{"id":"https://openalex.org/W226906271","doi":null,"title":"Structure and promoter organization of the human monoamine oxidase A and B genes.","display_name":"Structure and promoter organization of the human monoamine oxidase A and B genes.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W226906271","mag":"226906271","pmid":"https://pubmed.ncbi.nlm.nih.gov/8461277","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188472"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1188472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188472","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059277121","display_name":"Jean Chen Shih","orcid":"https://orcid.org/0000-0003-2952-3246","observed_orcids":["https://orcid.org/0000-0003-2952-3246"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Shih","raw_affiliation_strings":["Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084966112","display_name":"Joseph S. Grimsby","orcid":"https://orcid.org/0000-0002-0388-1427","observed_orcids":["https://orcid.org/0000-0002-0388-1427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Grimsby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012564901","display_name":"K Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068600567","display_name":"Qin\u2010shi Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q S Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4356,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.51329318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"1","first_page":"25","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.12460000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/monoamine-oxidase-b","display_name":"monoamine oxidase B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maoa-gene","display_name":"MAOA gene","score":0.7419999837875366},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.8019999861717224},{"id":"https://openalex.org/keywords/exon-intron-organization","display_name":"exon-intron organization","score":0.925000011920929},{"id":"https://openalex.org/keywords/promoter-organization","display_name":"promoter organization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.9480000138282776},{"id":"https://openalex.org/keywords/biogenic-amines","display_name":"biogenic amines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.7291219830513},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7173581123352051},{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.6949928402900696},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6696644425392151},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.6653776168823242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.660849392414093},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6509716510772705},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.6435528993606567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6409798264503479},{"id":"https://openalex.org/C114461151","wikidata":"https://www.wikidata.org/wiki/Q14888415","display_name":"Monoamine oxidase A","level":4,"score":0.621740996837616},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34090614318847656},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19371157884597778},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11729130148887634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11058974266052246}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008995","descriptor_name":"Monoamine Oxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015698","descriptor_name":"Genomic Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1188472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},{"id":"pmid:8461277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8461277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatry & neuroscience : JPN","raw_type":"Journal Article"},{"id":"mag:226906271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8461277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1188472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G29409113","display_name":"PROTEIN(S) INVOLVED IN NEUROTRANSMISSION","funder_award_id":"R01MH037020","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G42595986","display_name":"TWO TYPES OF MONOAMINE OXIDASE","funder_award_id":"R37MH039085","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6858929347","display_name":"MOLECULAR STUDIES OF MONOAMINE OXIDASES","funder_award_id":"K05MH000796","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1493718535","https://openalex.org/W1542836032","https://openalex.org/W1736849844","https://openalex.org/W1954929088","https://openalex.org/W1969600436","https://openalex.org/W1971583710","https://openalex.org/W1973458038","https://openalex.org/W1975957542","https://openalex.org/W1979814084","https://openalex.org/W1989205561","https://openalex.org/W2001829569","https://openalex.org/W2003600848","https://openalex.org/W2009077522","https://openalex.org/W2024298846","https://openalex.org/W2033579780","https://openalex.org/W2041086548","https://openalex.org/W2052570198","https://openalex.org/W2077611061","https://openalex.org/W2084078518","https://openalex.org/W2086208850","https://openalex.org/W2086858085","https://openalex.org/W2087662501","https://openalex.org/W2095451361","https://openalex.org/W2119125260","https://openalex.org/W2134757180","https://openalex.org/W2134996660","https://openalex.org/W2142710389","https://openalex.org/W2155411818","https://openalex.org/W2338614948","https://openalex.org/W2409579165","https://openalex.org/W2414843204","https://openalex.org/W2418194246","https://openalex.org/W2418950933","https://openalex.org/W4242005644","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W50989420","https://openalex.org/W1736849844","https://openalex.org/W47653480","https://openalex.org/W2024298846","https://openalex.org/W1967825186","https://openalex.org/W2061283235","https://openalex.org/W2165950251","https://openalex.org/W2041086548","https://openalex.org/W1992483976","https://openalex.org/W1602660250"],"abstract_inverted_index":{"Monoamine":[0],"oxidase":[1],"(MAO)":[2],"A":[3,17],"and":[4,18,24,37,53,64,97,131,139],"B":[5,19,38],"play":[6],"an":[7],"important":[8],"role":[9],"in":[10],"regulating":[11],"levels":[12],"of":[13,41,72,81,85,91,110,121,128],"biogenic":[14],"amines.":[15],"MAO":[16],"cDNAs":[20],"have":[21],"been":[22],"cloned":[23],"the":[25,62,70,129],"deduced":[26],"amino":[27],"acids":[28],"share":[29],"73%":[30],"sequence":[31],"identity.":[32],"The":[33,77,102,125],"genes":[34,66],"for":[35],"MAOA":[36,63,82,130],"are":[39,67],"comprised":[40,84],"15":[42],"exons":[43],"interspersed":[44],"by":[45],"14":[46],"introns,":[47],"span":[48],"at":[49],"least":[50],"60":[51],"kb":[52],"exhibit":[54],"identical":[55],"exon-intron":[56],"organization.":[57],"These":[58],"findings":[59],"suggest":[60],"that":[61],"MAOB":[65,103,132],"derived":[68],"from":[69],"duplication":[71],"a":[73,99,116,122],"common":[74],"ancestral":[75],"gene.":[76],"core":[78,104],"promoter":[79,105],"region":[80,106],"is":[83],"two":[86,94,108],"90":[87],"bp":[88],"repeats,":[89],"each":[90],"which":[92,114],"contains":[93,107],"Spl":[95,112],"elements":[96],"lacks":[98],"TATA":[100,123],"box.":[101,124],"sets":[109],"overlapping":[111],"sites":[113],"flank":[115],"CACCC":[117],"element":[118],"all":[119],"upstream":[120],"different":[126,137],"organization":[127],"promoters":[133],"may":[134],"underlie":[135],"their":[136],"cell":[138],"tissue":[140],"specific":[141],"expression.":[142]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
