{"id":"https://openalex.org/W22704884","doi":null,"title":"Predictors of disease onset and progression in early rheumatoid arthritis : A clinical, laboratory and radiological study","display_name":"Predictors of disease onset and progression in early rheumatoid arthritis : A clinical, laboratory and radiological study","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W22704884","mag":"22704884"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-669","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-669","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041771746","display_name":"Ewa H. Berglin","orcid":"https://orcid.org/0000-0002-9443-5376","observed_orcids":["https://orcid.org/0000-0002-9443-5376"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ewa Berglin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9443-5376","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041771746"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/disease-onset-prediction","display_name":"disease onset prediction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anti-ccp-antibodies","display_name":"anti-CCP antibodies","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5820000171661377},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.6629999876022339},{"id":"https://openalex.org/keywords/larsen-score","display_name":"Larsen score","score":0.8040000200271606},{"id":"https://openalex.org/keywords/radiographic-damage","display_name":"radiographic damage","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dual-energy-x-ray-absorptiometry","display_name":"dual-energy X-ray absorptiometry","score":0.8529999852180481},{"id":"https://openalex.org/keywords/conventional-radiography","display_name":"conventional radiography","score":0.6029999852180481},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.5609999895095825},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.4180000126361847},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6290000081062317},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7647442817687988},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7025761008262634},{"id":"https://openalex.org/C190892606","wikidata":"https://www.wikidata.org/wiki/Q3512464","display_name":"Radiological weapon","level":2,"score":0.6397850513458252},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5700380206108093},{"id":"https://openalex.org/C2910723750","wikidata":"https://www.wikidata.org/wiki/Q1187697","display_name":"Adult-onset Still's disease","level":3,"score":0.5156534910202026},{"id":"https://openalex.org/C2992264114","wikidata":"https://www.wikidata.org/wiki/Q1394551","display_name":"Clinical disease","level":3,"score":0.41179609298706055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37760117650032043},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23631930351257324}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-669","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-669","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:22704884","doi":null,"is_oa":false,"landing_page_url":"https://umu.diva-portal.org/smash/record.jsf?pid=diva2:144188","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-669","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-669","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151409106","https://openalex.org/W125469084","https://openalex.org/W2165045003","https://openalex.org/W2751594739","https://openalex.org/W2046540088","https://openalex.org/W2171882829","https://openalex.org/W2555478366","https://openalex.org/W2140410277","https://openalex.org/W2127501245","https://openalex.org/W2146455486"],"abstract_inverted_index":{"To":[0],"diagnose":[1],"rheumatoid":[2,118],"arthritis":[3],"(RA)":[4],"during":[5,230],"the":[6,10,45,108,128,156,161,187,231,251,280,284,292,371,400,405,411,415,430,573,577,584],"early":[7,55,145,157,271,293,406],"stages":[8],"of":[9,73,83,87,102,110,131,134,139,150,163,174,176,193,287,310,314,343,352,373,377,393,402,425,429,432,450,466,483,491,544,554,586,595],"disease":[11,16,29,88,140,217,440,443],"is":[12,50,560,591],"often":[13],"difficult.":[14],"The":[15,71,172,216,312,375,423,464,500,552],"course":[17],"shows":[18],"great":[19],"inter-individual":[20],"variation":[21],"from":[22,66,291,301,327],"mild,":[23],"self-limiting":[24],"to":[25,43,52,59,77,90,106,273,362],"very":[26],"severe":[27],"destruc-tive":[28],"with":[30,36,144,148,237,333,385,477,496,562],"extra-articular":[31],"manifestations.":[32],"Early":[33],"aggressive":[34],"treatment":[35],"potentially":[37],"toxic":[38],"drugs":[39],"has":[40],"been":[41,305],"shown":[42],"improve":[44],"long-term":[46],"outcome.":[47],"Thus,":[48],"it":[49],"desirable":[51],"make":[53],"an":[54,270],"reliable":[56],"di-agnosis":[57],"and":[58,80,96,105,121,136,168,181,195,199,213,222,233,250,262,283,317,321,331,348,357,367,380,410,414,428,435,438,445,452,458,472,517,537,546,550,557,576,582],"identify":[60],"those":[61],"patients":[62,143,190,290,403],"who":[63],"would":[64],"benefit":[65],"being":[67],"treated":[68],"most":[69],"aggressively.":[70],"aim":[72],"this":[74],"thesis":[75],"was":[76,184,219,234,253,267,323,383,447,475,481,494,502],"evaluate":[78],"laboratory":[79],"clinically":[81,221],"markers":[82,175],"inflammation":[84,177],"as":[85,100,137,480],"predic-tors":[86],"course,":[89],"compare":[91],"dual-energy":[92],"X-ray":[93],"absorptiometry":[94],"(DXA)":[95],"conventional":[97],"radiog-raphy":[98],"(CR)":[99],"measures":[101],"joint":[103,519,596],"destruction":[104,549,597],"investigate":[107],"significance":[109,424],"antibodies":[111,316,347,366,379,434,468,493,536,556],"against":[112],"cyclic":[113],"citrullinated":[114],"peptide":[115],"(anti-CCP":[116],"antibodies),":[117],"factors":[119],"(RFs)":[120],"HLA":[122],"shared":[123],"epitope":[124],"(SE)":[125],"alleles":[126,337,382,427,559],"for":[127,178,390,442,541,547,567],"relative":[129,388,565],"risk":[130,389,566],"future":[132,391,542,568],"development":[133,392],"RA":[135,149,158,294,353,407,545],"predictors":[138,540],"severity":[141,446],"in":[142,155,186,204,243,247,256,265,325,340,359,404,469,580],"RA.":[146,374,394,569],"Patients":[147],"recent":[151],"onset":[152,309,351,372,441,543],"are":[153,169,539],"included":[154],"programme":[159,295,408],"at":[160,209,240,439,456,473,486],"Department":[162],"Rheumatology,":[164],"University":[165],"Hospital,":[166],"Ume\u00e5":[167],"followed":[170],"longitudinally.":[171],"prediction":[173],"bone":[179,200,263,578],"loss":[180,264,579],"radiological":[182,478,498,523,574],"outcome":[183],"analyzed":[185],"first":[188],"43":[189],"recruited.":[191],"Radiographs":[192,449],"hands":[194,205,244,266,451,581],"feet":[196,453],"(Larsen":[197,462],"score)":[198],"mineral":[201],"density":[202],"(BMD)":[203],"(DXA),":[206],"were":[207,296,338,421,454],"assessed":[208,339,455],"baseline,":[210],"after":[211,459],"1":[212],"2":[214,460],"years.":[215],"activity":[218,444],"evaluated":[220],"by":[223,269,354,504],"labora-tory":[224],"tests.":[225],"Radiological":[226,260],"damage":[227],"increased":[228,358],"significantly":[229,246,369],"study":[232,278],"particularly":[235],"corre-lated":[236],"Larsen":[238],"score":[239],"baseline.":[241,487],"BMD":[242],"decreased":[245],"postmenopausal":[248],"women":[249],"decrease":[252],"greater":[254,497,522],"than":[255,598],"healthy":[257],"matched":[258,334],"controls.":[259,335],"progression":[261],"retarded":[268],"response":[272,528,571],"therapy.":[274],"In":[275,395,508,533],"a":[276,341,386,396,505,526,530,563,592],"case-control":[277],"within":[279],"Medical":[281,412],"Biobank":[282,413],"Maternity":[285,416],"cohort":[286],"Northern":[288],"Sweden,":[289],"identified":[297],"among":[298],"blood":[299],"donors":[300],"whom":[302],"samples":[303,326,420,471],"had":[304],"collected":[306],"years":[307,356,461],"before":[308,437],"symptoms.":[311],"prevalence":[313,360],"anti-CCP":[315,378,433,467,492,513,535,555,587],"RFs":[318,349,436,485],"(IgA-RF,":[319],"IgG-RF":[320],"IgM-RF)":[322],"investigated":[324],"83":[328],"individuals":[329],"(pre-patients)":[330],"com-pared":[332],"SE":[336,381,426,558],"sub-group":[342],"59":[344],"individuals.":[345],"Anti-CCP":[346,365],"preceded":[350],"several":[355],"closer":[361],"dis-ease":[363],"onset.":[364],"IgA-RF":[368,538],"predicted":[370,521,529],"combination":[376,553],"associated":[384,476,495],"high":[387,564],"later":[397],"co-analysis":[398],"between":[399],"register":[401],"(n=138)":[409],"cohort,":[417],"93":[418],"pre-patient":[419,470],"identified.":[422],"presence":[431,465,482],"studied.":[448],"baseline":[457,474],"score).":[463],"damage,":[479],"all":[484],"A":[488],"higher":[489],"titre":[490,501,585],"progression.":[499,551],"lowered":[503],"therapeutic":[506,527],"response.":[507],"multiple":[509],"logistic":[510],"regression":[511],"analyses":[512],"antibodies,":[514],"IgA-RF,":[515],"ESR":[516],"swollen":[518],"count":[520],"progression,":[524],"whilst":[525],"lesser":[531],"pro-gression.":[532],"conclusion,":[534],"radio-logical":[548],"associ-ated":[561],"Therapeutic":[570],"decreases":[572],"progres-sion":[575],"lowers":[583],"antibodies.":[588],"Conventional":[589],"radiography":[590],"better":[593],"measure":[594],"DXA.":[599]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}