{"id":"https://openalex.org/W2271595161","doi":null,"title":"Adaptive responses of central cholinergic systems in transgenic mice","display_name":"Adaptive responses of central cholinergic systems in transgenic mice","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2271595161","mag":"2271595161"},"language":"en","primary_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/10591","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/10591","pdf_url":"https://ttu-ir.tdl.org/bitstreams/e1624d33-34f0-4741-9d46-3d42421a6c94/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ttu-ir.tdl.org/bitstreams/e1624d33-34f0-4741-9d46-3d42421a6c94/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104064229","display_name":"Joachim Hartmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joachim Hartmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5104064229"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septohippocampal-cholinergic-system","display_name":"septohippocampal cholinergic system","score":0.9430000185966492},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9200000166893005},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8960000276565552},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8309999704360962},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8399999737739563},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.6930000185966492},{"id":"https://openalex.org/keywords/acetylcholinesterase-deficiency","display_name":"acetylcholinesterase deficiency","score":0.9010000228881836},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.6890000104904175},{"id":"https://openalex.org/keywords/high-affinity-choline-uptake","display_name":"high-affinity choline uptake","score":0.7979999780654907},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6483719944953918},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6106382608413696},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5712018609046936},{"id":"https://openalex.org/C2993864831","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic system","level":3,"score":0.5595899820327759},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5468305349349976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4467610716819763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09272107481956482},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04833263158798218}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ttu-ir.tdl.org:2346/10591","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/10591","pdf_url":"https://ttu-ir.tdl.org/bitstreams/e1624d33-34f0-4741-9d46-3d42421a6c94/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2271595161","doi":null,"is_oa":false,"landing_page_url":"https://ttu-ir.tdl.org/ttu-ir/bitstream/2346/1349/1/Hartmann_Joachim_Diss.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/10591","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/10591","pdf_url":"https://ttu-ir.tdl.org/bitstreams/e1624d33-34f0-4741-9d46-3d42421a6c94/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2271595161.pdf","grobid_xml":"https://content.openalex.org/works/W2271595161.grobid-xml"},"referenced_works_count":202,"referenced_works":["https://openalex.org/W144232035","https://openalex.org/W163208771","https://openalex.org/W196181025","https://openalex.org/W857238335","https://openalex.org/W1487315008","https://openalex.org/W1505518667","https://openalex.org/W1522048223","https://openalex.org/W1546840068","https://openalex.org/W1562398969","https://openalex.org/W1567125032","https://openalex.org/W1585244276","https://openalex.org/W1596931775","https://openalex.org/W1599179626","https://openalex.org/W1600934558","https://openalex.org/W1646232224","https://openalex.org/W1693283493","https://openalex.org/W1741718828","https://openalex.org/W1750238146","https://openalex.org/W1762207349","https://openalex.org/W1786528573","https://openalex.org/W1869587992","https://openalex.org/W1884672048","https://openalex.org/W1898171564","https://openalex.org/W1903216271","https://openalex.org/W1930427841","https://openalex.org/W1957736162","https://openalex.org/W1965493575","https://openalex.org/W1965573686","https://openalex.org/W1966917600","https://openalex.org/W1967464880","https://openalex.org/W1967526416","https://openalex.org/W1968942251","https://openalex.org/W1969932229","https://openalex.org/W1970437771","https://openalex.org/W1972854589","https://openalex.org/W1975722154","https://openalex.org/W1976438877","https://openalex.org/W1977002082","https://openalex.org/W1977526441","https://openalex.org/W1977892449","https://openalex.org/W1979995395","https://openalex.org/W1980774978","https://openalex.org/W1980787170","https://openalex.org/W1982180106","https://openalex.org/W1986216002","https://openalex.org/W1986260696","https://openalex.org/W1986628169","https://openalex.org/W1989282675","https://openalex.org/W1990351437","https://openalex.org/W1990543766","https://openalex.org/W1992947075","https://openalex.org/W1994067502","https://openalex.org/W1995172525","https://openalex.org/W1997087879","https://openalex.org/W1999514770","https://openalex.org/W2000027727","https://openalex.org/W2001210466","https://openalex.org/W2001931352","https://openalex.org/W2001985822","https://openalex.org/W2002558640","https://openalex.org/W2002985134","https://openalex.org/W2004213127","https://openalex.org/W2005603079","https://openalex.org/W2006372856","https://openalex.org/W2006563918","https://openalex.org/W2007274293","https://openalex.org/W2007295046","https://openalex.org/W2009272123","https://openalex.org/W2009294006","https://openalex.org/W2009804051","https://openalex.org/W2012921227","https://openalex.org/W2014127226","https://openalex.org/W2014636345","https://openalex.org/W2015670774","https://openalex.org/W2016931369","https://openalex.org/W2018434736","https://openalex.org/W2022396699","https://openalex.org/W2025922492","https://openalex.org/W2026074001","https://openalex.org/W2026576926","https://openalex.org/W2026907517","https://openalex.org/W2028469996","https://openalex.org/W2028674750","https://openalex.org/W2030083751","https://openalex.org/W2031305070","https://openalex.org/W2033658395","https://openalex.org/W2034127962","https://openalex.org/W2034205060","https://openalex.org/W2035558636","https://openalex.org/W2038334571","https://openalex.org/W2038553622","https://openalex.org/W2039194913","https://openalex.org/W2041834073","https://openalex.org/W2043846612","https://openalex.org/W2043949592","https://openalex.org/W2044281375","https://openalex.org/W2044627978","https://openalex.org/W2045866614","https://openalex.org/W2050042155","https://openalex.org/W2050608963","https://openalex.org/W2051429931","https://openalex.org/W2053098177","https://openalex.org/W2055603497","https://openalex.org/W2056980805","https://openalex.org/W2061265193","https://openalex.org/W2061891949","https://openalex.org/W2062706679","https://openalex.org/W2064568891","https://openalex.org/W2066366028","https://openalex.org/W2067885594","https://openalex.org/W2068265873","https://openalex.org/W2068369739","https://openalex.org/W2070641035","https://openalex.org/W2071702367","https://openalex.org/W2073686090","https://openalex.org/W2073741504","https://openalex.org/W2073988872","https://openalex.org/W2074576411","https://openalex.org/W2074620251","https://openalex.org/W2075171948","https://openalex.org/W2077340556","https://openalex.org/W2077422648","https://openalex.org/W2078117109","https://openalex.org/W2078170139","https://openalex.org/W2078443277","https://openalex.org/W2078530054","https://openalex.org/W2078938714","https://openalex.org/W2078941062","https://openalex.org/W2079361730","https://openalex.org/W2080032078","https://openalex.org/W2080274663","https://openalex.org/W2081391428","https://openalex.org/W2081881251","https://openalex.org/W2082869232","https://openalex.org/W2083192703","https://openalex.org/W2084910880","https://openalex.org/W2084991109","https://openalex.org/W2085958374","https://openalex.org/W2090663532","https://openalex.org/W2091149521","https://openalex.org/W2091240406","https://openalex.org/W2091505182","https://openalex.org/W2091686113","https://openalex.org/W2091906332","https://openalex.org/W2092141425","https://openalex.org/W2092727345","https://openalex.org/W2092894749","https://openalex.org/W2093374391","https://openalex.org/W2096410114","https://openalex.org/W2097585218","https://openalex.org/W2098437204","https://openalex.org/W2098951907","https://openalex.org/W2099433442","https://openalex.org/W2101965813","https://openalex.org/W2102367498","https://openalex.org/W2102632252","https://openalex.org/W2104227586","https://openalex.org/W2104594197","https://openalex.org/W2104624285","https://openalex.org/W2105469118","https://openalex.org/W2107355640","https://openalex.org/W2110159269","https://openalex.org/W2110888808","https://openalex.org/W2111207891","https://openalex.org/W2111863354","https://openalex.org/W2112572641","https://openalex.org/W2113460545","https://openalex.org/W2115478133","https://openalex.org/W2116876598","https://openalex.org/W2117100137","https://openalex.org/W2126800086","https://openalex.org/W2132266768","https://openalex.org/W2132743791","https://openalex.org/W2135309154","https://openalex.org/W2140313595","https://openalex.org/W2143440364","https://openalex.org/W2150190414","https://openalex.org/W2152864425","https://openalex.org/W2154100802","https://openalex.org/W2159332152","https://openalex.org/W2159866533","https://openalex.org/W2160991890","https://openalex.org/W2161875222","https://openalex.org/W2162446628","https://openalex.org/W2163077306","https://openalex.org/W2164517163","https://openalex.org/W2164855564","https://openalex.org/W2167258371","https://openalex.org/W2167541367","https://openalex.org/W2168334242","https://openalex.org/W2169152986","https://openalex.org/W2169527010","https://openalex.org/W2170030276","https://openalex.org/W2260604921","https://openalex.org/W2292283833","https://openalex.org/W2324912146","https://openalex.org/W2330253110","https://openalex.org/W2344670727","https://openalex.org/W2951178485","https://openalex.org/W3146038801","https://openalex.org/W4296217171","https://openalex.org/W4413980012"],"related_works":["https://openalex.org/W7070624290","https://openalex.org/W7135687699","https://openalex.org/W138733649","https://openalex.org/W2023848329","https://openalex.org/W1969932229","https://openalex.org/W1763420187","https://openalex.org/W2023742187","https://openalex.org/W2172035077","https://openalex.org/W2071544207","https://openalex.org/W1484830181"],"abstract_inverted_index":{"In":[0,157],"the":[1,4,7,43,96,106,148,174,183,195,244,256,269,306,327,345],"current":[2],"thesis,":[3,179],"function":[5],"of":[6,26,95,102,119,130,147,177,194,203,214,219,225,232,258,264,271,298,308,314,329,347,351,356,377,383],"septohippocampal":[8],"cholinergic":[9,38,150,170,369],"nervous":[10],"system":[11,151],"was":[12,32,136,285,293,319],"investigated":[13,33],"in":[14,42,48,71,105,199,206,234,238,255,283,305,326,344],"transgenic":[15,24,88],"mouse":[16,364],"models":[17,365],"pertinent":[18],"to":[19,34,122,132,152,154,268,274,335,373],"Alzheimer\u2019s":[20,200],"disease.":[21],"First,":[22],"a":[23,37,55,133,192,259,311,336,374,380],"model":[25,193],"increased":[27,229,288],"amyloid":[28,58,66,163],"formation":[29],"and":[30,61,64,68,90,142,273,353],"deposition":[31],"see":[35],"whether":[36],"deficit,":[39],"as":[40,191],"observed":[41],"human":[44,57,62],"disease,":[45,201],"is":[46,323,333],"present":[47],"those":[49],"animals.":[50],"These":[51],"mice":[52,89,141,180],"express":[53],"both":[54,363],"mutated":[56],"precursor":[59],"protein":[60],"presenilin-1":[63],"generate":[65],"peptide":[67],"neuritic":[69],"plaques":[70],"an":[72],"age-dependent":[73],"manner.":[74],"High-affinity":[75],"choline":[76],"uptake":[77],"(HACU)":[78],"into":[79],"corticohippocampal":[80],"synaptosomes":[81],"showed":[82],"no":[83],"difference":[84],"between":[85,115,139],"double":[86],"mutant":[87,140],"controls,":[91,143],"indicating":[92,144,287],"unchanged":[93,138],"turnover":[94],"neurotransmitter,":[97],"acetylcholine":[98],"(ACh).":[99],"Extracellular":[100],"levels":[101,121,213,218,231,263,297],"ACh,":[103,215],"measured":[104],"dorsal":[107,207],"hippocampus":[108,208],"using":[109],"microdialysis,":[110],"were":[111,187,221,266],"not":[112,237],"significantly":[113],"different":[114,155],"groups.":[116],"The":[117,321],"response":[118],"these":[120,230],"stimulation":[123],"with":[124,379],"either":[125],"scopolamine":[126],"or":[127],"by":[128,339],"exposure":[129],"animals":[131],"novel":[134],"environment":[135],"also":[137],"retained":[145],"capability":[146],"central":[149,368],"respond":[153,372],"challenges.":[156],"conclusion,":[158],"this":[159,178],"study":[160],"demonstrated":[161,294],"that":[162,250,295,367],"pathology":[164],"can":[165,252,371],"occur":[166],"without":[167],"compromising":[168],"hippocampal":[169],"neurotransmission.":[171],"\\n":[172,360],"\\nFor":[173],"second":[175],"part":[176],"deficient":[181],"for":[182,243,302],"enzyme":[184],"acetylcholinesterase":[185],"(AChE)":[186],"obtained;":[188],"they":[189],"serve":[190],"predominant":[196],"treatment":[197],"used":[198],"inhibition":[202,224],"AChE.":[204,309],"Microdialysis":[205],"revealed":[209],"vastly":[210],"elevated":[211],"baseline":[212,217],"whereas":[216],"Ch":[220,299],"reduced.":[222],"Selective":[223],"butyrylcholinesterase":[226],"(BChE)":[227],"further":[228],"ACh":[233,254,265,303,331],"AChE-deficient,":[235],"but":[236],"control":[239],"mice.":[240],"This":[241],"observation,":[242],"first":[245],"time,":[246],"provides":[247],"clear":[248],"evidence":[249],"BChE":[251],"hydrolyze":[253],"brain":[257],"living":[260],"organism.":[261],"Elevated":[262],"sensitive":[267],"absence":[270,307,328,346],"calcium":[272],"tetrodotoxin,":[275],"confirming":[276],"their":[277],"neuronal":[278],"origin.":[279],"A":[280],"compensatory":[281,342],"increase":[282],"HACU":[284,352],"found,":[286],"transmitter":[289],"turnover.":[290],"Furthermore,":[291],"it":[292],"extracellular":[296],"become":[300],"rate-limiting":[301],"release":[304],"Finally,":[310],"relative":[312],"failure":[313],"presynaptic":[315],"negative":[316],"autofeedback":[317,358],"receptors":[318],"observed.":[320],"conclusion":[322],"reached":[324],"that,":[325],"AChE,":[330],"hydrolysis":[332],"maintained":[334],"considerable":[337],"degree":[338,382],"BChE.":[340],"Moreover,":[341],"changes":[343],"AChE":[348],"include":[349],"upregulation":[350],"functional":[354],"loss":[355],"inhibitory":[357],"receptors.":[359],"\\nIn":[361],"summary,":[362],"demonstrate":[366],"systems":[370],"wide":[375],"range":[376],"challenges":[378],"remarkable":[381],"adaptation.":[384]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}