{"id":"https://openalex.org/W2269907893","doi":null,"title":"Auto-regulation of the MBNL1 pre-mRNA","display_name":"Auto-regulation of the MBNL1 pre-mRNA","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2269907893","mag":"2269907893"},"language":"en","primary_location":{"id":"pmh:oai:scholarsbank.uoregon.edu:1794/11533","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1794/11533","pdf_url":"http://hdl.handle.net/1794/11533","source":{"id":"https://openalex.org/S4377196436","display_name":"Scholars' Bank (University of Oregon)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181233156","host_organization_name":"University of Oregon","host_organization_lineage":["https://openalex.org/I181233156"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1794/11533","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086228567","display_name":"Devika P. Gates","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Devika P. Gates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086228567"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mbnl1","display_name":"MBNL1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myotonic-dystrophy","display_name":"myotonic dystrophy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8130000233650208},{"id":"https://openalex.org/keywords/rna-binding-motif","display_name":"RNA-binding motif","score":0.5199999809265137},{"id":"https://openalex.org/keywords/rna-binding","display_name":"RNA binding","score":0.33799999952316284},{"id":"https://openalex.org/keywords/rna-structure-probing","display_name":"RNA structure probing","score":0.5049999952316284},{"id":"https://openalex.org/keywords/footprinting","display_name":"footprinting","score":0.6600000262260437},{"id":"https://openalex.org/keywords/selex","display_name":"SELEX","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2823525071144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21901339292526245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.181915283203125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07869327068328857}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarsbank.uoregon.edu:1794/11533","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1794/11533","pdf_url":"http://hdl.handle.net/1794/11533","source":{"id":"https://openalex.org/S4377196436","display_name":"Scholars' Bank (University of Oregon)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181233156","host_organization_name":"University of Oregon","host_organization_lineage":["https://openalex.org/I181233156"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2269907893","doi":null,"is_oa":false,"landing_page_url":"https://scholarsbank.uoregon.edu/xmlui/handle/1794/11533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarsbank.uoregon.edu:1794/11533","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1794/11533","pdf_url":"http://hdl.handle.net/1794/11533","source":{"id":"https://openalex.org/S4377196436","display_name":"Scholars' Bank (University of Oregon)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181233156","host_organization_name":"University of Oregon","host_organization_lineage":["https://openalex.org/I181233156"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2269907893.pdf","grobid_xml":"https://content.openalex.org/works/W2269907893.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1555409852","https://openalex.org/W1869970222","https://openalex.org/W1965051773","https://openalex.org/W1971507786","https://openalex.org/W1972381152","https://openalex.org/W1972533328","https://openalex.org/W1979337694","https://openalex.org/W1982263419","https://openalex.org/W1985991078","https://openalex.org/W1990059209","https://openalex.org/W1992481904","https://openalex.org/W1992763151","https://openalex.org/W1994674028","https://openalex.org/W1997887889","https://openalex.org/W2004160760","https://openalex.org/W2004901342","https://openalex.org/W2011920499","https://openalex.org/W2012145036","https://openalex.org/W2016866962","https://openalex.org/W2020334159","https://openalex.org/W2021018226","https://openalex.org/W2036412199","https://openalex.org/W2048359227","https://openalex.org/W2063936397","https://openalex.org/W2069679667","https://openalex.org/W2077546371","https://openalex.org/W2079699077","https://openalex.org/W2080119769","https://openalex.org/W2081280332","https://openalex.org/W2081748748","https://openalex.org/W2087166511","https://openalex.org/W2088268015","https://openalex.org/W2092831145","https://openalex.org/W2093889952","https://openalex.org/W2098571862","https://openalex.org/W2099643329","https://openalex.org/W2100990361","https://openalex.org/W2103049574","https://openalex.org/W2109936378","https://openalex.org/W2110459103","https://openalex.org/W2111277734","https://openalex.org/W2112760828","https://openalex.org/W2120235717","https://openalex.org/W2123560621","https://openalex.org/W2130803788","https://openalex.org/W2131948930","https://openalex.org/W2132505931","https://openalex.org/W2132852866","https://openalex.org/W2143350291","https://openalex.org/W2151612484","https://openalex.org/W2155804510","https://openalex.org/W2158826174","https://openalex.org/W2165961683","https://openalex.org/W2167616277","https://openalex.org/W2171904397"],"related_works":["https://openalex.org/W1965733051","https://openalex.org/W2558889421","https://openalex.org/W1990507930","https://openalex.org/W2112760828","https://openalex.org/W2760469823","https://openalex.org/W7095159426","https://openalex.org/W2304827694","https://openalex.org/W2087166511","https://openalex.org/W2182015606","https://openalex.org/W2018952308"],"abstract_inverted_index":{"Muscleblind-like":[0],"1":[1],"(MBNL1)":[2],"is":[3,11,42,163,175,191,260,298],"a":[4,12,58,187,200],"splicing":[5,287],"factor":[6],"whose":[7],"improper":[8],"cellular":[9],"localization":[10],"central":[13],"component":[14],"of":[15,23,30,68,78,90,121,127,143,151,172,215,223,227,269,281,294,304],"myotonic":[16],"dystrophy":[17],"(DM).":[18],"In":[19,46,102],"DM,":[20],"the":[21,50,88,114,131,141,152,195,228,238,248,253,256,270,276,282,301],"lack":[22],"properly":[24],"localized":[25],"MBNL1":[26,37,54,71,108,132,139,153,220,264,277,286,305],"leads":[27,290],"to":[28,48,110,291],"mis-splicing":[29],"many":[31],"pre-mRNAs.":[32],"The":[33,149,169],"mechanism":[34,51],"by":[35,52,80,100,118],"which":[36,53,272,297],"regulates":[38,55,221],"it":[39,179],"pre-mRNA":[40],"targets":[41],"not":[43],"well":[44,316],"understood.":[45],"order":[47],"determine":[49],"alternative":[56],"splicing,":[57],"consensus":[59,84,115],"RNA":[60],"binding":[61,104],"motif":[62,116],"for":[63,87,326],"Mbl":[64],"(the":[65],"Drosophila":[66],"ortholog":[67],"MBNL1)":[69],"and":[70,134,159,186,212,244,255,263,289],"were":[72,124],"determined":[73],"using":[74],"SELEX":[75],"(Systematic":[76],"Evolution":[77],"Ligands":[79],"Exponential":[81],"Enrichment).":[82],"These":[83],"motifs":[85],"allowed":[86],"identification":[89],"high":[91],"affinity":[92],"endogenous":[93],"sites":[94,123],"within":[95,130,266],"pre-mRNAs":[96],"that":[97,107,112,138,155,178,190,202,219,233,247,322],"are":[98],"regulated":[99],"MBNL1.":[101],"vitro":[103],"studies":[105],"showed":[106],"bound":[109],"RNAs":[111],"contained":[113],"surrounded":[117],"pyrimidines.":[119],"Some":[120],"these":[122],"identified":[125],"upstream":[126],"exon":[128,144,157,204,208,213,224,295],"5":[129,145,158,211],"pre-mRNA,":[133,271],"we":[135,217,273],"have":[136,274],"shown":[137],"auto-regulates":[140],"exclusion":[142],"in":[146,166,177],"HeLa":[147],"cells.":[148],"region":[150,251,268],"gene":[154],"includes":[156,203,310],"flanking":[160],"intronic":[161],"sequence":[162],"highly":[164,249],"conserved":[165,250],"vertebrate":[167],"genomes.":[168],"3'":[170,183,196,257],"end":[171],"intron":[173,206,210,229],"4":[174,230],"non-canonical":[176],"contains":[180],"an":[181],"AAG":[182],"splice":[184,197,258],"site":[185,259],"predicted":[188,239],"branchpoint":[189,231,254],"141":[192],"nucleotides":[193],"from":[194],"site.":[198],"Using":[199],"mini-gene":[201],"4,":[205,207],"5,":[209,296],"6":[214],"MBNL1,":[216],"show":[218],"inclusion":[222,293],"5.":[225],"Mapping":[226],"confirms":[232],"branching":[234],"occurs":[235],"primarily":[236,261],"at":[237],"distant":[240],"branchpoint.":[241],"Structure":[242],"probing":[243],"footprinting":[245],"reveal":[246],"between":[252],"unstructured,":[262],"binds":[265],"this":[267],"termed":[275],"response":[278,283],"element.":[279],"Deletion":[280],"element":[284],"eliminates":[285],"regulation":[288],"complete":[292],"consistent":[299],"with":[300],"suppressive":[302],"effect":[303],"on":[306],"splicing.":[307],"This":[308],"dissertation":[309],"previously":[311],"published":[312],"co-authored":[313,320],"material":[314,321],"as":[315,317],"my":[318],"recent":[319],"has":[323],"been":[324],"submitted":[325],"publication.":[327]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}