{"id":"https://openalex.org/W2272047358","doi":null,"title":"Accelaratory effect of ethanolic extract of piper betel on gastrointestinal transit: involving calcium innervations in mice.","display_name":"Accelaratory effect of ethanolic extract of piper betel on gastrointestinal transit: involving calcium innervations in mice.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2272047358","mag":"2272047358"},"language":"en","primary_location":{"id":"mag:2272047358","doi":null,"is_oa":false,"landing_page_url":"https://sphinxsai.com/sphinxsaiVol_2No.1/PharmTech_Vol_2No.1/PharmTech_Vol_2No.1PDF/PT=89%20(563-567).pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764949835","display_name":"International Journal of PharmTech Research","issn_l":"0974-4304","issn":["0974-4304","2455-9563"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of PharmTech Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083536137","display_name":"Pushpendra Singh Dhaked","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pushpendra Singh Dhaked","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060177804","display_name":"G. B. Bairagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. B. Bairagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013378497","display_name":"A. D. Hatkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. D. Hatkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053013849","display_name":"S. D. Zaferuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. D. Zaferuddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111661945","display_name":"S. V. Tembhurne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. V. Tembhurne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112100755","display_name":"D. M. Sakarkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. Sakarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"563","last_page":"567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.14499999582767487,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piper-betle","display_name":"Piper betle","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ethanolic-plant-extract","display_name":"ethanolic plant extract","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gastrointestinal-transit","display_name":"gastrointestinal transit","score":0.8870000243186951},{"id":"https://openalex.org/keywords/small-intestinal-motility","display_name":"small intestine motility","score":0.9890000224113464},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.7919999957084656},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8880000114440918},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.875},{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.9010000228881836},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/antispasmodic-activity","display_name":"antispasmodic activity","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2777155639","wikidata":"https://www.wikidata.org/wiki/Q159536","display_name":"Piper","level":2,"score":0.6657431721687317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6146043539047241},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5810688734054565},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.5800284743309021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5401735305786133},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5088789463043213},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5065699815750122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26969078183174133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20989811420440674},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2272047358","doi":null,"is_oa":false,"landing_page_url":"https://sphinxsai.com/sphinxsaiVol_2No.1/PharmTech_Vol_2No.1/PharmTech_Vol_2No.1PDF/PT=89%20(563-567).pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764949835","display_name":"International Journal of PharmTech Research","issn_l":"0974-4304","issn":["0974-4304","2455-9563"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of PharmTech Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1516221483","https://openalex.org/W1989697076","https://openalex.org/W2011082914","https://openalex.org/W2035220621","https://openalex.org/W2070479673","https://openalex.org/W2123135608","https://openalex.org/W2158950531","https://openalex.org/W2163156834","https://openalex.org/W2171472795","https://openalex.org/W2184661563","https://openalex.org/W2397026945","https://openalex.org/W2428417710"],"related_works":["https://openalex.org/W1988390032","https://openalex.org/W4297168901","https://openalex.org/W2413416015","https://openalex.org/W1984881992","https://openalex.org/W2101701298","https://openalex.org/W2070212509","https://openalex.org/W2544214684","https://openalex.org/W2359945979","https://openalex.org/W2034964465","https://openalex.org/W3000074475"],"abstract_inverted_index":{"Piper":[0,68,264],"Betel":[1],"Popularly":[2],"known":[3],"as":[4,247,249,254],"\u2018Pan\u2019":[5],"in":[6,26,120,147,186],"India":[7],"belongs":[8],"to":[9,60,83,157,164,170,177,195,217,229],"family":[10],"Piperaceae.":[11],"Medicinally":[12],"it":[13,154,193],"has":[14],"stimulant,":[15],"antiseptic,":[16],"sialogogue":[17],"activity.":[18],"It":[19,34],"is":[20,24],"reported":[21],"that":[22,141],"calcium":[23,45,118,245],"involved":[25],"the":[27,44,62,100,144,159,197,202,260],"initiation":[28],"of":[29,31,64,67,113,117,133,138,191,199,213,224,235,263],"contraction":[30],"smooth":[32,48],"muscle.":[33],"increases":[35],"small":[36,72,267],"intestinal":[37,54,73,145,268],"motility":[38,74,122],"through":[39,244],"L-Type":[40],"channel.":[41],"Chlorpromazine":[42,180],"blocks":[43],"channel":[46,119],"on":[47,71,266],"muscle":[49],"and":[50,78,103],"relaxes":[51],"by":[52,184,250],"attenuating":[53],"motility.":[55],"The":[56,136,211],"present":[57],"study":[58,139],"was":[59,93,127,155,168,205],"evaluate":[61],"influence":[63],"ethanolic":[65],"extract":[66],"betel":[69,265],"(EtPB)":[70],"(SIT).":[75],"EtPB":[76,142,192,214,225,238],"(400":[77],"800":[79],"mg/kg":[80],"p.o.)":[81,97],"administered":[82,94],"15":[84],"hrs":[85],"fasted":[86],"Swiss":[87],"albino":[88],"mice.":[89,149,188],"4%":[90],"charcoal":[91],"meal":[92],"(10":[95],"ml/kg":[96],"1hr":[98],"after":[99,104],"drug":[101,134],"administration":[102,132],"20":[105],"min":[106,130],"all":[107],"animals":[108],"were":[109],"dissected":[110],"for":[111],"determination":[112],"SIT.":[114],"For":[115],"exploration":[116],"gastrointestinal":[121],"chlorpromazine":[123,226,255],"(5mg/kg":[124],"p.":[125],"o.)":[126],"administer":[128],"30":[129],"prior":[131],"respectively.":[135],"results":[137,212],"indicate":[140],"accelerate":[143,158],"transit":[146,160,183],"normal":[148,165,187],"A":[150],"highest":[151],"dose":[152],"(800mg/kg)":[153],"found":[156,169],"upto":[161,231],"91.4%":[162],"compared":[163,176],"mice":[166],"which":[167],"significant":[171,203],"at":[172,208],"(P":[173],"<":[174],"0.05)":[175],"vehicle":[178],"group.":[179],"inhibits":[181],"GI":[182],"28.85%":[185],"In":[189,222],"presence":[190,223],"able":[194,228],"reverse":[196],"effect":[198,204,243,262],"chlorpromazine,":[200],"while":[201],"observed":[206],"only":[207],"800mg/kg":[209],"EtPB.":[210],"are":[215],"comparable":[216],"standard":[218],"Metaclopramide":[219],"(10mg/kg":[220],"p.o.).":[221],"could":[227,239,256],"produce":[230,241],"26.68":[232],"%":[233],"inhibitions":[234],"SIT":[236],"indicates":[237],"partly":[240],"acceleratory":[242,261],"involvement":[246],"well":[248],"some":[251],"other":[252],"pathway":[253],"not":[257],"completely":[258],"inhibit":[259],"transit.":[269]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}