{"id":"https://openalex.org/W2266936611","doi":null,"title":"Sunitinib (SU11248) inhibits growth of human ovarian cancer in xenografted mice.","display_name":"Sunitinib (SU11248) inhibits growth of human ovarian cancer in xenografted mice.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2266936611","mag":"2266936611","pmid":"https://pubmed.ncbi.nlm.nih.gov/20944108"},"language":"en","primary_location":{"id":"pmid:20944108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080994672","display_name":"Dirk Bauerschlag","orcid":"https://orcid.org/0000-0001-8157-6121","observed_orcids":["https://orcid.org/0000-0001-8157-6121"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk O Bauerschlag","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Hospital Aachen, Pauwelsstra\u00dfe 30, 52074 Aachen, Germany. dbauerschlag@ukaachen.de","Department of Gynecology and Obstetrics, University Hospital Aachen, Pauwelsstra\u00dfe 30, 52074, Aachen, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Hospital Aachen, Pauwelsstra\u00dfe 30, 52074 Aachen, Germany. dbauerschlag@ukaachen.de","institution_ids":["https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Hospital Aachen, Pauwelsstra\u00dfe 30, 52074, Aachen, Germany,","institution_ids":["https://openalex.org/I4210120689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032626301","display_name":"Christian Schem","orcid":"https://orcid.org/0000-0001-8606-3077","observed_orcids":["https://orcid.org/0000-0001-8606-3077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Schem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078947839","display_name":"Sanjay Tiwari","orcid":"https://orcid.org/0000-0002-3804-3300","observed_orcids":["https://orcid.org/0000-0002-3804-3300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay Tiwari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112600288","display_name":"Jan Hendrik Egberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan H Egberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020636985","display_name":"Marion Tina Weigel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion T Weigel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040005604","display_name":"Holger Kalthoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holger Kalthoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111451713","display_name":"W. Jonat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Jonat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088720640","display_name":"Nicola\u00ec Maass","orcid":"https://orcid.org/0000-0002-1430-4676","observed_orcids":["https://orcid.org/0000-0002-1430-4676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolai Maass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090281574","display_name":"Ivo M. Meinhold-Heerlein","orcid":"https://orcid.org/0000-0002-0331-8781","observed_orcids":["https://orcid.org/0000-0002-0331-8781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivo Meinhold-Heerlein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9645,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86722933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"9","first_page":"3355","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":1.0},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.777999997138977},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.8009999990463257},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9539999961853027},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.7319999933242798},{"id":"https://openalex.org/keywords/platinum-refractory-disease","display_name":"platinum-refractory disease","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7868162393569946},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.7668639421463013},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6469120979309082},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5795737504959106},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5773789882659912},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4812469184398651},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4755675196647644},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4458165168762207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4273374378681183},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42309531569480896},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.42084527015686035},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4187943935394287},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.41109031438827515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4101922810077667},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.377259224653244},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3665744662284851},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.13616177439689636},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077210","descriptor_name":"Sunitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20944108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:184981","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/184981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anticancer research 30(9), 3355-3360 (2010).","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2266936611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1484771785","https://openalex.org/W1734151292","https://openalex.org/W1977601636","https://openalex.org/W1980637728","https://openalex.org/W2000763913","https://openalex.org/W2001282311","https://openalex.org/W2018929154","https://openalex.org/W2051275595","https://openalex.org/W2052271122","https://openalex.org/W2075885407","https://openalex.org/W2076424556","https://openalex.org/W2095882139","https://openalex.org/W2105651363","https://openalex.org/W2114195790","https://openalex.org/W2120760981","https://openalex.org/W2123334268","https://openalex.org/W2135123420","https://openalex.org/W2151842614","https://openalex.org/W2152657512","https://openalex.org/W2156408558","https://openalex.org/W2163738584","https://openalex.org/W2166819037"],"related_works":["https://openalex.org/W2248657646","https://openalex.org/W2318677238","https://openalex.org/W1976448012","https://openalex.org/W4241370145","https://openalex.org/W2150654881","https://openalex.org/W2241521827","https://openalex.org/W2080458443","https://openalex.org/W2124587459","https://openalex.org/W4232946477","https://openalex.org/W1972099322"],"abstract_inverted_index":{"BACKGROUND:":[0],"Treatment":[1],"of":[2,46,142,146],"ovarian":[3,74,152],"cancer":[4,75],"is":[5,15],"still":[6],"challenging":[7],"especially":[8],"in":[9,36,72],"recurrent":[10,47,149],"platinum":[11],"refractory":[12],"cases.":[13],"Sunitinib":[14,110],"a":[16,34,69,123],"multi":[17],"tyrosine":[18],"kinase":[19],"inhibitor":[20],"targeting":[21],"receptors":[22],"for":[23,43,65,139,144],"vascular":[24],"endothelial":[25],"growth":[26,30,102,114],"factor":[27,31],"and":[28,52,116,119],"platelet-derived":[29],"which":[32],"play":[33],"role":[35],"tumor":[37,113],"angiogenesis.":[38],"It":[39],"has":[40],"been":[41],"approved":[42],"the":[44,140],"treatment":[45,145],"gastro":[48],"intestinal":[49],"stroma":[50],"tumors":[51],"metastatic":[53],"renal":[54],"cancer.":[55,153],"MATERIALS":[56],"AND":[57],"METHODS:":[58],"In":[59],"this":[60],"study,":[61],"sunitinib":[62,97,143],"was":[63,103,120],"tested":[64],"its":[66],"effectiveness":[67],"as":[68],"single":[70],"agent":[71],"an":[73],"xenograft":[76],"mouse":[77],"model.":[78],"Skov3":[79],"cells":[80],"stably":[81],"expressing":[82],"firefly":[83],"luciferase":[84,107],"were":[85],"injected":[86],"into":[87],"SCID":[88],"beige":[89],"mice.":[90],"Mice":[91],"received":[92],"either":[93],"40":[94],"mg/kg":[95],"bodyweight":[96],"or":[98,150],"vehicle":[99],"control.":[100],"Tumor":[101],"monitored":[104],"longitudinally":[105],"by":[106],"signal.":[108],"RESULTS:":[109],"significantly":[111,124],"reduced":[112,125],"(p=0.0052)":[115],"peritoneal":[117],"metastases,":[118],"associated":[121],"with":[122,148],"microvessel":[126],"density":[127],"count":[128],"(p<0.001).":[129],"CONCLUSION:":[130],"These":[131],"results":[132],"suggest":[133],"that":[134],"clinical":[135],"trials":[136],"are":[137],"warranted":[138],"evaluation":[141],"patients":[147],"advanced":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
