{"id":"https://openalex.org/W2267508657","doi":"https://doi.org/10.4049/jimmunol.1501165","title":"Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-\u03baB\u2013Regulated Gene Network","display_name":"Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-\u03baB\u2013Regulated Gene Network","publication_year":2016,"publication_date":"2016-01-20","ids":{"openalex":"https://openalex.org/W2267508657","doi":"https://doi.org/10.4049/jimmunol.1501165","mag":"2267508657","pmid":"https://pubmed.ncbi.nlm.nih.gov/26792806"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1501165","doi":"https://doi.org/10.4049/jimmunol.1501165","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1501165","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075681627","display_name":"Stefan Toegel","orcid":"https://orcid.org/0000-0003-4317-1769","observed_orcids":["https://orcid.org/0000-0003-4317-1769"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Stefan Toegel","raw_affiliation_strings":["Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068089373","display_name":"Daniela Weinmann","orcid":"https://orcid.org/0000-0002-6298-4709","observed_orcids":["https://orcid.org/0000-0002-6298-4709"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Daniela Weinmann","raw_affiliation_strings":["Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022208227","display_name":"Sabine Andr\u00e9","orcid":"https://orcid.org/0000-0003-0850-0432","observed_orcids":["https://orcid.org/0000-0003-0850-0432"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Andr\u00e9","raw_affiliation_strings":["Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081553510","display_name":"Sonja Maria Walzer","orcid":"https://orcid.org/0000-0002-9056-4330","observed_orcids":["https://orcid.org/0000-0002-9056-4330"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sonja M Walzer","raw_affiliation_strings":["Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084491349","display_name":"Martin Bilban","orcid":"https://orcid.org/0000-0001-7043-7142","observed_orcids":["https://orcid.org/0000-0001-7043-7142"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martin Bilban","raw_affiliation_strings":["Department of Laboratory Medicine and Core Facility Genomics, Core Facilities, Medical University of Vienna , 1090 Vienna ,","\u2021Department of Laboratory Medicine and Core Facility Genomics, Core Facilities, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Core Facility Genomics, Core Facilities, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"\u2021Department of Laboratory Medicine and Core Facility Genomics, Core Facilities, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049923191","display_name":"Sebastian Schmidt","orcid":"https://orcid.org/0009-0006-6700-0437","observed_orcids":["https://orcid.org/0009-0006-6700-0437"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Schmidt","raw_affiliation_strings":["Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109901415","display_name":"Catharina Chiari","orcid":"https://orcid.org/0000-0001-6275-7453","observed_orcids":["https://orcid.org/0000-0001-6275-7453"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Catharina Chiari","raw_affiliation_strings":["Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000694792","display_name":"Reinhard Windhager","orcid":"https://orcid.org/0000-0002-6321-1804","observed_orcids":["https://orcid.org/0000-0002-6321-1804"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Reinhard Windhager","raw_affiliation_strings":["Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"*Karl Chiari Lab for Orthopaedic Biology, Department of Orthopaedics, Medical University of Vienna, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011284365","display_name":"Christoph Krall","orcid":"https://orcid.org/0000-0002-0721-1797","observed_orcids":["https://orcid.org/0000-0002-0721-1797"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christoph Krall","raw_affiliation_strings":["Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University Vienna , 1090 Vienna ,","\u00a7Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University Vienna, 1090 Vienna, Austria; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University Vienna , 1090 Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"\u00a7Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University Vienna, 1090 Vienna, Austria; and","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044486192","display_name":"Idriss M. Bennani-Ba\u00efti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Idriss M Bennani-Baiti","raw_affiliation_strings":["B2 Scientific Group , 1180 Vienna ,","\u00b6B2 Scientific Group, 1180 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B2 Scientific Group , 1180 Vienna ,","institution_ids":[]},{"raw_affiliation_string":"\u00b6B2 Scientific Group, 1180 Vienna, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061586215","display_name":"Hans\u2010Joachim Gabius","orcid":"https://orcid.org/0000-0003-3467-3900","observed_orcids":["https://orcid.org/0000-0003-3467-3900"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Joachim Gabius","raw_affiliation_strings":["Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich , 80539 Munich ,","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"\u2020Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany;","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000694792","https://openalex.org/A5068089373","https://openalex.org/A5075681627","https://openalex.org/A5109901415"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":10.3058,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.9874326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"196","issue":"4","first_page":"1910","last_page":"1921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lectin-glycan-binding","display_name":"lectin-glycan binding","score":0.7360000014305115},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.6340000033378601},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"subchondral bone","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glycomics","display_name":"glycomics","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6255185008049011},{"id":"https://openalex.org/C156293190","wikidata":"https://www.wikidata.org/wiki/Q83138026","display_name":"Galectin","level":2,"score":0.6114766597747803},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5661298036575317},{"id":"https://openalex.org/C2778735756","wikidata":"https://www.wikidata.org/wiki/Q18028523","display_name":"Galectin-1","level":2,"score":0.543023943901062},{"id":"https://openalex.org/C158650290","wikidata":"https://www.wikidata.org/wiki/Q3063952","display_name":"Glycome","level":4,"score":0.48715516924858093},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47829777002334595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4272023141384125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4209412634372711},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40299519896507263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35850220918655396},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24097007513046265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1928722858428955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13342884182929993},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.10028141736984253},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.0721181333065033},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054794","descriptor_name":"Glycomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.1501165","doi":"https://doi.org/10.4049/jimmunol.1501165","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1501165","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:26792806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26792806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W91644126","https://openalex.org/W117529435","https://openalex.org/W1483239677","https://openalex.org/W1498601328","https://openalex.org/W1510723804","https://openalex.org/W1566135918","https://openalex.org/W1787620003","https://openalex.org/W1967464329","https://openalex.org/W1977235269","https://openalex.org/W1980297880","https://openalex.org/W1984204238","https://openalex.org/W1986502923","https://openalex.org/W1992339843","https://openalex.org/W1994634559","https://openalex.org/W2007482697","https://openalex.org/W2010404343","https://openalex.org/W2017869529","https://openalex.org/W2019068821","https://openalex.org/W2019489405","https://openalex.org/W2021770734","https://openalex.org/W2022223746","https://openalex.org/W2029920223","https://openalex.org/W2035909252","https://openalex.org/W2051092054","https://openalex.org/W2057519153","https://openalex.org/W2058071009","https://openalex.org/W2069557642","https://openalex.org/W2070765391","https://openalex.org/W2071453752","https://openalex.org/W2073929498","https://openalex.org/W2075133717","https://openalex.org/W2079698011","https://openalex.org/W2080359449","https://openalex.org/W2084169296","https://openalex.org/W2085253343","https://openalex.org/W2085643068","https://openalex.org/W2086916803","https://openalex.org/W2088074851","https://openalex.org/W2091889824","https://openalex.org/W2091987365","https://openalex.org/W2092262181","https://openalex.org/W2106614869","https://openalex.org/W2113648377","https://openalex.org/W2131227563","https://openalex.org/W2132166259","https://openalex.org/W2132612143","https://openalex.org/W2152217106","https://openalex.org/W2156767976","https://openalex.org/W2156825177","https://openalex.org/W2157308941","https://openalex.org/W2157870305","https://openalex.org/W2160381249","https://openalex.org/W2168472158","https://openalex.org/W2168886164","https://openalex.org/W2170211949","https://openalex.org/W2461191590","https://openalex.org/W4211069396","https://openalex.org/W4246847445","https://openalex.org/W6684504115"],"related_works":["https://openalex.org/W2328322524","https://openalex.org/W2562918895","https://openalex.org/W3217351228","https://openalex.org/W2259730659","https://openalex.org/W3020279821","https://openalex.org/W3019763734","https://openalex.org/W2937289741","https://openalex.org/W2809291659","https://openalex.org/W3105892965","https://openalex.org/W4384914825"],"abstract_inverted_index":{"Osteoarthritis":[0],"is":[1,62,73,188],"a":[2,48,113,175],"degenerative":[3],"joint":[4],"disease":[5,28,116],"that":[6,53,60,70],"ranks":[7],"among":[8],"the":[9,34,40,45,58,95,139,165],"leading":[10],"causes":[11],"of":[12,42,47,50,84,115,135,138,149,155,157,178,201],"adult":[13],"disability.":[14],"Mechanisms":[15],"underlying":[16],"osteoarthritis":[17],"pathogenesis":[18],"are":[19],"not":[20],"yet":[21],"fully":[22],"elucidated,":[23],"putting":[24],"limits":[25],"to":[26,102,146,190,203],"current":[27],"management":[29],"and":[30,44,78,82,99,121],"treatment.":[31],"Based":[32],"on":[33,126],"phenomenological":[35],"evidence":[36],"for":[37,64],"dysregulation":[38],"within":[39],"glycome":[41],"chondrocytes":[43,104],"network":[46],"family":[49],"adhesion/growth-regulatory":[51],"lectins,":[52],"is,":[54],"galectins,":[55],"we":[56],"tested":[57],"hypothesis":[59],"Galectin-1":[61,71,110,173],"relevant":[63,180],"causing":[65],"degeneration.":[66,206],"Immunohistochemical":[67],"analysis":[68],"substantiated":[69],"upregulation":[72],"associated":[74],"with":[75],"osteoarthritic":[76,103,204],"cartilage":[77,191,205],"subchondral":[79],"bone":[80],"histopathology":[81],"severity":[83],"degeneration":[85,158,192],"(p":[86,131],"<":[87,132],"0.0001,":[88],"n":[89],"=":[90],"29":[91],"patients).":[92],"In":[93],"vitro,":[94],"lectin":[96],"was":[97],"secreted":[98],"it":[100],"bound":[101],"inhibitable":[105],"by":[106],"cognate":[107],"sugar.":[108],"Glycan-dependent":[109],"binding":[111],"induced":[112],"set":[114],"markers,":[117],"including":[118],"matrix":[119,162],"metalloproteinases":[120,163],"activated":[122],"NF-\u03baB,":[123],"hereby":[124],"switching":[125],"an":[127,198],"inflammatory":[128],"gene":[129],"signature":[130],"10(-16)).":[133],"Inhibition":[134],"distinct":[136],"components":[137],"NF-\u03baB":[140],"pathway":[141],"using":[142],"dedicated":[143],"inhibitors":[144],"led":[145],"dose-dependent":[147],"impairment":[148],"Galectin-1-mediated":[150],"transcriptional":[151],"activation.":[152],"Enhanced":[153],"secretion":[154],"effectors":[156],"such":[159],"as":[160,174],"three":[161],"underscores":[164],"data's":[166],"pathophysiological":[167],"relevance.":[168],"This":[169],"study":[170],"thus":[171],"identifies":[172],"master":[176],"regulator":[177],"clinically":[179],"inflammatory-response":[181],"genes,":[182],"working":[183],"via":[184],"NF-\u03baB.":[185],"Because":[186],"inflammation":[187],"critical":[189],"in":[193],"osteoarthritis,":[194],"this":[195],"report":[196],"reveals":[197],"intimate":[199],"relation":[200],"glycobiology":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
