{"id":"https://openalex.org/W2269799693","doi":"https://doi.org/10.1042/bj3300121","title":"Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis","display_name":"Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis","publication_year":1998,"publication_date":"1998-02-15","ids":{"openalex":"https://openalex.org/W2269799693","doi":"https://doi.org/10.1042/bj3300121","mag":"2269799693","pmid":"https://pubmed.ncbi.nlm.nih.gov/9461500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1219117"},"language":"en","primary_location":{"id":"doi:10.1042/bj3300121","doi":"https://doi.org/10.1042/bj3300121","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3300121","pdf_url":"https://portlandpress.com/biochemj/article-pdf/330/1/121/634232/bj3300121.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/330/1/121/634232/bj3300121.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071571265","display_name":"C. Sarah WOODCOCK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Sarah WOODCOCK","raw_affiliation_strings":["Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280802","display_name":"Evelyne Raux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Evelyne RAUX","raw_affiliation_strings":["Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050501279","display_name":"Florence Levillayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence LEVILLAYER","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Laboratoire associ\u00e9 \u00e0 l'Universit\u00e9 Pierre et Marie Curie, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Laboratoire associ\u00e9 \u00e0 l'Universit\u00e9 Pierre et Marie Curie, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076485251","display_name":"Claude Thermes","orcid":"https://orcid.org/0000-0002-0023-5294","observed_orcids":["https://orcid.org/0000-0002-0023-5294"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude THERMES","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Laboratoire associ\u00e9 \u00e0 l'Universit\u00e9 Pierre et Marie Curie, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Laboratoire associ\u00e9 \u00e0 l'Universit\u00e9 Pierre et Marie Curie, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082150636","display_name":"Alain Rambach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain RAMBACH","raw_affiliation_strings":["CHROMagar, Rue Lecourbe, Paris, 75015, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHROMagar, Rue Lecourbe, Paris, 75015, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032458818","display_name":"Martin J. Warren","orcid":"https://orcid.org/0000-0002-6028-6456","observed_orcids":["https://orcid.org/0000-0002-6028-6456","https://orcid.org/0000-0001-6363-6936"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Martin WARREN","raw_affiliation_strings":["Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, U.K","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035280802"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":0.5811,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.64986132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"330","issue":"1","first_page":"121","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12-biosynthesis","display_name":"vitamin B12 biosynthesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/uroporphyrinogen-iii","display_name":"uroporphyrinogen III","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transmethylation","display_name":"transmethylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dehydrogenation","display_name":"dehydrogenation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nad-binding-site","display_name":"NAD+ binding site","score":0.9079999923706055},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8169999718666077},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pseudomonas-denitrificans","display_name":"Pseudomonas denitrificans","score":0.9319999814033508},{"id":"https://openalex.org/keywords/coba","display_name":"Coba","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.8243309259414673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6898751258850098},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5899043679237366},{"id":"https://openalex.org/C80315684","wikidata":"https://www.wikidata.org/wiki/Q2737583","display_name":"Methionine synthase","level":4,"score":0.5874428153038025},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5195732116699219},{"id":"https://openalex.org/C2780676250","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Cobalamin","level":3,"score":0.5003952980041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49033546447753906},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.45795902609825134},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4456595778465271},{"id":"https://openalex.org/C172110603","wikidata":"https://www.wikidata.org/wiki/Q409065","display_name":"Uroporphyrinogen III decarboxylase","level":4,"score":0.41993483901023865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40644434094429016},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32444900274276733},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.29471683502197266},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.2886868119239807},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22858521342277527},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1862664520740509},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj3300121","doi":"https://doi.org/10.1042/bj3300121","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3300121","pdf_url":"https://portlandpress.com/biochemj/article-pdf/330/1/121/634232/bj3300121.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1219117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1219117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:9461500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9461500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:kar.kent.ac.uk:11078","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9461500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1042/bj3300121","doi":"https://doi.org/10.1042/bj3300121","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3300121","pdf_url":"https://portlandpress.com/biochemj/article-pdf/330/1/121/634232/bj3300121.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2269799693.pdf","grobid_xml":"https://content.openalex.org/works/W2269799693.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1480296056","https://openalex.org/W1490433135","https://openalex.org/W1507968675","https://openalex.org/W1534471640","https://openalex.org/W1546737769","https://openalex.org/W1557851388","https://openalex.org/W1571190187","https://openalex.org/W1584578721","https://openalex.org/W1632119174","https://openalex.org/W1652691445","https://openalex.org/W1672854538","https://openalex.org/W1702365358","https://openalex.org/W1754273217","https://openalex.org/W1843598751","https://openalex.org/W1851569163","https://openalex.org/W1967507598","https://openalex.org/W1970899646","https://openalex.org/W1982719164","https://openalex.org/W1994602112","https://openalex.org/W1999418327","https://openalex.org/W2013532427","https://openalex.org/W2013970851","https://openalex.org/W2016614729","https://openalex.org/W2016778798","https://openalex.org/W2031346225","https://openalex.org/W2036829488","https://openalex.org/W2049712012","https://openalex.org/W2050917233","https://openalex.org/W2063633971","https://openalex.org/W2064653134","https://openalex.org/W2070160526","https://openalex.org/W2075355025","https://openalex.org/W2100082305","https://openalex.org/W2110406675","https://openalex.org/W2118151074","https://openalex.org/W2118881590","https://openalex.org/W2125780042","https://openalex.org/W2128750592","https://openalex.org/W2139686119","https://openalex.org/W2160528924","https://openalex.org/W2314225431","https://openalex.org/W2315336301","https://openalex.org/W2323778292","https://openalex.org/W2416134876","https://openalex.org/W2465607096","https://openalex.org/W4239833500","https://openalex.org/W6600237667","https://openalex.org/W6600248585","https://openalex.org/W6601600055","https://openalex.org/W6603147192","https://openalex.org/W6603517598","https://openalex.org/W6653496121"],"related_works":["https://openalex.org/W2068605104","https://openalex.org/W1632119174","https://openalex.org/W1571190187","https://openalex.org/W2013970851","https://openalex.org/W2029229751","https://openalex.org/W2100082305","https://openalex.org/W2315336301","https://openalex.org/W2416134876","https://openalex.org/W7098818626","https://openalex.org/W2150416975"],"abstract_inverted_index":{"The":[0],"Escherichia":[1],"coli":[2,162],"CysG":[3],"protein":[4],"(sirohaem":[5],"synthase)":[6],"catalyses":[7],"four":[8],"separate":[9],"reactions":[10],"that":[11,126,172],"are":[12,151],"required":[13],"for":[14,131,153],"the":[15,33,40,50,57,63,66,73,78,83,91,97,111,118,135,138,147,154,176,197],"transformation":[16],"of":[17,39,56,65,69,77,85,94,99,102,120,137,156,190,199],"uroporphyrinogen":[18],"III":[19],"into":[20],"sirohaem,":[21],"initially":[22],"two":[23],"S-adenosyl-l-methionine-dependent":[24],"transmethylations":[25],"at":[26,187],"positions":[27],"2":[28],"and":[29,42,46],"7,":[30],"mediated":[31,48],"through":[32,49],"C-terminal,":[34],"or":[35,52,146],"CysGA,":[36,95],"catalytic":[37,54,92],"domain":[38,55],"protein,":[41],"subsequently":[43],"a":[44,100,173,184],"ferrochelation":[45],"dehydrogenation,":[47],"N-terminal,":[51],"CysGB,":[53],"enzyme.":[58],"This":[59],"report":[60],"describes":[61],"how":[62],"deletion":[64,164],"NAD+-binding":[67],"site":[68],"CysG,":[70],"located":[71],"within":[72,106,175],"first":[74],"35":[75],"residues":[76,105],"N-terminus,":[79],"is":[80,108,128,167,192],"detrimental":[81,109],"to":[82,110,170,194],"activity":[84,93,119],"CysGB":[86,127],"but":[87,114],"does":[88,115],"not":[89,116,129],"affect":[90,117],"whereas":[96],"mutation":[98],"number":[101],"phylogenetically":[103],"conserved":[104],"CysGA":[107],"transmethylation":[112],"reaction":[113],"CysGB.":[121],"Further":[122],"studies":[123],"have":[124],"shown":[125],"essential":[130],"cobalamin":[132],"biosynthesis":[133],"because":[134],"presence":[136],"Salmonella":[139],"typhimurium":[140,178],"CobI":[141,179],"operon":[142,180],"with":[143],"either":[144],"cysGA":[145],"Pseudomonas":[148],"denitrificans":[149],"cobA":[150],"sufficient":[152],"synthesis":[155,198],"cobyric":[157],"acid":[158],"in":[159,196],"an":[160],"E.":[161],"cysG":[163],"strain.":[165],"Evidence":[166],"also":[168],"presented":[169],"suggest":[171],"gene":[174],"S.":[177],"might":[181],"act":[182],"as":[183],"chelatase":[185],"that,":[186],"low":[188],"levels":[189],"cobalt,":[191],"able":[193],"aid":[195],"sirohaem.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
