{"id":"https://openalex.org/W2267775737","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","title":"Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent glioblastoma multiforme","display_name":"Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent glioblastoma multiforme","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2267775737","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","mag":"2267775737"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.1568","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069314279","display_name":"Jennifer A. Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Quinn","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014505996","display_name":"James J. Vredenburgh","orcid":"https://orcid.org/0000-0002-2935-6057","observed_orcids":["https://orcid.org/0000-0002-2935-6057"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. Vredenburgh","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021296578","display_name":"Jeremy N. Rich","orcid":"https://orcid.org/0000-0001-7845-5302","observed_orcids":["https://orcid.org/0000-0001-7845-5302"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. N. Rich","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059965175","display_name":"David A. Reardon","orcid":"https://orcid.org/0000-0001-6674-0157","observed_orcids":["https://orcid.org/0000-0001-6674-0157"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Reardon","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002201007","display_name":"Annick Desjardins","orcid":"https://orcid.org/0000-0003-3869-8283","observed_orcids":["https://orcid.org/0000-0003-3869-8283"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Desjardins","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030436451","display_name":"Sri Gururangan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Gururangan","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109006216","display_name":"Allan H. Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. H. Friedman","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Lavin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Lavin","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085537336","display_name":"Sith Sathornsumetee","orcid":"https://orcid.org/0000-0003-1350-0672","observed_orcids":["https://orcid.org/0000-0003-1350-0672"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Sathornsumetee","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050271991","display_name":"Stevie Threatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Threatt","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057371623","display_name":"Henry S. Friedman","orcid":"https://orcid.org/0000-0001-7588-032X","observed_orcids":["https://orcid.org/0000-0001-7588-032X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. S. Friedman","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"1568","last_page":"1568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gliadel-wafers","display_name":"Gliadel wafers","score":0.9150000214576721},{"id":"https://openalex.org/keywords/o6-benzylguanine","display_name":"O6-benzylguanine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/suicide-inactivation","display_name":"suicide inactivation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4819999933242798},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.47600001096725464},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9169999957084656},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-leak","display_name":"cerebrospinal fluid leak","score":0.8199999928474426},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neurosurgery","display_name":"neurosurgery","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8528509140014648},{"id":"https://openalex.org/C2780147359","wikidata":"https://www.wikidata.org/wiki/Q415869","display_name":"Carmustine","level":4,"score":0.742946207523346},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5863049626350403},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5229763984680176},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4653609097003937},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44893017411231995},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4329158663749695},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4020983874797821},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.375335693359375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37187057733535767},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3454750180244446},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3347449004650116},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13548284769058228},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.10794830322265625},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.09962305426597595},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.1568","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.1568","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075420298","https://openalex.org/W1996671197","https://openalex.org/W4248628718","https://openalex.org/W2067699690","https://openalex.org/W2135581898","https://openalex.org/W2093595602","https://openalex.org/W4241371299","https://openalex.org/W1976166525","https://openalex.org/W2015771273","https://openalex.org/W2767281916"],"abstract_inverted_index":{"1568":[0],"Background.":[1],"The":[2,233,245],"major":[3],"mechanism":[4],"of":[5,27,89,123,131,161,172,183,218,222,226,253,259,268,277,310,326],"resistance":[6],"to":[7,98,146,180,287],"alkylnitrosourea":[8],"therapy":[9],"involves":[10],"the":[11,25,87,118,121,142,207,239,249,308],"DNA":[12],"repair":[13],"protein":[14],"O6-alkylguanine-DNA":[15],"alkyltransferase":[16],"(AGT)":[17],"which":[18],"removes":[19],"chloroethylation":[20],"or":[21],"methylation":[22],"damage":[23],"from":[24],"O6-position":[26],"guanine.":[28],"O6-BG":[29,132,143,196],"is":[30,236,242],"an":[31,158,305],"AGT":[32,36,152,185],"substrate":[33],"that":[34,49],"inhibits":[35],"by":[37,103,168],"suicide":[38],"inactivation.":[39],"A":[40],"previous":[41],"phase":[42,112],"III":[43],"randomized,":[44],"placebo-controlled":[45,296],"trial":[46,114],"has":[47],"shown":[48],"Gliadel":[50,58,69,90,124,193,293,297,311],"wafer":[51],"significantly":[52],"prolongs":[53],"6-month":[54,234],"survival":[55,65,93,235,241],"(55.5%":[56],"for":[57,61,68,73,175,187,322],"vs.":[59,70],"35.6%":[60],"placebo)":[62,74],"and":[63,120,203,238,274],"median":[64,240],"(28":[66],"weeks":[67,72],"20":[71],"in":[75,91,125,133,149,285,290,294,307],"patients":[76,134,213,228,291,318],"with":[77,127,135,314],"recurrent":[78,136],"glioblastoma":[79],"multiforme":[80],"(GBM)":[81],"(Brem":[82],"et":[83],"al":[84],"1995).":[85],"Despite":[86],"success":[88,102],"prolonging":[92],"we":[94,108,116],"may":[95],"be":[96,147,320],"able":[97],"improve":[99],"on":[100,200],"this":[101,195,302],"depleting":[104,150],"AGT.":[105],"Methods.":[106],"Thus,":[107],"have":[109,214],"designed":[110],"a":[111,128,139,169,219,323],"2":[113,251],"where":[115],"define":[117],"activity":[119,153,186],"toxicity":[122],"combination":[126],"5-day":[129],"infusion":[130,171],"GBM.":[137],"In":[138,178],"prior":[140,230,295],"study":[141],"dose":[144],"found":[145],"effective":[148],"tumor":[151,184],"at":[154,188,262],"48":[155,176],"hours":[156],"was":[157,198],"IV":[159],"bolus":[160,197],"120":[162],"mg/m2":[163],"over":[164],"1":[165],"hour":[166],"followed":[167],"continuous":[170],"30":[173],"mg/m2/d":[174],"hours.":[177],"order":[179],"guarantee":[181],"depletion":[182],"least":[189],"5":[190,204,266],"days":[191,201],"after":[192],"placement,":[194],"repeated":[199],"3":[202,271,275],"while":[205],"continuing":[206],"infusion.":[208],"Results.":[209],"To":[210],"date,":[211],"24":[212],"been":[215],"enrolled":[216,321],"out":[217],"planned":[220],"accrual":[221,325],"50":[223,327],"patients.":[224,328],"Seventeen":[225],"these":[227],"received":[229],"nitrosourea":[231],"therapy.":[232],"68%":[237],"36":[243],"weeks.":[244],"adverse":[246,281],"events":[247,282],"include":[248],"following:":[250],"episodes":[252,258,267,276],"CSF":[254],"leak":[255],"(8%),":[256],"4":[257],"wound":[260],"infection":[261],"craniotomy":[263],"site":[264],"(16%),":[265],"grade":[269],"\u2265":[270],"seizures":[272],"(21%)":[273],"hyponatremia":[278],"(12%).":[279],"These":[280],"were":[283],"similar":[284],"frequency":[286],"those":[288],"seen":[289],"receiving":[292],"trials.":[298],"Conclusions.":[299],"Thus":[300],"far,":[301],"data":[303],"demonstrates":[304],"increase":[306],"efficacy":[309],"when":[312],"combined":[313],"O6-BG.":[315],"Twenty-six":[316],"additional":[317],"will":[319],"total":[324],"[Table:":[329],"see":[330],"text]":[331]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
