{"id":"https://openalex.org/W2271928751","doi":null,"title":"Evaluation of topoisomerase I inhibitors, antitubulin inhibitors, and antimetabolites in bone marrow CFU-GM assays","display_name":"Evaluation of topoisomerase I inhibitors, antitubulin inhibitors, and antimetabolites in bone marrow CFU-GM assays","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2271928751","mag":"2271928751"},"language":"en","primary_location":{"id":"mag:2271928751","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/C221","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110472282","display_name":"Rebecca G. Bagley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca G. Bagley","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001253246","display_name":"Leslie S. Kurtzberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie Kurtzberg","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041880587","display_name":"C\u00e9cile Rouleau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9cile Rouleau","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035349962","display_name":"Min Yao","orcid":"https://orcid.org/0000-0002-3743-8300","observed_orcids":["https://orcid.org/0000-0002-3743-8300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Yao","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":"https://orcid.org/0000-0002-3743-8300","affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103531329","display_name":"Xian\u2010Jie Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian\u2010Jie Yu","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040137655","display_name":"Beverly A. Teicher","orcid":"https://orcid.org/0000-0003-1535-7304","observed_orcids":["https://orcid.org/0000-0003-1535-7304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beverly A. Teicher","raw_affiliation_strings":["Genzyme Corporation, Framingham, MA"],"raw_orcid":"https://orcid.org/0000-0003-1535-7304","affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17844485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antitubulin-agents","display_name":"antitubulin agents","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antimetabolites","display_name":"antimetabolites","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9010000228881836},{"id":"https://openalex.org/keywords/granulocyte-macrophage-progenitor-cells","display_name":"granulocyte-macrophage progenitor cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.8519999980926514},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.996999979019165},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.871999979019165},{"id":"https://openalex.org/keywords/clofarabine","display_name":"clofarabine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ic90","display_name":"IC90","score":0.781000018119812},{"id":"https://openalex.org/keywords/anticancer-drug-toxicity","display_name":"anticancer drug toxicity","score":0.42899999022483826},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6908119320869446},{"id":"https://openalex.org/C2781209748","wikidata":"https://www.wikidata.org/wiki/Q419953","display_name":"Topotecan","level":3,"score":0.6686185002326965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5837878584861755},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5696460008621216},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.5644977688789368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44770270586013794},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.4300180971622467},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.42976775765419006},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.4181172251701355},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41578397154808044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37684619426727295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3428284823894501},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31783202290534973},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29500436782836914},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28906118869781494},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.26716649532318115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21554982662200928},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08710554242134094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2271928751","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/C221","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096394765","https://openalex.org/W2035973118","https://openalex.org/W2005986662","https://openalex.org/W1995743646","https://openalex.org/W2118642576","https://openalex.org/W1982667027","https://openalex.org/W2418382380","https://openalex.org/W211465876","https://openalex.org/W1992992082","https://openalex.org/W2736850621"],"abstract_inverted_index":{"C221":[0],"Bone":[2],"marrow":[3,31,54,171,353],"toxicity":[4],"is":[5,16,105,138,150,156],"often":[6],"a":[7,157,181,185,335,342],"dose-limiting":[8],"side":[9],"effect":[10],"of":[11,28,45,90,337,344,366,431],"anticancer":[12],"chemotherapeutic":[13],"agents":[14,73,271,303],"that":[15,376,417],"not":[17],"observed":[18],"in":[19,49,140,184,370,421],"preclinical":[20],"efficacy":[21],"models":[22,207],"due":[23],"to":[24,37,122,177,203,330,341,358,385,402],"the":[25,98,116,141,164,230,269,359,367,389,399,414,422],"greater":[26,380],"tolerance":[27],"murine":[29,50,169,329,386,409],"bone":[30,53,99,170,352,363],"cells":[32,95,174],"(BMC)":[33],"vs.":[34,408],"human":[35,52,167,222,236,265,297,331,351,382,406,435],"BMC":[36,383,407,410],"these":[38,178,403,432],"agents.":[39],"Small":[40],"molecules":[41],"with":[42,393],"different":[43,397],"mechanisms":[44],"action":[46],"were":[47,63,175,192,198,227,239,272,304,355,377],"tested":[48,369,391],"and":[51,77,92,110,115,129,131,145,205,208,214,223,235,242,249,255,258,264,275,282,287,290,296,307,314,319,322],"granulocyte_macrophage":[55],"progenitor":[56,173],"colony":[57],"forming":[58],"assays":[59,372],"(CFU-GM).":[60],"IC90":[61,215,225,298,328,374],"values":[62,226,299],"determined":[64,220],"for":[65,86,108,143,152,216,221,229,245,252,261,268,278,285,293,301,310,317,325,339,346,413],"topoisomerase":[66,134,231],"I":[67,135,161,232],"inhibitors":[68],"(topotecan,":[69],"irinotecan,":[70],"ARC111,":[71,246],"anti-tubulin":[72,102,270],"(paclitaxel,":[74],"tasidotin,":[75],"vincristine),":[76],"anti-metabolites":[78,83],"(cladribine,":[79],"fludarabine,":[80,318],"clofarabine).":[81],"The":[82,101,133,195,327],"are":[84,120],"approved":[85,107,151],"treating":[87],"various":[88],"forms":[89],"leukemias":[91],"lymphomas,":[93],"malignant":[94],"originating":[96],"from":[97,334],"marrow.":[100,364],"agent":[103,118],"vincristine":[104],"also":[106],"lymphoma":[109],"leukemia":[111],"patients":[112],"while":[113,148,188],"paclitaxel":[114],"investigational":[117],"tasidotin":[119],"used":[121,139],"treat":[123],"solid":[124],"tumors":[125],"such":[126],"as":[127],"breast":[128],"lung":[130,146],"melanoma.":[132],"inhibitor":[136],"topotecan":[137],"clinic":[142,423],"ovarian":[144],"cancer":[147,394],"irinotecan":[149,253],"colon":[153],"cancer;":[154],"ARC111":[155],"novel":[158],"experimental":[159],"topisomerase":[160],"inhibitor.":[162],"In":[163,348],"CFU-GM":[165,354,371],"assays,":[166],"or":[168],"granulocyte-macrophage":[172],"exposed":[176],"drugs":[179,368,404],"over":[180],"2-week":[182],"period":[183],"methylcellulose":[186],"matrix":[187],"colonies":[189],"formed.":[190],"Colonies":[191],"counted":[193],"manually.":[194],"survival":[196],"data":[197],"analyzed":[199],"by":[200,396,405],"curve":[201],"fitting":[202],"exponential":[204],"probit":[206],"95%":[209],"confidence":[210],"intervals":[211],"around":[212],"IC50":[213],"each":[217],"compound":[218],"was":[219],"mouse.":[224],"lowest":[228],"inhibitors.":[233],"Murine":[234,263,295],"IC90s":[237],"respectively":[238,300],"35":[240],"nM":[241,244,248,251,257,260],"5":[243,276],"250":[247],"19":[250],"(SN38),":[254],">500":[256],"20":[259],"topotecan.":[262,347],"IC90s,":[266],"respectively,":[267],"28":[273],"uM":[274,277,281,284,289,292,306,309,313,316,321,324],"paclitaxel,":[279],"23":[280],"3.3":[283],"vincristine,":[286],">300":[288],"43":[291],"tasidotin.":[294],"anti-metabolite":[302],"1.4":[305,320],"0.13":[308],"cladribine,":[311],"62":[312],"5.2":[315],"0.47":[323],"clofarabine.":[326],"differentials":[332,375],"varied":[333],"low":[336],"3-fold":[338],"clofarabine":[340],"high":[343],">25":[345],"all":[349],"cases,":[350],"more":[356],"sensitive":[357],"compounds":[360,433],"than":[361,434],"mouse":[362],"Many":[365],"generated":[373],"7-13":[378],"fold":[379],"on":[381],"compared":[384],"BMC.":[387],"Although":[388],"chemotherapeutics":[390],"interfere":[392],"growth":[395],"mechanisms,":[398],"increased":[400],"sensitivity":[401],"has":[411],"implications":[412],"therapeutic":[415],"index":[416],"would":[418],"be":[419],"experienced":[420],"since":[424],"mice":[425],"can":[426],"tolerate":[427],"higher":[428],"doses/blood":[429],"levels":[430],"patients.":[436]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
