{"id":"https://openalex.org/W2268601721","doi":null,"title":"Determination of glomerular filtration rate using technetium-99m-DTPA with differing degrees of renal function.","display_name":"Determination of glomerular filtration rate using technetium-99m-DTPA with differing degrees of renal function.","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2268601721","mag":"2268601721","pmid":"https://pubmed.ncbi.nlm.nih.gov/9239614"},"language":"en","primary_location":{"id":"pmid:9239614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9239614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine technology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010229998","display_name":"Kathryn A. Morton","orcid":"https://orcid.org/0000-0001-9861-3478","observed_orcids":["https://orcid.org/0000-0001-9861-3478"]},"institutions":[{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Morton","raw_affiliation_strings":["Imaging Service, VA Medical Center, Portland, Oregon 97207, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Service, VA Medical Center, Portland, Oregon 97207, USA","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D E Pisani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Pisani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011012872","display_name":"John H. Whiting","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Whiting","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054409151","display_name":"Alfred K. Cheung","orcid":"https://orcid.org/0000-0002-7304-9476","observed_orcids":["https://orcid.org/0000-0002-7304-9476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K Cheung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081462473","display_name":"John M. Arias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Arias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112999028","display_name":"Sonia Valdivia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Valdivia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3238,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.63867908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"2","first_page":"110","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":1.0},{"id":"https://openalex.org/keywords/tc-99m-dtpa","display_name":"Tc-99m DTPA","score":0.9850000143051147},{"id":"https://openalex.org/keywords/plasma-clearance","display_name":"plasma clearance","score":0.8130000233650208},{"id":"https://openalex.org/keywords/iothalamate-clearance","display_name":"iothalamate clearance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6019999980926514},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/method-comparison","display_name":"method comparison","score":0.5870000123977661},{"id":"https://openalex.org/keywords/24-hour-creatinine-clearance","display_name":"24-hour creatinine clearance","score":0.6600000262260437},{"id":"https://openalex.org/keywords/inulin-clearance","display_name":"inulin clearance","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.9243347644805908},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.7381981015205383},{"id":"https://openalex.org/C2779742124","wikidata":"https://www.wikidata.org/wiki/Q201552","display_name":"Inulin","level":2,"score":0.666393518447876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5888327956199646},{"id":"https://openalex.org/C3018403923","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Plasma clearance","level":3,"score":0.5753398537635803},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5431690216064453},{"id":"https://openalex.org/C177669144","wikidata":"https://www.wikidata.org/wiki/Q2043674","display_name":"PAH clearance","level":5,"score":0.5252135396003723},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.5187299847602844},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.49538910388946533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4440910220146179},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4169093072414398},{"id":"https://openalex.org/C21652263","wikidata":"https://www.wikidata.org/wiki/Q5347278","display_name":"Effective renal plasma flow","level":4,"score":0.36703455448150635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3370784521102905},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.2222960889339447},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.09029704332351685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007483","descriptor_name":"Iothalamic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014462","descriptor_name":"Ultrafiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016284","descriptor_name":"Technetium Tc 99m Pentetate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9239614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9239614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine technology","raw_type":"Journal Article"},{"id":"mag:2268601721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9239614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/1"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W345345927","https://openalex.org/W1512742807","https://openalex.org/W1737333750","https://openalex.org/W1825891077","https://openalex.org/W1892107811","https://openalex.org/W1993940215","https://openalex.org/W2006090662","https://openalex.org/W2054652839","https://openalex.org/W2056806782","https://openalex.org/W2123973380","https://openalex.org/W2141308966","https://openalex.org/W2150884269","https://openalex.org/W2168197856","https://openalex.org/W2257386476","https://openalex.org/W2276618902","https://openalex.org/W2412771192","https://openalex.org/W2416923599","https://openalex.org/W2418943146"],"related_works":["https://openalex.org/W2150884269","https://openalex.org/W2094250617","https://openalex.org/W2064348578","https://openalex.org/W2271897027","https://openalex.org/W2127957708","https://openalex.org/W2145463318","https://openalex.org/W2425618185","https://openalex.org/W2168197856","https://openalex.org/W2411640496","https://openalex.org/W1737333750"],"abstract_inverted_index":{"UNLABELLED:":[0],"Glomerular":[1],"filtration":[2],"rate":[3],"(GFR)":[4],"is":[5],"an":[6],"important":[7],"index":[8],"of":[9,50,56,86,92,115,127,147,169,238],"renal":[10,21,81,99,137,188,247],"function.":[11,22,82],"Twenty-four-hour":[12],"creatinine":[13],"clearance":[14,91,114,237],"overestimates":[15],"GFR":[16,33,88,110,148,170,212,230],"in":[17,72,96,240],"patients":[18,185,242],"with":[19,132,186,245],"poor":[20,203],"Inulin":[23],"and":[24,37,119,121,153,199,210],"iothalamate":[25,66,154,200],"clearances":[26],"are":[27,35],"accepted":[28],"reference":[29],"standards":[30],"for":[31],"determining":[32],"but":[34],"expensive":[36],"laborious.":[38],"We":[39],"have":[40],"previously":[41],"reported":[42],"that":[43,73,229],"GFRs":[44],"obtained":[45,63,149,172,214],"by":[46,64,89,113,150,173,215,235],"measuring":[47,87],"the":[48,65,69,125,143,151,167,174,194,197,211,216],"disappearance":[49],"99mTc-DTPA":[51,93,239],"from":[52,102,117],"ultrafiltered":[53],"(protein-free)":[54],"samples":[55],"plasma":[57,90,236],"were":[58,219],"virtually":[59],"identical":[60],"to":[61,77,104,134],"those":[62,244],"method.":[67],"However,":[68],"subjects":[70,97,131],"used":[71,123],"study":[74],"had":[75],"normal":[76,103,133],"only":[78],"moderately":[79,135],"decreased":[80],"METHODS:":[83],"The":[84,164],"accuracy":[85],"was":[94,111,122,156,177,202],"determined":[95,233],"where":[98],"function":[100,138],"varied":[101],"severely":[105],"impaired.":[106],"In":[107,184],"all":[108,241],"subjects,":[109],"established":[112],"125I-iothalamate":[116],"urine":[118],"serum":[120],"as":[124],"standard":[126],"reference.":[128],"RESULTS:":[129],"For":[130],"diminished":[136],"(GFR":[139,190],">":[140,182],"20":[141,192],"ml/min),":[142,193],"correlation":[144,195],"between":[145,166,196],"values":[146,171,213],"DTPA":[152,198],"methods":[155,176,201,218],"high":[157],"(n":[158,204],"=":[159,162,205,208],"18,":[160],"r":[161,207],"0.966).":[163],"difference":[165],"pairs":[168],"two":[175,217],"not":[178],"statistically":[179,220],"significant":[180],"(p":[181,222],"0.1).":[183],"severe":[187,246],"insufficiency":[189],"<":[191,223],"11,":[206],"0.236),":[209],"different":[221],"0.01).":[224],"CONCLUSION:":[225],"These":[226],"results":[227],"suggest":[228],"can":[231],"be":[232],"accurately":[234],"except":[243],"insufficiency.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}