{"id":"https://openalex.org/W2271259136","doi":"https://doi.org/10.1161/hyp.62.suppl_1.a2","title":"Abstract 2: Compensatory Activation of the Sympathetic Nervous System after Deletion of Angiotensin Type 1 Receptors from Vascular Smooth Muscle Cells","display_name":"Abstract 2: Compensatory Activation of the Sympathetic Nervous System after Deletion of Angiotensin Type 1 Receptors from Vascular Smooth Muscle Cells","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2271259136","doi":"https://doi.org/10.1161/hyp.62.suppl_1.a2","mag":"2271259136"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.62.suppl_1.a2","doi":"https://doi.org/10.1161/hyp.62.suppl_1.a2","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.62.suppl_1.a2","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073741442","display_name":"Matthew A. Sparks","orcid":"https://orcid.org/0000-0003-2075-2691","observed_orcids":["https://orcid.org/0000-0003-2075-2691"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A Sparks","raw_affiliation_strings":["Duke Univ, Durham, NC","Matthew A Sparks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Matthew A Sparks","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042121599","display_name":"Johannes Stegbauer","orcid":"https://orcid.org/0000-0001-8994-8102","observed_orcids":["https://orcid.org/0000-0001-8994-8102"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Stegbauer","raw_affiliation_strings":["Heinrich-Heine Univ, Du\u0308sseldorf, Germany","Johannes Stegbauer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Heine Univ, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Johannes Stegbauer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044082368","display_name":"Daian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daian Chen","raw_affiliation_strings":["Duke Univ, Durham, NC","Daian Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Daian Chen","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose A Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A Gomez","raw_affiliation_strings":["Duke Univ, Durham, NC","Jose A Gomez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Jose A Gomez","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063556836","display_name":"Marcela Herrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcela Herrera","raw_affiliation_strings":["Duke Univ, Durham, NC","Marcela Herrera"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Marcela Herrera","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053197427","display_name":"Susan B. Gurley","orcid":"https://orcid.org/0000-0002-2659-6485","observed_orcids":["https://orcid.org/0000-0002-2659-6485"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan B Gurley","raw_affiliation_strings":["Duke Univ, Durham, NC","Susan B Gurley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Susan B Gurley","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059424230","display_name":"Thomas M. Coffman","orcid":"https://orcid.org/0000-0002-8433-1629","observed_orcids":["https://orcid.org/0000-0002-8433-1629"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M Coffman","raw_affiliation_strings":["Duke Univ, Durham, NC","Thomas M Coffman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Thomas M Coffman","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8830000162124634},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/at1a-receptor","display_name":"AT1a receptor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.7409999966621399},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.7229999899864197},{"id":"https://openalex.org/keywords/at1b-receptor","display_name":"AT1B receptor","score":0.6959999799728394},{"id":"https://openalex.org/keywords/angiotensin-ii-induced-hypertension","display_name":"angiotensin II-induced hypertension","score":0.7739999890327454},{"id":"https://openalex.org/keywords/renal-vasoconstriction","display_name":"renal vasoconstriction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cell-specific-gene-deletion","display_name":"cell-specific gene deletion","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cre-loxp-system","display_name":"Cre-loxP system","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.817080557346344},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.8036463260650635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7299822568893433},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.7207488417625427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7118258476257324},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.7105949521064758},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6242308616638184},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5407329797744751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48368293046951294},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.4695972204208374},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.42022547125816345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34172773361206055},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3234715461730957},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.06976443529129028}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.62.suppl_1.a2","doi":"https://doi.org/10.1161/hyp.62.suppl_1.a2","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.62.suppl_1.a2","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091413013","https://openalex.org/W2584727005","https://openalex.org/W7096484588","https://openalex.org/W2110073846","https://openalex.org/W4206236758","https://openalex.org/W2275704943","https://openalex.org/W2152159778","https://openalex.org/W2029244935","https://openalex.org/W4312475679","https://openalex.org/W2081605468"],"abstract_inverted_index":{"Vasoconstriction":[0],"is":[1,309],"a":[2,40,125,134,227,290],"signature":[3],"physiological":[4,16],"action":[5],"of":[6,18,21,34,63,98,116,204,230,239,259,295,329,333,344],"angiotensin":[7],"II":[8,65,83,111,160],"(Ang":[9],"II).":[10],"In":[11],"order":[12],"to":[13,60,80,96,109,157,170,298],"define":[14],"the":[15,143,180,202,231,240,257,296,318,322,330,342],"role":[17],"direct":[19],"actions":[20],"AT1":[22],"receptors":[23],"(AT1":[24],"R)":[25],"in":[26,51,66,71,86,91,122,130,142,149,161,263,277,307,317],"VSMCs,":[27],"we":[28,193,224,288],"generated":[29,194],"mice":[30,67],"with":[31,88,124,133],"cell-specific":[32],"deletion":[33,332],"AT1A":[35,69,117],"R":[36,70],"from":[37,335],"VSMCs":[38,72,308,336],"using":[39],"floxed":[41],"Agtr1a":[42],"allele":[43],"and":[44,74,168,340],"transgenic":[45],"mouse":[46],"lines":[47],"expressing":[48],"Cre":[49],"only":[50,93],"VSMC":[52],"lineages.":[53],"We":[54],"first":[55],"compared":[56],"systemic":[57,107,154,319],"vascular":[58,155,191],"responses":[59,79,156],"acute":[61,158,190,300],"infusions":[62],"Ang":[64,82,110,139,159,171,249,260,301,345],"lacking":[68],"(SMKOs)":[73],"controls.":[75],"Surprisingly,":[76],"brisk":[77,315],"vasoconstrictor":[78],"1\u03bcg/kg":[81],"were":[84],"preserved":[85,153],"SMKOs":[87,195,278],"peak":[89],"increases":[90],"MAP":[92],"modestly":[94],"reduced":[95,167],"\u224875%":[97],"control":[99],"levels":[100],"(15\u00b12":[101],"vs.":[102,215,267,281],"23\u00b11":[103,266],"mmHg":[104],"P<0.05).":[105],"Robust":[106],"vasoconstriction":[108,141,262,276,303,316],"was":[112,119,146,166,174],"observed":[113],"whether":[114,179],"elimination":[115],"Rs":[118,206],"carried":[120],"out":[121],"utero":[123],"constitutively":[126],"expressed":[127],"SM-Cre":[128],"or":[129],"adult":[131],"animals":[132],"tamoxifen-inducible":[135],"SM-Cre.":[136],"By":[137],"contrast,":[138],"II-dependent":[140,172,261,302,346],"renal":[144,323],"circulation":[145],"largely":[147],"abrogated":[148,275],"SMKOs.":[150],"Moreover,":[151],"despite":[152,326],"SMKOs,":[162],"their":[163,188],"baseline":[164,338],"BP":[165,339],"susceptibility":[169],"hypertension":[173],"significantly":[175],"attenuated.":[176],"To":[177],"determine":[178],"minor":[181],"AT1BR":[182],"isoform":[183],"might":[184],"be":[185],"responsible":[186],"for":[187,226,293],"residual":[189],"responses,":[192],"on":[196,256],"an":[197,221],"AT1B-null":[198],"background":[199],"(SMKO":[200,212],"1B-/-);":[201],"absence":[203],"AT1B":[205],"did":[207],"not":[208,321],"affect":[209],"this":[210],"response":[211],"1B-/-":[213],"16\u00b12":[214],"SMKO-1B+/+":[216],"15\u00b12":[217,280],"mmHg;":[218],"ns).":[219],"As":[220],"alternative":[222],"explanation,":[223],"tested":[225],"possible":[228],"involvement":[229],"sympathetic":[232],"nervous":[233],"system":[234],"(SNS)":[235],"by":[236],"infusing":[237],"400\u03bcg/kg":[238],"\u03b1-adrenergic":[241],"blocker":[242],"phentolamine":[243],"(PT)":[244],"5":[245],"min":[246],"before":[247],"giving":[248],"II.":[250],"While":[251],"PT":[252],"had":[253],"no":[254],"effect":[255],"intensity":[258],"controls":[264],"(pre-PT:":[265,279],"post-PT:":[268,282],"23\u00b13":[269],"mm":[270,284],"Hg),":[271],"it":[272],"almost":[273],"completely":[274],"3\u00b11":[283],"Hg;":[285],"P<0.005).":[286],"Thus,":[287],"find":[289],"significant":[291],"capacity":[292],"activation":[294,328],"SNS":[297],"maintain":[299],"when":[304],"AT1R":[305],"signaling":[306],"absent.":[310],"This":[311],"pathway":[312],"can":[313],"induce":[314],"but":[320],"circulation.":[324],"Furthermore,":[325],"compensatory":[327],"SNS,":[331],"AT1Rs":[334],"reduces":[337],"attenuates":[341],"severity":[343],"hypertension.":[347]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}