{"id":"https://openalex.org/W2271352688","doi":null,"title":"Structural Studies of the Inner Membrane Ring of the Bacterial Type III Secretion System","display_name":"Structural Studies of the Inner Membrane Ring of the Bacterial Type III Secretion System","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2271352688","mag":"2271352688"},"language":"en","primary_location":{"id":"pmh:hdl:10068/1004928","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1004928","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076669457","display_name":"Susan M. Lea","orcid":"https://orcid.org/0000-0001-9287-8053","observed_orcids":["https://orcid.org/0000-0001-9287-8053"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susan M. Lea","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9287-8053","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076669457"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.8360000252723694},{"id":"https://openalex.org/keywords/shigella-flexneri","display_name":"Shigella flexneri","score":0.875},{"id":"https://openalex.org/keywords/forkhead-associated-domain","display_name":"forkhead-associated domain","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c-ring","display_name":"C ring","score":0.6480000019073486},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.6650000214576721},{"id":"https://openalex.org/keywords/periplasmic-domain","display_name":"periplasmic domain","score":0.7770000100135803},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.4749999940395355},{"id":"https://openalex.org/keywords/solution-structure","display_name":"solution structure","score":0.4560000002384186},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5464122295379639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.473471075296402},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.45343083143234253},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3495279848575592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29867833852767944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21033307909965515},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/1004928","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1004928","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:2271352688","doi":null,"is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:0c877900-d171-495b-80c1-6a7e5d6c2b21","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2972976783","https://openalex.org/W2977829812","https://openalex.org/W3006619688","https://openalex.org/W564928","https://openalex.org/W1582112697","https://openalex.org/W2008046059","https://openalex.org/W2615664314","https://openalex.org/W2074084995","https://openalex.org/W2056590044","https://openalex.org/W1971302592","https://openalex.org/W2085019401","https://openalex.org/W1565748377","https://openalex.org/W2168020961","https://openalex.org/W2626279335","https://openalex.org/W2239147181","https://openalex.org/W47000143","https://openalex.org/W2090516793","https://openalex.org/W1992764122","https://openalex.org/W119032068","https://openalex.org/W2102227347"],"abstract_inverted_index":{"Shigella":[0],"flexneri":[1,141],"attacks":[2],"cells":[3,34],"of":[4,67,73,90,94,111,129,171,185,200,214,232,236,261,275],"the":[5,24,51,62,68,77,91,119,130,133,139,149,179,183,206,212,215,222,233,259,262,293,299,303],"intestinal":[6],"tract,":[7],"causing":[8],"over":[9],"1":[10,281],"million":[11],"deaths":[12],"annually":[13],"from":[14],"bacterial":[15],"dysentery.":[16],"A":[17],"type":[18],"III":[19],"secretion":[20],"system":[21],"(T3SS)":[22],"initiates":[23],"host-pathogen":[25],"interaction":[26,257],"and":[27,44,56,86,153,174,191,253],"transports":[28],"virulence":[29],"factors":[30],"directly":[31],"into":[32],"host":[33],"via":[35,124],"a":[36,103,255,279],"needle":[37,43],"complex":[38,282,288],"(NC)":[39],"comprising":[40],"an":[41,245,271],"extracellular":[42],"membrane-spanning":[45],"basal":[46,187],"body.":[47],"Rings":[48],"formed":[49,278],"by":[50,195],"single-pass":[52],"membrane":[53,64],"proteins":[54],"MxiG":[55,74,152],"MxiJ":[57,154],"are":[58],"arranged":[59],"concentrically":[60],"within":[61,182],"inner":[63],"ring":[65,209],"(IMR)":[66],"NC.":[69],"The":[70,197,229],"Neterminal":[71],"domain":[72,235],"(MxiG-N)":[75],"is":[76],"predominant":[78],"IMR":[79,181],"cytoplasmic":[80,208],"structure,":[81],"however":[82],"it":[83,100,115],"was":[84,189,226,239,268],"structurally":[85,227],"functionally":[87],"uncharacterised.":[88,228],"Determination":[89],"solution":[92],"structure":[93,131,231],"MxiG-N":[95,201],"in":[96,122,132,148,165,193,241,285,316],"this":[97,166,242],"study":[98],"revealed":[99],"to":[101,163,204,301],"be":[102,203,311],"forkhead":[104],"associated":[105],"(FHA)":[106],"domain,":[107],"although":[108],"subsequent":[109],"analyses":[110],"conserved":[112],"residues":[113],"suggested":[114],"does":[116],"not":[117],"have":[118,156],"canonical":[120],"role":[121],"cell-signalling":[123],"phospho-threonine":[125],"recognition.":[126],"Subsequent":[127],"positioning":[128],"electron":[134],"microscopy":[135],"(EM)":[136],"density":[137],"for":[138,220,292,313],"S.":[140,317],"NC":[142],"supported":[143],"models":[144],"with":[145,250,258,283],"24-fold":[146],"symmetry":[147],"IMR.":[150],"Both":[151],"also":[155],"significant":[157],"periplasmic":[158],"domains,":[159],"which":[160],"were":[161],"purified":[162],"homogeneity":[164],"study,":[167,243],"facilitating":[168],"preliminary":[169],"characterisation":[170],"their":[172],"structures":[173,252],"intermolecular":[175],"interactions.":[176],"In":[177],"addition,":[178],"entire":[180],"context":[184],"intact":[186],"bodies":[188],"isolated":[190],"visualised":[192],"vitro":[194],"EM.":[196],"essential":[198],"function":[199],"could":[202],"localise":[205],"putative":[207],"(Cering)":[210],"at":[211],"base":[213],"T3SS.":[216],"Although":[217],"absolutely":[218],"required":[219,312],"secretion,":[221],"Csring":[223],"component,":[224],"Spa33,":[225],"crystal":[230],"Cvterminal":[234],"Spa33":[237,284,297],"(Spa33-C)":[238],"determined":[240],"showing":[244],"intertwined":[246],"dimer":[247],"that":[248,277,296,309],"aligned":[249],"homologous":[251],"exhibited":[254],"novel":[256],"N-terminus":[260],"ATPase":[263],"regulator,":[264],"MxiN.":[265],"Subsequently,":[266],"Spa33-C":[267],"identified":[269],"as":[270],"altemative":[272],"translation":[273],"product":[274],"spa33":[276],"2:":[280],"vitro.":[286],"This":[287],"oligomerised":[289],"further,":[290],"demonstrating":[291],"first":[294],"time":[295],"has":[298],"propensity":[300],"form":[302],"ordered,":[304],"high":[305],"molecular":[306],"weight":[307],"assemblies":[308],"would":[310],"C-ring":[314],"formation":[315],"flexneri.":[318]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2025-10-10T00:00:00"}
