{"id":"https://openalex.org/W227048668","doi":"https://doi.org/10.4264/numa.71.282","title":"Polypoidal Choroidal Vasculopathy","display_name":"Polypoidal Choroidal Vasculopathy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W227048668","doi":"https://doi.org/10.4264/numa.71.282","mag":"227048668","pmid":"https://pubmed.ncbi.nlm.nih.gov/22568102"},"language":"ja","primary_location":{"id":"doi:10.4264/numa.71.282","doi":"https://doi.org/10.4264/numa.71.282","is_oa":true,"landing_page_url":"https://doi.org/10.4264/numa.71.282","pdf_url":"https://www.jstage.jst.go.jp/article/numa/71/4/71_282/_pdf","source":{"id":"https://openalex.org/S173940643","display_name":"Journal of Nihon University Medical Association","issn_l":"0029-0424","issn":["0029-0424","1884-0779"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nihon University Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/numa/71/4/71_282/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112269808","display_name":"Mitsuko Yuzawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuko Yuzawa","raw_affiliation_strings":["Division of Ophthalmology, Department of Visual Science, Nihon University, School of Medicine, Chiyoda-ku, Tokyo, Japan. yuzawa.mitsuko@nihon-u.ac.jp","Division of Ophthalmology, Department of Visual Science, Nihon University, School of Medicine, Chiyoda-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Ophthalmology, Department of Visual Science, Nihon University, School of Medicine, Chiyoda-ku, Tokyo, Japan. yuzawa.mitsuko@nihon-u.ac.jp","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Ophthalmology, Department of Visual Science, Nihon University, School of Medicine, Chiyoda-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I104946051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112269808"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":null,"apc_paid":null,"fwci":1.4115,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79343243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"4","first_page":"282","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polypoidal-choroidal-vasculopathy","display_name":"polypoidal choroidal vasculopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.953000009059906},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bruch-s-membrane","display_name":"Bruch's membrane","score":0.8209999799728394},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9330000281333923},{"id":"https://openalex.org/keywords/feeder-vessels","display_name":"feeding vessels","score":0.5429999828338623},{"id":"https://openalex.org/keywords/indocyanine-green-angiography","display_name":"indocyanine green angiography","score":0.847000002861023},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.8859999775886536},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9746801853179932},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5063706636428833}],"mesh":[{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015862","descriptor_name":"Choroid Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015862","descriptor_name":"Choroid Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015862","descriptor_name":"Choroid Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015862","descriptor_name":"Choroid Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4264/numa.71.282","doi":"https://doi.org/10.4264/numa.71.282","is_oa":true,"landing_page_url":"https://doi.org/10.4264/numa.71.282","pdf_url":"https://www.jstage.jst.go.jp/article/numa/71/4/71_282/_pdf","source":{"id":"https://openalex.org/S173940643","display_name":"Journal of Nihon University Medical Association","issn_l":"0029-0424","issn":["0029-0424","1884-0779"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nihon University Medical Association","raw_type":"journal-article"},{"id":"pmid:22568102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22568102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nippon Ganka Gakkai zasshi","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.4264/numa.71.282","doi":"https://doi.org/10.4264/numa.71.282","is_oa":true,"landing_page_url":"https://doi.org/10.4264/numa.71.282","pdf_url":"https://www.jstage.jst.go.jp/article/numa/71/4/71_282/_pdf","source":{"id":"https://openalex.org/S173940643","display_name":"Journal of Nihon University Medical Association","issn_l":"0029-0424","issn":["0029-0424","1884-0779"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nihon University Medical Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W227048668.pdf","grobid_xml":"https://content.openalex.org/works/W227048668.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017727648","https://openalex.org/W7084037754","https://openalex.org/W2064565985","https://openalex.org/W3131428361","https://openalex.org/W2375572528","https://openalex.org/W2351447969","https://openalex.org/W2037139149","https://openalex.org/W2053989131","https://openalex.org/W2155683225","https://openalex.org/W2105442461"],"abstract_inverted_index":{"Polypoidal":[0,512,745],"choroidal":[1,91,155,227,773],"vasculopathy":[2],"(PCV)":[3],"is":[4,23,147,321,505,662,747,767,791],"characterized":[5,741],"by":[6,185,422,621,742],"a":[7,26,138,257,325,576,638,654,664,702,795],"branching":[8,598,613],"vascular":[9,599,614],"network":[10,85,121,128,283,299,309,363,389,432,452,546,600,615],"with":[11,343,519,549,653,697],"polypoidal":[12,104,133,143,286,302,319,472,550,557,605,622,684,727],"lesions":[13,303,558,606],"under":[14,330,754],"the":[15,41,51,74,107,145,154,160,169,178,219,239,253,267,278,305,308,315,328,331,336,349,358,362,370,376,379,388,393,404,415,429,437,448,471,479,489,492,497,545,553,565,594,597,610,644,678,681,732,737,755,764],"retinal":[16,268],"pigment":[17,269],"epithelium":[18,270],"(RPE).":[19],"In":[20,73,106,333,477,591],"Japan,":[21],"it":[22],"classified":[24,723],"as":[25,633,637,782],"specific":[27],"form":[28,298],"of":[29,45,57,90,95,103,125,127,140,153,166,175,191,226,277,307,312,327,352,378,395,417,466,481,525,544,547,555,649,657,683,704,752,779],"exudative":[30,194],"age-related":[31,509,520,758],"macular":[32,510,521,759],"degeneration.":[33,511,522],"However,":[34,569],"several":[35,418],"issues":[36],"which":[37,181,243,264,313,361,374,451,661],"we":[38],"investigated":[39,50],"regarding":[40],"pathogenesis":[42],"and":[43,55,79,84,117,189,202,273,285,301,421,474,496,552,586,604,618,718,729],"treatment":[44,56,640,796],"PCV":[46,158,167,176,217,334,490,592,642,721,730,735,762,786],"remain":[47],"unresolved.":[48],"We":[49],"pathogenesis,":[52],"clinical":[53],"findings":[54,89,165,214],"PCV.":[58,527,799],"1.":[59],"Indocyanine":[60],"green":[61,71,713],"angiographic":[62],"findings.":[63,233,458],"There":[64,459],"were":[65,82,101,115,119,187,208,460,559],"two":[66],"different":[67],"patterns":[68],"on":[69,98],"indocyanine":[70,712],"angiograms.":[72],"first":[75],"pattern,":[76,109],"both":[77,311],"feeder":[78,111,258],"draining":[80,113],"vessels":[81,86,100,114,129,207,284,289,300,399,420,427,548],"visible":[83,116],"showed":[87],"characteristic":[88],"neovascularization":[92],"(CNV).":[93],"Points":[94],"focal":[96],"dilatation":[97,188],"marginal":[99],"comprised":[102],"lesions.":[105,134,287],"second":[108],"neither":[110],"nor":[112],"there":[118],"few":[120],"vessels.":[122,228,390,433],"The":[123,135,172,213,260,381,434,500,612,776],"points":[124],"deformation":[126,139,326,751],"appeared":[130],"to":[131,149,256,266,281,292,297,323,348,357,387,407,414,442,508,516,564,575,579,582,692,749,769,772,793],"be":[132,401,440,517,693,770],"former":[136],"represents":[137],"CNV,":[141],"i.e.":[142,157],"CNV;":[144],"latter":[146],"thought":[148,291,322,515,748,768],"result":[150],"from":[151,223,392,425],"abnormalities":[152],"vessels,":[156,192,310],"in":[159,168,177,196,218,238,335,369,410,436,463,491,567,593,643,671,731,736,757,763],"strict":[161,170,179,220,337,493,595,645,733,738,765],"sense.":[162,171,646,734],"2.":[163],"Pathological":[164],"histopathological":[173,396],"characteristics":[174],"sense,":[180,338,596],"had":[182,573],"been":[183],"eliminated":[184],"vitrectomy,":[186],"hyalinization":[190],"massive":[193,423],"changes":[195],"blood":[197],"plasma,":[198],"basement":[199],"membrane-like":[200],"deposits":[201],"scant":[203],"granulomatous":[204],"tissue.":[205],"These":[206,627],"located":[209],"beneath":[210],"Bruch's":[211,245,295],"membrane.":[212,246],"indicate":[215,629],"that":[216,562,580,630],"sense":[221,494,739,766],"arises":[222],"hyalinized":[224],"arteriolosclerosis":[225],"3.":[229],"Optical":[230],"coherence":[231,716],"tomographic":[232],"A":[234,367],"break":[235,254],"was":[236,250,271,372,383,514,619,687,722,740,787],"found":[237],"high":[240,261],"reflective":[241,248,262,345],"line":[242,263,342],"revealed":[244],"Low":[247],"tissue":[249],"observed":[251,373],"at":[252,304,360,431,447,450,584,609,705],"corresponding":[255,356,386],"vessel.":[259],"corresponded":[265,280,563],"uneven,":[272],"highly":[274,344],"elevated":[275],"portions":[276],"RPE":[279,316,371,382,405,438,756],"thick":[282],"Feeder":[288],"are":[290],"invade":[293],"via":[294],"membrane":[296],"termini":[306],"push":[314],"upward.":[317],"Therefore,":[318],"CNV":[320,329,473,513,623,728,746,753],"represent":[324,750],"RPE.":[332],"an":[339,408],"irregular":[340],"thickened":[341],"substances":[346],"adhering":[347],"lower":[350],"portion":[351],"it,":[353],"curved":[354],"downward":[355],"site":[359],"vessel":[364,453,774],"filling":[365,454],"began.":[366,455],"dimple":[368,435],"paralleled":[375],"curve":[377],"line.":[380],"pushed":[384,402],"upward,":[385],"Judging":[391],"results":[394,628],"studies,":[397],"abnormal":[398],"may":[400],"up":[403],"secondary":[406],"increase":[409],"intravascular":[411],"pressure":[412,444],"due":[413,771],"presence":[416],"dilated":[419],"exudation":[424],"these":[426],"within":[428],"choroid":[430],"might":[439],"attributable":[441],"intra-choroidal":[443],"being":[445],"decreased":[446,574],"point":[449],"4.":[456],"Genetic":[457],"significant":[461],"differences":[462],"all":[464],"distributions":[465],"ARMS":[467,482,501],"2":[468,483,502,585,725],"(A69S)":[469,484,503],"between":[470,488],"control":[475,498],"groups.":[476],"contrast,":[478],"distribution":[480],"did":[485],"not":[486,663],"differ":[487],"group":[495],"group.":[499],"gene":[504],"closely":[506],"related":[507],"associated":[518],"5.":[523],"Treatment":[524],"subfoveal":[526,556,785],"Mean":[528],"visual":[529,539,571,655,673,699],"acuity":[530,572,656,674,700],"improved":[531],"1":[532,675],"year":[533,676],"after":[534,589,602,677],"photodynamic":[535],"therapy":[536],"(PDT).":[537],"Good":[538],"acuity,":[540],"small":[541],"lesion":[542,685],"size":[543],"lesions,":[551],"absence":[554],"pre-PDT":[560],"predictors":[561],"improvement":[566,670],"vision.":[568],"mean":[570,672],"level":[577],"similar":[578],"prior":[581],"PDT":[583,781],"3":[587],"years":[588],"treatment.":[590],"persisted":[601],"PDT,":[603,632,668],"frequently":[607],"recurred":[608],"termini.":[611],"sometimes":[616],"expanded":[617],"accompanied":[620],"or":[624,659],"classic":[625],"CNV.":[626],"repeated":[631,780],"monotherapy,":[634,783],"has":[635],"limitations":[636],"long-term":[639,777],"for":[641,651,667,695,701,784,798],"Intravitreal":[647],"injection":[648],"ranibizumab":[650],"eyes":[652,696],"0.6":[658],"more,":[660],"good":[665,698],"indication":[666],"achieved":[669],"treatment,":[679],"though":[680],"frequency":[682],"regression":[686],"low.":[688],"This":[689],"procedure":[690],"seems":[691],"useful":[694],"period":[703],"least":[706],"one":[707],"year.":[708],"6.":[709],"Conclusion.":[710],"Using":[711],"angiography,":[714],"optical":[715],"tomography":[717],"genetic":[719],"testing,":[720],"into":[724],"groups,":[726],"arteriolsclerosis":[743],"histopathologically.":[744],"degeneration,":[760],"while":[761],"abnormalities.":[775],"efficacy":[778],"limited.":[788],"Further":[789],"evaluation":[790],"necessary":[792],"establish":[794],"algorithm":[797]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}