{"id":"https://openalex.org/W2268659154","doi":null,"title":"A Phase I study to evaluate the feasibility, safety and biological effects of intratumoural administration of wild-type Reovirus (REOLYSIN (R)) in combination with radiation in patients with advanced malignancies.","display_name":"A Phase I study to evaluate the feasibility, safety and biological effects of intratumoural administration of wild-type Reovirus (REOLYSIN (R)) in combination with radiation in patients with advanced malignancies.","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2268659154","mag":"2268659154"},"language":"en","primary_location":{"id":"pmh:oai:alma.44SUR_INST:11139388060002346","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000251969000382&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=11d2a86992e85fb529977dad66a846d5","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103222461","display_name":"Deborah R. Harris","orcid":"https://orcid.org/0000-0002-8342-2764","observed_orcids":["https://orcid.org/0000-0002-8342-2764"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deborah Harris","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8342-2764","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101520157","display_name":"Laura Vidal","orcid":"https://orcid.org/0000-0001-7519-3319","observed_orcids":["https://orcid.org/0000-0001-7519-3319"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Vidal","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7519-3319","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069116024","display_name":"Alan A. Melcher","orcid":"https://orcid.org/0000-0002-2042-3380","observed_orcids":["https://orcid.org/0000-0002-2042-3380"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Melcher","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2042-3380","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028801087","display_name":"Kate L. Newbold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Newbold","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112937394","display_name":"A Anthony","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Anthony","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113716496","display_name":"Karavasilis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karavasilis","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rajiv Agarwal","orcid":"https://orcid.org/0000-0002-3146-7231","observed_orcids":["https://orcid.org/0000-0002-3146-7231"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rajiv Agarwal","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3146-7231","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christine White","orcid":"https://orcid.org/0000-0002-4242-3533","observed_orcids":["https://orcid.org/0000-0002-4242-3533"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christine White","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4242-3533","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090144505","display_name":"Katie R. Twigger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katie Twigger","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078521568","display_name":"Matt C. Coffey","orcid":"https://orcid.org/0000-0002-7211-829X","observed_orcids":["https://orcid.org/0000-0002-7211-829X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matt Coffey","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087028329","display_name":"Karl L. Mettinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.L. Mettinger","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce Thompson","orcid":"https://orcid.org/0000-0002-5885-0652","observed_orcids":["https://orcid.org/0000-0002-5885-0652"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bruce Thompson","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-5885-0652","affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017447126","display_name":"H. S. Pandha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Pandha","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann S. de Bono","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072284989","display_name":"Kevin Joseph Harrington","orcid":"https://orcid.org/0000-0002-6014-348X","observed_orcids":["https://orcid.org/0000-0002-6014-348X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin J. Harrington","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.5359,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69980175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reolysin","display_name":"Reolysin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.8899999856948853},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.4659999907016754},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.75},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.828000009059906},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.4749999940395355},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.41600000858306885},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7394483089447021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7025629281997681},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5636235475540161},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49610862135887146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4739556312561035},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4342227876186371},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42770248651504517},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34673893451690674},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33685174584388733}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.44SUR_INST:11139388060002346","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000251969000382&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=11d2a86992e85fb529977dad66a846d5","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:epubs.surrey.ac.uk:824018","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/824018/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2268659154","doi":null,"is_oa":false,"landing_page_url":"http://mct.aacrjournals.org/content/6/11_Supplement/B81","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2275527108","https://openalex.org/W2283838201","https://openalex.org/W107421448","https://openalex.org/W2028577286","https://openalex.org/W2623027129","https://openalex.org/W2243057854","https://openalex.org/W2255506974","https://openalex.org/W1974638172","https://openalex.org/W2592499472","https://openalex.org/W1590408437"],"abstract_inverted_index":{"B81":[0],"Background:":[3],"Wild-type":[4],"reovirus":[5],"(REOLYSIN\u00ae)":[6],"is":[7,451,465,478],"a":[8,137,406],"dsRNA":[9],"virus":[10,135],"which":[11],"results":[12],"in":[13,16,24,55,92,105,110,125,156,166,178,194,214,229,247,256,275,376,391,408,423,461,467],"asymptomatic":[14],"infection":[15],"humans":[17],"and":[18,25,69,83,123,176,192,197,200,204,212,217,220,224,227,245,251,254,272,298,331,337,346,356,366,368,428,475],"has":[19,313],"been":[20,286,314],"demonstrated":[21],"to":[22,28,65,136,154,278,288,308],"replicate":[23],"prove":[26],"cytopathic":[27],"Ras":[29],"activated":[30],"cells,":[31],"while":[32],"sparing":[33],"normal":[34],"cells.\u2028":[35],"Methods:":[36],"An":[37],"open":[38],"label,":[39],"dose":[40,150,351,415],"escalating,":[41],"multicentre":[42],"phase":[43],"I":[44],"study":[45,295,484],"of":[46,49,71,86,103,116,134,161,171,188,208,265,321,371,378,393,443,446,458],"intratumoural":[47,444],"injections":[48,115,163,445,460],"REOLYSIN":[50,117,162,447],"with":[51,57,112,128,290,304,317,382,395,402,433,449,463,482],"concurrent":[52],"fractionated":[53],"radiotherapy":[54,149,450,464],"patients":[56,284,300,381],"advanced":[58],"solid":[59],"tumours.":[60],"The":[61,96,159,441,456,470],"primary":[62],"objectives":[63],"are":[64],"determine":[66],"the":[67,78,84,148,182,248,257,294,310,349,400,413,424,483],"feasibility":[68],"safety":[70],"this":[72],"intervention":[73],"as":[74,76],"well":[75,315],"assessing":[77],"antitumour":[79],"activity,":[80],"viral":[81,476],"replication":[82,477],"development":[85],"immune":[87,473],"response.":[88],"Patients":[89],"were":[90,164,431],"treated":[91,372],"sequential":[93],"3-patient":[94],"cohorts.":[95,259],"treatment":[97,388],"plan":[98],"initially":[99],"involved":[100],"local":[101],"irradiation":[102],"20Gy":[104,249],"5":[106],"consecutive":[107],"daily":[108],"fractions":[109],"combination":[111],"two":[113,169,353],"intratumour":[114],"(108":[118],"TCID50":[119],"on":[120,302,472],"days":[121,198,218,225,243,252],"2":[122,175,191,211,223,299,338,392],"4":[124,177,193,213],"week":[126,179,195,202,215,222,230],"1)":[127,180],"successive":[129],"cohorts":[130,250],"receiving":[131],"escalating":[132],"doses":[133,170,187,207],"maximum":[138],"1010TCID50":[139,172,189,209],".":[140],"As":[141],"no":[142],"dose-limiting":[143],"toxicity":[144],"(DLT)":[145],"was":[146,151,240,261,374],"encountered":[147],"increased":[152],"up":[153],"36Gy":[155,258],"12":[157],"fractions.":[158],"number":[160],"escalated":[165],"conjunction":[167],"from":[168],"(days":[174,190,210],"for":[181,263],"first":[183],"cohort":[184,352,416],"then":[185],"four":[186],"1":[196,216,336,417],"9":[199,219],"11":[201,221,379],"2)":[203],"finally":[205],"6":[206,429],"16":[226],"18":[228],"3).\u2028":[231],"Tumour":[232],"evaluation":[233],"using":[234],"imaging(RECIST":[235],"criteria)":[236],"or":[237],"clinical":[238],"examination":[239],"performed":[241],"at":[242,386,437,480],"33":[244],"61":[246],"29":[253],"59":[255],"Blood":[260],"collected":[262],"assessment":[264],"T":[266,269],"cell":[267,270],"subsets,":[268],"proliferation":[271],"cytokine":[273],"production":[274],"association":[276,462],"response":[277,474],"tumour":[279,324,326],"associated":[280],"antigens.\u2028":[281],"Results:":[282],"24":[283],"have":[285],"enrolled":[287],"date":[289],"15":[291],"having":[292],"completed":[293],"(7":[296],"withdrawals/replacements":[297],"still":[301],"study)":[303],"one":[305,434],"patient":[306,401],"required":[307],"complete":[309],"study.":[311],"Treatment":[312],"tolerated":[316,452],"grade":[318,335],"3":[319],"toxicities":[320,339],"fatigue(4),":[322],"hypokalaemia(3),":[323],"pain(1),":[325],"necrosis(1),":[327],"diarrhoea(1),":[328],"dysphagia(1),":[329],"cellulitis(1)":[330],"anorexia(1)":[332],"seen.":[333],"Common":[334],"include":[340],"lymphopenia,":[341],"fatigue,":[342],"vomiting,":[343],"fever,":[344],"rash":[345],"neutropenia.":[347],"In":[348,412],"low":[350],"pts":[354],"(oesophageal":[355],"skin":[357],"squamous":[358],"carcinoma)":[359],"had":[360,405],"significant":[361,454],"partial":[362,418],"responses":[363],"(PR)":[364],"(70%":[365],"50%)":[367],"stable":[369,396],"disease(SD)":[370],"site":[373],"seen":[375,432],"8":[377],"evaluable":[380,426],"disease":[383],"progression":[384,436],"noted":[385],"non":[387],"lesion":[389],"sites":[390],"those":[394],"disease.":[397,411],"Of":[398],"note":[399],"oesophageal":[403],"cancer":[404],"PR":[407],"non-irradiated":[409],"mediastinal":[410],"high":[414],"response(PR)":[419],"(in":[420],"colorectal":[421],"cancer)":[422],"7":[425],"patients,":[427],"SD":[430],"showing":[435],"non-treated":[438],"sites.\u2028":[439],"Conclusion:":[440],"use":[442],"combined":[448],"without":[453],"toxicity.":[455],"administration":[457],"multiple":[459],"feasible":[466],"selected":[468],"patients.":[469],"data":[471],"ongoing":[479],"present":[481],"nearing":[485],"planned":[486],"completion.":[487]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
