{"id":"https://openalex.org/W2270822502","doi":"https://doi.org/10.1093/nsr/nwv046","title":"An unexpected role for ergothioneine","display_name":"An unexpected role for ergothioneine","publication_year":2015,"publication_date":"2015-07-29","ids":{"openalex":"https://openalex.org/W2270822502","doi":"https://doi.org/10.1093/nsr/nwv046","mag":"2270822502"},"language":"en","primary_location":{"id":"doi:10.1093/nsr/nwv046","doi":"https://doi.org/10.1093/nsr/nwv046","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nsr/nwv046","pdf_url":"https://academic.oup.com/nsr/article-pdf/2/4/382/31566115/nwv046.pdf","source":{"id":"https://openalex.org/S2734413303","display_name":"National Science Review","issn_l":"2053-714X","issn":["2053-714X","2095-5138"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Science Review","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/nsr/article-pdf/2/4/382/31566115/nwv046.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015046053","display_name":"Zedu Huang","orcid":"https://orcid.org/0000-0003-3320-3392","observed_orcids":["https://orcid.org/0000-0003-3320-3392"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4405271866","display_name":"Carl R. Woese Institute for Genomic Biology","ror":"https://ror.org/036j6yj81","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271866"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zedu Huang","raw_affiliation_strings":["Institute for Genomic Biology, Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomic Biology, Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225","https://openalex.org/I4405271866"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067523147","display_name":"Wilfred A. van der Donk","orcid":"https://orcid.org/0000-0002-5467-7071","observed_orcids":["https://orcid.org/0000-0002-5467-7071"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4405271866","display_name":"Carl R. Woese Institute for Genomic Biology","ror":"https://ror.org/036j6yj81","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271866"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilfred A. van der Donk","raw_affiliation_strings":["Institute for Genomic Biology, Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomic Biology, Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225","https://openalex.org/I4405271866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067523147"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225","https://openalex.org/I4405271866"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.1662,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55861627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"4","first_page":"382","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.17599999904632568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ergothioneine","display_name":"ergothioneine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycothiol","display_name":"mycothiol","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sulfur-donors","display_name":"sulfur donors","score":0.4129999876022339},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5220000147819519},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6430000066757202},{"id":"https://openalex.org/keywords/bacillithiol","display_name":"bacillithiol","score":0.8100000023841858},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.6790000200271606},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/redox-buffering","display_name":"redox buffering","score":0.45399999618530273},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis","display_name":"antibiotic biosynthesis","score":0.5220000147819519},{"id":"https://openalex.org/keywords/thiol-conjugation","display_name":"thiol conjugation","score":0.36399999260902405},{"id":"https://openalex.org/keywords/xenobiotic-detoxification","display_name":"xenobiotic detoxification","score":0.6050000190734863},{"id":"https://openalex.org/keywords/gliotoxin","display_name":"gliotoxin","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777771644","wikidata":"https://www.wikidata.org/wiki/Q614788","display_name":"Ergothioneine","level":3,"score":0.9787135720252991},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7224809527397156},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6548535227775574},{"id":"https://openalex.org/C2778169975","wikidata":"https://www.wikidata.org/wiki/Q130914","display_name":"Actinobacteria","level":4,"score":0.6261672377586365},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5753480195999146},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47720155119895935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.470826655626297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4400939345359802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4341588020324707},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.30675697326660156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.057195037603378296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.053516507148742676},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/nsr/nwv046","doi":"https://doi.org/10.1093/nsr/nwv046","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nsr/nwv046","pdf_url":"https://academic.oup.com/nsr/article-pdf/2/4/382/31566115/nwv046.pdf","source":{"id":"https://openalex.org/S2734413303","display_name":"National Science Review","issn_l":"2053-714X","issn":["2053-714X","2095-5138"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Science Review","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/nsr/nwv046","doi":"https://doi.org/10.1093/nsr/nwv046","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nsr/nwv046","pdf_url":"https://academic.oup.com/nsr/article-pdf/2/4/382/31566115/nwv046.pdf","source":{"id":"https://openalex.org/S2734413303","display_name":"National Science Review","issn_l":"2053-714X","issn":["2053-714X","2095-5138"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Science Review","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2270822502.pdf","grobid_xml":"https://content.openalex.org/works/W2270822502.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1993849862","https://openalex.org/W1994025158","https://openalex.org/W2035256207","https://openalex.org/W2048255582","https://openalex.org/W2127726140","https://openalex.org/W2166945596","https://openalex.org/W2167116907"],"related_works":["https://openalex.org/W1993849862","https://openalex.org/W2159104220","https://openalex.org/W2035256207","https://openalex.org/W4205451029","https://openalex.org/W1580330659","https://openalex.org/W2911430216","https://openalex.org/W2142705616","https://openalex.org/W7156059118","https://openalex.org/W2024176632","https://openalex.org/W2794510294"],"abstract_inverted_index":{"Ever":[0],"since":[1,64],"the":[2,25,118,144,147,190,222,246,255,277,287,299,314,323,326,339,345,366,374,377,385,398,438,456,459,468,495,506,520,534,541,546,565,577,587,596,611,623,668,672,688,696,702,708,725,734,739,785,800,813,818],"appearance":[3],"of":[4,111,143,174,183,192,224,248,289,302,307,316,325,342,368,376,403,440,446,453,455,471,488,497,505,522,548,589,599,610,671,674,711,728,736,742,753,780,788,802,823],"atmospheric":[5],"oxygen,":[6],"organisms":[7],"have":[8,44,92,716],"needed":[9],"ways":[10],"to":[11,30,100,168,203,270,354,436,538,557,573,604,626,636,644,647,707,724,797],"protect":[12],"themselves":[13],"from":[14,34,134,199,261,451,552,695],"damage":[15],"caused":[16],"by":[17,77,85,280,555,568,586,595,650],"oxidative":[18,35,762],"stress.":[19,36],"Glutathione":[20],"(GSH,":[21],"Fig.":[22,50,74,532],"1A)":[23,75,293,333],"is":[24,117,122,197,338,352,372,525,582,615,642,667,681,698,808],"dominant":[26],"organothiol":[27],"in":[28,56,61,67,93,141,189,236,245,258,272,313,344,406,433,458,467,494,509,514,531,576,617,663,676,730,755,774,784],"eukarya":[29],"detoxify":[31,214],"products":[32],"formed":[33],"In":[37,201,722,810],"bacteria,":[38],"several":[39,355,651],"different":[40],"small":[41],"molecule":[42],"thiols":[43],"evolved":[45],"including":[46],"GSH,":[47,175],"mycothiol":[48],"(MSH,":[49],"1A),":[51],"a":[52,124,243,310,401,411,423,478,608,661,684,750,805],"cysteinyl":[53],"pseudo-disaccharide":[54],"found":[55,66],"actinomycetes,":[57],"bacillithiol":[58],"discovered":[59],"first":[60,386,669,726],"bacilli":[62],"and":[63,71,79,81,87,104,178,186,212,219,240,284,381,420,432,602,630,764,825,828],"then":[65,518,583,620],"specific":[68,163],"bacterial":[69],"genera,":[70],"ergothioneine":[72],"(EGT,":[73],"produced":[76],"fungi":[78],"actinobacteria":[80],"widely":[82],"taken":[83],"up":[84],"plants":[86],"vertebrates":[88],"[1].":[89],"These":[90],"compounds":[91,218,231],"common":[94],"that":[95,121,153,336,349,371,474,540,614,657,714,746],"they":[96,382,501],"are":[97,782],"more":[98],"stable":[99],"oxidation":[101],"than":[102,692],"cysteine,":[103],"hence":[105],"serve":[106,233],"as":[107,206,234,660,683,738,769,804],"an":[108,207,369,486,559,718,731,770],"improved":[109],"reservoir":[110],"reducing":[112],"agents.":[113],"Of":[114],"these,":[115],"EGT":[116,184,265,351,408,476,508,524,556,560,566,658,675,680,719,729],"only":[119,361,758],"compound":[120,472,590,628,640],"not":[123,267,360,699,757],"direct":[125],"cysteine":[126,135],"derivative,":[127],"although":[128,161],"its":[129,157,162],"sulfur":[130,256,343,413,416,740,772,806],"atom":[131],"still":[132],"derives":[133],"[2].":[136],"EGT's":[137],"thiol\u2013thione":[138],"equilibrium":[139],"lies":[140],"favor":[142],"thione,":[145],"but":[146,348,701,767],"thione":[148],"has":[149,166,334],"thiolate":[150],"resonance":[151],"character":[152],"may":[154,409,715],"account":[155],"for":[156,389,400,511,687,759,820],"reported":[158],"antioxidant":[159],"activity,":[160],"physiological":[164],"role":[165,205,244],"yet":[167],"be":[169,410,571,574,634,645,705,749,795],"elucidated":[170],"[3].":[171],"(A)":[172],"Structures":[173],"MSH,":[176],"EGT,":[177],"lincomycin":[179,193,290,330,441,460,498,648,664,743],"A.":[180,194,442],"(B)":[181],"Involvement":[182],"(red)":[185],"MSH":[187,213,337,513,694,737,747,803,824],"(blue)":[188],"biosynthesis":[191,247,288,315,324,367,439,496,666],"Panel":[195],"B":[196],"adapted":[198],"[7].":[200,294,393,654],"addition":[202,723],"their":[204,225,447],"intracellular":[208],"redox":[209],"buffer,":[210],"GSH":[211,241,262,754],"many":[215],"endogenous":[216],"electrophilic":[217,765],"xenobiotics":[220],"through":[221],"action":[223,598],"nucleophilic":[226],"sulfhydryl":[227],"group":[228,297],"[4,5].":[229],"Both":[230],"also":[232,373,383,396,768],"cofactors":[235],"some":[237,249],"isomerization":[238],"reactions,":[239],"plays":[242],"important":[250,771],"natural":[251,317,346,775,791],"products.":[252,318],"For":[253],"example,":[254],"atoms":[257],"gliotoxin":[259],"originate":[260],"[6].":[263],"However,":[264],"had":[266,717],"been":[268],"observed":[269],"engage":[271],"any":[273],"enzymatic":[274,391,503,677,732],"reactions":[275,392,690],"until":[276],"recent":[278,320],"work":[279,321,449,816],"Professor":[281,418],"Wen":[282],"Liu":[283,296,419],"coworkers":[285,421],"on":[286],"A":[291,331,443,649,665,744],"(Fig.":[292,332,482],"The":[295,580,655],"at":[298],"Shanghai":[300],"Institute":[301],"Organic":[303],"Chemistry,":[304],"Chinese":[305],"Academy":[306],"Sciences":[308],"holds":[309],"long-standing":[311],"interest":[312],"Their":[319,358],"regarding":[322],"clinically":[327],"used":[328,422,575,635,682],"antibiotic":[329,370],"revealed":[335],"ultimate":[340],"donor":[341,741,773,807],"product,":[347],"unexpectedly,":[350],"conjugated":[353],"biosynthetic":[356,461,786],"intermediates.":[357],"findings":[359],"provide":[362],"key":[363,444],"insights":[364],"into":[365,527],"precursor":[375],"semisynthetic":[378],"drug":[379],"clindamycin,":[380],"present":[384,783],"biochemical":[387,830],"evidence":[388],"EGT-associated":[390],"This":[394,516],"report":[395],"sets":[397],"stage":[399],"search":[402],"other":[404,789],"examples":[405],"which":[407,465,632],"temporary":[412,685],"carrier":[414,662],"during":[415],"metabolism.":[417],"state-of-the-art":[424],"approach":[425],"combining":[426],"genome":[427],"sequencing,":[428],"synthetic":[429],"chemistry,":[430],"genetics,":[431],"vitro":[434],"biochemistry":[435],"unravel":[437],"piece":[445],"detective":[448],"came":[450],"inactivation":[452],"one":[454],"genes":[457],"gene":[462],"cluster":[463],"(lmbV),":[464],"resulted":[466],"unexpected":[469],"accumulation":[470],"1":[473,510],"contained":[475],"via":[477],"\u03b2-S":[479],"glycosidic":[480],"linkage":[481],"1B).":[483],"Then,":[484],"using":[485],"ortholog":[487],"LmbV":[489,569],"(the":[490],"enzyme":[491],"CcbV":[492],"involved":[493,616],"cousin":[499],"celesticetin),":[500],"demonstrated":[502],"exchange":[504],"\u03b2-linked":[507],"\u03b1-linked":[512],"2.":[515],"result":[517],"raised":[519],"question":[521],"how":[523],"incorporated":[526],"1.":[528,606],"As":[529,778],"summarized":[530],"1B,":[533],"authors":[535],"were":[536],"able":[537],"demonstrate":[539],"glycosyltransferase":[542],"(GTase)":[543],"LmbT":[544,578],"catalyzes":[545],"displacement":[547],"guanosine":[549],"diphosphate":[550],"(GDP)":[551],"GDP-D-\u03b1-D-lincosamide":[553],"(3)":[554],"generate":[558],"S-conjugated":[561],"lincosamine":[562],"(4).":[563],"Thus,":[564],"released":[567],"can":[570,633,748],"recycled":[572],"reaction.":[579],"pathway":[581],"driven":[584],"forward":[585],"coupling":[588],"4":[591],"with":[592],"4-propyl-l-proline":[593],"(PPL)":[594],"combined":[597],"LmbC,":[600],"LmbN,":[601],"LmbD":[603],"afford":[605],"LmbE,":[607],"member":[609],"amidase":[612],"family":[613],"MSH-mediated":[618],"detoxification,":[619],"selectively":[621],"cleaves":[622],"amide":[624],"bond":[625],"furnish":[627],"5":[629,641],"GlcN-Ins,":[631],"regenerate":[637],"MSH.":[638],"Finally,":[639],"expected":[643],"transformed":[646],"downstream":[652],"enzymes":[653,713],"demonstration":[656,670],"acts":[659],"involvement":[673],"reactions.":[678],"Why":[679],"scaffold":[686],"LmbCDN":[689],"rather":[691],"installing":[693],"start":[697],"clear,":[700],"answer":[703],"might":[704],"related":[706],"evolutionary":[709],"history":[710],"these":[712],"binding":[720],"site.":[721],"use":[727,801],"reaction,":[733],"establishment":[735],"indicates":[745],"functional":[751],"surrogate":[752],"actinomycetes":[756],"protection":[760],"against":[761],"stress":[763],"toxins,":[766],"product":[776],"biosynthesis.":[777],"homologs":[779],"LmbE":[781],"pathways":[787],"sulfur-containing":[790],"products,":[792],"it":[793],"will":[794],"interesting":[796],"see":[798],"if":[799],"common.":[809],"this":[811],"regard,":[812],"current":[814],"groundbreaking":[815],"lays":[817],"foundation":[819],"future":[821],"study":[822],"EGT-dependent":[826],"proteins":[827],"associated":[829],"processes.":[831]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2016-06-24T00:00:00"}