{"id":"https://openalex.org/W2265772129","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","title":"Leukemic blasts fail to differentiate into mature antigen presenting cells, and may hinder dendritic cell maturation in vitro and in vivo","display_name":"Leukemic blasts fail to differentiate into mature antigen presenting cells, and may hinder dendritic cell maturation in vitro and in vivo","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2265772129","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","mag":"2265772129"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.10556","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054346063","display_name":"Jacalyn M. Rosenblatt","orcid":"https://orcid.org/0000-0001-5582-8161","observed_orcids":["https://orcid.org/0000-0001-5582-8161"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Rosenblatt","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071023119","display_name":"Richard Maury Stone","orcid":"https://orcid.org/0000-0002-7526-2633","observed_orcids":["https://orcid.org/0000-0002-7526-2633"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Stone","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035380922","display_name":"C. Lenahan","orcid":"https://orcid.org/0000-0003-3632-0252","observed_orcids":["https://orcid.org/0000-0003-3632-0252"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Lenahan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100905334","display_name":"Z. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Wu","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072612101","display_name":"Baldev Vasir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Vasir","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022280493","display_name":"Adam M. Bissonnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Bissonnette","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051795460","display_name":"Ilene A Galinsky","orcid":"https://orcid.org/0000-0002-9158-5061","observed_orcids":["https://orcid.org/0000-0002-9158-5061"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Galinsky","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109564798","display_name":"Kenneth B. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Miller","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112222630","display_name":"James D. Levine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Levine","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028590331","display_name":"Robin Joyce","orcid":"https://orcid.org/0000-0002-7251-8082","observed_orcids":["https://orcid.org/0000-0002-7251-8082"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Joyce","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052641327","display_name":"David Avigan","orcid":"https://orcid.org/0000-0003-4624-6017","observed_orcids":["https://orcid.org/0000-0003-4624-6017"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Avigan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"10556","last_page":"10556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/leukemic-blasts","display_name":"leukemic blasts","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9940000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.5759999752044678},{"id":"https://openalex.org/keywords/leukemia-immunotherapy","display_name":"leukemia immunotherapy","score":0.37700000405311584},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6069999933242798},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7035585641860962},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.699087917804718},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.5648255348205566},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5405264496803284},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5349346995353699},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5192070603370667},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5180287957191467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49980926513671875},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.48605185747146606},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.45911142230033875},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4372323155403137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4224906861782074},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4204113483428955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41168081760406494},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37614837288856506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36244237422943115},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34868043661117554},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34069448709487915},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3083474636077881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3020707368850708},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2711576223373413},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2545100748538971},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2540433406829834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.10556","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.10556","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2282896831","https://openalex.org/W2535006634","https://openalex.org/W2060304585","https://openalex.org/W2054785324","https://openalex.org/W2316308520","https://openalex.org/W2563616913","https://openalex.org/W2015490435","https://openalex.org/W2086441372","https://openalex.org/W2264743292","https://openalex.org/W1964280007"],"abstract_inverted_index":{"10556":[0],"Background:":[1],"Dendritic":[2,17],"cells":[3,18,126,135,181,225],"(DC)":[4],"play":[5],"a":[6,28,137,196,287,321],"key":[7],"role":[8],"in":[9,31,48,85,106,136,195,200,240,243,266,278,332,335,347],"the":[10,35,42,52,58,86,117,154,168,210,244,267,341],"development":[11],"of":[12,40,45,54,60,74,88,98,119,153,212,229,235,246,250,275,289,343],"tumor":[13,29,322],"specific":[14],"immune":[15],"responses.":[16],"differentiated":[19,242],"from":[20,63,71,129,231],"leukemic":[21,55,326],"blasts":[22,56,68,84,120,271,327],"(LDC)":[23],"are":[24],"being":[25],"explored":[26],"as":[27,320],"vaccine":[30],"AML.":[32,78],"We":[33],"examined":[34],"phenotypic":[36,43,313],"and":[37,51,91,102,140,145,158,163,165,204,253,259,296,299,314,334],"functional":[38,315],"characteristics":[39,44,274],"LDC,":[41],"native":[46,276],"DC":[47,61,122,230,241,277,330],"AML":[49,107,281,348],"patients,":[50],"effect":[53,118],"on":[57,121],"phenotype":[59,97],"generated":[62,81,265],"normal":[64,130,232],"donors.":[65],"Methods:":[66],"Leukemia":[67],"were":[69,80,127,282],"isolated":[70,128],"peripheral":[72],"blood":[73],"24":[75],"patients":[76,108,279],"with":[77,133,142,187,190,280,325],"LDC":[79,148,188,192,311],"by":[82,111,178],"culturing":[83],"presence":[87,245,268],"GM-CSF,":[89,143],"IL-4":[90],"TNFa":[92],"for":[93,263],"7":[94],"days.":[95],"The":[96],"circulating":[99],"DC1":[100,298],"(CD11C+/lin-)":[101],"DC2":[103,290,300],"(CD123+/":[104],"lin-)":[105],"was":[109,182,238,255,291],"assessed":[110,222],"multichannel":[112],"FACS":[113],"analysis.":[114],"To":[115],"assess":[116],"maturation,":[123],"adherent":[124],"mononuclear":[125],"donors,":[131],"combined":[132],"leukemia":[134,213,224],"10:1":[138],"ratio,":[139],"cultured":[141],"IL-4,":[144],"TNFa.":[146],"Results:":[147],"demonstrate":[149],"only":[150],"modest":[151],"expression":[152,161,173,249,305],"costimulatory":[155,236],"molecules":[156,237],"CD80":[157],"CD86":[159,254],"(mean":[160,172,304],"10%":[162],"32%)":[164],"poorly":[166,301],"express":[167],"maturation":[169,331],"marker":[170],"CD83":[171,303],"4%).":[174],"Interferon":[175],"gamma":[176],"production":[177],"autologous":[179],"T":[180,207],"not":[183],"higher":[184],"after":[185],"stimulation":[186],"than":[189],"blasts.":[191,247],"stimlation":[193],"resulted":[194],"2":[197],"fold":[198],"increase":[199],"both":[201,297],"CD4+/CD25+/CD69+":[202],"(activated)":[203],"CD4+/CD25+/FOXP3+":[205],"(regulatory)":[206],"cells.":[208],"Given":[209],"inability":[211],"progenitors":[214],"to":[215,340,354],"differentiate":[216],"into":[217],"phenotypically":[218],"mature":[219],"DC,":[220],"we":[221],"whether":[223],"directly":[226],"inhibit":[227,329],"differentiation":[228],"progenitors.":[233],"Expression":[234],"decreased":[239],"Mean":[248],"CD80,":[251],"CD83,":[252],"16%,":[256],"2%,":[257],"83%":[258],"49%,":[260],"10%,":[261],"99%":[262],"DCs":[264],"or":[269],"absence":[270],"respectively.":[272],"Phenotypic":[273],"examined.":[283],"In":[284],"3":[285],"experiments,":[286],"predominance":[288],"seen":[292],"(ratio":[293],"DC2/DC1":[294],"5),":[295],"expressed":[302],"9%":[306],"DC1,":[307],"0.9%":[308],"DC2).":[309],"Conclusions:":[310],"have":[312],"deficiencies,":[316],"limiting":[317],"their":[318],"efficacy":[319],"vaccine.":[323],"Contact":[324],"may":[328,338],"vitro":[333],"vivo,":[336],"which":[337],"contribute":[339],"lack":[342],"effective":[344],"antitumor":[345],"immunity":[346],"patients.":[349],"No":[350],"significant":[351],"financial":[352],"relationships":[353],"disclose.":[355]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}