{"id":"https://openalex.org/W2268459205","doi":null,"title":"ACTIONS OF ALCOHOL AND ISCHAEMIC BRAIN INFARCTION","display_name":"ACTIONS OF ALCOHOL AND ISCHAEMIC BRAIN INFARCTION","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2268459205","mag":"2268459205"},"language":"en","primary_location":{"id":"mag:2268459205","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514257227.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066095930","display_name":"Heikki Numminen","orcid":"https://orcid.org/0000-0001-9343-0269","observed_orcids":["https://orcid.org/0000-0001-9343-0269"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heikki Numminen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9343-0269","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066095930"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8330000042915344},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7369999885559082},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/heavy-drinking","display_name":"heavy drinking","score":0.5690000057220459},{"id":"https://openalex.org/keywords/red-wine","display_name":"red wine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/acute-alcohol-intoxication","display_name":"acute alcohol intoxication","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cardioembolism","display_name":"cardiac embolism","score":0.7329999804496765},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/cryptogenic-stroke","display_name":"cryptogenic stroke","score":0.6480000019073486},{"id":"https://openalex.org/keywords/large-artery-atherosclerosis","display_name":"large artery atherosclerosis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.593999981880188},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7300271987915039},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6838383674621582},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5218302607536316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48249340057373047},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.480328232049942},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.46068882942199707},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.44717785716056824},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.418877512216568},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37299710512161255},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3684889078140259},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2530381679534912}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2268459205","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514257227.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":319,"referenced_works":["https://openalex.org/W7183868","https://openalex.org/W15186908","https://openalex.org/W45316589","https://openalex.org/W95067618","https://openalex.org/W101671075","https://openalex.org/W138570360","https://openalex.org/W142384375","https://openalex.org/W184705411","https://openalex.org/W301270488","https://openalex.org/W326618517","https://openalex.org/W1512547055","https://openalex.org/W1513266031","https://openalex.org/W1548579074","https://openalex.org/W1550165881","https://openalex.org/W1558266538","https://openalex.org/W1560978008","https://openalex.org/W1561189761","https://openalex.org/W1565449544","https://openalex.org/W1577086711","https://openalex.org/W1580297542","https://openalex.org/W1812573532","https://openalex.org/W1821090434","https://openalex.org/W1821528277","https://openalex.org/W1874621311","https://openalex.org/W1876949150","https://openalex.org/W1920976164","https://openalex.org/W1933244338","https://openalex.org/W1938528378","https://openalex.org/W1963536396","https://openalex.org/W1963674766","https://openalex.org/W1963865674","https://openalex.org/W1964398327","https://openalex.org/W1965570480","https://openalex.org/W1966285376","https://openalex.org/W1966540696","https://openalex.org/W1967204038","https://openalex.org/W1968988253","https://openalex.org/W1970132235","https://openalex.org/W1971456138","https://openalex.org/W1972003072","https://openalex.org/W1972577093","https://openalex.org/W1972656123","https://openalex.org/W1973939375","https://openalex.org/W1974611002","https://openalex.org/W1974742589","https://openalex.org/W1977306146","https://openalex.org/W1978099978","https://openalex.org/W1978224033","https://openalex.org/W1978285417","https://openalex.org/W1978883377","https://openalex.org/W1979017631","https://openalex.org/W1980169000","https://openalex.org/W1980200605","https://openalex.org/W1980581864","https://openalex.org/W1980619762","https://openalex.org/W1980855715","https://openalex.org/W1981069294","https://openalex.org/W1981271895","https://openalex.org/W1981517237","https://openalex.org/W1982660761","https://openalex.org/W1983532143","https://openalex.org/W1984232284","https://openalex.org/W1984663087","https://openalex.org/W1985400269","https://openalex.org/W1985551860","https://openalex.org/W1986992922","https://openalex.org/W1987391024","https://openalex.org/W1988252598","https://openalex.org/W1988817638","https://openalex.org/W1989147122","https://openalex.org/W1989938745","https://openalex.org/W1990718973","https://openalex.org/W1990986783","https://openalex.org/W1992757231","https://openalex.org/W1992821905","https://openalex.org/W1993721566","https://openalex.org/W1993981607","https://openalex.org/W1994514269","https://openalex.org/W1995024224","https://openalex.org/W1995051621","https://openalex.org/W1995723704","https://openalex.org/W1996199707","https://openalex.org/W1997945009","https://openalex.org/W1998779872","https://openalex.org/W2001295505","https://openalex.org/W2001322531","https://openalex.org/W2001506832","https://openalex.org/W2004258197","https://openalex.org/W2004617556","https://openalex.org/W2005674313","https://openalex.org/W2006185526","https://openalex.org/W2008054762","https://openalex.org/W2009085956","https://openalex.org/W2009513175","https://openalex.org/W2009598035","https://openalex.org/W2010408682","https://openalex.org/W2011185649","https://openalex.org/W2011340325","https://openalex.org/W2011579224","https://openalex.org/W2011592348","https://openalex.org/W2011676042","https://openalex.org/W2012214760","https://openalex.org/W2012753018","https://openalex.org/W2013745698","https://openalex.org/W2014931073","https://openalex.org/W2015013806","https://openalex.org/W2015195433","https://openalex.org/W2016566683","https://openalex.org/W2018368404","https://openalex.org/W2018587767","https://openalex.org/W2020359210","https://openalex.org/W2020995725","https://openalex.org/W2021046633","https://openalex.org/W2021548939","https://openalex.org/W2021566081","https://openalex.org/W2021808506","https://openalex.org/W2022184380","https://openalex.org/W2022974885","https://openalex.org/W2024662921","https://openalex.org/W2024784515","https://openalex.org/W2025159859","https://openalex.org/W2025780518","https://openalex.org/W2027358064","https://openalex.org/W2028329146","https://openalex.org/W2028769877","https://openalex.org/W2028855119","https://openalex.org/W2031004827","https://openalex.org/W2031300771","https://openalex.org/W2031872468","https://openalex.org/W2032337316","https://openalex.org/W2032427890","https://openalex.org/W2032430567","https://openalex.org/W2032838456","https://openalex.org/W2034396873","https://openalex.org/W2034536826","https://openalex.org/W2035233894","https://openalex.org/W2035447376","https://openalex.org/W2037072061","https://openalex.org/W2038234821","https://openalex.org/W2039361931","https://openalex.org/W2039448868","https://openalex.org/W2040000378","https://openalex.org/W2040692157","https://openalex.org/W2040914563","https://openalex.org/W2041493322","https://openalex.org/W2041700294","https://openalex.org/W2041848844","https://openalex.org/W2042291337","https://openalex.org/W2043132407","https://openalex.org/W2043690096","https://openalex.org/W2043928136","https://openalex.org/W2044559736","https://openalex.org/W2044880765","https://openalex.org/W2045196210","https://openalex.org/W2045911724","https://openalex.org/W2046500815","https://openalex.org/W2049125259","https://openalex.org/W2049282259","https://openalex.org/W2049360519","https://openalex.org/W2049728749","https://openalex.org/W2050270388","https://openalex.org/W2052433549","https://openalex.org/W2052572649","https://openalex.org/W2052760576","https://openalex.org/W2053156863","https://openalex.org/W2053745592","https://openalex.org/W2053900103","https://openalex.org/W2054166084","https://openalex.org/W2055033832","https://openalex.org/W2055503182","https://openalex.org/W2055612010","https://openalex.org/W2056587162","https://openalex.org/W2056780629","https://openalex.org/W2058794132","https://openalex.org/W2059223228","https://openalex.org/W2059394372","https://openalex.org/W2059815224","https://openalex.org/W2061063621","https://openalex.org/W2062548334","https://openalex.org/W2062813307","https://openalex.org/W2063495439","https://openalex.org/W2064808544","https://openalex.org/W2065082958","https://openalex.org/W2065734138","https://openalex.org/W2066404926","https://openalex.org/W2066439386","https://openalex.org/W2066443992","https://openalex.org/W2066793315","https://openalex.org/W2068141314","https://openalex.org/W2068477112","https://openalex.org/W2069064977","https://openalex.org/W2070367463","https://openalex.org/W2070610982","https://openalex.org/W2070834527","https://openalex.org/W2071350010","https://openalex.org/W2072034381","https://openalex.org/W2072357322","https://openalex.org/W2072477146","https://openalex.org/W2074452453","https://openalex.org/W2074914768","https://openalex.org/W2075013504","https://openalex.org/W2076700990","https://openalex.org/W2077251049","https://openalex.org/W2078061467","https://openalex.org/W2078593638","https://openalex.org/W2078944165","https://openalex.org/W2079012946","https://openalex.org/W2079252646","https://openalex.org/W2079920229","https://openalex.org/W2080881601","https://openalex.org/W2082180862","https://openalex.org/W2085083783","https://openalex.org/W2085177307","https://openalex.org/W2085897854","https://openalex.org/W2086743626","https://openalex.org/W2087345941","https://openalex.org/W2088355928","https://openalex.org/W2089616004","https://openalex.org/W2090205938","https://openalex.org/W2091351073","https://openalex.org/W2091808989","https://openalex.org/W2091883570","https://openalex.org/W2092032815","https://openalex.org/W2092193929","https://openalex.org/W2092345229","https://openalex.org/W2094077872","https://openalex.org/W2094091913","https://openalex.org/W2096251920","https://openalex.org/W2098524938","https://openalex.org/W2099026857","https://openalex.org/W2099246517","https://openalex.org/W2101350667","https://openalex.org/W2104093946","https://openalex.org/W2104840130","https://openalex.org/W2106276722","https://openalex.org/W2108361166","https://openalex.org/W2109477643","https://openalex.org/W2109789725","https://openalex.org/W2115893200","https://openalex.org/W2116404715","https://openalex.org/W2118226840","https://openalex.org/W2118744914","https://openalex.org/W2120325617","https://openalex.org/W2123403865","https://openalex.org/W2123520002","https://openalex.org/W2127740581","https://openalex.org/W2130617740","https://openalex.org/W2131371483","https://openalex.org/W2132106617","https://openalex.org/W2136537532","https://openalex.org/W2136855859","https://openalex.org/W2138557629","https://openalex.org/W2138595885","https://openalex.org/W2139028216","https://openalex.org/W2139464225","https://openalex.org/W2140573178","https://openalex.org/W2141340123","https://openalex.org/W2147665626","https://openalex.org/W2149504963","https://openalex.org/W2151869895","https://openalex.org/W2152845939","https://openalex.org/W2153321322","https://openalex.org/W2153403468","https://openalex.org/W2159257792","https://openalex.org/W2162996439","https://openalex.org/W2169030528","https://openalex.org/W2171141631","https://openalex.org/W2179084513","https://openalex.org/W2184297876","https://openalex.org/W2203355042","https://openalex.org/W2227189395","https://openalex.org/W2263943539","https://openalex.org/W2269050221","https://openalex.org/W2301963978","https://openalex.org/W2335477357","https://openalex.org/W2335592377","https://openalex.org/W2336611876","https://openalex.org/W2336672206","https://openalex.org/W2337056362","https://openalex.org/W2338441777","https://openalex.org/W2395414708","https://openalex.org/W2396345262","https://openalex.org/W2396999746","https://openalex.org/W2397086360","https://openalex.org/W2399314553","https://openalex.org/W2401609042","https://openalex.org/W2406456490","https://openalex.org/W2407760336","https://openalex.org/W2408670450","https://openalex.org/W2409121817","https://openalex.org/W2409314498","https://openalex.org/W2410708288","https://openalex.org/W2410832636","https://openalex.org/W2411505220","https://openalex.org/W2412034882","https://openalex.org/W2412375554","https://openalex.org/W2413370224","https://openalex.org/W2413646831","https://openalex.org/W2413874946","https://openalex.org/W2414159824","https://openalex.org/W2414506814","https://openalex.org/W2415757482","https://openalex.org/W2416081126","https://openalex.org/W2417660421","https://openalex.org/W2417674571","https://openalex.org/W2417791203","https://openalex.org/W2418095263","https://openalex.org/W2420229366","https://openalex.org/W2436909348","https://openalex.org/W2440255464","https://openalex.org/W2441616473","https://openalex.org/W2443019382","https://openalex.org/W2443443420","https://openalex.org/W2465153533","https://openalex.org/W2465478581","https://openalex.org/W2476263554","https://openalex.org/W2554037808","https://openalex.org/W4239471829","https://openalex.org/W4302089322"],"related_works":["https://openalex.org/W2031359967","https://openalex.org/W2101598988","https://openalex.org/W2059211446","https://openalex.org/W2079012946","https://openalex.org/W2011185649","https://openalex.org/W1982639175","https://openalex.org/W2025780518","https://openalex.org/W164053869","https://openalex.org/W2090110541","https://openalex.org/W2109477643"],"abstract_inverted_index":{"Alcohol":[0,113],"drinking":[1,114,266,275,291,339,362],"may":[2,16],"exercise":[3,122],"both":[4,181,237],"beneficial":[5],"and":[6,12,23,46,54,83,103,184,203,239,315],"untoward":[7,334,375],"effects":[8,74,119,335],"on":[9,123,212,377],"the":[10,27,101,118,149,171,220,248,260,287,330,346,359],"haemostatic":[11],"fibrinolytic":[13,61,195],"systems.":[14],"It":[15],"also":[17,292],"predispose":[18,295],"individuals":[19],"to":[20,33,161,286,294,297,308,312,322,345],"arterial":[21],"thrombosis":[22],"trigger":[24],"embolism":[25,285,310],"in":[26,60,86,91,132,191,207,256,325],"brain.":[28,288],"The":[29,72,254],"aim":[30],"here":[31],"is":[32],"examine":[34],"these":[35,319],"problems.":[36],"Methods":[37],"used":[38,98],"for":[39,99,283],"evaluating":[40],"platelet":[41,44,52,124,163,201,227,243,257],"function":[42,204,258],"were":[43,63,89,97,205],"aggregation":[45,164],"associated":[47],"thromboxane":[48,146],"B2":[49],"release,":[50],"shear-induced":[51],"aggregation,":[53],"measurement":[55],"of":[56,75,105,120,136,144,153,157,169,189,214,276,301,336,340,348,363,367],"urinary":[57,142],"prostaglandins.":[58],"Changes":[59],"system":[62],"evaluated":[64,206],"by":[65,140],"measuring":[66],"plasminogen":[67],"activator":[68],"inhibitor":[69],"type":[70],"1.":[71],"combined":[73],"alcohol":[76,111,190,277],"drinking,":[77],"physical":[78,121],"exercise,":[79],"eating":[80],"a":[81,133,145,154,176,185,198,223,364],"meal":[82,177],"circadian":[84],"rhythms":[85],"healthy":[87,378],"volunteers":[88],"examined":[90],"three":[92],"experimental":[93],"studies.":[94,327],"Case-control":[95],"studies":[96],"assessing":[100],"mechanism":[102],"etiology":[104],"ischaemic":[106,302],"brain":[107,216,252,303,349],"infarction":[108,304,350],"triggered":[109],"during":[110],"intoxication.":[112],"did":[115,370],"not":[116,371],"potentiate":[117],"function.":[125],"Sleeping":[126],"while":[127],"under":[128],"acute":[129,187,215,337],"intoxication":[130],"resulted":[131],"significant":[134],"activation":[135],"platelets,":[137],"as":[138,306,352,355],"shown":[139],"increased":[141],"excretion":[143],"metabolite.":[147],"On":[148,358],"other":[150,249,299,360],"hand,":[151,361],"ingestion":[152],"moderate":[155,365],"dose":[156,188,366],"red":[158,182,368],"wine":[159,172,183,369],"seemed":[160,293],"attenuate":[162],"measured":[165],"ex":[166],"vivo,":[167],"irrespective":[168],"whether":[170],"was":[173,229,278],"consumed":[174],"with":[175,219,251],"or":[178,354],"alone.":[179],"However,":[180],"larger":[186,326],"fruit":[192],"juice":[193],"inhibited":[194],"activity.":[196],"In":[197,328],"case-control":[199,269],"study,":[200],"count":[202,228],"426":[208],"consecutive":[209],"patients":[210,250],"hospitalized":[211],"account":[213],"infarction.":[217,253],"Compared":[218],"hospital-based":[221],"controls,":[222],"higher":[224,238],"than":[225,241,247],"normal":[226,242],"observed":[230],"immediately":[231],"after":[232],"admission.":[233],"Heavy":[234],"drinkers":[235,262],"showed":[236],"lower":[240],"counts":[244],"more":[245],"often":[246],"changes":[255],"among":[259],"heavy":[261,274,290,338],"reflected":[263],"their":[264],"recent":[265,273],"habits.":[267],"Another":[268],"study":[270],"indicated":[271],"that":[272],"an":[279],"independent":[280],"risk":[281],"factor":[282],"cardiogenic":[284],"Recent":[289],"subjects":[296],"some":[298,333],"types":[300],"such":[305],"artery":[307,309],"due":[311],"large-artery":[313],"atherosclerosis":[314],"cryptogenic":[316],"stroke,":[317],"but":[318],"observations":[320],"need":[321],"be":[323],"confirmed":[324],"conclusion,":[329],"results":[331],"show":[332],"alcohol,":[341],"which":[342],"could":[343],"contribute":[344],"onset":[347],"either":[351],"triggering":[353],"predisposing":[356],"factors.":[357],"have":[372],"any":[373],"clear":[374],"effect":[376],"human":[379],"volunteers.":[380]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}