{"id":"https://openalex.org/W2268208682","doi":"https://doi.org/10.1155/2016/4851081","title":"Human Amnion\u2010Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway","display_name":"Human Amnion\u2010Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway","publication_year":2015,"publication_date":"2015-11-30","ids":{"openalex":"https://openalex.org/W2268208682","doi":"https://doi.org/10.1155/2016/4851081","mag":"2268208682","pmid":"https://pubmed.ncbi.nlm.nih.gov/26697075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677248"},"language":"en","primary_location":{"id":"doi:10.1155/2016/4851081","doi":"https://doi.org/10.1155/2016/4851081","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/4851081","pdf_url":"http://downloads.hindawi.com/journals/sci/2016/4851081.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/sci/2016/4851081.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuli Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuli Wang","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030893545","display_name":"Fei Jiang","orcid":"https://orcid.org/0000-0002-2380-1498","observed_orcids":["https://orcid.org/0000-0002-2380-1498","https://orcid.org/0000-0002-3287-5405","https://orcid.org/0009-0003-0623-7682","https://orcid.org/0009-0008-2268-1894"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Jiang","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102358724","display_name":"Yi Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liang","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089199336","display_name":"Ming Shen","orcid":"https://orcid.org/0000-0002-1968-3177","observed_orcids":["https://orcid.org/0000-0002-1968-3177","https://orcid.org/0000-0001-8354-9266","https://orcid.org/0009-0007-0439-1802"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Shen","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100446719","display_name":"Ning Chen","orcid":"https://orcid.org/0000-0003-4785-5076","observed_orcids":["https://orcid.org/0000-0003-4785-5076"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Chen","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, Jiangsu 210029","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089199336","https://openalex.org/A5100446719"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":{"value":2570,"currency":"USD","value_usd":2570},"fwci":2.4264,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.89046777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2016","issue":"1","first_page":"4851081","last_page":"4851081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bone-deficiency","display_name":"bone deficiency","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.5130000114440918},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.902999997138977},{"id":"https://openalex.org/keywords/u0126","display_name":"U0126","score":0.7279999852180481},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6119999885559082},{"id":"https://openalex.org/keywords/osteogenic-marker-genes","display_name":"osteogenic marker genes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.782139778137207},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.700485348701477},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.642760157585144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.614438533782959},{"id":"https://openalex.org/C2779886569","wikidata":"https://www.wikidata.org/wiki/Q7168661","display_name":"Periodontal ligament stem cells","level":4,"score":0.5090205669403076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3915431797504425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3533894121646881},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32802432775497437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16515937447547913},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2016/4851081","doi":"https://doi.org/10.1155/2016/4851081","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/4851081","pdf_url":"http://downloads.hindawi.com/journals/sci/2016/4851081.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3661914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4677248","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677248","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Int","raw_type":"Text"},{"id":"pmid:26697075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26697075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells international","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2cb1329ef564d079160c2cd1d30ac7d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d2cb1329ef564d079160c2cd1d30ac7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells International, Vol 2016 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2016/4851081","doi":"https://doi.org/10.1155/2016/4851081","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/4851081","pdf_url":"http://downloads.hindawi.com/journals/sci/2016/4851081.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1955728446","display_name":null,"funder_award_id":"81271109","funder_id":"https://openalex.org/F4320327518","funder_display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions"},{"id":"https://openalex.org/G835717708","display_name":"\u7f8a\u819c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u9aa8\u7f3a\u635f\u79cd\u690d\u4e2d\u4fc3\u8fdb\u9aa8\u518d\u751f\u7684\u4f5c\u7528\u548c\u673a\u5236\u7814\u7a76","funder_award_id":"81271109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2268208682.pdf","grobid_xml":"https://content.openalex.org/works/W2268208682.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1578357314","https://openalex.org/W1815345219","https://openalex.org/W1836348293","https://openalex.org/W1961427389","https://openalex.org/W1967402039","https://openalex.org/W1975362411","https://openalex.org/W1975621622","https://openalex.org/W1976385326","https://openalex.org/W1978228345","https://openalex.org/W1980430159","https://openalex.org/W1990236071","https://openalex.org/W1990677784","https://openalex.org/W1994667536","https://openalex.org/W1999311463","https://openalex.org/W1999524369","https://openalex.org/W2000114849","https://openalex.org/W2015050458","https://openalex.org/W2021053451","https://openalex.org/W2027540026","https://openalex.org/W2032025186","https://openalex.org/W2036003924","https://openalex.org/W2038618794","https://openalex.org/W2042909388","https://openalex.org/W2043686790","https://openalex.org/W2046275989","https://openalex.org/W2048286723","https://openalex.org/W2063389600","https://openalex.org/W2066113694","https://openalex.org/W2073280139","https://openalex.org/W2082686172","https://openalex.org/W2094760960","https://openalex.org/W2097767628","https://openalex.org/W2109967735","https://openalex.org/W2113442798","https://openalex.org/W2128284635","https://openalex.org/W2132309525","https://openalex.org/W2150883469","https://openalex.org/W2316401659","https://openalex.org/W4233568691","https://openalex.org/W4243623494"],"related_works":["https://openalex.org/W7097955454","https://openalex.org/W2800178103","https://openalex.org/W2082686172","https://openalex.org/W2464839438","https://openalex.org/W2973220298","https://openalex.org/W2763783563","https://openalex.org/W3027834264","https://openalex.org/W2025439281","https://openalex.org/W2781919626","https://openalex.org/W2432118357"],"abstract_inverted_index":{"Human":[0],"amnion-derived":[1],"mesenchymal":[2,83],"stem":[3,37,84],"cells":[4,60,85],"(HAMSCs)":[5],"are":[6],"considered":[7],"to":[8,73],"be":[9,41],"an":[10],"important":[11],"resource":[12],"in":[13,79,87,111,180],"the":[14,54,153,184,191,200],"field":[15],"of":[16,20,36,56,102,126,144,155,166,193,202],"tissue":[17],"engineering":[18],"because":[19],"their":[21,30],"anti-inflammatory":[22],"properties":[23],"and":[24,50,76,99,107,123,148],"fewer":[25],"ethical":[26],"issues":[27],"associated":[28],"with":[29,33],"use":[31],"compared":[32],"other":[34],"sources":[35],"cells.":[38],"HAMSCs":[39,57,70,135,156,176,194],"can":[40],"obtained":[42],"from":[43],"human":[44,80],"amniotic":[45],"membranes,":[46],"a":[47,88,162,196],"readily":[48],"available":[49],"abundant":[51],"tissue.":[52],"However,":[53],"potential":[55,192],"as":[58,195],"seed":[59,197],"for":[61,199],"treating":[62],"bone":[63,81,203],"deficiency":[64],"is":[65],"unknown.":[66],"In":[67],"this":[68],"study,":[69],"were":[71,94,109],"used":[72],"promote":[74,177],"proliferation":[75],"osteoblastic":[77],"differentiation":[78,106,179],"marrow":[82],"(HBMSCs)":[86],"Transwell":[89],"coculture":[90],"system.":[91],"Proliferation":[92],"levels":[93],"investigated":[95],"by":[96,160,182],"flow":[97],"cytometry":[98],"immunofluorescence":[100],"staining":[101],"5-ethynyl-2'-deoxyuridine":[103],"(EdU).":[104],"Osteoblastic":[105],"mineralization":[108],"evaluated":[110],"chromogenic":[112],"alkaline":[113,138],"phosphatase":[114,139],"(ALP)":[115,140],"activity":[116],"substrate":[117],"assays,":[118],"Alizarin":[119],"red":[120],"S":[121],"staining,":[122],"RT-PCR":[124],"analysis":[125],"early":[127],"HBMSCs":[128,181],"osteogenic":[129,145,178],"marker":[130,146],"expression.":[131],"We":[132,173],"demonstrated":[133],"that":[134,175],"stimulated":[136],"increased":[137],"activity,":[141],"mRNA":[142],"expression":[143],"genes,":[147],"mineralized":[149],"matrix":[150],"deposition.":[151],"Moreover,":[152],"effect":[154],"was":[157],"significantly":[158],"inhibited":[159],"U0126,":[161],"highly":[163],"selective":[164],"inhibitor":[165],"extracellular":[167],"signaling-regulated":[168],"kinase":[169],"1/2":[170],"(ERK1/2)":[171],"signaling.":[172],"demonstrate":[174],"influencing":[183],"ERK1/2":[185],"signaling":[186],"pathway.":[187],"These":[188],"observations":[189],"confirm":[190],"cell":[198],"treatment":[201],"deficiency.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}