{"id":"https://openalex.org/W2267997482","doi":"https://doi.org/10.1242/dev.119628","title":"ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm","display_name":"ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2267997482","doi":"https://doi.org/10.1242/dev.119628","mag":"2267997482","pmid":"https://pubmed.ncbi.nlm.nih.gov/26417042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4712875"},"language":"en","primary_location":{"id":"doi:10.1242/dev.119628","doi":"https://doi.org/10.1242/dev.119628","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.119628","pdf_url":"https://dev.biologists.org/content/develop/142/22/3821.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://dev.biologists.org/content/develop/142/22/3821.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pam Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pam Ellis","raw_affiliation_strings":["The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086266721","display_name":"Sarah Burbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Burbridge","raw_affiliation_strings":["The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081800264","display_name":"Sandrine C. Soubes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandrine Soubes","raw_affiliation_strings":["The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108284234","display_name":"Kyoji Ohyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kyoji Ohyama","raw_affiliation_strings":["The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035219127","display_name":"Nadav Ben-Haim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272759","display_name":"ISREC Foundation","ror":"https://ror.org/04p69na38","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4405272759"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadav Ben-Haim","raw_affiliation_strings":["ISREC, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH 1066 Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISREC, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH 1066 Epalinges, Switzerland","institution_ids":["https://openalex.org/I4405272759","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059885627","display_name":"Canhe Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Canhe Chen","raw_affiliation_strings":["Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center,1130 St. Nicholas Ave. New York, NY 10032, USA","Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore\u2008138673","Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Avenue, New York, NY 10032, USA","Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center,1130 St. Nicholas Ave. New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore\u2008138673","institution_ids":["https://openalex.org/I75573869"]},{"raw_affiliation_string":"Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Avenue, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore","institution_ids":["https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040352573","display_name":"Jacqueline Kim Dale","orcid":"https://orcid.org/0000-0002-9294-947X","observed_orcids":["https://orcid.org/0000-0002-9294-947X"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kim Dale","raw_affiliation_strings":["College of Life Sciences, University of Dundee, Dundee, Scotland, DD1 5EH\u2008UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, University of Dundee, Dundee, Scotland, DD1 5EH\u2008UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125161","display_name":"Michael M. Shen","orcid":"https://orcid.org/0000-0002-4042-1657","observed_orcids":["https://orcid.org/0000-0002-4042-1657"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Shen","raw_affiliation_strings":["Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center,1130 St. Nicholas Ave. New York, NY 10032, USA","Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Avenue, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center,1130 St. Nicholas Ave. New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Departments of Medicine and Genetics & Development, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Avenue, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064346931","display_name":"Daniel B. Constam","orcid":"https://orcid.org/0000-0002-6256-3891","observed_orcids":["https://orcid.org/0000-0002-6256-3891"]},"institutions":[{"id":"https://openalex.org/I4405272759","display_name":"ISREC Foundation","ror":"https://ror.org/04p69na38","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4405272759"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Constam","raw_affiliation_strings":["ISREC, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH 1066 Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISREC, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH 1066 Epalinges, Switzerland","institution_ids":["https://openalex.org/I4405272759","https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066046626","display_name":"Marysia Placzek","orcid":"https://orcid.org/0000-0002-4106-9229","observed_orcids":["https://orcid.org/0000-0002-4106-9229"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Marysia Placzek","raw_affiliation_strings":["The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5066046626"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.6574,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67281773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"142","issue":"22","first_page":"3821","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prechordal-mesoderm","display_name":"prechordal mesoderm","score":0.9779999852180481},{"id":"https://openalex.org/keywords/nodal-signaling","display_name":"Nodal signaling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/gsc","display_name":"Gsc","score":0.6930000185966492},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/smad1-5-8","display_name":"Smad1/5/8","score":0.972000002861023},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.8207753300666809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7835978269577026},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.7371952533721924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6101669669151306},{"id":"https://openalex.org/C66332042","wikidata":"https://www.wikidata.org/wiki/Q5425488","display_name":"FGF and mesoderm formation","level":5,"score":0.5704115033149719},{"id":"https://openalex.org/C182928434","wikidata":"https://www.wikidata.org/wiki/Q6047369","display_name":"Intermediate mesoderm","level":5,"score":0.4538789987564087},{"id":"https://openalex.org/C205583638","wikidata":"https://www.wikidata.org/wiki/Q7046607","display_name":"Nodal signaling","level":5,"score":0.4276520609855652},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.4101918041706085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2569763660430908},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.23297446966171265},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.15098083019256592},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.13225623965263367},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12810778617858887},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.11708974838256836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055457","descriptor_name":"Nodal Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055457","descriptor_name":"Nodal Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1242/dev.119628","doi":"https://doi.org/10.1242/dev.119628","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.119628","pdf_url":"https://dev.biologists.org/content/develop/142/22/3821.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4712875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4712875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:26417042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26417042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:106404","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/106404/1/3821.full.pdf","pdf_url":"http://eprints.whiterose.ac.uk/106404/1/3821.full.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/0e4fa768-cf02-4cab-b9c6-a893cb730432","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/0e4fa768-cf02-4cab-b9c6-a893cb730432","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ellis, P S, Burbridge, S, Soubes, S, Ohyama, K, Ben-Haim, N, Chen, C, Dale, K, Shen, M M, Constam, D & Placzek, M 2015, 'Pronodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm', Development, vol. 142, no. 22, pp. 3821-3832. https://doi.org/10.1242/dev.119628","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:216648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:216648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1242/dev.119628","doi":"https://doi.org/10.1242/dev.119628","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.119628","pdf_url":"https://dev.biologists.org/content/develop/142/22/3821.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1848062621","display_name":null,"funder_award_id":"HD42837","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4442541924","display_name":"Functional analysis of Cripto in mouse embryogenesis","funder_award_id":"R01HD042837","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8105045749","display_name":null,"funder_award_id":"G0401310","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2267997482.pdf","grobid_xml":"https://content.openalex.org/works/W2267997482.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W999172585","https://openalex.org/W1489916230","https://openalex.org/W1513929030","https://openalex.org/W1651423553","https://openalex.org/W1848248739","https://openalex.org/W1902497723","https://openalex.org/W1933140282","https://openalex.org/W1949779925","https://openalex.org/W1950508909","https://openalex.org/W1960015501","https://openalex.org/W1964316050","https://openalex.org/W1964691304","https://openalex.org/W1965186550","https://openalex.org/W1966435498","https://openalex.org/W1983146536","https://openalex.org/W1984222668","https://openalex.org/W1984470870","https://openalex.org/W1992488668","https://openalex.org/W1993183396","https://openalex.org/W1993736057","https://openalex.org/W1993902328","https://openalex.org/W1994758141","https://openalex.org/W1995473388","https://openalex.org/W1997433626","https://openalex.org/W2002549741","https://openalex.org/W2005089193","https://openalex.org/W2005487923","https://openalex.org/W2005494875","https://openalex.org/W2006305927","https://openalex.org/W2007636457","https://openalex.org/W2010041789","https://openalex.org/W2018252151","https://openalex.org/W2019436391","https://openalex.org/W2019598289","https://openalex.org/W2024671803","https://openalex.org/W2024813334","https://openalex.org/W2026150045","https://openalex.org/W2027874487","https://openalex.org/W2029150089","https://openalex.org/W2029514251","https://openalex.org/W2032490027","https://openalex.org/W2034017651","https://openalex.org/W2034735471","https://openalex.org/W2046980494","https://openalex.org/W2047475767","https://openalex.org/W2047642636","https://openalex.org/W2047727235","https://openalex.org/W2051433930","https://openalex.org/W2055726879","https://openalex.org/W2059432588","https://openalex.org/W2059614045","https://openalex.org/W2060029591","https://openalex.org/W2060900500","https://openalex.org/W2063023858","https://openalex.org/W2065200502","https://openalex.org/W2069693786","https://openalex.org/W2071353985","https://openalex.org/W2072000337","https://openalex.org/W2072629065","https://openalex.org/W2073234446","https://openalex.org/W2079065029","https://openalex.org/W2082214835","https://openalex.org/W2083249373","https://openalex.org/W2088972764","https://openalex.org/W2090275710","https://openalex.org/W2091362392","https://openalex.org/W2102130285","https://openalex.org/W2104633606","https://openalex.org/W2108057299","https://openalex.org/W2108311888","https://openalex.org/W2109745264","https://openalex.org/W2111323588","https://openalex.org/W2112461805","https://openalex.org/W2112909601","https://openalex.org/W2113133809","https://openalex.org/W2114324859","https://openalex.org/W2120410199","https://openalex.org/W2126245868","https://openalex.org/W2127202275","https://openalex.org/W2129095196","https://openalex.org/W2129835280","https://openalex.org/W2132584224","https://openalex.org/W2136222099","https://openalex.org/W2136732727","https://openalex.org/W2138643777","https://openalex.org/W2142931826","https://openalex.org/W2147350988","https://openalex.org/W2151941602","https://openalex.org/W2160860113","https://openalex.org/W2161282017","https://openalex.org/W2164563970","https://openalex.org/W2169147580","https://openalex.org/W2187316952","https://openalex.org/W2258374813","https://openalex.org/W2296436253","https://openalex.org/W2338536031","https://openalex.org/W2403679102","https://openalex.org/W2409632561","https://openalex.org/W2883986816"],"related_works":["https://openalex.org/W2346476745","https://openalex.org/W2989534848","https://openalex.org/W2142986021","https://openalex.org/W2186211575","https://openalex.org/W7099664385","https://openalex.org/W2034017651","https://openalex.org/W7148295521","https://openalex.org/W2109907626","https://openalex.org/W2075278305","https://openalex.org/W2082417115"],"abstract_inverted_index":{"The":[0],"secreted":[1],"glycoprotein":[2],"sonic":[3],"hedgehog":[4],"(Shh)":[5],"is":[6,28,33,47,54,79,91,165,214,244],"expressed":[7,48],"in":[8,18,35,42,50,161,184,187],"the":[9,23,43,67],"prechordal":[10,36,51,61,158,182],"mesoderm,":[11,52],"where":[12],"it":[13],"plays":[14],"a":[15,100,113],"crucial":[16],"role":[17],"induction":[19],"and":[20,53,85,138,141,202,204,233],"patterning":[21],"of":[22,60,127,129,178],"ventral":[24],"forebrain.":[25],"Currently":[26],"little":[27],"known":[29],"about":[30],"how":[31],"Shh":[32,46,84,107,152,189,226,239],"regulated":[34],"tissue.":[37],"Here":[38],"we":[39],"show":[40,205],"that":[41,77,132,206,222,234],"embryonic":[44],"chick,":[45],"transiently":[49],"governed":[55],"by":[56,112,121,167,228],"unprocessed":[57],"Nodal.":[58,124],"Exposure":[59],"mesoderm":[62,159,183],"microcultures":[63],"to":[64,72,81,103,171,173,181,216],"Nodal-conditioned":[65],"medium,":[66],"Nodal":[68,78,97,115],"inhibitor":[69,75],"CerS,":[70],"or":[71],"an":[73,196],"ALK4/5/7":[74],"reveals":[76],"required":[80],"maintain":[82,104],"both":[83],"Gsc":[86,90,155],"expression,":[87],"but":[88,119],"whereas":[89],"largely":[92],"maintained":[93,111],"through":[94,99],"canonical":[95,230],"signalling,":[96,212,232],"signals":[98],"non-canonical":[101],"route":[102],"Shh.":[105,218],"Further,":[106,157],"expression":[108,164],"can":[109],"be":[110],"recombinant":[114],"cleavage":[116],"mutant,":[117],"proNodal,":[118],"not":[120],"purified":[122],"mature":[123],"A":[125],"number":[126],"lines":[128],"evidence":[130],"suggest":[131,221],"proNodal":[133,142],"acts":[134],"via":[135],"FGFR3.":[136],"ProNodal":[137],"FGFR3":[139,144,150],"co-immunoprecipitate":[140],"increases":[143],"tyrosine":[145],"phosphorylation.":[146],"In":[147],"microcultures,":[148],"soluble":[149],"abolishes":[151],"without":[153,191],"affecting":[154,192],"expression.":[156],"cells":[160],"which":[162,213],"Fgfr3":[163,168,179],"reduced":[166],"siRNA":[169,180],"fail":[170],"bind":[172],"proNodal.":[174],"Finally,":[175],"targeted":[176],"electroporation":[177],"vivo":[185],"results":[186],"premature":[188],"downregulation":[190],"Gsc.":[193],"We":[194],"report":[195],"inverse":[197],"correlation":[198],"between":[199],"proNodal-FGFR3":[200,207],"signalling":[201,208,224,243],"pSmad1/5/8,":[203],"antagonises":[209],"BMP-mediated":[210],"pSmad1/5/8":[211],"poised":[215],"downregulate":[217],"Our":[219],"studies":[220],"proNodal/FGFR3":[223],"governs":[225],"duration":[227],"repressing":[229],"BMP":[231],"local":[235],"BMPs":[236],"rapidly":[237],"silence":[238],"once":[240],"endogenous":[241],"Nodal-FGFR3":[242],"downregulated.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
