{"id":"https://openalex.org/W227168154","doi":null,"title":"Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism","display_name":"Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism","publication_year":1998,"publication_date":"1998-05-22","ids":{"openalex":"https://openalex.org/W227168154","mag":"227168154"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26903566","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Microdialysis_sampling_from_skeletal_muscle_and_adipose_tissue_with_special_reference_to_the_effects_of_insulin_on_tissue_blood_flow_and_glucose_metabolism/26903566","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085477833","display_name":"Hans G. Rosdahl","orcid":"https://orcid.org/0000-0001-8161-5610","observed_orcids":["https://orcid.org/0000-0001-8161-5610"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hans Rosdahl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8161-5610","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085477833"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.953000009059906},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8130000233650208},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tissue-blood-flow","display_name":"tissue blood flow","score":0.8999999761581421},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8790000081062317},{"id":"https://openalex.org/keywords/interstitial-fluid","display_name":"interstitial fluid","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ethanol-diffusion","display_name":"ethanol diffusion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8230000138282776},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/amino-acid-release","display_name":"amino acid release","score":0.8809999823570251},{"id":"https://openalex.org/keywords/insulin-induced-hypoglycemia","display_name":"insulin-induced hypoglycemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/arteriovenous-glucose-difference","display_name":"arteriovenous glucose difference","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dextran-70","display_name":"dextran 70","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.9300045967102051},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7534691095352173},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7090944647789001},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5297359228134155},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4900428056716919},{"id":"https://openalex.org/C2778514504","wikidata":"https://www.wikidata.org/wiki/Q797559","display_name":"Muscle tissue","level":2,"score":0.4864194393157959},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4703899621963501},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.44456571340560913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4432843327522278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40583041310310364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32930177450180054},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26903566","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Microdialysis_sampling_from_skeletal_muscle_and_adipose_tissue_with_special_reference_to_the_effects_of_insulin_on_tissue_blood_flow_and_glucose_metabolism/26903566","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/43938","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10616/43938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:227168154","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/43938","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095334865","https://openalex.org/W2116851381","https://openalex.org/W2085722628","https://openalex.org/W3112562248","https://openalex.org/W2002297820","https://openalex.org/W1972209552","https://openalex.org/W2152105525","https://openalex.org/W7207764129","https://openalex.org/W1621525738","https://openalex.org/W2111697760"],"abstract_inverted_index":{"The":[0,319,348,431,454,478],"general":[1],"aim":[2],"of":[3,12,19,22,86,122,137,161,180,193,210,241,350,433,456,471,480,494,550],"the":[4,10,20,51,64,78,84,120,135,140,178,197,203,208,234,236,239,291,301,307,314,322,328,336,339,344,374,380,407,446,492,504,539,544],"present":[5,204,545],"thesis":[6],"was":[7,104,143,248,288,304,333,411,435,451,458,485,499,528],"to":[8,373,437,538,554],"explore":[9],"possibility":[11],"using":[13,355,419,551],"rnicrodialysis":[14],"in":[15,30,50,77,108,124,127,130,163,173,196,222,233,238,243,267,272,282,290,306,313,321,327,338,352,424,440,448,460,464,476,482,489,496,517,561],"vivo,":[16],"for":[17,71,413],"studies":[18],"effects":[21,85,209,386],"insulin":[23,370],"on":[24,212,387],"glucose":[25,123,242,325,341,389,434],"metabolism":[26,215,390,562],"and":[27,33,62,83,129,147,169,293,330,357,383,409,417,428,443,507,521,563],"blood":[28,109,165,174,263,286,302,564],"flow":[29,166,175,264,287,303,516],"skeletal":[31,189,223,254,268,353,426,449,461,483,505,519],"muscle":[32,224,354,427,450,462,484,506,520],"adipose":[34,246,273,309,429,441,465,497,522],"tissue.":[35,430],"With":[36,73,277,512],"microdialysis":[37,96,141,396,552],"sampling,":[38],"a":[39,44,58,159,218,361,513,524],"probe":[40],"is":[41,371],"perfused":[42],"with":[43,115,145,149,360,394],"physiological":[45,278],"solution.":[46],"Water":[47],"soluble":[48],"substances":[49,76],"interstitial":[52,101,198,381,401],"fluid":[53],"(lSF)":[54],"will":[55,68,377],"diffuse":[56,378],"across":[57],"semipermeable":[59],"dialysis":[60,358],"membrane":[61],"enter":[63],"perfusate,":[65,375],"which":[66],"finally":[67],"be":[69,81,91,156,184,438,533],"collected":[70],"analysis.":[72],"this":[74,201],"technique,":[75],"ISF":[79,410],"can":[80,90,183],"monitored":[82,186],"locally":[87],"delivered":[88],"drugs":[89],"studied.":[92],"Studies":[93,393],"at":[94],"non-equilibrium":[95],"conditions":[97,397],"(dialysate":[98,398],"concentration":[99,121,240,399,432,447,455,479,493],"<":[100],"concentration)":[102],"It":[103],"found":[105,436],"that":[106,152,207,252,368],"changes":[107,162,172,560],"flow,":[110],"induced":[111],"by":[112,191,260,298,535],"local":[113,385],"perfusion":[114,422,515],"vasoactive":[116],"agents,":[117],"markedly":[118,500],"influenced":[119],"dialysate,":[125],"both":[126,468,503],"rat":[128,188],"human":[131,425,518],"experiments.":[132],"In":[133],"addition,":[134],"diffusion":[136,154],"ethanol":[138,153,299],"from":[139,187,217,245,253],"perfusate":[142,408,526,540],"increased":[144,262,285,305],"vasodilatation":[146],"decreased":[148],"vasoconstriction,":[150],"indicating":[151],"may":[155],"used":[157],"as":[158],"marker":[160],"tissue":[164,247,274,310,388,442,469,498],"(study":[167,228,275,346,391,510,541],"I":[168],"II).":[170],"If":[171],"are":[176],"considered,":[177],"release":[179],"amino":[181,213],"acids":[182],"indirectly":[185],"muscle,":[190,269],"measurements":[192],"their":[194],"concentrations":[195,470],"space.":[199],"Using":[200],"approach":[202],"data":[205],"support":[206],"adrenaline":[211],"acid":[214],"originate":[216],"direct":[219],"hormonal":[220],"interaction":[221],"via":[225],"b-adrenergic":[226],"stimulation":[227],"III).":[229],"During":[230],"insulin-induced":[231,559],"hypoglycaemia":[232],"rat,":[235],"decrease":[237],"dialysate":[244],"significantly":[249],"greater":[250,334],"than":[251,335,463,475,488,502],"muscle.":[255],"These":[256],"decreases":[257],"were":[258,473],"accompanied":[259],"an":[261,284],"(ethanol":[265],"diffusion)":[266],"but":[270,311],"not":[271,312],"IV).":[276],"hyperinsulinaemia":[279],"(at":[280],"euglycaemia)":[281],"humans,":[283],"achieved":[289,412],"calf":[292],"forearm":[294,345],"(plethysmography).":[295],"As":[296],"determined":[297],"diffusion,":[300],"subcutaneous":[308],"gastrocnemius":[315,329],"or":[316],"brachioradialis":[317,331],"muscles.":[318],"increase":[320,337],"estimated":[323],"arterial-interstitial":[324],"difference":[326,342],"muscles":[332],"arterio-venous":[340],"over":[343],"V).":[347],"result":[349],"experiments":[351],"dextran-70":[356,537],"membranes":[359],"large":[362],"pore":[363],"size":[364],"(100":[365],"kDa),":[366],"indicate":[367,547],"when":[369],"added":[372],"it":[376],"into":[379],"space":[382],"exert":[384],"IX).":[392],"equilibrium":[395],"=":[400],"concentration.":[402],"A":[403],"complete":[404],"equilibration":[405],"between":[406],"glucose,":[414],"lactate,":[415],"glycerol":[416,481,495],"urea":[418],"very":[420],"low":[421,514],"flows":[423],"equal":[439],"plasma,":[444,490],"while":[445,491],"clearly":[452],"lower.":[453],"lactate":[457,472],"higher":[459,474,501],"tissue,":[466,523],"whereas":[467],"blood.":[477],"slightly":[486],"lower":[487],"plasma":[508],"levels":[509],"VIII).":[511],"substantial":[525],"loss":[527],"observed":[529],"which,":[530],"however,":[531],"could":[532],"prevented":[534],"adding":[536],"VI).":[542],"Overall,":[543],"investigations":[546],"several":[548],"possibilities":[549],"sampling":[553],"obtain":[555],"tissue-specific":[556],"information":[557],"about":[558],"flow.":[565]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}