{"id":"https://openalex.org/W2266988004","doi":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","title":"Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1- regulated molecules, CD64 and macrophage colony-stimulating factor receptor","display_name":"Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1- regulated molecules, CD64 and macrophage colony-stimulating factor receptor","publication_year":1996,"publication_date":"1996-11-15","ids":{"openalex":"https://openalex.org/W2266988004","doi":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","mag":"2266988004","pmid":"https://pubmed.ncbi.nlm.nih.gov/8916938"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v88.10.3741.bloodjournal88103741","doi":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028004266","display_name":"Johanna Olweus","orcid":"https://orcid.org/0000-0002-1898-3100","observed_orcids":["https://orcid.org/0000-0002-1898-3100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Olweus","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"PA Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PA Thompson","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018839831","display_name":"Fridtjof Lund\u2010Johansen","orcid":"https://orcid.org/0000-0002-2445-1258","observed_orcids":["https://orcid.org/0000-0002-2445-1258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Lund-Johansen","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131\u20131807, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.8089,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91218441,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"88","issue":"10","first_page":"3741","last_page":"3754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.7760000228881836},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor-receptor","display_name":"macrophage colony-stimulating factor receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cd64","display_name":"CD64","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lineage-specific-gene-regulation","display_name":"lineage-specific gene regulation","score":0.593999981880188},{"id":"https://openalex.org/keywords/cfu-m","display_name":"CFU-M","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cfu-g","display_name":"CFU-G","score":0.9919999837875366},{"id":"https://openalex.org/keywords/colony-forming-units","display_name":"colony-forming units","score":0.6620000004768372},{"id":"https://openalex.org/keywords/receptor-downmodulation","display_name":"receptor downmodulation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2776447464","wikidata":"https://www.wikidata.org/wiki/Q17927763","display_name":"CD64","level":3,"score":0.8466984033584595},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7196654081344604},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6660196781158447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6642143130302429},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6140866875648499},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5729087591171265},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5458115339279175},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.5003659725189209},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5000789165496826},{"id":"https://openalex.org/C64921476","wikidata":"https://www.wikidata.org/wiki/Q14914524","display_name":"Granulocyte macrophage colony-stimulating factor receptor","level":5,"score":0.43812820315361023},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.4363785684108734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4101913571357727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3684201240539551},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33121436834335327},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.23472273349761963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0868997573852539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07589483261108398},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06637564301490784},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099232","descriptor_name":"Proto-Oncogene Protein Spi-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016186","descriptor_name":"Receptor, Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016186","descriptor_name":"Receptor, Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v88.10.3741.bloodjournal88103741","doi":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v88.10.3741.bloodjournal88103741","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:8916938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8916938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W6579396","https://openalex.org/W74017565","https://openalex.org/W188422528","https://openalex.org/W1536628513","https://openalex.org/W1565389310","https://openalex.org/W1606710461","https://openalex.org/W1846624269","https://openalex.org/W1974164942","https://openalex.org/W2014338731","https://openalex.org/W2016011359","https://openalex.org/W2041972573","https://openalex.org/W2046235729","https://openalex.org/W2049423476","https://openalex.org/W2050347737","https://openalex.org/W2050602931","https://openalex.org/W2056604536","https://openalex.org/W2086026340","https://openalex.org/W2086551569","https://openalex.org/W2087934471","https://openalex.org/W2122968144","https://openalex.org/W2123480703","https://openalex.org/W2299362120","https://openalex.org/W2300382603","https://openalex.org/W2320629665","https://openalex.org/W2342346441","https://openalex.org/W2399040425","https://openalex.org/W2405881143","https://openalex.org/W2406496995","https://openalex.org/W2414854471","https://openalex.org/W2416051049","https://openalex.org/W2416298840","https://openalex.org/W2417400078","https://openalex.org/W2417720024","https://openalex.org/W2418294955","https://openalex.org/W2419103756"],"related_works":["https://openalex.org/W2288126169","https://openalex.org/W1846624269","https://openalex.org/W2327045840","https://openalex.org/W7055163031","https://openalex.org/W2080219027","https://openalex.org/W2398033328","https://openalex.org/W2443765976","https://openalex.org/W2031436487","https://openalex.org/W2121664102","https://openalex.org/W1981694046"],"abstract_inverted_index":{"The":[0,57,80,164],"present":[1,60],"study":[2],"investigated":[3],"the":[4,19,55,68,121,126,137,153,156,168,184,205,223,236,268],"possibility":[5],"that":[6,25,47,64,104,188,225,253,272],"macrophage":[7,146],"colony-stimulating":[8],"factor":[9],"(M-CSF)":[10],"responsiveness":[11],"of":[12,21,36,51,88,97,120,136,152,171,204,267],"hematopoietic":[13,259],"progenitor":[14,62,260,284],"cells":[15,53,63,99,103,124,139,144,166,175,207,224,261],"is":[16,262,274],"regulated":[17],"at":[18],"level":[20],"receptor":[22,27],"expression":[23],"and":[24,90,118,173,176,270,282],"M-CSF":[26,254],"(M-CSFR)":[28],"may":[29],"be":[30,84],"used":[31],"as":[32],"an":[33,43],"early":[34],"marker":[35,70,277],"monocyte":[37,195],"lineage":[38],"commitment.":[39],"Immunofluorescence":[40],"measurements":[41],"with":[42,167],"anti-M-CSFR":[44],"antibody":[45],"showed":[46],"44%":[48],"+/-":[49],"5%":[50],"CD34hi":[52],"expressed":[54],"receptor.":[56],"M-CSFR":[58,189,210,269,273],"was":[59,100],"on":[61,74],"were":[65,105,129,145,159,181,245],"positive":[66,106],"for":[67,107],"granulo-monocytic":[69,116],"CD64,":[71,109],"but":[72],"not":[73],"primitive,":[75],"erythroid,":[76],"or":[77,110],"lymphoid":[78],"progenitors.":[79],"CD34hiCD64+":[81],"population":[82,128,158,215,238],"could":[83],"divided":[85],"into":[86],"subsets":[87],"M-CSFRhi":[89,165,227,237],"M-CSFRlo":[91,248],"cells.":[92,133,249,285],"In":[93,233],"addition,":[94],"a":[95,202,275],"subset":[96,203],"CD34hiCD64-M-CSFRhi":[98],"found.":[101],"CD34+":[102,127],"M-CSFR,":[108],"both":[111],"gave":[112,216,228],"rise":[113,217,229],"exclusively":[114,219,230],"to":[115,212,220,231,240,278],"cells,":[117],"65%":[119],"granulomonocytic":[122],"colony-forming":[123,138,147,161,172],"in":[125,155,183,200],"recovered":[130],"from":[131,142],"these":[132],"Approximately":[134],"70%":[135],"(CFCs)":[140],"derived":[141],"CD34hiM-CSFRhi":[143,206],"units":[148,162],"(CFU-M),":[149],"whereas":[150,222,242],"91%":[151],"CFCs":[154],"CD34hiCD64+M-CSFRlo":[157],"granulocyte":[160],"(CFU-G).":[163],"highest":[169],"frequency":[170],"bipotent":[174],"largest":[177],"average":[178],"colony":[179],"size":[180],"found":[182],"CD64-":[185],"subset,":[186],"indicating":[187],"appears":[190],"earlier":[191],"than":[192],"CD64":[193],"during":[194],"development.":[196],"After":[197],"60":[198],"hours":[199],"culture,":[201],"had":[208],"downmodulated":[209],"(29%":[211],"38%).":[213],"This":[214],"almost":[218],"granulocytes,":[221],"remained":[226],"monocytes.":[232],"all":[234],"experiments,":[235],"responded":[239],"M-CSF,":[241],"minimal":[243],"responses":[244],"observed":[246],"among":[247,257],"These":[250],"results":[251],"suggest":[252],"target":[255],"specificity":[256],"human":[258],"determined":[263],"by":[264],"lineage-specific":[265],"regulation":[266],"show":[271],"useful":[276],"discriminate":[279],"between":[280],"monocytic":[281],"granulocytic":[283]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
