{"id":"https://openalex.org/W226610099","doi":null,"title":"Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers.","display_name":"Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W226610099","mag":"226610099","pmid":"https://pubmed.ncbi.nlm.nih.gov/15611600"},"language":"en","primary_location":{"id":"pmid:15611600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15611600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021480371","display_name":"Jana Plevkov\u00e1","orcid":"https://orcid.org/0000-0003-2857-0593","observed_orcids":["https://orcid.org/0000-0003-2857-0593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Plevkova","raw_affiliation_strings":["Department of Pathophysiology, Jessenius School of Medicine, Martin Comenius University, Martin, Slovakia. plevkova@jfmed.uniba.sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Jessenius School of Medicine, Martin Comenius University, Martin, Slovakia. plevkova@jfmed.uniba.sk","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010798016","display_name":"Mariana Brozmanov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brozmanova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Pecova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Pecova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113833373","display_name":"M Tat\u00e1r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tatar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2872,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.88261528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"55 Suppl 3","issue":null,"first_page":"101","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cough-reflex","display_name":"cough reflex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sinusitis","display_name":"sinusitis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/chronic-cough","display_name":"chronic cough","score":0.9210000038146973},{"id":"https://openalex.org/keywords/upper-airway-stimulation","display_name":"upper airway stimulation","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C40956017","wikidata":"https://www.wikidata.org/wiki/Q975803","display_name":"Cough reflex","level":3,"score":0.9232374429702759},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.8817498087882996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7837051749229431},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.7204794883728027},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6664959192276001},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6649953126907349},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5777519941329956},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.48915913701057434},{"id":"https://openalex.org/C2777707825","wikidata":"https://www.wikidata.org/wiki/Q60791486","display_name":"Chronic cough","level":3,"score":0.4364965558052063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18959230184555054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1753006875514984},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.09203144907951355},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08339530229568481},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07891622185707092}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15611600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15611600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:226610099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15611600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1583516842","https://openalex.org/W1853568877","https://openalex.org/W1980623786","https://openalex.org/W1985866011","https://openalex.org/W2097279301","https://openalex.org/W2126289657","https://openalex.org/W2738714530","https://openalex.org/W2754755686"],"related_works":["https://openalex.org/W1985607589","https://openalex.org/W2118682594","https://openalex.org/W1986257767","https://openalex.org/W2095277502","https://openalex.org/W1561513264","https://openalex.org/W1485504360","https://openalex.org/W2146152889","https://openalex.org/W1745155352","https://openalex.org/W2170673139","https://openalex.org/W2511211498"],"abstract_inverted_index":{"Rhinosinusitis":[0],"is":[1,10,26],"the":[2,22,36,43,73,79,88,93,98,113,125,132,135,180,194,205,212],"most":[3],"common":[4],"cause":[5],"of":[6,47,63,66,95,97,117,134,145,150,193,208,219],"chronic":[7],"cough.":[8],"There":[9],"clinical":[11],"experience":[12],"that":[13,30,175,185],"cough":[14,44,74,80,99,127,139,164,195,220],"can":[15,40],"be":[16,198],"elicited":[17],"from":[18],"lower":[19],"airways":[20],"including":[21],"larynx.":[23],"However,":[24],"there":[25],"no":[27],"experimental":[28],"evidence,":[29],"afferent":[31,206],"nerve":[32],"endings":[33],"localized":[34],"in":[35,82,105,156,159,187],"nose":[37],"or":[38],"sinuses":[39],"directly":[41],"mediate":[42],"reflex.":[45,75],"Stimulation":[46],"nasal":[48,67,151,209],"afferents":[49,68,152],"affects":[50],"breathing":[51],"pattern":[52],"(apnea)":[53],"and":[54,84,124,155,211],"bronchial":[55],"smooth":[56],"muscles":[57],"(nasobronchial":[58],"reflex).":[59],"The":[60,115,163,191],"question":[61],"arises":[62],"whether":[64],"stimulation":[65,149],"could":[69,197],"also":[70],"interfere":[71],"with":[72,153,174],"Intranasal":[76],"capsaicin":[77,103,119,154,169],"enhances":[78],"response":[81,100,140,165,196],"cats":[83],"guinea":[85],"pigs.":[86],"In":[87],"present":[89],"study":[90],"we":[91],"address":[92],"problem":[94],"modulation":[96],"by":[101,143,200],"intranasal":[102,118,168],"challenge":[104],"humans.":[106],"Twelve":[107],"healthy":[108],"volunteers":[109],"were":[110,129],"recruited":[111],"for":[112,217],"study.":[114],"effect":[116],"(25":[120],"microl,":[121],"750":[122],"microM)":[123],"airway":[126],"threshold":[128],"determined":[130],"at":[131],"start":[133],"experiment.":[136],"After":[137],"that,":[138],"was":[141,170,182],"provoked":[142,166],"inhalation":[144],"a":[146,160,201],"tussigen":[147],"during":[148,167,176],"control":[157,177],"conditions":[158],"randomized":[161],"order.":[162],"significantly":[171],"enhanced":[172],"compared":[173],"conditions.":[178],"Thus,":[179],"result":[181],"similar":[183],"to":[184],"obtained":[186],"previous":[188],"animal":[189],"studies.":[190],"enhancement":[192],"explained":[199],"facilitating":[202],"interaction":[203],"between":[204],"information":[207],"origin":[210],"central":[213],"neuronal":[214],"network":[215],"responsible":[216],"creation":[218],"pattern.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
