{"id":"https://openalex.org/W2268810752","doi":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","title":"Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements","display_name":"Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements","publication_year":1996,"publication_date":"1996-03-15","ids":{"openalex":"https://openalex.org/W2268810752","doi":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","mag":"2268810752","pmid":"https://pubmed.ncbi.nlm.nih.gov/8630417"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v87.6.2506.bloodjournal8762506","doi":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Choi","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013268702","display_name":"SJ Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SJ Greenberg","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102178705","display_name":"TL Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TL Du","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112037048","display_name":"PM Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PM Ward","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110309846","display_name":"P. M. Overturf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PM Overturf","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049497859","display_name":"Martin L. Brecher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ML Brecher","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037734477","display_name":"Mark C. Ballow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Ballow","raw_affiliation_strings":["Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Roswell Park Cancer Institute, Buffalo, NY 14263 USA","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.4318,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.94367402,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"87","issue":"6","first_page":"2506","last_page":"2512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oligoclonality","display_name":"oligoclonality","score":0.8519999980926514},{"id":"https://openalex.org/keywords/b-cell-maturation","display_name":"B cell maturation","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8507398366928101},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.661653459072113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5692688226699829},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.5536612868309021},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.522487461566925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4830258786678314},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.4814862012863159},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4784802794456482},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.47516530752182007},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.42192208766937256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015326","descriptor_name":"Gene Rearrangement, B-Lymphocyte, Heavy Chain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045567","descriptor_name":"VDJ Recombinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v87.6.2506.bloodjournal8762506","doi":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v87.6.2506.bloodjournal8762506","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:8630417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8630417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/190817","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/190817","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W89203722","https://openalex.org/W125367401","https://openalex.org/W569951484","https://openalex.org/W1520792648","https://openalex.org/W1532190041","https://openalex.org/W1556978242","https://openalex.org/W1964625649","https://openalex.org/W1969499881","https://openalex.org/W1981498836","https://openalex.org/W1981960541","https://openalex.org/W1984724325","https://openalex.org/W1989877475","https://openalex.org/W2009803738","https://openalex.org/W2013835825","https://openalex.org/W2016588772","https://openalex.org/W2019450981","https://openalex.org/W2021485331","https://openalex.org/W2039151199","https://openalex.org/W2055873492","https://openalex.org/W2068320049","https://openalex.org/W2069501059","https://openalex.org/W2076899085","https://openalex.org/W2079725260","https://openalex.org/W2082173634","https://openalex.org/W2085881249","https://openalex.org/W2088653018","https://openalex.org/W2096313716","https://openalex.org/W2126464081","https://openalex.org/W2128133990","https://openalex.org/W2128478938","https://openalex.org/W2138270253","https://openalex.org/W2140489687","https://openalex.org/W2147499495","https://openalex.org/W2183123827","https://openalex.org/W2184822132","https://openalex.org/W2284363354","https://openalex.org/W2348816642","https://openalex.org/W2387730648","https://openalex.org/W2409311106","https://openalex.org/W2414924902","https://openalex.org/W2465287901","https://openalex.org/W2578150941","https://openalex.org/W4246601070","https://openalex.org/W4250892538"],"related_works":["https://openalex.org/W162807019","https://openalex.org/W2019753023","https://openalex.org/W2348816642","https://openalex.org/W2371324266","https://openalex.org/W4366290719","https://openalex.org/W1970475185","https://openalex.org/W2104728365","https://openalex.org/W2284363354","https://openalex.org/W2414116326","https://openalex.org/W2408715374"],"abstract_inverted_index":{"B-cell":[0,133,271],"acute":[1],"lymphoblastic":[2],"leukemia":[3],"(B-ALL),":[4],"more":[5],"frequently":[6],"than":[7],"any":[8],"other":[9],"B-lineage":[10],"neoplasm,":[11],"exhibits":[12],"oligoclonal":[13,240],"Ig":[14],"heavy":[15],"chain":[16,112],"(IgH)":[17],"gene":[18,53,81,88,100,108,135,186,207],"rearrangement":[19,83],"in":[20,48,194],"15%":[21],"to":[22,77,86,184,209,264],"43%":[23],"of":[24,42,74,125,138,153,216,232],"all":[25,217],"cases":[26],"studied.":[27],"To":[28],"study":[29],"the":[30,94,131,154,172,198,265],"molecular":[31,249],"processes":[32,73],"that":[33,61,129],"promote":[34],"multiple":[35],"IgH":[36,52],"rearrangements,":[37],"a":[38,43,62,105,123,189,210,229],"comprehensive":[39],"sequence":[40],"analysis":[41],"B-ALL":[44],"case":[45],"was":[46,115,142,202,224],"performed":[47],"which":[49],"seven":[50,253],"clonal":[51,192,218],"rearrangements":[54,208,241],"were":[55,102],"identified.":[56],"The":[57,214],"genetic":[58,250],"profiles":[59],"suggested":[60],"single":[63],"leukemic":[64,233],"progenitor":[65],"clone":[66],"evolved":[67,242],"into":[68,159],"several":[69],"subclones":[70,234],"through":[71],"dual":[72],"variable":[75],"(VH)":[76],"preexisting":[78],"diversity-joining":[79],"(DJH)":[80],"segment":[82],"and":[84,93,122,227],"VH":[85,87,183,206],"replacement.":[89],"Predominant":[90],"IgH-V":[91,127,134],"usage":[92],"uniquely":[95],"rearranged":[96,139],"clonotype-specific":[97],"VHDJH":[98,140,156,185],"region":[99,169],"sequences":[101,180],"identified":[103],"using":[104],"novel":[106],"DNA-based":[107],"amplification":[109],"strategy.":[110],"Polymerase":[111],"reaction":[113],"(PCR)":[114],"directed":[116],"by":[117,144,163,204,236,243],"an":[118],"IgH-J":[119],"generic":[120],"primer":[121],"complement":[124],"family-specific":[126],"primers":[128],"defined":[130,162],"major":[132],"usage.":[136],"Clonality":[137],"bands":[141],"substantiated":[143],"high":[145],"resolution":[146],"denaturant":[147],"gel":[148],"electrophoretic":[149],"analysis.":[150],"Sequence":[151],"patterns":[152],"amplified":[155],"fragments":[157],"segregated":[158],"two":[160,244],"groups":[161],"common":[164,211],"DJH":[165,179,212],"sequences.":[166],"Partial":[167],"N":[168],"homology":[170],"at":[171],"VHD":[173],"junction":[174],"as":[175,177,188],"well":[176],"shared":[178],"firmly":[181],"established":[182],"replacement":[187],"mechanism":[190],"generating":[191],"evolution":[193],"one":[195],"group.":[196],"In":[197],"second":[199],"subset,":[200],"oligoclonality":[201],"propagated":[203],"independent":[205],"precursor.":[213],"contributions":[215],"Ig-VHDJH":[219,257],"repertoires":[220],"for":[221],"each":[222],"group":[223],"approximately":[225],"50%":[226],"reflected":[228],"symmetric":[230],"distribution":[231],"generated":[235],"either":[237],"process.":[238],"Thus,":[239],"independent,":[245],"yet":[246],"seemingly":[247],"contemporaneous":[248],"mechanisms.":[251],"All":[252],"clones":[254],"displayed":[255],"nonfunctional":[256],"recombinations.":[258],"These":[259],"observations":[260],"may":[261],"have":[262],"relevance":[263],"recombinatorial":[266],"opportunities":[267],"available":[268],"during":[269],"normal":[270],"maturation.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}