{"id":"https://openalex.org/W2267663115","doi":null,"title":"Efeito do \u00e1cido glut\u00e1rico sobre par\u00e2metros do sistema glutamat\u00e9rgico em c\u00e9rebro de ratos ao longo do desenvolvimento","display_name":"Efeito do \u00e1cido glut\u00e1rico sobre par\u00e2metros do sistema glutamat\u00e9rgico em c\u00e9rebro de ratos ao longo do desenvolvimento","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2267663115","mag":"2267663115"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3194762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/7670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/7670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026628044","display_name":"Karina Borges Dalcin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karina Borges Dalcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026628044"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutaric-acid","display_name":"glutaric acid","score":0.9259999990463257},{"id":"https://openalex.org/keywords/glutaric-aciduria-type-i","display_name":"glutaric aciduria type I","score":0.9279999732971191},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.6399999856948853},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.31200000643730164},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.5149999856948853},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9200000166893005},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lysine-metabolism","display_name":"lysine metabolism","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.529365062713623}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3194762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/7670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/7670","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/7670","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/7670","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/7670","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2267663115","doi":null,"is_oa":false,"landing_page_url":"https://lume.ufrgs.br/handle/10183/7670","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3194762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/7670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W24506938","https://openalex.org/W30036994","https://openalex.org/W87155003","https://openalex.org/W215415418","https://openalex.org/W324759871","https://openalex.org/W624861119","https://openalex.org/W636807714","https://openalex.org/W783873688","https://openalex.org/W1483242733","https://openalex.org/W1506990787","https://openalex.org/W1511076704","https://openalex.org/W1522715708","https://openalex.org/W1537111269","https://openalex.org/W1539131248","https://openalex.org/W1563427807","https://openalex.org/W1587695200","https://openalex.org/W1597223461","https://openalex.org/W1603110302","https://openalex.org/W1775749144","https://openalex.org/W1842711843","https://openalex.org/W1920015810","https://openalex.org/W1963487339","https://openalex.org/W1963682871","https://openalex.org/W1964006105","https://openalex.org/W1964291240","https://openalex.org/W1965591468","https://openalex.org/W1965877738","https://openalex.org/W1968001076","https://openalex.org/W1968299844","https://openalex.org/W1969400861","https://openalex.org/W1970306774","https://openalex.org/W1971509018","https://openalex.org/W1971639674","https://openalex.org/W1972728329","https://openalex.org/W1976289522","https://openalex.org/W1976754780","https://openalex.org/W1977613928","https://openalex.org/W1978025103","https://openalex.org/W1978182363","https://openalex.org/W1978348298","https://openalex.org/W1982116658","https://openalex.org/W1983197885","https://openalex.org/W1983661921","https://openalex.org/W1983836947","https://openalex.org/W1986240433","https://openalex.org/W1986652233","https://openalex.org/W1988726352","https://openalex.org/W1989727987","https://openalex.org/W1990649763","https://openalex.org/W1991220482","https://openalex.org/W1991701465","https://openalex.org/W1994120446","https://openalex.org/W1996942781","https://openalex.org/W1998510465","https://openalex.org/W2000257649","https://openalex.org/W2000448133","https://openalex.org/W2001846103","https://openalex.org/W2002775774","https://openalex.org/W2003179182","https://openalex.org/W2003802096","https://openalex.org/W2003930457","https://openalex.org/W2005989543","https://openalex.org/W2009190178","https://openalex.org/W2009196550","https://openalex.org/W2010801776","https://openalex.org/W2011448874","https://openalex.org/W2011559284","https://openalex.org/W2014832859","https://openalex.org/W2014856221","https://openalex.org/W2016681907","https://openalex.org/W2017088936","https://openalex.org/W2018876270","https://openalex.org/W2019793131","https://openalex.org/W2019927467","https://openalex.org/W2023811880","https://openalex.org/W2025541801","https://openalex.org/W2025595391","https://openalex.org/W2026256617","https://openalex.org/W2030194659","https://openalex.org/W2030281545","https://openalex.org/W2037414045","https://openalex.org/W2038599206","https://openalex.org/W2040875570","https://openalex.org/W2043166209","https://openalex.org/W2044238889","https://openalex.org/W2044332231","https://openalex.org/W2044490121","https://openalex.org/W2046505293","https://openalex.org/W2047277425","https://openalex.org/W2047300365","https://openalex.org/W2049949557","https://openalex.org/W2054683291","https://openalex.org/W2057522300","https://openalex.org/W2058382351","https://openalex.org/W2058948754","https://openalex.org/W2059335320","https://openalex.org/W2059416860","https://openalex.org/W2061376564","https://openalex.org/W2062547323","https://openalex.org/W2067694285","https://openalex.org/W2067853814","https://openalex.org/W2069012658","https://openalex.org/W2069075518","https://openalex.org/W2069631533","https://openalex.org/W2070139625","https://openalex.org/W2073215621","https://openalex.org/W2074683128","https://openalex.org/W2074830850","https://openalex.org/W2075274292","https://openalex.org/W2076536920","https://openalex.org/W2077997289","https://openalex.org/W2087268155","https://openalex.org/W2088879677","https://openalex.org/W2092358916","https://openalex.org/W2094673798","https://openalex.org/W2096675020","https://openalex.org/W2096712001","https://openalex.org/W2108040927","https://openalex.org/W2108596837","https://openalex.org/W2110089243","https://openalex.org/W2116447221","https://openalex.org/W2123443649","https://openalex.org/W2126033464","https://openalex.org/W2129108032","https://openalex.org/W2129766810","https://openalex.org/W2131408584","https://openalex.org/W2135499849","https://openalex.org/W2138733394","https://openalex.org/W2153819784","https://openalex.org/W2162925265","https://openalex.org/W2186957023","https://openalex.org/W2215656063","https://openalex.org/W2274641679","https://openalex.org/W2402265099","https://openalex.org/W2439615999","https://openalex.org/W2906790474","https://openalex.org/W3038005352"],"related_works":["https://openalex.org/W156041665","https://openalex.org/W2286778101","https://openalex.org/W2305489266","https://openalex.org/W7018487173","https://openalex.org/W34384457","https://openalex.org/W2261024109","https://openalex.org/W7055300856","https://openalex.org/W2278815380","https://openalex.org/W7018497358","https://openalex.org/W7014408036"],"abstract_inverted_index":{"A":[0,31,444],"acidemia":[1],"glut\u00e1rica":[2],"do":[3,12,55,60,76,147,152,201,261,329,332,340,465],"tipo":[4],"I":[5,135],"(AG":[6],"I)":[7],"\u00e9":[8],"um":[9,322,472],"erro":[10],"inato":[11],"metabolismo":[13,477],"causado":[14],"pela":[15,273,455],"defici\u00eancia":[16,32],"da":[17,26,33,35,251,446,533],"glutaril-CoA":[18],"desidrogenase":[19],"(GCDH),":[20],"uma":[21,71,233,249,259],"enzima":[22],"respons\u00e1vel":[23],"pelo":[24],"catabolismo":[25],"lisina,":[27],"hidroxilisina":[28],"e":[29,43,51,59,70,87,104,112,119,167,178,192,220,227,239,280,296,310,314,331,459],"triptofano.":[30],"atividade":[34],"GCDH":[36],"leva":[37],"ao":[38,68,130,199,334,527],"ac\u00famulo":[39],"nos":[40],"fluidos":[41],"corporais":[42],"no":[44],"c\u00e9rebro":[45,195,221,348,378],"predominantemente":[46],"de":[47,80,90,96,159,169,173,181,189,197,211,217,223,225,230,244,253,275,277,287,289,292,300,306,350,352,355,366,370,390,400,404,407,409,412,421,448,483,495],"\u00e1cido":[48,56,61],"glut\u00e1rico":[49],"(AG)":[50],"em":[52,100,284,308,347,373,377,517,529],"menor":[53],"grau":[54],"3-":[57],"hidroxiglut\u00e1rico":[58],"glutac\u00f4nico.":[62],"Clinicamente,":[63],"os":[64,126],"pacientes":[65,440],"apresentam":[66],"macrocefalia":[67],"nascimento":[69],"hipomieliniza\u00e7\u00e3o":[72],"ou":[73,194,479],"desmieliniza\u00e7\u00e3o":[74],"progressiva":[75],"c\u00f3rtex":[77,190,218,285,374,405],"cerebral.":[78],"Crises":[79],"descompensa\u00e7\u00e3o":[81],"metab\u00f3lica":[82],"ocorrem":[83],"usualmente":[84],"entre":[85,236],"6":[86],"24":[88],"meses":[89],"vida,":[91,231,293,413],"resultando":[92,516],"numa":[93],"destrui\u00e7\u00e3o":[94],"irrevers\u00edvel":[95],"regi\u00f5es":[97],"cerebrais":[98,122,177],"suscet\u00edveis,":[99],"particular":[101],"o":[102,143,206,237,240,294,297,360,384,395,414,429,435,476,489,505,509,513,522],"estriado,":[103,381],"subseq\u00fcentemente":[105],"altera\u00e7\u00f5es":[106,120],"severas":[107],"dos":[108,115,439],"movimentos,":[109],"como":[110,156,376],"distonia":[111],"discinesia.":[113],"Apesar":[114],"sintomas":[116],"neurol\u00f3gicos":[117],"severos":[118],"neuropatol\u00f3gicas":[121],"importantes":[123],"(atrofia":[124],"cerebral),":[125],"mecanismos":[127],"que":[128,205,248,315,326,383,394,415,430,462,488,504,524],"levam":[129],"dano":[131,436],"cerebral":[132,191,219,286,375,406,437],"na":[133,165,368,423],"AG":[134,148,207,241,262,268,295,330,361,385,396,442,466,490,506,534],"s\u00e3o":[136],"pouco":[137],"conhecidos.":[138],"No":[139],"presente":[140],"estudo,":[141],"investigamos":[142,266],"efeito":[144,323,473],"in":[145],"vitro":[146],"sobre":[149,521],"v\u00e1rios":[150],"par\u00e2metros":[151],"sistema":[153,510],"glutamat\u00e9rgico,":[154],"tais":[155],"a":[157,161,171,179,209,214,304,316,327,364,398,471,481,493,531],"uni\u00e3o":[158,210,252,305,328,365],"glutamato":[160,174,182,212,238,254,307,367,401,422,449,496],"membranas":[162,215],"plasm\u00e1ticas":[163],"sin\u00e1pticas":[164,216],"presen\u00e7a":[166,369],"aus\u00eancia":[168],"s\u00f3dio,":[170],"capta\u00e7\u00e3o":[172,399,447],"por":[175,184,186,242,402,450,498,500],"fatias":[176,403,451],"libera\u00e7\u00e3o":[180,494],"induzida":[183],"pot\u00e1ssio":[185,499],"prepara\u00e7\u00f5es":[187],"sinaptossomais":[188],"estriado":[193],"m\u00e9dio":[196,222,349,379],"ratos":[198,224,288,351,408],"longo":[200],"desenvolvimento.":[202],"Primeiro,":[203],"observamos":[204,393],"diminui":[208,397],"Na+-independente":[213],"7":[226,410],"15":[228,290,353],"dias":[229,291,354,411],"evidenciando":[232],"poss\u00edvel":[234],"competi\u00e7\u00e3o":[235],"s\u00edtios":[243],"receptores":[245,264,271,278,301],"glutamat\u00e9rgicos.":[246],"Visto":[247],"diminui\u00e7\u00e3o":[250],"Na+-":[255],"independente":[256],"pode":[257,416,431,507],"representar":[258],"intera\u00e7\u00e3o":[260],"com":[263,270,434,441,457],"glutamat\u00e9rgicos,":[265],"se":[267,469],"interage":[269],"glutamat\u00e9rgicos":[272],"adi\u00e7\u00e3o":[274],"antagonistas":[276],"NMDA":[279],"n\u00e3o-NMDA.":[281],"Verificamos":[282],"que,":[283],"CNQX":[298,333],"(antagonista":[299],"n\u00e3o-NMDA)":[302],"diminuem":[303],"20":[309],"40":[311],"%,":[312],"respectivamente,":[313],"co-incuba\u00e7\u00e3o":[317],"desses":[318],"compostos":[319],"n\u00e3o":[320,362,386,452,468,491],"provoca":[321],"aditivo,":[324],"sugerindo":[325,382,461],"receptor":[335],"n\u00e3o-NMDA":[336],"ocorre":[337],"provavelmente":[338,417,467],"atrav\u00e9s":[339],"mesmo":[341],"s\u00edtio.":[342],"Resultados":[343],"semelhantes":[344],"foram":[345],"encontrados":[346],"vida.":[356],"Por":[357],"outro":[358],"lado,":[359],"alterou":[363,492],"s\u00f3dio":[371],"tanto":[372],"e/ou":[380],"compete":[387],"pelos":[388],"transportadores":[389],"glutamato.":[391],"Tamb\u00e9m":[392],"resultar":[418],"num":[419],"excesso":[420],"fenda":[424],"sin\u00e1ptica":[425],"levando":[426],"\u00e0":[427],"excitotoxicidade,":[428],"ser":[432],"relacionado":[433],"caracter\u00edstico":[438],"I.":[443,535],"inibi\u00e7\u00e3o":[445],"foi":[453],"prevenida":[454],"pr\u00e9-incuba\u00e7\u00e3o":[456],"creatina":[458],"N-acetilciste\u00edna,":[460],"essa":[463],"a\u00e7\u00e3o":[464],"deva":[470],"indireto":[474],"reduzindo":[475],"energ\u00e9tico":[478],"aumentando":[480],"produ\u00e7\u00e3o":[482],"radicais":[484],"livres.":[485],"Finalmente,":[486],"verificamos":[487],"estimulada":[497],"sinaptossomas.":[501],"Assim,":[502],"conclu\u00edmos":[503],"alterar":[508],"glutamat\u00e9rgico":[511],"durante":[512],"desenvolvimento":[514],"cerebral,":[515],"poss\u00edveis":[518],"a\u00e7\u00f5es":[519],"delet\u00e9rias":[520],"SNC":[523],"podem":[525],"explicar":[526],"menos":[528],"parte":[530],"neuropatogenia":[532]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
