{"id":"https://openalex.org/W2268138347","doi":null,"title":"Resveratrol\u00fcn h\u00fccresel ya\u015flanman\u0131n ind\u00fcklenmesi ve sirt\u00fcinlerin aktivasyonunda rol\u00fcn\u00fcn insan dermal fibroblastlar\u0131nda ara\u015ft\u0131r\u0131lmas\u0131","display_name":"Resveratrol\u00fcn h\u00fccresel ya\u015flanman\u0131n ind\u00fcklenmesi ve sirt\u00fcinlerin aktivasyonunda rol\u00fcn\u00fcn insan dermal fibroblastlar\u0131nda ara\u015ft\u0131r\u0131lmas\u0131","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2268138347","mag":"2268138347"},"language":"tr","primary_location":{"id":"pmh:oai:adudspace.adu.edu.tr:8080:11607/640","doi":null,"is_oa":true,"landing_page_url":"http://194.27.38.21/web/catalog/info.php?idx=50423070&idt=1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196591","display_name":"eArsiv - Adu (Adnan Menderes University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76806599","host_organization_name":"Adnan Menderes University","host_organization_lineage":["https://openalex.org/I76806599"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://194.27.38.21/web/catalog/info.php?idx=50423070&idt=1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035796446","display_name":"Ayten K\u0131l\u0131n\u00e7l\u0131","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ayten K\u0131l\u0131n\u00e7l\u0131","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035796446"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sirt3","display_name":"SIRT3","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sirt6","display_name":"SIRT6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sirt7","display_name":"SIRT7","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nad-dependent-histone-deacetylase","display_name":"NAD+-dependent histone deacetylase","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.7100769281387329},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.45745575428009033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3852827548980713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3059840202331543}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:adudspace.adu.edu.tr:8080:11607/640","doi":null,"is_oa":true,"landing_page_url":"http://194.27.38.21/web/catalog/info.php?idx=50423070&idt=1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196591","display_name":"eArsiv - Adu (Adnan Menderes University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76806599","host_organization_name":"Adnan Menderes University","host_organization_lineage":["https://openalex.org/I76806599"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2268138347","doi":null,"is_oa":false,"landing_page_url":"http://adudspace.adu.edu.tr:8080/xmlui/handle/11607/640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:adudspace.adu.edu.tr:8080:11607/640","doi":null,"is_oa":true,"landing_page_url":"http://194.27.38.21/web/catalog/info.php?idx=50423070&idt=1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196591","display_name":"eArsiv - Adu (Adnan Menderes University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76806599","host_organization_name":"Adnan Menderes University","host_organization_lineage":["https://openalex.org/I76806599"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W135874311","https://openalex.org/W215095023","https://openalex.org/W1510697806","https://openalex.org/W1599464745","https://openalex.org/W1731618434","https://openalex.org/W1881147845","https://openalex.org/W1885503255","https://openalex.org/W1903297931","https://openalex.org/W1910928745","https://openalex.org/W1970396523","https://openalex.org/W1974010102","https://openalex.org/W1974208182","https://openalex.org/W1975342712","https://openalex.org/W1976929342","https://openalex.org/W1978778821","https://openalex.org/W1979501382","https://openalex.org/W1980214124","https://openalex.org/W1984963280","https://openalex.org/W1986776963","https://openalex.org/W1989969820","https://openalex.org/W1991235534","https://openalex.org/W1995175684","https://openalex.org/W1996094302","https://openalex.org/W1996395636","https://openalex.org/W2003286160","https://openalex.org/W2004475776","https://openalex.org/W2006937382","https://openalex.org/W2007842741","https://openalex.org/W2007923680","https://openalex.org/W2008760491","https://openalex.org/W2017056741","https://openalex.org/W2017821950","https://openalex.org/W2019433277","https://openalex.org/W2019490742","https://openalex.org/W2028416255","https://openalex.org/W2030892059","https://openalex.org/W2031402508","https://openalex.org/W2032273584","https://openalex.org/W2035889318","https://openalex.org/W2037723157","https://openalex.org/W2039464457","https://openalex.org/W2040435660","https://openalex.org/W2041241505","https://openalex.org/W2043932983","https://openalex.org/W2045037598","https://openalex.org/W2047074918","https://openalex.org/W2049632644","https://openalex.org/W2052862307","https://openalex.org/W2057962646","https://openalex.org/W2060464465","https://openalex.org/W2060787688","https://openalex.org/W2060826509","https://openalex.org/W2065013450","https://openalex.org/W2068223162","https://openalex.org/W2069238469","https://openalex.org/W2071845780","https://openalex.org/W2072995534","https://openalex.org/W2074740541","https://openalex.org/W2074831400","https://openalex.org/W2082709188","https://openalex.org/W2082852887","https://openalex.org/W2082995884","https://openalex.org/W2083460692","https://openalex.org/W2084603699","https://openalex.org/W2086393402","https://openalex.org/W2086396311","https://openalex.org/W2087019732","https://openalex.org/W2088381487","https://openalex.org/W2090493150","https://openalex.org/W2099348677","https://openalex.org/W2099386481","https://openalex.org/W2100740404","https://openalex.org/W2101063496","https://openalex.org/W2103416697","https://openalex.org/W2105237310","https://openalex.org/W2106715610","https://openalex.org/W2108445817","https://openalex.org/W2111817213","https://openalex.org/W2112157036","https://openalex.org/W2112238025","https://openalex.org/W2113305156","https://openalex.org/W2117293711","https://openalex.org/W2118964113","https://openalex.org/W2122462367","https://openalex.org/W2124541044","https://openalex.org/W2125855766","https://openalex.org/W2126619846","https://openalex.org/W2126804276","https://openalex.org/W2127514222","https://openalex.org/W2132737274","https://openalex.org/W2133719663","https://openalex.org/W2134461109","https://openalex.org/W2135560386","https://openalex.org/W2142851289","https://openalex.org/W2147097971","https://openalex.org/W2149266016","https://openalex.org/W2151089147","https://openalex.org/W2151687023","https://openalex.org/W2152101492","https://openalex.org/W2155023973","https://openalex.org/W2158655179","https://openalex.org/W2161809170","https://openalex.org/W2162711901","https://openalex.org/W2166926510","https://openalex.org/W2171467827","https://openalex.org/W2352811888","https://openalex.org/W2398756899","https://openalex.org/W2435507289","https://openalex.org/W7098997929"],"related_works":["https://openalex.org/W7139656395","https://openalex.org/W231185638","https://openalex.org/W7046875577","https://openalex.org/W2289958057","https://openalex.org/W2390622125","https://openalex.org/W2157108841","https://openalex.org/W1989666486","https://openalex.org/W1975258835","https://openalex.org/W1582507932","https://openalex.org/W7099552622"],"abstract_inverted_index":{"Resveratrol\u00fcn":[0,60,87],"\u00e7e\u015fitli":[1],"model":[2],"organizmalarda":[3],"(NAD)-ba\u011f\u0131ml\u0131":[4],"histon":[5],"deasetilaz":[6],"ailesi":[7],"sirt\u00fcinlerin":[8],"\u00fcyesi":[9],"olan":[10,56],"Sirt1'":[11],"i":[12],"aktive":[13],"ederek":[14],"ya\u015fam":[15],"s\u00fcresini":[16],"uzatt\u0131\u011f\u0131":[17],"bilinmektedir.":[18],"Ancak":[19],"resveratrol\u00fcn":[20,44,104,156],"h\u00fccresel":[21,95,132,162],"d\u00fczeyde":[22],"h\u00fccre":[23,70,110],"d\u00f6ng\u00fcs\u00fcn\u00fc":[24],"durdurdu\u011fu,":[25],"erken":[26],"ya\u015flanmaya":[27],"ve":[28,54,74,78,90,121,137,146,158,165,170],"apoptozise":[29],"yol":[30],"a\u00e7t\u0131\u011f\u0131":[31],"bilindi\u011fi":[32],"i\u00e7in":[33],"ya\u015flanmay\u0131":[34,96,163],"engelleyici":[35],"etkileri":[36],"tart\u0131\u015fmal\u0131":[37],"hale":[38],"gelmi\u015ftir.":[39],"Bu":[40],"nedenle":[41],"bu":[42,84],"\u00e7al\u0131\u015fmada,":[43],"insan":[45],"normal":[46],"dermal":[47],"fibroblastlar\u0131nda":[48],"(BJ)":[49],"ya\u015flanma":[50],"\u00fczerine":[51],"olas\u0131":[52],"etkilerinin":[53],"sirt\u00fcinlerle":[55],"ili\u015fkisinin":[57],"ara\u015ft\u0131r\u0131lmas\u0131":[58],"ama\u00e7lanm\u0131\u015ft\u0131r.":[59],"72":[61],"saatlik":[62],"ink\u00fcbasyon":[63],"sonras\u0131nda":[64],"25":[65],"'''":[66],"dan":[67],"itibaren":[68],"BJ":[69],"proliferasyonunu":[71],"azaltt\u0131\u011f\u0131":[72],"WST-1":[73],"BrdU":[75],"testleriyle":[76],"saptanm\u0131\u015f":[77],"Ki-67":[79],"imm\u00fcn":[80],"boyama":[81],"y\u00f6ntemiyle":[82,127],"de":[83],"sonu\u00e7":[85],"desteklenmi\u015ftir.":[86],"25,":[88],"50":[89],"100":[91],"'M":[92,108],"konsantrasyonlarda":[93,106],"ise":[94,131,150],"ind\u00fckledi\u011fi":[97,164],"Sa\u00df-Gal":[98],"boyamas\u0131":[99],"ile":[100],"g\u00f6sterilmi\u015ftir.":[101],"Bunun":[102],"yan\u0131s\u0131ra":[103],"y\u00fcksek":[105],"(300":[107],")":[109],"\u00f6l\u00fcm\u00fcne":[111],"neden":[112],"oldu\u011fu":[113,142],"TUNEL":[114],"boyamas\u0131yla":[115],"belirlenmi\u015ftir.":[116],"Sirt1,":[117],"2,":[118],"3,":[119],"6":[120,145],"7'":[122,147],"nin":[123,139,148,172],"ifadelerinin":[124,173],"Western":[125],"Blot":[126],"analiz":[128],"edilmesi":[129],"sonucunda":[130],"ya\u015flanman\u0131n":[133],"g\u00f6r\u00fcld\u00fc\u011f\u00fc":[134],"dozlarda":[135],"Sirt1":[136,169],"2'":[138,171],"ifadesinde":[140],"azalma":[141],"ancak":[143],"Sirt3,":[144],"ifadelerinde":[149],"de\u011fi\u015fiklik":[151],"olmad\u0131\u011f\u0131":[152],"bulunmu\u015ftur.":[153,175],"Sonu\u00e7":[154],"olarak":[155,161,168],"doza":[157],"zamana":[159],"ba\u011fl\u0131":[160,167],"buna":[166],"azald\u0131\u011f\u0131":[174]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}