{"id":"https://openalex.org/W2271353523","doi":"https://doi.org/10.1182/asheducation-2015.1.559","title":"Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders","display_name":"Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders","publication_year":2015,"publication_date":"2015-12-05","ids":{"openalex":"https://openalex.org/W2271353523","doi":"https://doi.org/10.1182/asheducation-2015.1.559","mag":"2271353523","pmid":"https://pubmed.ncbi.nlm.nih.gov/26637772"},"language":"en","primary_location":{"id":"doi:10.1182/asheducation-2015.1.559","doi":"https://doi.org/10.1182/asheducation-2015.1.559","is_oa":true,"landing_page_url":"https://doi.org/10.1182/asheducation-2015.1.559","pdf_url":"https://ashpublications.org/hematology/article-pdf/2015/1/559/1249460/bep00115000559.pdf","source":{"id":"https://openalex.org/S4210206817","display_name":"Hematology","issn_l":"1520-4383","issn":["1520-4383","1520-4391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320264","host_organization_name":"American Society of Hematology","host_organization_lineage":["https://openalex.org/P4310320264"],"host_organization_lineage_names":["American Society of Hematology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/hematology/article-pdf/2015/1/559/1249460/bep00115000559.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006499960","display_name":"Carl E. Allen","orcid":"https://orcid.org/0000-0002-6625-739X","observed_orcids":["https://orcid.org/0000-0002-6625-739X","https://orcid.org/0000-0002-2241-5712"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl E. Allen","raw_affiliation_strings":["Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX;","Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX;","Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX;","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX;","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX;","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041203888","display_name":"Donald Williams Parsons","orcid":"https://orcid.org/0000-0002-8775-3501","observed_orcids":["https://orcid.org/0000-0002-8775-3501"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Williams Parsons","raw_affiliation_strings":["Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX;","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX;","Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX;","Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; and","Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX;","Division of Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX;","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX;","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX;","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; and","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX;","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.796,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.62037363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2015","issue":"1","first_page":"559","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/langerhans-cell-histiocytosis","display_name":"Langerhans cell histiocytosis","score":1.0},{"id":"https://openalex.org/keywords/juvenile-xanthogranuloma","display_name":"juvenile xanthogranuloma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erdheim-chester-disease","display_name":"Erdheim-Chester disease","score":1.0},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9599999785423279},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.921999990940094},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.8880000114440918},{"id":"https://openalex.org/keywords/histiocytic-disorders","display_name":"histiocytic disorders","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-of-origin","display_name":"cell of origin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.7953414916992188},{"id":"https://openalex.org/C2780174970","wikidata":"https://www.wikidata.org/wiki/Q1411740","display_name":"Histiocytosis","level":3,"score":0.7166765928268433},{"id":"https://openalex.org/C2777484599","wikidata":"https://www.wikidata.org/wiki/Q374036","display_name":"Langerhans cell histiocytosis","level":3,"score":0.7113372683525085},{"id":"https://openalex.org/C2779945361","wikidata":"https://www.wikidata.org/wiki/Q1349259","display_name":"Erdheim\u2013Chester disease","level":4,"score":0.5966410636901855},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.5946252942085266},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5557079315185547},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.46525460481643677},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.45461663603782654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4530172646045685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4353010654449463},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4299619793891907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39945104718208313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3816923499107361},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.3442320227622986},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23451945185661316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1822308897972107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17530396580696106}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006646","descriptor_name":"Histiocytosis, Langerhans-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006646","descriptor_name":"Histiocytosis, Langerhans-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014972","descriptor_name":"Xanthogranuloma, Juvenile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014972","descriptor_name":"Xanthogranuloma, Juvenile","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031249","descriptor_name":"Erdheim-Chester Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D031249","descriptor_name":"Erdheim-Chester Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/asheducation-2015.1.559","doi":"https://doi.org/10.1182/asheducation-2015.1.559","is_oa":true,"landing_page_url":"https://doi.org/10.1182/asheducation-2015.1.559","pdf_url":"https://ashpublications.org/hematology/article-pdf/2015/1/559/1249460/bep00115000559.pdf","source":{"id":"https://openalex.org/S4210206817","display_name":"Hematology","issn_l":"1520-4383","issn":["1520-4383","1520-4391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320264","host_organization_name":"American Society of Hematology","host_organization_lineage":["https://openalex.org/P4310320264"],"host_organization_lineage_names":["American Society of Hematology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},{"id":"pmid:26637772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26637772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology. American Society of Hematology. Education Program","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/asheducation-2015.1.559","doi":"https://doi.org/10.1182/asheducation-2015.1.559","is_oa":true,"landing_page_url":"https://doi.org/10.1182/asheducation-2015.1.559","pdf_url":"https://ashpublications.org/hematology/article-pdf/2015/1/559/1249460/bep00115000559.pdf","source":{"id":"https://openalex.org/S4210206817","display_name":"Hematology","issn_l":"1520-4383","issn":["1520-4383","1520-4391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320264","host_organization_name":"American Society of Hematology","host_organization_lineage":["https://openalex.org/P4310320264"],"host_organization_lineage_names":["American Society of Hematology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2271353523.pdf","grobid_xml":"https://content.openalex.org/works/W2271353523.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1489684088","https://openalex.org/W1543819161","https://openalex.org/W1582569027","https://openalex.org/W1967246357","https://openalex.org/W1973260302","https://openalex.org/W1979509921","https://openalex.org/W2001499003","https://openalex.org/W2009347177","https://openalex.org/W2016532282","https://openalex.org/W2017348615","https://openalex.org/W2033613747","https://openalex.org/W2035001481","https://openalex.org/W2041650858","https://openalex.org/W2041958591","https://openalex.org/W2046137334","https://openalex.org/W2048765718","https://openalex.org/W2055389755","https://openalex.org/W2057410184","https://openalex.org/W2067096214","https://openalex.org/W2072254771","https://openalex.org/W2073487236","https://openalex.org/W2079216025","https://openalex.org/W2081151196","https://openalex.org/W2083168581","https://openalex.org/W2085180073","https://openalex.org/W2089231470","https://openalex.org/W2091364998","https://openalex.org/W2093884670","https://openalex.org/W2095514651","https://openalex.org/W2104261840","https://openalex.org/W2106451155","https://openalex.org/W2107166045","https://openalex.org/W2110172112","https://openalex.org/W2124794993","https://openalex.org/W2126417952","https://openalex.org/W2131878781","https://openalex.org/W2138879809","https://openalex.org/W2150959582","https://openalex.org/W2161282095","https://openalex.org/W2161616892","https://openalex.org/W2163188200","https://openalex.org/W2168827093","https://openalex.org/W2325716909","https://openalex.org/W2411184154"],"related_works":["https://openalex.org/W2055389755","https://openalex.org/W2768425751","https://openalex.org/W3168739199","https://openalex.org/W2979513065","https://openalex.org/W4408832290","https://openalex.org/W3109248406","https://openalex.org/W2938550938","https://openalex.org/W2093884670","https://openalex.org/W7097578079","https://openalex.org/W4388201551"],"abstract_inverted_index":{"Langerhans":[0],"cell":[1],"histiocytosis":[2],"(LCH),":[3],"juvenile":[4],"xanthogranuloma":[5],"(JXG),":[6],"and":[7,29,79,94,118,176,210],"Erdheim-Chester":[8],"disease":[9],"(ECD)":[10],"represent":[11],"histiocytic":[12],"disorders":[13,142,186],"with":[14,59,155,187],"a":[15,69,98,179,188,203],"wide":[16],"range":[17],"of":[18,24,35,56,62,73,92,102,140,149,151,164,168,173,181,191,213],"clinical":[19,138],"manifestations.":[20],"Until":[21],"recently,":[22],"mechanisms":[23],"pathogenesis":[25],"have":[26,44,132],"been":[27,45,134],"speculative":[28],"debate":[30],"has":[31],"focused":[32],"on":[33,202,207],"classification":[34],"these":[36,141,200],"conditions":[37],"as":[38,51,53,112,114,178],"reactive":[39],"versus":[40],"neoplastic.":[41],"Genomic":[42],"studies":[43],"challenged":[46],"by":[47],"scarce":[48],"tissue":[49],"specimens,":[50],"well":[52,113],"heterogeneous":[54,137],"nature":[55],"the":[57,90,127,146,211],"lesions":[58],"variable":[60],"infiltration":[61],"pathologic":[63],"histiocytes.":[64],"Whole-exome":[65],"sequencing":[66],"recently":[67],"revealed":[68],"very":[70,99],"low":[71],"frequency":[72,101],"somatic":[74],"mutations":[75,104,125,153,209],"in":[76,89,105,116,120,126],"LCH,":[77,174],"JXG,":[78,175],"ECD":[80,177],"compared":[81],"to":[82],"other":[83,159],"neoplastic":[84,185],"disorders.":[85],"However,":[86],"at":[87,161],"least":[88],"cases":[91],"LCH":[93,117],"ECD,":[95,123],"there":[96],"is":[97],"high":[100],"activating":[103],"MAPK":[106,152],"pathway":[107,129],"genes,":[108],"most":[109],"notably":[110],"BRAF-V600E,":[111],"MAP2K1,":[115],"NRAS":[119],"ECD.":[121],"In":[122],"recurrent":[124],"PI3K":[128],"gene":[130],"PIK3CA":[131],"also":[133],"described.":[135],"The":[136],"manifestations":[139],"may":[143],"therefore":[144],"be":[145],"cumulative":[147],"result":[148],"activation":[150],"(along":[154],"modifying":[156],"signals":[157],"from":[158],"pathways)":[160],"distinct":[162],"stages":[163],"myeloid":[165,184],"differentiation.":[166],"Implications":[167],"this":[169],"model":[170,194],"include":[171],"redefinition":[172],"group":[180],"clinically":[182],"diverse":[183],"common":[189],"mechanism":[190],"pathogenesis.":[192],"This":[193],"supports":[195],"refocusing":[196],"therapeutic":[197],"strategies":[198],"for":[199],"diseases":[201],"personalized":[204],"approach":[205],"based":[206],"specific":[208],"cell(s)":[212],"origin.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
