{"id":"https://openalex.org/W2268412694","doi":null,"title":"Modulation of the immune response to mycobacteria: implications on protection and pathology","display_name":"Modulation of the immune response to mycobacteria: implications on protection and pathology","publication_year":2009,"publication_date":"2009-12-22","ids":{"openalex":"https://openalex.org/W2268412694","mag":"2268412694"},"language":"en","primary_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/10857","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/10857","pdf_url":"http://hdl.handle.net/1822/10857","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1822/10857","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007216508","display_name":"Daniela Maria Ramos Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Daniela Maria Ramos Pereira","raw_affiliation_strings":["Univ. of Minho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Minho","institution_ids":["https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007216508"],"corresponding_institution_ids":["https://openalex.org/I99682543"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.8529999852180481},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5979999899864197},{"id":"https://openalex.org/keywords/route-of-infection","display_name":"infection route","score":0.6639999747276306},{"id":"https://openalex.org/keywords/intranasal-infection","display_name":"intranasal infection","score":0.781000018119812},{"id":"https://openalex.org/keywords/intravenous-infection","display_name":"intravenous infection","score":0.9409999847412109},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.6370000243186951},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.37400001287460327},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7785371541976929},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.729362964630127},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7209066152572632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6895291805267334},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.527925968170166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.519224226474762},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.5177564024925232},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5035733580589294},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4837367832660675},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4178369641304016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3553752303123474},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19538697600364685}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/10857","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/10857","pdf_url":"http://hdl.handle.net/1822/10857","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},{"id":"pmh:oai:repositorium.uminho.pt:1822/10857","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/10857","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2268412694","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.sdum.uminho.pt/bitstream/1822/10857/1/tese.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/10857","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/10857","pdf_url":"http://hdl.handle.net/1822/10857","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2268412694.pdf","grobid_xml":"https://content.openalex.org/works/W2268412694.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W1483961794","https://openalex.org/W1487729161","https://openalex.org/W1489330398","https://openalex.org/W1496007453","https://openalex.org/W1507266487","https://openalex.org/W1513558205","https://openalex.org/W1517658874","https://openalex.org/W1518367075","https://openalex.org/W1520745913","https://openalex.org/W1537905428","https://openalex.org/W1538029215","https://openalex.org/W1558427660","https://openalex.org/W1566992315","https://openalex.org/W1578877546","https://openalex.org/W1581627029","https://openalex.org/W1591161561","https://openalex.org/W1591708612","https://openalex.org/W1597390649","https://openalex.org/W1604235714","https://openalex.org/W1624493175","https://openalex.org/W1637461528","https://openalex.org/W1646851899","https://openalex.org/W1671840178","https://openalex.org/W1751145801","https://openalex.org/W1754134899","https://openalex.org/W1755443043","https://openalex.org/W1765079284","https://openalex.org/W1811586967","https://openalex.org/W1841012357","https://openalex.org/W1891447727","https://openalex.org/W1901576288","https://openalex.org/W1921564254","https://openalex.org/W1930233965","https://openalex.org/W1943952697","https://openalex.org/W1966117438","https://openalex.org/W1974781378","https://openalex.org/W1979636314","https://openalex.org/W1980300969","https://openalex.org/W1980690619","https://openalex.org/W1981276060","https://openalex.org/W1987733838","https://openalex.org/W1989883893","https://openalex.org/W1992551577","https://openalex.org/W1993600630","https://openalex.org/W1994353768","https://openalex.org/W2006249161","https://openalex.org/W2008626549","https://openalex.org/W2008998437","https://openalex.org/W2009921790","https://openalex.org/W2013800646","https://openalex.org/W2016755802","https://openalex.org/W2022705758","https://openalex.org/W2022901323","https://openalex.org/W2023000424","https://openalex.org/W2023650245","https://openalex.org/W2024147595","https://openalex.org/W2030904598","https://openalex.org/W2031551451","https://openalex.org/W2034358979","https://openalex.org/W2036971564","https://openalex.org/W2038535814","https://openalex.org/W2040117967","https://openalex.org/W2040248182","https://openalex.org/W2041345462","https://openalex.org/W2042826001","https://openalex.org/W2043043717","https://openalex.org/W2048492877","https://openalex.org/W2051139401","https://openalex.org/W2053875845","https://openalex.org/W2054629245","https://openalex.org/W2055563269","https://openalex.org/W2055618586","https://openalex.org/W2056108991","https://openalex.org/W2057277470","https://openalex.org/W2057467743","https://openalex.org/W2058425124","https://openalex.org/W2059122129","https://openalex.org/W2059342656","https://openalex.org/W2060308790","https://openalex.org/W2060966727","https://openalex.org/W2061021775","https://openalex.org/W2062173234","https://openalex.org/W2062409682","https://openalex.org/W2063696360","https://openalex.org/W2064521374","https://openalex.org/W2065791817","https://openalex.org/W2066403587","https://openalex.org/W2070157434","https://openalex.org/W2071165876","https://openalex.org/W2073555741","https://openalex.org/W2075322893","https://openalex.org/W2079039349","https://openalex.org/W2079409189","https://openalex.org/W2081601920","https://openalex.org/W2082734149","https://openalex.org/W2085201002","https://openalex.org/W2085842563","https://openalex.org/W2085961848","https://openalex.org/W2088618181","https://openalex.org/W2089323062","https://openalex.org/W2090278975","https://openalex.org/W2092325349","https://openalex.org/W2096877987","https://openalex.org/W2097655644","https://openalex.org/W2098700395","https://openalex.org/W2100531445","https://openalex.org/W2100990607","https://openalex.org/W2101771134","https://openalex.org/W2102578857","https://openalex.org/W2102625516","https://openalex.org/W2105368166","https://openalex.org/W2105923122","https://openalex.org/W2105960411","https://openalex.org/W2106447712","https://openalex.org/W2107361191","https://openalex.org/W2108811173","https://openalex.org/W2109484445","https://openalex.org/W2110931762","https://openalex.org/W2110965952","https://openalex.org/W2111717604","https://openalex.org/W2112789179","https://openalex.org/W2112866067","https://openalex.org/W2113687012","https://openalex.org/W2114220827","https://openalex.org/W2114231746","https://openalex.org/W2115438934","https://openalex.org/W2115637819","https://openalex.org/W2115993724","https://openalex.org/W2116394003","https://openalex.org/W2118001355","https://openalex.org/W2119724532","https://openalex.org/W2120384479","https://openalex.org/W2121499583","https://openalex.org/W2124232678","https://openalex.org/W2124593045","https://openalex.org/W2126197815","https://openalex.org/W2126245681","https://openalex.org/W2126321883","https://openalex.org/W2126476469","https://openalex.org/W2126604656","https://openalex.org/W2126748546","https://openalex.org/W2129710335","https://openalex.org/W2129869755","https://openalex.org/W2129996072","https://openalex.org/W2131731929","https://openalex.org/W2132578266","https://openalex.org/W2133488263","https://openalex.org/W2134320007","https://openalex.org/W2135437388","https://openalex.org/W2135811667","https://openalex.org/W2135943092","https://openalex.org/W2136097155","https://openalex.org/W2138989146","https://openalex.org/W2139196708","https://openalex.org/W2139754661","https://openalex.org/W2140490542","https://openalex.org/W2141205048","https://openalex.org/W2141912213","https://openalex.org/W2144217393","https://openalex.org/W2145078103","https://openalex.org/W2145788769","https://openalex.org/W2147532748","https://openalex.org/W2147541651","https://openalex.org/W2147896853","https://openalex.org/W2147971659","https://openalex.org/W2148021940","https://openalex.org/W2149200346","https://openalex.org/W2149349606","https://openalex.org/W2150216599","https://openalex.org/W2151788046","https://openalex.org/W2152906249","https://openalex.org/W2153188511","https://openalex.org/W2153271703","https://openalex.org/W2157907856","https://openalex.org/W2158134039","https://openalex.org/W2159112596","https://openalex.org/W2159586303","https://openalex.org/W2160883911","https://openalex.org/W2161074777","https://openalex.org/W2162815684","https://openalex.org/W2163188970","https://openalex.org/W2163931695","https://openalex.org/W2165246875","https://openalex.org/W2165948328","https://openalex.org/W2167630911","https://openalex.org/W2168637154","https://openalex.org/W2170967684","https://openalex.org/W2171429463","https://openalex.org/W2319922541","https://openalex.org/W4313333717","https://openalex.org/W4313333757","https://openalex.org/W4313333836"],"related_works":["https://openalex.org/W2519766518","https://openalex.org/W3193430503","https://openalex.org/W4392495704","https://openalex.org/W2275869799","https://openalex.org/W2525900167","https://openalex.org/W6982364196","https://openalex.org/W4235050972","https://openalex.org/W639375051","https://openalex.org/W7038465872","https://openalex.org/W4366086832"],"abstract_inverted_index":{"Effective":[0],"control":[1,129,177],"of":[2,9,18,49,63,73,90,94,104,111,130,152,159,163,173,183,188,195,203,222,232,239,248,266,299,320,329,335,341,350],"Mycobacterium":[3],"tuberculosis":[4,69,77,205,307,337],"infection":[5,78,167,196,272,304],"requires":[6],"the":[7,26,30,47,50,58,71,88,98,101,105,109,121,128,144,150,160,171,181,192,201,246,249,264,276,281,287,297,314,318,327,333,348],"induction":[8,214,231],"inflammatory":[10],"T":[11],"helper":[12],"(Th)":[13],"1":[14],"responses":[15],"and":[16,35,149,259,283],"avoidance":[17],"tissue":[19],"damage.":[20],"However,":[21,56,251],"little":[22],"is":[23,44,79,308],"known":[24],"about":[25],"mechanisms":[27,285],"that":[28,60,242,273,296,317],"rule":[29],"fine":[31],"balance":[32],"between":[33,257],"protection":[34],"pathology":[36],"in":[37,68,108,200,209,216,220,228,347],"this":[38,84],"infection.":[39,112,161,206,338],"The":[40],"anti-inflammatory":[41],"cytokine":[42,269],"IL-10":[43,64,74,126,153,164,213,233,300,355],"important":[45],"for":[46,313],"regulation":[48],"immune":[51,106],"response":[52],"to":[53,176,225,235],"several":[54],"pathogens.":[55],"despite":[57],"fact":[59],"elevated":[61],"levels":[62],"have":[65],"been":[66],"detected":[67],"patients,":[70],"role":[72],"during":[75,96,191,271,302],"M.":[76,140,204,226,306,336],"not":[80,169],"clearly":[81],"understood.":[82],"In":[83,185],"study,":[85],"we":[86,115,311],"evaluated":[87],"impact":[89,298],"a":[91,117,131,217],"transient":[92,218],"over-expression":[93,187],"IL-10,":[95],"either":[97,142],"innate":[99],"or":[100,146,268,357],"adaptive":[102],"phases":[103],"response,":[107],"outcome":[110,334],"For":[113],"this,":[114],"used":[116],"novel":[118],"animal":[119],"model,":[120],"PMT-10":[122,174,223,240,261],"mice,":[123],"which":[124],"over-express":[125],"under":[127],"zinc-inducible":[132],"promoter.":[133],"These":[134],"transgenic":[135],"animals":[136],"were":[137,255],"infected":[138],"with":[139,305],"tuberculosis,":[141,227],"via":[143],"intranasal":[145,229],"intravenous":[147,210],"route":[148,182,328],"expression":[151,270,301,323,356],"was":[154,243],"induced":[155,258],"at":[156],"different":[157,277],"stages":[158],"Over-expression":[162],"early":[165],"after":[166],"did":[168],"influence":[170],"capacity":[172],"mice":[175,224,241,262],"bacterial":[178],"growth,":[179],"regardless":[180],"inoculation.":[184],"contrast,":[186],"IL-":[189,321],"10":[190,322],"chronic":[193],"phase":[194],"caused":[197],"significant":[198],"effects":[199],"progression":[202],"Interestingly,":[207],"whereas":[208],"infection,":[211,230],"late":[212],"resulted":[215],"increase":[219],"susceptibility":[221],"led":[234],"an":[236,303],"increased":[237],"resistance":[238],"maintained":[244],"until":[245],"end":[247],"experiment.":[250],"no":[252],"major":[253],"differences":[254,288],"observed":[256,289],"noninduced":[260],"concerning":[263],"dynamic":[265],"cells":[267],"could":[274],"explain":[275],"outcomes":[278],"observed.":[279],"Although":[280],"cellular":[282],"molecular":[284],"underlying":[286],"remain":[290],"unknown,":[291],"altogether":[292],"our":[293,342],"data":[294],"suggest":[295],"variable.":[309],"Indeed,":[310],"show":[312],"first":[315],"time":[316],"timing":[319],"as":[324,326],"well":[325],"inoculation":[330],"can":[331],"determine":[332],"Further":[339],"understanding":[340],"observations":[343],"might":[344],"be":[345],"useful":[346],"context":[349],"immunomodulatory":[351],"strategies":[352],"based":[353],"on":[354],"suppression.":[358]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}