],"in":[8,12,16,50,59,77,81,100,113,126,148,154,170,176,180,196,201,217,230],"diet":[10],"resulted":[11,175],"food":[13,33,163,188,227],"intake":[14,85,164,228],"reduction":[15],"both":[17,39,127,155],"lean":[18,42,82,133,158,203,233],"and":[19,41,73,129,132,157,165,205,213,232],"obese":[20,25,40,78,131,156,171,197,218,231],"Zucker":[21,44,134,198,234],"rats;":[22],"however,":[23],"rats":[26,79,135,159,199],"were":[27,124],"much":[28],"more":[29,194],"sensitive":[30],"to":[31,145,226],"intake-reducing":[34,189],"activity":[35],"simmondsin.":[37],"In":[38],"simmondsin-treated":[43,128],"rats,":[45,52,172],"growth":[46],"was":[47,54,142],"slower":[48],"than":[49,80,200],"control":[51,138],"but":[53,106,169],"same":[56],"as":[57,87],"that":[58,186],"pair-fed":[60,130],"animals.":[61],"The":[62],"24":[63],"h":[64],"heat":[65,102,118],"production":[66],"pattern":[67],"showed":[68],"a":[69,74,88,98,111],"smaller":[70],"diurnal":[71,115],"variation":[72,116],"lower":[75],"mean":[76,101],"rats.":[83,235],"Food":[84],"reduction,":[86],"result":[89],"either":[91],"simmondsin":[92,173,192,223],"treatment":[93,174],"or":[94],"pair":[95,108],"feeding,":[96,109],"caused":[97,110],"decrease":[99,112,179],"production.":[103,119],"Simmondsin":[104],"treatment,":[105],"not":[107],"Plasma":[120],"total":[121,214],"cholesterol":[122,215],"levels":[123,153],"increased":[125],"compared":[136],"with":[137,161],"animals;":[139],"this":[140],"increase":[141,147],"mainly":[143],"due":[144],"an":[146,177],"HDL-cholesterol":[149],"levels.":[150,182],"Blood":[151],"leptin":[152,181,212],"decreased":[160,162,166],"fat":[167],"deposition,":[168],"additional":[178],"It":[183],"is":[184,193],"concluded":[185],"effect":[190],"pronounced":[195],"their":[202],"littermates,":[204,219],"except":[206],"for":[207],"simmondsin-specific":[209],"effects":[210,221],"on":[211],"values":[216],"are":[224],"related":[225],"restriction":[229]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}