{"id":"https://openalex.org/W2269736883","doi":"https://doi.org/10.1159/000388815","title":"Fluorescent Organophosphates: Novel Probes for Studying Aging-Induced Conformational Changes in Inhibited Acetylcholinesterase and for Localization of Cholinesterase in Nervous Tissue","display_name":"Fluorescent Organophosphates: Novel Probes for Studying Aging-Induced Conformational Changes in Inhibited Acetylcholinesterase and for Localization of Cholinesterase in Nervous Tissue","publication_year":2015,"publication_date":"2015-04-15","ids":{"openalex":"https://openalex.org/W2269736883","doi":"https://doi.org/10.1159/000388815","mag":"2269736883","pmid":"https://pubmed.ncbi.nlm.nih.gov/7015117"},"language":"en","primary_location":{"id":"doi:10.1159/000388815","doi":"https://doi.org/10.1159/000388815","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000388815","pdf_url":null,"source":{"id":"https://openalex.org/S2764783919","display_name":"Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences","issn_l":"0300-5186","issn":["0300-5186","1420-2441","1660-4431","1662-2804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Neurology and Neuroscience","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110147104","display_name":"Gavriel Amitai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Amitai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020039830","display_name":"Yaacov Ashani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Ashani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Shahar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Shahar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111786834","display_name":"Ari Gafni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Gafni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025933576","display_name":"Israel Silman","orcid":"https://orcid.org/0000-0003-1923-0829","observed_orcids":["https://orcid.org/0000-0003-1923-0829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Silman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.10889774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":"70","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/enzyme-aging","display_name":"enzyme aging","score":0.6320000290870667},{"id":"https://openalex.org/keywords/organophosphate-inhibitors","display_name":"organophosphate inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.5879999995231628},{"id":"https://openalex.org/keywords/diisopropyl-fluorophosphate","display_name":"diisopropylfluorophosphate","score":0.8669999837875366},{"id":"https://openalex.org/keywords/enzyme-reactivation","display_name":"enzyme reactivation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.7059999704360962},{"id":"https://openalex.org/keywords/fluorescence-lifetime","display_name":"fluorescence lifetime","score":0.6470000147819519},{"id":"https://openalex.org/keywords/enzyme-conformational-change","display_name":"enzyme conformational change","score":0.6470000147819519},{"id":"https://openalex.org/keywords/electric-eel-acetylcholinesterase","display_name":"electric eel acetylcholinesterase","score":0.8220000267028809},{"id":"https://openalex.org/keywords/peripheral-anionic-site","display_name":"peripheral anionic site","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7608382701873779},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7070798873901367},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7004857659339905},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5703640580177307},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5452057719230652},{"id":"https://openalex.org/C2776588719","wikidata":"https://www.wikidata.org/wiki/Q411097","display_name":"Organophosphate","level":3,"score":0.44155967235565186},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4232538640499115},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4015324115753174},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33107349276542664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32464906573295593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09839564561843872},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004557","descriptor_name":"Electric Organ","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000388815","doi":"https://doi.org/10.1159/000388815","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000388815","pdf_url":null,"source":{"id":"https://openalex.org/S2764783919","display_name":"Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences","issn_l":"0300-5186","issn":["0300-5186","1420-2441","1660-4431","1662-2804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Neurology and Neuroscience","raw_type":"book-chapter"},{"id":"pmid:7015117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7015117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monographs in neural sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028756805","https://openalex.org/W1992245205","https://openalex.org/W1528309806","https://openalex.org/W250934192","https://openalex.org/W2071918135","https://openalex.org/W2130236439","https://openalex.org/W2001965999","https://openalex.org/W2075865713","https://openalex.org/W6987562887","https://openalex.org/W4409372998"],"abstract_inverted_index":{"Aging":[0],"of":[1,14,40,110,121,154,165,187,243,245,273],"acetylcholinesterase":[2],"(AChE)":[3],"inhibited":[4,89,101],"by":[5,27,90,97,254],"certain":[6],"organophosphates":[7,46],"such":[8,30],"as":[9,31,214],"diisopropylfluorophosphate":[10],"apparently":[11],"involves":[12],"dealkylation":[13],"the":[15,21,152,155,162,166,175,194,199,212,217,229,232,239,249,255,267,299,303,318],"bound":[16],"organophosphoryl":[17,233],"moiety;":[18],"this":[19,49,61],"renders":[20],"inactive":[22],"enzyme":[23,100],"resistant":[24],"to":[25,53,174,216,238],"reactivation":[26],"quaternary":[28],"oximes":[29],"2-pyridinealdoxime":[32],"methiodide":[33],"(2-PAM)":[34],"which":[35,58],"are":[36],"used":[37],"in":[38,48,146,228,248,285,310,313,326,351,362],"therapy":[39],"organophosphate":[41],"intoxication.":[42],"The":[43,63,137],"fluorescent":[44,337],"pyrenyl":[45],"synthesized":[47],"study":[50],"were":[51,108,135,160,191],"designed":[52],"detect":[54],"putative":[55],"conformational":[56,264,283],"changes":[57],"might":[59],"explain":[60],"resistance.":[62],"following":[64],"inhibitors:":[65],"1-pyrenebutyl":[66,69,73],"phosphorodichloride":[67],"(PBPDC),":[68],"ethylphosphorochloridate":[70],"(PBEPC),":[71],"and":[72,92,113,132,157,203,251,270,312,329,344,353],"ethylphosphorofluoridate":[74],"(PBEPF),":[75],"react":[76],"specifically":[77],"with":[78,115,365],"purified":[79],"electric":[80],"eel":[81],"AChE":[82,88],"(ki":[83],"=":[84],"10(6)-10(7)":[85],"M-1":[86],"min-1).":[87],"PBEPC":[91,112],"PBEPF":[93,321],"was":[94,169],"readily":[95],"reactivated":[96],"2-PAM,":[98],"while":[99],"PBPDC":[102,114],"could":[103,359],"not":[104],"be":[105,360],"reactivated.":[106],"Conjugates":[107],"prepared":[109],"both":[111,286],"AChE,":[116],"each":[117],"containing":[118],"one":[119],"molecule":[120],"florophore":[122],"per":[123],"catalytic":[124],"subunit.":[125],"Thus":[126],"two":[127,138,183,268],"stoichiometric":[128],"conjugates,":[129,269],"PBEP-AChE":[130],"(non-aged)":[131],"POBP-AChE":[133],"(aged),":[134],"obtained.":[136],"complexes":[139],"exhibited":[140],"identical":[141],"absorption":[142],"spectra,":[143],"but":[144],"differed":[145],"their":[147],"steady-state":[148],"fluorescence":[149,164,179,247,358],"spectra.":[150],"Although":[151],"wave-lenths":[153],"excitation":[156],"emission":[158],"spectra":[159],"similar,":[161],"pyrene":[163,188,246],"non-aged":[167,200,213,252,304],"conjugate":[168,202,231,305],"ca.":[170,206],"50%":[171,207],"quenched":[172],"relative":[173,314],"aged":[176,195,218,230,250,319],"conjugate.":[177,219,320],"Nanosecond":[178],"decay":[180,300],"studies":[181],"revealed":[182,204,276,291],"principal":[184],"lifetime":[185,289,311],"components":[186],"fluorescence.":[189],"Both":[190],"longer":[192],"for":[193,198,211,223,302,317],"(PBP-AChE)":[196],"than":[197],"(PBEP-AChE)":[201],"a":[205,281,308],"lower":[208],"quantum":[209,315],"yield":[210,316],"compared":[215],"A":[220],"possible":[221],"interpretation":[222],"these":[224],"results":[225],"is":[226,235,347],"that":[227,277,292],"moiety":[234],"less":[236],"acessible":[237],"external":[240],"medium.":[241],"Measurement":[242],"quenching":[244],"conjugates":[253],"peripheral":[256],"anionic":[257],"site":[258],"ligand":[259],"propidium":[260,278,294],"also":[261],"indicated":[262],"marked":[263],"differences":[265],"between":[266],"circular":[271],"polarization":[272],"luminescence":[274],"measurements":[275,290],"itself":[279],"induced":[280],"substantial":[282],"change":[284],"conjugates.":[287],"Fluorescence":[288,332],"whereas":[293],"had":[295],"little":[296],"effect":[297],"on":[298],"parameters":[301],"it":[306],"caused":[307],"decrease":[309],"virtually":[322],"eliminated":[323],"cholinesterase":[324],"activity":[325],"dissociated":[327],"cord":[328],"brain":[330],"cultures.":[331],"microscopy":[333],"reveals":[334],"fine":[335],"green":[336],"grains":[338],"distinctly":[339],"located":[340],"throughout":[341],"many":[342],"neurons":[343],"glia.":[345],"Labelling":[346],"much":[348],"more":[349],"pronounced":[350],"larger":[352],"older":[354],"neurons.":[355],"No":[356],"specific":[357],"detected":[361],"cultures":[363],"preincubated":[364],"nonfluorescent":[366],"organophosphates.":[367]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
