{"id":"https://openalex.org/W2269313656","doi":"https://doi.org/10.1089/mab.2015.0036","title":"Design and Generation of Humanized Single-chain Fv Derived from Mouse Hybridoma for Potential Targeting Application","display_name":"Design and Generation of Humanized Single-chain Fv Derived from Mouse Hybridoma for Potential Targeting Application","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2269313656","doi":"https://doi.org/10.1089/mab.2015.0036","mag":"2269313656","pmid":"https://pubmed.ncbi.nlm.nih.gov/26683180","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685505"},"language":"en","primary_location":{"id":"doi:10.1089/mab.2015.0036","doi":"https://doi.org/10.1089/mab.2015.0036","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mab.2015.0036","pdf_url":null,"source":{"id":"https://openalex.org/S2764482970","display_name":"Monoclonal Antibodies in Immunodiagnosis and Immunotherapy","issn_l":"2167-9436","issn":["2167-9436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monoclonal Antibodies in Immunodiagnosis and Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685505","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018773685","display_name":"Kannika Khantasup","orcid":"https://orcid.org/0000-0002-7163-513X","observed_orcids":["https://orcid.org/0000-0002-7163-513X"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kannika Khantasup","raw_affiliation_strings":["Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004143697","display_name":"Warangkana Chantima","orcid":"https://orcid.org/0000-0003-1541-7098","observed_orcids":["https://orcid.org/0000-0003-1541-7098"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210107674","display_name":"National Nanotechnology Center","ror":"https://ror.org/01neh8064","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I4210107674"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Warangkana Chantima","raw_affiliation_strings":["Graduate Program in Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]},{"raw_affiliation_string":"National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4210107674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003737061","display_name":"Chak Sangma","orcid":"https://orcid.org/0000-0002-2627-8073","observed_orcids":["https://orcid.org/0000-0002-2627-8073"]},"institutions":[{"id":"https://openalex.org/I198105771","display_name":"Kasetsart University","ror":"https://ror.org/05gzceg21","country_code":"TH","type":"education","lineage":["https://openalex.org/I198105771"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chak Sangma","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand","institution_ids":["https://openalex.org/I198105771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040378610","display_name":"Kanokwan Poomputsa","orcid":"https://orcid.org/0000-0002-3301-6952","observed_orcids":["https://orcid.org/0000-0002-3301-6952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanokwan Poomputsa","raw_affiliation_strings":["Biotechnology Program, School of Bioresources and Technology, King Mongkut's University of Technology, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Program, School of Bioresources and Technology, King Mongkut's University of Technology, Bangkok, Thailand","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014992399","display_name":"Tararaj Dharakul","orcid":"https://orcid.org/0000-0002-5602-0778","observed_orcids":["https://orcid.org/0000-0002-5602-0778"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210107674","display_name":"National Nanotechnology Center","ror":"https://ror.org/01neh8064","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I4210107674"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Tararaj Dharakul","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]},{"raw_affiliation_string":"National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4210107674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014992399"],"corresponding_institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I1332387789","https://openalex.org/I25399158","https://openalex.org/I4210107674"],"apc_list":null,"apc_paid":null,"fwci":0.2697,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.64087927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"34","issue":"6","first_page":"404","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.777999997138977},{"id":"https://openalex.org/keywords/humanization","display_name":"humanization","score":0.640999972820282},{"id":"https://openalex.org/keywords/cdr-grafting","display_name":"CDR grafting","score":0.9629999995231628},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.984000027179718},{"id":"https://openalex.org/keywords/periplasmic-expression","display_name":"periplasmic expression","score":0.7350000143051147},{"id":"https://openalex.org/keywords/recombinant-antibody-production","display_name":"recombinant antibody production","score":0.6940000057220459},{"id":"https://openalex.org/keywords/targeted-immunotherapy","display_name":"targeted immunotherapy","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2777092746","wikidata":"https://www.wikidata.org/wiki/Q5939625","display_name":"Humanized antibody","level":4,"score":0.8032565116882324},{"id":"https://openalex.org/C2776967038","wikidata":"https://www.wikidata.org/wiki/Q290671","display_name":"Single-chain variable fragment","level":4,"score":0.5469184517860413},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.542899489402771},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5290328860282898},{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.5221443772315979},{"id":"https://openalex.org/C85630698","wikidata":"https://www.wikidata.org/wiki/Q3826179","display_name":"Complementarity determining region","level":4,"score":0.5025477409362793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44052261114120483},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.43831345438957214},{"id":"https://openalex.org/C125823703","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Fragment crystallizable region","level":3,"score":0.42687541246414185},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.4264713525772095},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.4239782691001892},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4187653958797455},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.41802695393562317},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.41700273752212524},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.41204074025154114},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3884213864803314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38423818349838257},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.38094672560691833},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.21260949969291687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17761561274528503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13039696216583252},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12846243381500244},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071858","descriptor_name":"Epithelial Cell Adhesion Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/mab.2015.0036","doi":"https://doi.org/10.1089/mab.2015.0036","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mab.2015.0036","pdf_url":null,"source":{"id":"https://openalex.org/S2764482970","display_name":"Monoclonal Antibodies in Immunodiagnosis and Immunotherapy","issn_l":"2167-9436","issn":["2167-9436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monoclonal Antibodies in Immunodiagnosis and Immunotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4685505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monoclon Antib Immunodiagn Immunother","raw_type":"Text"},{"id":"pmid:26683180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26683180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monoclonal antibodies in immunodiagnosis and immunotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4685505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monoclon Antib Immunodiagn Immunother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322401","display_name":"Mahidol University","ror":"https://ror.org/01znkr924"},{"id":"https://openalex.org/F4320322437","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61"},{"id":"https://openalex.org/F4320324123","display_name":"National Nanotechnology Center","ror":"https://ror.org/01neh8064"},{"id":"https://openalex.org/F4320335223","display_name":"Thailand Graduate Institute of Science and Technology","ror":"https://ror.org/02edr8z79"},{"id":"https://openalex.org/F4320336004","display_name":"Faculty of Medicine Siriraj Hospital, Mahidol University","ror":"https://ror.org/0331zs648"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W40742011","https://openalex.org/W1608855442","https://openalex.org/W1964119722","https://openalex.org/W1966612175","https://openalex.org/W1972461780","https://openalex.org/W1975304761","https://openalex.org/W1976465701","https://openalex.org/W1982258330","https://openalex.org/W1983257260","https://openalex.org/W1985534496","https://openalex.org/W1989719910","https://openalex.org/W1994323576","https://openalex.org/W2002313714","https://openalex.org/W2007084987","https://openalex.org/W2009247863","https://openalex.org/W2009573319","https://openalex.org/W2013140311","https://openalex.org/W2014158928","https://openalex.org/W2022964898","https://openalex.org/W2026010661","https://openalex.org/W2029499367","https://openalex.org/W2031771095","https://openalex.org/W2034196741","https://openalex.org/W2037182203","https://openalex.org/W2039077615","https://openalex.org/W2040503566","https://openalex.org/W2052440346","https://openalex.org/W2053599146","https://openalex.org/W2058548073","https://openalex.org/W2062793526","https://openalex.org/W2063581254","https://openalex.org/W2067094969","https://openalex.org/W2068239390","https://openalex.org/W2076352786","https://openalex.org/W2084141349","https://openalex.org/W2084414069","https://openalex.org/W2089429604","https://openalex.org/W2100986336","https://openalex.org/W2105741172","https://openalex.org/W2107557025","https://openalex.org/W2114065017","https://openalex.org/W2118032120","https://openalex.org/W2119475808","https://openalex.org/W2129739217","https://openalex.org/W2132859649","https://openalex.org/W2143467722","https://openalex.org/W2153329352","https://openalex.org/W2158741313","https://openalex.org/W2169280597","https://openalex.org/W2170471837","https://openalex.org/W2216319005","https://openalex.org/W3025167509"],"related_works":["https://openalex.org/W2115859119","https://openalex.org/W2368661681","https://openalex.org/W2357873333","https://openalex.org/W2008992691","https://openalex.org/W2378264914","https://openalex.org/W1976465701","https://openalex.org/W2009247863","https://openalex.org/W3025167509","https://openalex.org/W2079099443","https://openalex.org/W2039723096"],"abstract_inverted_index":{"Single-chain":[0],"variable":[1,69],"antibody":[2,35],"fragments":[3],"(scFvs)":[4],"are":[5],"attractive":[6],"candidates":[7],"for":[8,28,186,189],"targeted":[9],"immunotherapy":[10],"in":[11,92,151,191,212,216,223,229],"several":[12],"human":[13],"diseases.":[14],"In":[15,173],"this":[16,155,224],"study,":[17],"a":[18,50,181,209],"concise":[19],"humanization":[20,231],"strategy":[21,221],"combined":[22],"with":[23,108,180],"an":[24],"optimized":[25,200],"production":[26,204,213],"method":[27],"humanizing":[29],"scFvs":[30,161,177],"was":[31,101,132,198],"successfully":[32,158],"employed.":[33],"Two":[34],"clones,":[36],"one":[37],"directed":[38],"against":[39,48],"the":[40,46,57,60,83,95,99,109,136,164,175,230],"hemagglutinin":[41],"of":[42,59,71,85,98,111,138,167,214,232],"H5N1":[43],"influenza":[44],"virus,":[45],"other":[47,233],"EpCAM,":[49],"cancer":[51],"biomarker,":[52],"were":[53,78,146,178],"used":[54],"to":[55,82,134,201],"demonstrate":[56],"validity":[58],"method.":[61],"Heavy":[62],"chain":[63,67],"(VH)":[64],"and":[65,80,128,142,149],"light":[66],"(VL)":[68],"regions":[70],"immunoglobulin":[72],"genes":[73,145],"from":[74,236],"mouse":[75,86,112,127,170,237],"hybridoma":[76],"cells":[77],"sequenced":[79],"subjected":[81],"construction":[84],"scFv":[87,100,130,144,171],"3-D":[88],"structure.":[89],"Based":[90],"on":[91],"silico":[93],"modeling,":[94],"humanized":[96,129,143,160,176],"version":[97],"designed":[102],"via":[103],"complementarity-determining":[104],"region":[105,114],"(CDR)":[106],"grafting":[107],"retention":[110],"framework":[113],"(FR)":[115],"residues":[116],"identified":[117],"by":[118],"primary":[119],"sequence":[120],"analysis.":[121],"Root-mean-square":[122],"deviation":[123],"(RMSD)":[124],"value":[125],"between":[126],"structures":[131],"calculated":[133],"evaluate":[135],"preservation":[137],"CDR":[139],"conformation.":[140],"Mouse":[141],"then":[147],"constructed":[148],"expressed":[150],"Escherichia":[152],"coli.":[153],"Using":[154],"method,":[156],"we":[157],"generated":[159],"that":[162],"retained":[163],"targeting":[165,193],"activity":[166],"their":[168],"respective":[169],"counterparts.":[172],"addition,":[174],"engineered":[179],"C-terminal":[182],"cysteine":[183],"residue":[184],"(hscFv-C)":[185],"site-directed":[187],"conjugation":[188],"use":[190],"future":[192],"applications.":[194],"The":[195,206,220],"hscFv-C":[196],"expression":[197],"extensively":[199],"improve":[202],"protein":[203],"yield.":[205],"protocol":[207],"yielded":[208],"20-fold":[210],"increase":[211],"hscFv-Cs":[215],"E.":[217],"coli":[218],"periplasm.":[219],"described":[222],"study":[225],"may":[226],"be":[227],"applicable":[228],"antibodies":[234],"derived":[235],"hybridoma.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
