{"id":"https://openalex.org/W2267006017","doi":"https://doi.org/10.1111/head.12767","title":"A Randomized Trial of Ketorolac vs Sumatripan vs Placebo Nasal Spray (KSPN) for Acute Migraine","display_name":"A Randomized Trial of Ketorolac vs Sumatripan vs Placebo Nasal Spray (KSPN) for Acute Migraine","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2267006017","doi":"https://doi.org/10.1111/head.12767","mag":"2267006017","pmid":"https://pubmed.ncbi.nlm.nih.gov/26840902"},"language":"en","primary_location":{"id":"doi:10.1111/head.12767","doi":"https://doi.org/10.1111/head.12767","is_oa":false,"landing_page_url":"https://doi.org/10.1111/head.12767","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4822712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008934124","display_name":"Aruna S. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aruna S. Rao","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901002","display_name":"Bizu Gelaye","orcid":"https://orcid.org/0000-0001-7934-548X","observed_orcids":["https://orcid.org/0000-0001-7934-548X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bizu Gelaye","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, Department of Epidemiology Boston MA USA","Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, Department of Epidemiology Boston MA USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044562854","display_name":"Tobias Kurth","orcid":"https://orcid.org/0000-0001-7169-2620","observed_orcids":["https://orcid.org/0000-0001-7169-2620","https://orcid.org/0000-0002-8994-7860"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tobias Kurth","raw_affiliation_strings":["Division of Preventive Medicine Brigham and Women's Hospital Boston MA","Institute of Public Health, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany","Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine Brigham and Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Institute of Public Health, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032336198","display_name":"Paul D. Dash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Dash","raw_affiliation_strings":["Johns Hopkins Community Physicians, Department of Neurology Baltimore MD USA","Johns Hopkins Community Physicians, Department of Neurology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Community Physicians, Department of Neurology Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Johns Hopkins Community Physicians, Department of Neurology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032076253","display_name":"Haley L. Nitchie","orcid":"https://orcid.org/0009-0000-2669-1362","observed_orcids":["https://orcid.org/0009-0000-2669-1362"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley Nitchie","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080014078","display_name":"Barbara Lee Peterlin","orcid":"https://orcid.org/0000-0002-5298-5185","observed_orcids":["https://orcid.org/0000-0002-5298-5185"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Lee Peterlin","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5080014078"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.3235,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.86956015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"56","issue":"2","first_page":"331","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketorolac","display_name":"ketorolac","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.6830000281333923},{"id":"https://openalex.org/keywords/acute-migraine-treatment","display_name":"acute migraine treatment","score":0.8939999938011169},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7580000162124634},{"id":"https://openalex.org/keywords/migraine-associated-symptoms","display_name":"migraine-associated symptoms","score":0.621999979019165},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dysgeusia","display_name":"dysgeusia","score":0.777999997138977},{"id":"https://openalex.org/keywords/crossover-design","display_name":"crossover design","score":0.45100000500679016},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7170000076293945},{"id":"https://openalex.org/keywords/triptans","display_name":"triptans","score":0.9769999980926514},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.4729999899864197},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.9517067074775696},{"id":"https://openalex.org/C2778446825","wikidata":"https://www.wikidata.org/wiki/Q2014797","display_name":"Ketorolac","level":3,"score":0.8781572580337524},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8513946533203125},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8500530123710632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7981371879577637},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6905311346054077},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47098299860954285},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.4392234683036804},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.2258807122707367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1860537827014923},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.09192261099815369},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020910","descriptor_name":"Ketorolac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020910","descriptor_name":"Ketorolac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020910","descriptor_name":"Ketorolac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058825","descriptor_name":"Serotonin 5-HT1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058825","descriptor_name":"Serotonin 5-HT1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058825","descriptor_name":"Serotonin 5-HT1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D065588","descriptor_name":"Nasal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065588","descriptor_name":"Nasal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065588","descriptor_name":"Nasal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/head.12767","doi":"https://doi.org/10.1111/head.12767","is_oa":false,"landing_page_url":"https://doi.org/10.1111/head.12767","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},{"id":"pmid:26840902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26840902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:3792907","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4822712","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4822712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4822712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Headache","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4822712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4822712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Headache","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3809360018","display_name":null,"funder_award_id":"K23 NS078345","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1915266560","https://openalex.org/W1966041812","https://openalex.org/W1984816331","https://openalex.org/W2001032397","https://openalex.org/W2019660771","https://openalex.org/W2032666115","https://openalex.org/W2057556593","https://openalex.org/W2064709253","https://openalex.org/W2085587616","https://openalex.org/W2123545227","https://openalex.org/W2134578184","https://openalex.org/W2139220804","https://openalex.org/W2162104155","https://openalex.org/W2167004463","https://openalex.org/W2167732022","https://openalex.org/W4247292047"],"related_works":["https://openalex.org/W2066109424","https://openalex.org/W2398429995","https://openalex.org/W2410008476","https://openalex.org/W2139652169","https://openalex.org/W2283929251","https://openalex.org/W2004944265","https://openalex.org/W2007717420","https://openalex.org/W2142329717","https://openalex.org/W2061216198","https://openalex.org/W2118480693"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,16,92,148,287,315],"efficacy":[4],"of":[5,19,134,169,228,319],"ketorolac":[6,37,175,231,259,300],"nasal":[7],"spray":[8],"(NS)":[9],"vs.":[10,94,96],"placebo":[11,27,46,192,224,240,264,305],"and":[12,28,55,132,138,143,159,181,198,233,284,306],"sumatriptan":[13,41,182,218,234,312],"NS":[14,38,42,176,183,232,235,260,301,313],"for":[15,91,166,194,241,265,292,314],"acute":[17,316],"treatment":[18,106,318],"migraine.":[20,320],"METHODS:":[21],"This":[22,296],"was":[23,122,220,261],"a":[24,66,109,113,167],"randomized,":[25],"double-blind,":[26],"active-comparator,":[29],"crossover":[30],"study.":[31,101],"Adult":[32,77],"migraineurs":[33],"were":[34,75,89,103,188,236,286],"randomized":[35,104,150],"to":[36,47,51,72,105,263,304,311],"31.5":[39],"mg,":[40,44],"20":[43],"or":[45,69],"treat":[48],"three":[49,164],"moderate":[50],"severe":[52],"migraine":[53,81,85,100,135,172],"attacks":[54,86],"switched":[56],"treatments":[57],"with":[58,79],"each":[59],"attack.":[60],"Patients":[61],"seeking":[62],"headache":[63,67],"care":[64],"at":[65,155],"center":[68],"in":[70,112,225],"response":[71],"community":[73],"advertisement":[74],"recruited.":[76],"participants":[78],"episodic":[80],"who":[82],"experienced":[83],"\u22652":[84],"per":[87],"month":[88],"eligible":[90],"Ketorolac":[93,214],"Sumatriptan":[95],"Placebo":[97],"Nasal":[98,282],"Spray":[99],"Participants":[102],"arms":[107],"by":[108],"research":[110],"pharmacist,":[111],"1:1:1":[114],"ratio":[115],"using":[116],"computer-generated":[117],"lists.":[118],"The":[119],"primary":[120],"outcome":[121],"2-hour":[123,129,195,199,226],"pain":[124,130,141,144,196,200,244,280],"relief.":[125],"Secondary":[126],"outcomes":[127],"included":[128],"freedom":[131,201],"absence":[133,227],"associated":[136],"symptoms,":[137],"24-hour":[139,242,266],"sustained":[140,243,279],"relief":[142,197,245],"freedom.":[145,281],"RESULTS:":[146],"Of":[147],"72":[149],"participants,":[151],"54":[152],"(75%)":[153],"treated":[154,171],"least":[156],"one":[157],"attack":[158],"49":[160],"(68%)":[161],"completed":[162],"all":[163],"treatments,":[165],"total":[168],"152":[170],"attacks.":[173],"Both":[174,230],"(72.5%,":[177],"P":[178,185,204,209,248,253,269,274],"<":[179,249],".001)":[180,187],"(69.4%,":[184],"=":[186,205,210,254,270,275],"more":[189,221,237],"effective":[190,222,238],"than":[191,223,239],"(38.3%)":[193],"(ketorolac:":[202,246,267],"43.1%,":[203],".004;":[206],"sumatriptan:":[207,251,272],"36.7%,":[208],".046;":[211],"placebo:":[212,256,277],"18.4%).":[213],"NS,":[215,219],"but":[216],"not":[217],"nausea.":[229],"49%,":[247],".001;":[250],"31%,":[252],".01,":[255],"20%).":[257],"Only":[258],"superior":[262,303],"35.3%,":[268],".003;":[271],"22.4%,":[273],".18,":[276],"12.2%)":[278],"burning":[283],"dysgeusia":[285],"most":[288],"common":[289],"adverse":[290],"effects":[291],"active":[293],"treatments.":[294],"CONCLUSIONS:":[295],"study":[297],"supports":[298],"that":[299,307],"is":[302,309],"it":[308],"non-inferior":[310],"abortive":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}