{"id":"https://openalex.org/W2265701833","doi":null,"title":"Reviving Stentor coeruleus as a Modem Model for Morphogenesis: RNA interference reveals Mobl as an asymmetrically localized polarity protein","display_name":"Reviving Stentor coeruleus as a Modem Model for Morphogenesis: RNA interference reveals Mobl as an asymmetrically localized polarity protein","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2265701833","mag":"2265701833"},"language":"en","primary_location":{"id":"mag:2265701833","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6tb3c3h1/qt6tb3c3h1.pdf?t=pqrwhq","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002555115","display_name":"Mark M. Slabodnick","orcid":"https://orcid.org/0000-0003-0324-1662","observed_orcids":["https://orcid.org/0000-0003-0324-1662"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark M. Slabodnick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0324-1662","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002555115"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1543675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stentor-coeruleus","display_name":"Stentor coeruleus","score":1.0},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"pattern formation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5879999995231628},{"id":"https://openalex.org/keywords/asymmetric-protein-localization","display_name":"asymmetric protein localization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/polarity-proteins","display_name":"polarity proteins","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ciliates","display_name":"ciliates","score":0.7269999980926514},{"id":"https://openalex.org/keywords/gene-copy-number","display_name":"gene copy number","score":0.8930000066757202},{"id":"https://openalex.org/keywords/small-subunit-rrna-gene","display_name":"small subunit rRNA gene","score":0.9359999895095825},{"id":"https://openalex.org/keywords/regeneration","display_name":"regeneration","score":0.7770000100135803},{"id":"https://openalex.org/keywords/algal-endosymbionts","display_name":"algal endosymbionts","score":0.7730000019073486},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8760970830917358},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7626823782920837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7073813676834106},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5953776836395264},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.5006279945373535},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4534086287021637},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41982170939445496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3724193871021271},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29166093468666077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2493305206298828},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20436128973960876}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2265701833","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6tb3c3h1/qt6tb3c3h1.pdf?t=pqrwhq","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6986980543","https://openalex.org/W2157654873","https://openalex.org/W7096034802","https://openalex.org/W2042587629","https://openalex.org/W2989197934","https://openalex.org/W7162574829","https://openalex.org/W2587530849","https://openalex.org/W2785917385","https://openalex.org/W4289836806","https://openalex.org/W7084254149"],"abstract_inverted_index":{"Author(s):":[0],"Slabodnick,":[1],"Mark":[2],"Maddock":[3],"|":[4,9],"Advisor(s):":[5],"Marshall,":[6],"Wallace":[7],"F":[8],"Abstract:":[10],"Over":[11],"the":[12,49,58,61,83,99,121,133,167,174,208,218,231,305,318,324,380,392],"last":[13],"few":[14,79],"decades":[15],"scientists":[16,112],"have":[17,89,96,200,360],"often":[18],"turned":[19,201],"to":[20,31,74,81,113,127,132,142,147,166,202,246,272,303,383],"one":[21],"of":[22,25,35,40,53,60,103,123,135,170,176,315,347,350,366,407],"a":[23,33,78,203,313,397],"handful":[24,134,314],"well-established":[26],"model":[27,107,206,398],"systems":[28,55],"in":[29,93,156,164,181,196,225,239,263,270,294,310,334],"order":[30],"address":[32,128,143],"number":[34,293,309],"questions":[36,124,139],"about":[37],"how":[38],"all":[39,188],"biology":[41,169],"functions.":[42],"This":[43,109],"is":[44,223,280,327,372],"absolutely":[45],"useful":[46],"and":[47,105,149,172,178,242,261,274,287,338,359,364,386],"at":[48],"time":[50],"that":[51,95,217],"many":[52,91,404],"these":[54,367],"were":[56,64],"adopted":[57],"state":[59],"art":[62],"technologies":[63],"much":[65,71],"more":[66,72],"limited,":[67],"which":[68,152],"made":[69],"it":[70],"efficient":[73],"focus":[75],"on":[76,119,284],"just":[77],"organisms":[80],"set":[82],"scientific":[84],"standards.":[85],"However,":[86],"recently":[87],"there":[88,371],"been":[90],"advances":[92],"technology":[94],"allowed":[97],"for":[98,256,290,312,375,394,403],"relatively":[100],"quick":[101],"development":[102,260],"new":[104,385],"interesting":[106,387],"organisms.":[108],"should":[110],"allow":[111],"tailor":[114],"what":[115],"we":[116,125],"are":[117,144,153,193],"working":[118],"with":[120,236,401],"types":[122],"want":[126],"without":[129],"being":[130],"limited":[131],"established":[136],"models.":[137],"The":[138],"I":[140,199,215,229,268,300,344,369],"seek":[141],"those":[145],"related":[146],"morphogenesis":[148,177,243],"pattern":[150,179],"formation,":[151],"vital":[154],"processes":[155],"any":[157],"organism":[158],"whether":[159],"unicellular":[160,205],"or":[161],"multicellular.":[162],"But":[163],"contrast":[165],"developmental":[168],"plants":[171,245],"animals,":[173],"principles":[175],"formation":[180],"single":[182],"cells":[183,189],"remain":[184],"largely":[185],"unknown.":[186],"Although":[187],"develop":[190],"patterns,":[191],"they":[192],"most":[194],"obvious":[195],"ciliates;":[197],"hence":[198],"classical":[204],"system,":[207],"giant":[209],"Heterotrich":[210,285],"ciliate":[211],"Stentor":[212,311,325,352,381,395],"coeruleus.":[213],"Here":[214],"show":[216],"RNA":[219],"interference":[220],"(RNAi)":[221],"machinery":[222],"conserved":[224,237],"Stentor.":[226,264,295],"Using":[227,296],"RNAi,":[228],"identified":[230,345],"kinase":[232],"co-activator":[233],"Mob1":[234],"-":[235,248],"functions":[238],"cell":[240],"division":[241],"from":[244],"humans":[247],"as":[249,396],"an":[250],"asymmetrically":[251],"localized":[252],"patterning":[253,258],"protein":[254],"required":[255],"global":[257],"during":[259],"regeneration":[262,399],"During":[265],"this":[266],"process":[267],"worked":[269],"collaboration":[271],"sequence":[273],"assemble":[275],"Stentor's":[276],"macronuclear":[277],"genome.":[278],"There":[279],"almost":[281],"no":[282,288],"information":[283],"genomes":[286],"estimates":[289],"gene":[291],"copy":[292,308],"digital":[297],"droplet":[298],"PCR,":[299],"was":[301],"able":[302],"determine":[304],"average":[306],"contig":[307],"loci":[316],"including":[317],"small":[319],"subunit":[320],"rDNA":[321],"gene.":[322],"Finally,":[323],"genus":[326,382],"amazingly":[328],"diverse.":[329],"Different":[330],"species":[331,349],"can":[332],"vary":[333],"size,":[335],"shape,":[336],"color,":[337],"some":[339],"even":[340],"contain":[341],"algal":[342],"endosymbionts.":[343],"sources":[346],"five":[348],"wild":[351],"near":[353],"Woods":[354],"Hole":[355],"Marine":[356],"Biological":[357],"Laboratory":[358],"also":[361],"included":[362],"methods":[363],"descriptions":[365],"species.":[368],"think":[370],"great":[373],"potential":[374,402],"tapping":[376],"natural":[377],"diversity":[378],"within":[379],"discover":[384],"biology.":[388],"My":[389],"work":[390],"reopens":[391],"door":[393],"system":[400],"other":[405],"areas":[406],"study.":[408]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}