{"id":"https://openalex.org/W2265690782","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","title":"Phase I trial of escalating doses of ABI-007 (nanoparticle albumin-bound paclitaxel) and gemcitabine in patients (pts) with thoracic malignancies","display_name":"Phase I trial of escalating doses of ABI-007 (nanoparticle albumin-bound paclitaxel) and gemcitabine in patients (pts) with thoracic malignancies","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2265690782","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","mag":"2265690782"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.18094","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067533624","display_name":"C. B. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. B. Lee","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014554706","display_name":"Thomas E. Stinchcombe","orcid":"https://orcid.org/0000-0002-3595-8011","observed_orcids":["https://orcid.org/0000-0002-3595-8011"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. E. Stinchcombe","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078629724","display_name":"Mark A. Socinski","orcid":"https://orcid.org/0000-0003-2915-9325","observed_orcids":["https://orcid.org/0000-0003-2915-9325","https://orcid.org/0000-0002-8213-0137"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Socinski","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068906036","display_name":"David Neil Hayes","orcid":"https://orcid.org/0000-0001-6203-7771","observed_orcids":["https://orcid.org/0000-0001-6203-7771"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. N. Hayes","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080788977","display_name":"Richard M. Goldberg","orcid":"https://orcid.org/0000-0003-0308-8223","observed_orcids":["https://orcid.org/0000-0003-0308-8223","https://orcid.org/0000-0003-3713-6895"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Goldberg","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103887854","display_name":"Michael Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Hawkins","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016064449","display_name":"Coleman K. Obasaju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. K. Obasaju","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111928230","display_name":"E. Claire Dees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. C. Dees","raw_affiliation_strings":["Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Chapel Hill, NC; Abraxis Oncology, Los Angeles, CA; Lilly Oncology, Indianapolis, IN","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"18094","last_page":"18094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.18240000307559967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.996999979019165},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.996999979019165},{"id":"https://openalex.org/keywords/thoracic-tumors","display_name":"thoracic tumors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6370000243186951},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.44600000977516174},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.7170000076293945},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7730000019073486},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9392850399017334},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7678753137588501},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.747589111328125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6068875789642334},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5822632312774658},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5763987898826599},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.5234919786453247},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5030519366264343},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4638192057609558},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.43179571628570557},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.42118144035339355},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3876305818557739},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3531005084514618}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.18094","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.18094","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320821919","https://openalex.org/W2078775260","https://openalex.org/W2124447659","https://openalex.org/W2289118048","https://openalex.org/W1993184235","https://openalex.org/W2165004581","https://openalex.org/W7095801560","https://openalex.org/W3148035859","https://openalex.org/W2257757576","https://openalex.org/W2153017356"],"abstract_inverted_index":{"18094":[0],"Background:":[1],"ABI-007,":[2],"nanoparticle":[3],"albumin-bound":[4],"paclitaxel,":[5],"has":[6],"a":[7,15,50,251,276],"different":[8],"toxicity":[9],"profile":[10],"than":[11],"solvent-based":[12],"paclitaxel":[13],"including":[14],"lower":[16],"rate":[17],"of":[18,32,53,86,127,185,195,216,243,247,254,268,272,319,348],"severe":[19],"neutropenia.":[20],"This":[21,368],"trial":[22],"was":[23,131,312,370],"designed":[24],"to":[25,48,259,387],"determine":[26],"the":[27,93,128,134,151,180,186,320],"maximum":[28],"tolerated":[29,372],"dose":[30,107,130,242,267,316],"(MTD)":[31],"ABI-007":[33,80,241,266,349],"in":[34,39,76,178,193,317,355,376],"combination":[35,356,369],"with":[36,41,357],"gemcitabine":[37],"(G)":[38],"patients":[40,200,274],"thoracic":[42],"malignancies.":[43],"Methods:":[44],"Patients":[45,67],"were":[46,148,155,191,201,206,325],"required":[47],"have":[49],"performance":[51],"status":[52],"0\u20131,":[54],"=3":[55],"cytotoxic":[56],"chemotherapy":[57],"regimens,":[58],"and":[59,63,79,125,154,203,236,263,283,290,373,380],"preserved":[60],"renal,":[61],"hepatic,":[62],"bone":[64],"marrow":[65],"function.":[66],"received":[68],"G":[69,106,110,129,257,311,358],"1,000":[70,359],"mg/m2":[71,90,270,352,360],"on":[72,81,92,361],"days":[73,98,362],"1,":[74,363],"8":[75,105,188,256,364],"all":[77,300],"cohorts":[78,194],"day":[82,187,255,353],"1":[83,237,246,285,354],"at":[84,264,314],"doses":[85],"260,":[87],"300,":[88],"340":[89,269],"depending":[91],"treatment":[94],"cohort":[95],"every":[96,365],"21":[97,102,366],"(1":[99,278],"cycle":[100,153],"=":[101,170,173],"days).":[103],"Day":[104],"modifications":[108],"were:":[109,302],"held":[111],"for":[112,172,327],"ANC":[113,135,169,260],"<":[114,121,261],"500":[115,171],"x":[116,123,137,142],"109/L":[117,138],"or":[118,139,167,183,295],"platelets":[119],"(plts)":[120],"50,000":[122],"109/L,":[124],"75%":[126],"given":[132,313],"if":[133],"500\u2013999":[136],"plts":[140],"50,000\u201399,000":[141],"109/L.":[143],"Dose":[144],"limiting":[145],"toxicities":[146,297],"(DLT)":[147],"assessed":[149],"after":[150],"first":[152],"defined":[156],"as:":[157],"grade":[158,164,280,287,293],"3":[159,273,281,288,294],"non-hematologic":[160],"toxicity,":[161],"febrile":[162,308],"neutropenia,":[163],"4":[165,296,331,338],"anemia":[166],"thrombocytopenia,":[168],"7":[174],"days,":[175],"2-week":[176],"delay":[177],"initiating":[179],"second":[181],"cycle,":[182],"omission":[184],"G.":[189],"Doses":[190],"escalated":[192],"3\u20136":[196],"pts.":[197],"Results:":[198],"Thirteen":[199],"consented":[202],"12":[204],"pts":[205,249,324],"treated":[207,378],"(median":[208],"age":[209],"62.5":[210],"years":[211],"(range":[212,220],"35\u201375);":[213],"median":[214],"number":[215],"prior":[217],"treatments":[218],"2.5":[219],"1\u20134);":[221],"tumor":[222],"types:":[223],"6":[224,248],"non-small":[225],"cell":[226,232],"lung":[227,233],"cancer":[228,234],"(NSCLC),":[229],"5":[230],"small":[231],"(SCLC),":[235],"esophageal.":[238],"At":[239],"an":[240,265],"300":[244,351],"mg/m2,":[245],"experienced":[250,275],"DLT":[252,277],"(omission":[253],"due":[258],"500),":[262],"2":[271],"pt":[279,286],"rash":[282],"pruritus;":[284],"fatigue":[289],"anorexia).":[291],"Additional":[292],"observed":[298],"over":[299],"cycles":[301],"neutropenia":[303,309],"(n=2),":[304],"sensory":[305],"neuropathy":[306],"(n=1),":[307],"(n=1).":[310],"full":[315],"38":[318],"39":[321],"cycles.":[322],"Eight":[323],"evaluable":[326],"response":[328],"by":[329],"RECIST:":[330],"partial":[332],"responses":[333],"(SCLC,":[334],"n=2;":[335],"NSCLC,":[336],"n=2),":[337],"stable":[339],"disease":[340],"(NSCLC,":[341],"n=3;":[342],"esophageal,":[343],"n=1).":[344],"Conclusions:":[345],"The":[346],"MTD":[347],"is":[350],"days.":[367],"well":[371],"demonstrated":[374],"activity":[375],"previously":[377],"NSCLC":[379],"SCLC":[381],"patients.":[382],"No":[383],"significant":[384],"financial":[385],"relationships":[386],"disclose.":[388]},"counts_by_year":[],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2016-06-24T00:00:00"}
