{"id":"https://openalex.org/W2270624586","doi":"https://doi.org/10.1371/journal.ppat.1005408","title":"IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid","display_name":"IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2270624586","doi":"https://doi.org/10.1371/journal.ppat.1005408","mag":"2270624586","pmid":"https://pubmed.ncbi.nlm.nih.gov/26829557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4734697"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1005408","doi":"https://doi.org/10.1371/journal.ppat.1005408","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005408","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005408&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005408&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061837600","display_name":"Jan Naujoks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Naujoks","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083072710","display_name":"Christoph Tabeling","orcid":"https://orcid.org/0000-0001-9189-4318","observed_orcids":["https://orcid.org/0000-0001-9189-4318"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Tabeling","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055794973","display_name":"Brian D. Dill","orcid":"https://orcid.org/0000-0002-4532-3044","observed_orcids":["https://orcid.org/0000-0002-4532-3044"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian D. Dill","raw_affiliation_strings":["MRC Protein Phosphorylation Unit, University of Dundee, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Protein Phosphorylation Unit, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103503401","display_name":"Christine Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261663","display_name":"Max-von-Pettenkofer-Institut f\u00fcr Hygiene und Medizinische Mikrobiologie","ror":"https://ror.org/05na4hm84","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405261663","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Hoffmann","raw_affiliation_strings":["Max-von-Pettenkofer Institute, Ludwig Maximilian University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-von-Pettenkofer Institute, Ludwig Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I4405261663","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013262175","display_name":"Andrew Stephen Brown","orcid":"https://orcid.org/0000-0002-1163-8283","observed_orcids":["https://orcid.org/0000-0002-1163-8283"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew S. Brown","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028959929","display_name":"Mareike Kunze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mareike Kunze","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058786533","display_name":"Stefan Kempa","orcid":"https://orcid.org/0000-0002-0696-9299","observed_orcids":["https://orcid.org/0000-0002-0696-9299"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Kempa","raw_affiliation_strings":["Integrative Metabolomics and Proteomics, Institute of Medical Systems Biology/Max-Delbrueck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Metabolomics and Proteomics, Institute of Medical Systems Biology/Max-Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrea Peter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Peter","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024513852","display_name":"Hans\u2010Joachim Mollenkopf","orcid":"https://orcid.org/0000-0003-1167-4783","observed_orcids":["https://orcid.org/0000-0003-1167-4783"]},"institutions":[{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Joachim Mollenkopf","raw_affiliation_strings":["Max Planck Institute for Infection Biology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Infection Biology, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022339560","display_name":"Anca Dorhoi","orcid":"https://orcid.org/0000-0003-1739-749X","observed_orcids":["https://orcid.org/0000-0003-1739-749X"]},"institutions":[{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anca Dorhoi","raw_affiliation_strings":["Max Planck Institute for Infection Biology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Infection Biology, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089828225","display_name":"Olivia Kershaw","orcid":"https://orcid.org/0000-0002-3686-9993","observed_orcids":["https://orcid.org/0000-0002-3686-9993"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olivia Kershaw","raw_affiliation_strings":["Department of Veterinary Pathology, Free University Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Free University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011653179","display_name":"Achim Dieter Gruber","orcid":"https://orcid.org/0000-0002-4502-0393","observed_orcids":["https://orcid.org/0000-0002-4502-0393"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Achim D. Gruber","raw_affiliation_strings":["Department of Veterinary Pathology, Free University Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Free University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040615109","display_name":"Leif Erik Sander","orcid":"https://orcid.org/0000-0002-0476-9947","observed_orcids":["https://orcid.org/0000-0002-0476-9947","https://orcid.org/0000-0002-3807-473X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leif E. Sander","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048444402","display_name":"Martin Witzenrath","orcid":"https://orcid.org/0000-0002-9787-5633","observed_orcids":["https://orcid.org/0000-0002-9787-5633"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Witzenrath","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018046421","display_name":"Susanne Herold","orcid":"https://orcid.org/0000-0001-6343-0911","observed_orcids":["https://orcid.org/0000-0001-6343-0911"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Herold","raw_affiliation_strings":["Medizinische Klinik II, University Giessen and Marburg Lung Center, Justus-Liebig-University Giessen, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, University Giessen and Marburg Lung Center, Justus-Liebig-University Giessen, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103075647","display_name":"Andreas G. Nerlich","orcid":"https://orcid.org/0000-0001-8577-2744","observed_orcids":["https://orcid.org/0000-0001-8577-2744"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Nerlich","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026009","display_name":"Andreas Christian Hocke","orcid":"https://orcid.org/0000-0002-6935-8612","observed_orcids":["https://orcid.org/0000-0002-6935-8612"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas C. Hocke","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031541436","display_name":"Ian Richard van Driel","orcid":"https://orcid.org/0000-0001-5371-120X","observed_orcids":["https://orcid.org/0000-0001-5371-120X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian van Driel","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040973193","display_name":"Norbert Suttorp","orcid":"https://orcid.org/0000-0002-3958-1151","observed_orcids":["https://orcid.org/0000-0002-3958-1151"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Suttorp","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061330101","display_name":"Sammy Bedoui","orcid":"https://orcid.org/0000-0002-7443-0543","observed_orcids":["https://orcid.org/0000-0002-7443-0543"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sammy Bedoui","raw_affiliation_strings":["The Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061765661","display_name":"Hubert Hilbi","orcid":"https://orcid.org/0000-0002-5462-9301","observed_orcids":["https://orcid.org/0000-0002-5462-9301"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4405261663","display_name":"Max-von-Pettenkofer-Institut f\u00fcr Hygiene und Medizinische Mikrobiologie","ror":"https://ror.org/05na4hm84","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405261663","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Hubert Hilbi","raw_affiliation_strings":["Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland","Max-von-Pettenkofer Institute, Ludwig Maximilian University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Max-von-Pettenkofer Institute, Ludwig Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I4405261663","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000162520","display_name":"Matthias Trost","orcid":"https://orcid.org/0000-0002-5732-700X","observed_orcids":["https://orcid.org/0000-0002-5732-700X"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthias Trost","raw_affiliation_strings":["MRC Protein Phosphorylation Unit, University of Dundee, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Protein Phosphorylation Unit, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031735316","display_name":"Bastian Opitz","orcid":"https://orcid.org/0000-0003-1276-836X","observed_orcids":["https://orcid.org/0000-0003-1276-836X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bastian Opitz","raw_affiliation_strings":["Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5031735316"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":18.7497,"has_fulltext":true,"cited_by_count":267,"citation_normalized_percentile":{"value":0.99757399,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"2","first_page":"e1005408","last_page":"e1005408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8240000009536743},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/legionella-pneumophila","display_name":"Legionella pneumophila","score":0.9940000176429749},{"id":"https://openalex.org/keywords/legionnaires-disease","display_name":"Legionnaires' disease","score":0.8629999756813049},{"id":"https://openalex.org/keywords/legionella-containing-vacuole","display_name":"Legionella-containing vacuole","score":0.8489999771118164},{"id":"https://openalex.org/keywords/irg1","display_name":"IRG1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/itaconic-acid","display_name":"itaconic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9309999942779541},{"id":"https://openalex.org/keywords/intracellular-bacterial-infection","display_name":"intracellular bacterial infection","score":0.722000002861023},{"id":"https://openalex.org/keywords/antimicrobial-metabolites","display_name":"antimicrobial metabolites","score":0.6100000143051147},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.9359999895095825},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.5479999780654907},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.8715593814849854},{"id":"https://openalex.org/C2776118409","wikidata":"https://www.wikidata.org/wiki/Q147885","display_name":"Legionella pneumophila","level":3,"score":0.767808198928833},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7647866010665894},{"id":"https://openalex.org/C2779990784","wikidata":"https://www.wikidata.org/wiki/Q903311","display_name":"Itaconic acid","level":4,"score":0.6972329616546631},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6547819972038269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6507692337036133},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5929577946662903},{"id":"https://openalex.org/C2779164008","wikidata":"https://www.wikidata.org/wiki/Q158013","display_name":"Legionella","level":3,"score":0.4876357614994049},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4840790331363678},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4554767608642578},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.4292113780975342},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2885271906852722},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27556055784225464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21388298273086548},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.1960306465625763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17262956500053406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09945294260978699},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":16,"locations":[{"id":"doi:10.1371/journal.ppat.1005408","doi":"https://doi.org/10.1371/journal.ppat.1005408","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005408","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005408&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmid:26829557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26829557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/f2e64dc4-b09d-4c55-8f8e-435cb3efe2fb","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/f2e64dc4-b09d-4c55-8f8e-435cb3efe2fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naujoks, J, Tabeling, C, Dill, B D, Hoffmann, C, Brown, A S, Kunze, M, Kempa, S, Peter, A, Mollenkopf, H J, Dorhoi, A, Kershaw, O, Gruber, A D, Sander, L E, Witzenrath, M, Herold, S, Nerlich, A, Hocke, A C, van Driel, I, Suttorp, N, Bedoui, S, Hilbi, H, Trost, M & Opitz, B 2016, 'IFNs Modify the Proteome of Legionella -Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid', PLoS Pathogens, vol. 12, no. 2, e1005408. https://doi.org/10.1371/journal.ppat.1005408","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4734697","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4734697/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:edoc.mdc-berlin.de:15430","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/15430/1/15430oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/15430/1/15430oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:www.zora.uzh.ch:128957","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/128957/1/128957.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/128957/1/128957.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2273201","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002A-4DBF-B","pdf_url":"https://hdl.handle.net/11858/00-001M-0000-002A-4DC1-3","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:eaa236391a7d4f88ad687cf6bf355f63","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eaa236391a7d4f88ad687cf6bf355f63","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 12, Iss 2, p e1005408 (2016)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:38092","doi":null,"is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-38092-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Pathogens","raw_type":"doc-type:article"},{"id":"pmh:oai:escidoc.org:escidoc:2273201","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002A-4DBF-B","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/2578576","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/IFNs_Modify_the_Proteome_of_i_Legionella_i_Containing_Vacuoles_and_Restrict_Infection_Via_IRG1_Derived_Itaconic_Acid/2578576","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/258941","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/258941","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/16678","doi":null,"is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/16678","pdf_url":null,"source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/123599","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/123599","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., \u2026 Opitz, B. (2016). IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid. PLoS Pathogens, 12, e1005408. https://doi.org/10.1371/journal.ppat.1005408","raw_type":"Journal Article"},{"id":"doi:10.17169/refubium-20859","doi":"https://doi.org/10.17169/refubium-20859","is_oa":true,"landing_page_url":"https://doi.org/10.17169/refubium-20859","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5167/uzh-128957","doi":"https://doi.org/10.5167/uzh-128957","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-128957","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1005408","doi":"https://doi.org/10.1371/journal.ppat.1005408","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005408","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005408&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1805043563","display_name":null,"funder_award_id":"SPP1580/OP86/10-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3541515630","display_name":null,"funder_award_id":"SPP 1580","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G569136689","display_name":null,"funder_award_id":"SFB\u2010TR84","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320317967","display_name":"International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","ror":null},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":"https://ror.org/04hazks31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2270624586.pdf","grobid_xml":"https://content.openalex.org/works/W2270624586.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W170699244","https://openalex.org/W1542673149","https://openalex.org/W1544733216","https://openalex.org/W1574907278","https://openalex.org/W1768897650","https://openalex.org/W1947117981","https://openalex.org/W1964037649","https://openalex.org/W1972726560","https://openalex.org/W1973723338","https://openalex.org/W1974652539","https://openalex.org/W1975556592","https://openalex.org/W1977039417","https://openalex.org/W1979921905","https://openalex.org/W1980376664","https://openalex.org/W1984035213","https://openalex.org/W1986639500","https://openalex.org/W1988197452","https://openalex.org/W1988651019","https://openalex.org/W1989102699","https://openalex.org/W1989652111","https://openalex.org/W1992762970","https://openalex.org/W1994691573","https://openalex.org/W1995878762","https://openalex.org/W1997313407","https://openalex.org/W1998923995","https://openalex.org/W2009101093","https://openalex.org/W2012193854","https://openalex.org/W2014824541","https://openalex.org/W2016503643","https://openalex.org/W2019997079","https://openalex.org/W2023368253","https://openalex.org/W2032303370","https://openalex.org/W2040516599","https://openalex.org/W2053089215","https://openalex.org/W2053818267","https://openalex.org/W2058235794","https://openalex.org/W2058277625","https://openalex.org/W2061912939","https://openalex.org/W2070479570","https://openalex.org/W2077493798","https://openalex.org/W2078646756","https://openalex.org/W2078710631","https://openalex.org/W2080752012","https://openalex.org/W2080827095","https://openalex.org/W2081393349","https://openalex.org/W2081535038","https://openalex.org/W2081613861","https://openalex.org/W2082889122","https://openalex.org/W2084045789","https://openalex.org/W2084604444","https://openalex.org/W2085202049","https://openalex.org/W2087470992","https://openalex.org/W2096221337","https://openalex.org/W2104416424","https://openalex.org/W2113120391","https://openalex.org/W2119242392","https://openalex.org/W2124846950","https://openalex.org/W2125404003","https://openalex.org/W2130776456","https://openalex.org/W2132309323","https://openalex.org/W2144206275","https://openalex.org/W2150558072","https://openalex.org/W2150761285","https://openalex.org/W2151684454","https://openalex.org/W2155417514","https://openalex.org/W2157403238","https://openalex.org/W2157783137","https://openalex.org/W2159675211","https://openalex.org/W2161320421","https://openalex.org/W2168638958","https://openalex.org/W2171030481"],"related_works":["https://openalex.org/W2271970244","https://openalex.org/W945508491","https://openalex.org/W1986649720","https://openalex.org/W2992401849","https://openalex.org/W2665125655","https://openalex.org/W1544733216","https://openalex.org/W2101141686","https://openalex.org/W7100790622","https://openalex.org/W2151684454","https://openalex.org/W1947117981"],"abstract_inverted_index":{"Macrophages":[0],"can":[1],"be":[2,149],"niches":[3],"for":[4],"bacterial":[5,50,128],"pathogens":[6],"or":[7,143],"antibacterial":[8],"effector":[9],"cells":[10],"depending":[11],"on":[12],"the":[13,18,118],"pathogen":[14],"and":[15,27,40,65,73,92,112,130,155],"signals":[16],"from":[17],"immune":[19,46],"system.":[20],"Here":[21],"we":[22],"show":[23],"that":[24,48,58,86],"type":[25],"I":[26],"II":[28],"IFNs":[29,60,83,121],"are":[30],"master":[31],"regulators":[32],"of":[33,42,71,95,127,134],"gene":[34,78],"expression":[35],"during":[36,52],"Legionella":[37],"pneumophila":[38,105],"infection,":[39],"activators":[41],"an":[43],"alveolar":[44],"macrophage-intrinsic":[45],"response":[47],"restricts":[49],"growth":[51],"pneumonia.":[53],"Quantitative":[54],"mass":[55],"spectrometry":[56],"revealed":[57],"both":[59],"substantially":[61],"modify":[62],"Legionella-containing":[63,90],"vacuoles,":[64,91],"comparative":[66],"analyses":[67],"reveal":[68],"distinct":[69],"subsets":[70],"transcriptionally":[72],"spatially":[74],"IFN-regulated":[75],"proteins.":[76],"Immune-responsive":[77],"(IRG)1":[79],"is":[80,100],"induced":[81],"by":[82],"in":[84,123,131],"mitochondria":[85],"closely":[87],"associate":[88],"with":[89],"mediates":[93],"production":[94,133],"itaconic":[96,136,146],"acid.":[97],"This":[98],"metabolite":[99],"bactericidal":[101],"against":[102],"intravacuolar":[103,140],"L.":[104],"as":[106,108],"well":[107],"extracellular":[109],"multidrug-resistant":[110],"Gram-positive":[111],"-negative":[113],"bacteria.":[114,157],"Our":[115],"study":[116],"explores":[117],"overall":[119],"role":[120],"play":[122],"inducing":[124],"substantial":[125],"remodeling":[126],"vacuoles":[129],"stimulating":[132],"IRG1-derived":[135],"acid":[137,147],"which":[138],"targets":[139],"pathogens.":[141],"IRG1":[142],"its":[144],"product":[145],"might":[148],"therapeutically":[150],"targetable":[151],"to":[152],"fight":[153],"intracellular":[154],"drug-resistant":[156]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
