{"id":"https://openalex.org/W2269726836","doi":"https://doi.org/10.1159/000437094","title":"Bilateral Truncal Ligation of the Inferior Thyroid Artery during Bilateral Subtotal Thyroidectomy Causes a Decrease in Parathormone without Clinically Manifest Hypoparathyroidism: A Randomized Clinical Trial","display_name":"Bilateral Truncal Ligation of the Inferior Thyroid Artery during Bilateral Subtotal Thyroidectomy Causes a Decrease in Parathormone without Clinically Manifest Hypoparathyroidism: A Randomized Clinical Trial","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2269726836","doi":"https://doi.org/10.1159/000437094","mag":"2269726836","pmid":"https://pubmed.ncbi.nlm.nih.gov/26278126"},"language":"en","primary_location":{"id":"doi:10.1159/000437094","doi":"https://doi.org/10.1159/000437094","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000437094","pdf_url":null,"source":{"id":"https://openalex.org/S163499983","display_name":"European Surgical Research","issn_l":"0014-312X","issn":["0014-312X","1421-9921"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055997773","display_name":"Astrid Kebsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094380","display_name":"SRH Wald-Klinikum Gera","ror":"https://ror.org/00q236z92","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094380"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Kebsch","raw_affiliation_strings":["Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, Germany","Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, Germany","institution_ids":["https://openalex.org/I4210094380","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, and","institution_ids":["https://openalex.org/I4210094380","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041279223","display_name":"Utz Settmacher","orcid":"https://orcid.org/0000-0003-2417-7196","observed_orcids":["https://orcid.org/0000-0003-2417-7196"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Utz Settmacher","raw_affiliation_strings":["Department of General, Visceral und Vascular Surgery, Jena University Hospital, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral und Vascular Surgery, Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080687042","display_name":"Thomas G. Lesser","orcid":"https://orcid.org/0000-0001-7543-0193","observed_orcids":["https://orcid.org/0000-0001-7543-0193"]},"institutions":[{"id":"https://openalex.org/I4210094380","display_name":"SRH Wald-Klinikum Gera","ror":"https://ror.org/00q236z92","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094380"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lesser","raw_affiliation_strings":["Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, and"],"raw_orcid":"https://orcid.org/0000-0001-7543-0193","affiliations":[{"raw_affiliation_string":"Department of Thoracic and Vascular Surgery, SRH Wald-Klinikum Gera, Teaching Hospital of Friedrich Schiller University of Jena, Gera, and","institution_ids":["https://openalex.org/I4210094380","https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9249,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72012362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"55","issue":"3","first_page":"141","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inferior-thyroid-artery","display_name":"inferior thyroid artery","score":0.7990000247955322},{"id":"https://openalex.org/keywords/subtotal-thyroidectomy","display_name":"subtotal thyroidectomy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hypoparathyroidism","display_name":"hypoparathyroidism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/residual-thyroid-tissue","display_name":"residual thyroid tissue","score":0.7680000066757202},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9223002195358276},{"id":"https://openalex.org/C2779714868","wikidata":"https://www.wikidata.org/wiki/Q488711","display_name":"Inferior thyroid artery","level":4,"score":0.8224673271179199},{"id":"https://openalex.org/C2775941721","wikidata":"https://www.wikidata.org/wiki/Q1586088","display_name":"Hypoparathyroidism","level":2,"score":0.7667300701141357},{"id":"https://openalex.org/C2778812048","wikidata":"https://www.wikidata.org/wiki/Q936382","display_name":"Hypocalcaemia","level":3,"score":0.7141113877296448},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5652497410774231},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5061578154563904},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.48358339071273804},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.4338303804397583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.305738627910614},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.12334537506103516},{"id":"https://openalex.org/C2776109941","wikidata":"https://www.wikidata.org/wiki/Q740541","display_name":"Recurrent laryngeal nerve","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006044","descriptor_name":"Goiter, Nodular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006044","descriptor_name":"Goiter, Nodular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006044","descriptor_name":"Goiter, Nodular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007011","descriptor_name":"Hypoparathyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007011","descriptor_name":"Hypoparathyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000437094","doi":"https://doi.org/10.1159/000437094","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000437094","pdf_url":null,"source":{"id":"https://openalex.org/S163499983","display_name":"European Surgical Research","issn_l":"0014-312X","issn":["0014-312X","1421-9921"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Surgical Research","raw_type":"journal-article"},{"id":"pmid:26278126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26278126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W28726459","https://openalex.org/W68836595","https://openalex.org/W140469396","https://openalex.org/W1748312191","https://openalex.org/W1971939771","https://openalex.org/W1977105036","https://openalex.org/W1986486774","https://openalex.org/W1996807540","https://openalex.org/W1997925550","https://openalex.org/W1999977682","https://openalex.org/W2003139792","https://openalex.org/W2011053278","https://openalex.org/W2013116900","https://openalex.org/W2019832593","https://openalex.org/W2026851343","https://openalex.org/W2042101876","https://openalex.org/W2061739746","https://openalex.org/W2066711787","https://openalex.org/W2076573103","https://openalex.org/W2083586358","https://openalex.org/W2094671125","https://openalex.org/W2163511070","https://openalex.org/W2413210562","https://openalex.org/W2415370400","https://openalex.org/W2418187226","https://openalex.org/W2419302420","https://openalex.org/W2426476007"],"related_works":["https://openalex.org/W2094671125","https://openalex.org/W3087636439","https://openalex.org/W7047492047","https://openalex.org/W2976864259","https://openalex.org/W3021558137","https://openalex.org/W1748312191","https://openalex.org/W4406700354","https://openalex.org/W7033254001","https://openalex.org/W2418187226","https://openalex.org/W2467303535"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bilateral":[1],"truncal":[2],"ligation":[3],"(BTL)":[4],"of":[5,21,55,184,191,207,226,247,252],"the":[6,19,29,68,86,103,135,143,170,227,253],"inferior":[7],"thyroid":[8,50,70,182,262],"artery":[9],"(ITA)":[10],"is":[11],"frequently":[12],"used":[13],"during":[14,229],"subtotal":[15,230],"thyroidectomy":[16,231],"to":[17,27,45,60,152,242],"reduce":[18,28],"risk":[20,268],"post-operative":[22,93,110,128,271],"bleeding":[23],"as":[24,26],"well":[25],"blood":[30],"loss":[31],"intra-operatively.":[32],"However,":[33],"its":[34],"effect":[35],"on":[36,72,92,109,127],"parathyroid":[37],"function":[38],"has":[39],"not":[40,240],"been":[41],"evaluated":[42],"in":[43,105,134,142,150,165,169,194,212,236],"relation":[44],"age,":[46],"residual":[47,69,181],"and":[48,81,91,96,120,258],"resected":[49],"volume.":[51],"METHODS:":[52],"A":[53],"total":[54],"83":[56],"patients":[57,154],"were":[58,84,115,188],"randomized":[59],"receive":[61],"non-BTL":[62,144],"or":[63,118],"BTL.":[64],"After":[65],"bilateral":[66],"resection,":[67],"tissue":[71],"each":[73,195],"side":[74],"was":[75,102,131,167,211],"measured":[76],"by":[77],"intra-operative":[78],"ultrasonography.":[79],"Laboratory":[80],"clinical":[82],"examinations":[83],"performed":[85],"day":[87,111,129],"before":[88],"operation,":[89],"intra-operatively":[90],"days":[94],"2":[95],"5.":[97,112],"The":[98,162,204],"primary":[99],"outcome":[100],"measure":[101],"difference":[104],"intact":[106],"parathormone":[107],"(PTHi)":[108],"Secondary":[113],"outcomes":[114],"laboratory-diagnosed":[116],"hypocalcaemia":[117],"hypoparathyroidism":[119,193,210],"clinically":[121,208,248],"manifest":[122,209,249],"hypoparathyroidism,":[123],"respectively.":[124],"RESULTS:":[125],"PTHi":[126,166],"5":[130],"significantly":[132,244],"lower":[133],"BTL":[136,171,214,225,251],"group":[137,172,196,215],"(29.4":[138],"vs.":[139,156,198],"34.7":[140],"ng/l":[141,174],"group,":[145],"p":[146,159,176,201,221],"=":[147,160,177,202,222],"0.033),":[148],"especially":[149],"61-":[151],"80-year-old":[153],"(0":[155],"-7.91":[157],"ng/l,":[158],"0.029).":[161],"biggest":[163],"decline":[164],"found":[168],"(-14.067":[173],"PTH,":[175],"0.018)":[178],"with":[179],"a":[180,213,233,243,259],"volume":[183],"0.5-1.9":[185],"ml.":[186],"There":[187],"two":[189],"cases":[190],"asymptomatic":[192],"(5.1":[197],"4.8%,":[199],"respectively,":[200],"1.000).":[203,223],"only":[205],"case":[206],"patient":[216],"aged":[217],"64":[218],"years":[219],"(2.4%,":[220],"CONCLUSION:":[224],"ITA":[228],"causes":[232],"larger":[234],"decrease":[235],"PTH":[237],"but":[238],"does":[239],"lead":[241],"higher":[245],"rate":[246],"hypoparathyroidism.":[250,272],"ITA,":[254],"age":[255],">61":[256],"years,":[257],"very":[260],"small":[261],"remnant":[263],"(<2":[264],"ml)":[265],"may":[266],"be":[267],"factors":[269],"for":[270]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}