{"id":"https://openalex.org/W2271351171","doi":"https://doi.org/10.1200/jco.1999.17.6.1802","title":"Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer","display_name":"Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W2271351171","doi":"https://doi.org/10.1200/jco.1999.17.6.1802","mag":"2271351171","pmid":"https://pubmed.ncbi.nlm.nih.gov/10561218"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1999.17.6.1802","doi":"https://doi.org/10.1200/jco.1999.17.6.1802","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1999.17.6.1802","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040950589","display_name":"M. Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Michael","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058949386","display_name":"Bojana Babic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. Babic","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044186566","display_name":"Rama Khokha","orcid":"https://orcid.org/0000-0002-6028-1524","observed_orcids":["https://orcid.org/0000-0002-6028-1524"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Khokha","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073362806","display_name":"Ming\u2010Sound Tsao","orcid":"https://orcid.org/0000-0002-9160-5405","observed_orcids":["https://orcid.org/0000-0002-9160-5405"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Tsao","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030417585","display_name":"Jcm Ho","orcid":"https://orcid.org/0000-0003-4499-5284","observed_orcids":["https://orcid.org/0000-0003-4499-5284"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Ho","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031467567","display_name":"Melania Pintilie","orcid":"https://orcid.org/0000-0002-8238-8365","observed_orcids":["https://orcid.org/0000-0002-8238-8365"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Pintilie","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081445796","display_name":"Kevin J. Leco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. Leco","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038792930","display_name":"Dean W. Chamberlain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. Chamberlain","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075347427","display_name":"Frances A. Shepherd","orcid":"https://orcid.org/0000-0002-3610-3533","observed_orcids":["https://orcid.org/0000-0002-3610-3533"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F. A. Shepherd","raw_affiliation_strings":["From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Oncology and Hematology, Departments of Medical Biophysics, Laboratory Medicine and Pathobiology, and Biostatistics, Princess Margaret Hospital/Ontario Cancer Institute, The Toronto Hospital, and the University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7025,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.90233074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"6","first_page":"1802","last_page":"1802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.15489999949932098,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.984000027179718},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mmp11","display_name":"MMP11","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":1.0},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7559999823570251},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8980000019073486},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.597000002861023},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7727752327919006},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6378288865089417},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6091071367263794},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5706965923309326},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5500836968421936},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5110765695571899},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5090712904930115},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5030283331871033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47099775075912476},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4552331268787384},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4425915777683258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1692827045917511},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097792","descriptor_name":"Tissue Inhibitor of Metalloproteinase-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097792","descriptor_name":"Tissue Inhibitor of Metalloproteinase-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097792","descriptor_name":"Tissue Inhibitor of Metalloproteinase-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097792","descriptor_name":"Tissue Inhibitor of Metalloproteinase-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019717","descriptor_name":"Tissue Inhibitor of Metalloproteinase-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019717","descriptor_name":"Tissue Inhibitor of Metalloproteinase-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019717","descriptor_name":"Tissue Inhibitor of Metalloproteinase-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019717","descriptor_name":"Tissue Inhibitor of Metalloproteinase-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1999.17.6.1802","doi":"https://doi.org/10.1200/jco.1999.17.6.1802","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1999.17.6.1802","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:10561218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10561218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1532707101","https://openalex.org/W1582708241","https://openalex.org/W1585336990","https://openalex.org/W1654417943","https://openalex.org/W1670469303","https://openalex.org/W1821157394","https://openalex.org/W1959321636","https://openalex.org/W1964769567","https://openalex.org/W1965136288","https://openalex.org/W1966740136","https://openalex.org/W1968817120","https://openalex.org/W1975253827","https://openalex.org/W1977208190","https://openalex.org/W1983219998","https://openalex.org/W2015849738","https://openalex.org/W2025590649","https://openalex.org/W2026151657","https://openalex.org/W2027002640","https://openalex.org/W2052626837","https://openalex.org/W2055656047","https://openalex.org/W2076492194","https://openalex.org/W2080247945","https://openalex.org/W2083070422","https://openalex.org/W2104692426","https://openalex.org/W2119050264","https://openalex.org/W2126060102","https://openalex.org/W2138752972","https://openalex.org/W2147204267","https://openalex.org/W2232660545","https://openalex.org/W2245825504","https://openalex.org/W2270009322","https://openalex.org/W2340732325","https://openalex.org/W2415803114","https://openalex.org/W2418699465","https://openalex.org/W3151254939"],"related_works":["https://openalex.org/W43051378","https://openalex.org/W2292402945","https://openalex.org/W640825770","https://openalex.org/W3031328390","https://openalex.org/W2081165140","https://openalex.org/W4386623055","https://openalex.org/W2602725667","https://openalex.org/W2155030722","https://openalex.org/W4238456428","https://openalex.org/W1494554257"],"abstract_inverted_index":{"PURPOSE:":[0],"Matrix":[1],"metalloproteinases":[2],"(MMPs)":[3],"and":[4,14,25,52,56,77,79,83,116,125,158,167,171,173,175,203,229,242,247,258,271],"their":[5,59],"tissue":[6],"inhibitors":[7,288],"(TIMPs)":[8],"are":[9,38,260],"important":[10],"in":[11,28,54,160,177,192,263,289],"tumor":[12,106,165,182,220,231],"development":[13],"progression.":[15],"MMP":[16,246,287],"expression":[17,49,97,206,233,249,267],"has":[18],"been":[19],"correlated":[20],"with":[21,291],"advanced":[22],"clinical":[23],"stage":[24,202,221],"poor":[26],"survival":[27,218],"some":[29],"tumors,":[30],"but":[31],"data":[32,102],"for":[33,156,168,211,217,278],"small-cell":[34],"lung":[35],"cancer":[36],"(SCLC)":[37],"lacking.":[39],"The":[40,280],"aim":[41],"of":[42,50,70,98,164,181,186,196,207,234,268,285],"this":[43],"study":[44],"was":[45,85,93,154,190],"to":[46,57,62,95,162,179,188],"assess":[47],"the":[48,283],"MMPs":[51,257],"TIMPs":[53,259],"SCLC":[55],"evaluate":[58],"importance":[60],"relative":[61],"standard":[63],"prognostic":[64,276],"factors.":[65],"PATIENTS":[66],"AND":[67],"METHODS:":[68],"Expression":[69],"MMP-1,":[71],"-2,":[72,81],"-3,":[73,82],"-9,":[74],"-11,":[75,270],"-13,":[76,170],"-14":[78,172,272],"TIMP-1,":[80],"-4":[84],"evaluated":[86],"by":[87],"immunohistochemistry":[88],"(IHC).":[89],"In":[90],"situ":[91],"hybridization":[92],"used":[94],"confirm":[96],"specific":[99],"mRNAs.":[100],"Clinical":[101],"collected":[103],"included":[104],"sex,":[105],"stage,":[107],"performance":[108,148],"status,":[109],"weight":[110,224],"loss,":[111],"hematology":[112],"(hemoglobin,":[113],"WBC,":[114],"platelets)":[115],"biochemistry":[117],"(sodium,":[118],"albumin,":[119],"alkaline":[120],"phosphatase,":[121],"lactate":[122],"dehydrogenase),":[123],"treatment,":[124],"survival.":[126,279],"RESULTS:":[127],"Samples":[128],"from":[129],"46":[130],"patients":[131,290],"were":[132,209,219,273],"evaluated:":[133],"30":[134],"males,":[135],"16":[136],"females;":[137],"29":[138],"limited,":[139],"17":[140],"extensive":[141],"stage;":[142],"35":[143],"Eastern":[144],"Cooperative":[145],"Oncology":[146],"Group":[147],"status":[149],"0-1.":[150],"Positive":[151],"IHC":[152],"staining":[153,185],"evident":[155],"MMP-1":[157],"-9":[159],"60%":[161],"70%":[163,178],"cells,":[166],"MMP-11,":[169],"TIMP-2":[174],"-3":[176,189],"100%":[180],"cells.":[183],"Stromal":[184],"TIMP-1":[187,208],"present":[191],"less":[193],"than":[194],"30%":[195],"specimens.":[197],"On":[198],"multivariate":[199],"analysis,":[200],"only":[201],"decreased":[204],"tumoral":[205,266],"significant":[210],"response":[212],"(P":[213,222,226,236,239,244],"=.043).":[214],"Significant":[215],"factors":[216,277],"=.0021);":[223],"loss":[225],"=.":[227,240],"013);":[228],"high":[230],"cell":[232],"MMP-3":[235],"=.077),":[237],"MMP-11":[238],"031),":[241],"MMP-14":[243],"=.019).":[245],"TIMP":[248],"did":[250],"not":[251],"differ":[252],"significantly":[253],"between":[254],"stages.":[255],"CONCLUSION:":[256],"widely":[261],"expressed":[262],"SCLC.":[264,292],"Increased":[265],"MMP-3,":[269],"independent":[274],"negative":[275],"results":[281],"support":[282],"evaluation":[284],"synthetic":[286]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}