{"id":"https://openalex.org/W2265489082","doi":null,"title":"T cell differentiation by human parvovirus B19 non-structural protein 1 induced apoptotic bodies","display_name":"T cell differentiation by human parvovirus B19 non-structural protein 1 induced apoptotic bodies","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2265489082","mag":"2265489082"},"language":"en","primary_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/47543","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077304073","display_name":"Kati Karvonen","orcid":"https://orcid.org/0000-0002-6888-4928","observed_orcids":["https://orcid.org/0000-0002-6888-4928"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kati Karvonen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6888-4928","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077304073"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvovirus-b19","display_name":"parvovirus B19","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ns1-protein","display_name":"NS1 protein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cd4-t-helper-cells","display_name":"CD4+ T helper cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/apoptotic-bodies","display_name":"apoptotic bodies","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.4650000035762787},{"id":"https://openalex.org/keywords/mhc-class-ii-antigen-presentation","display_name":"MHC class II antigen presentation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7029416561126709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6208140254020691},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5688768625259399},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4868856966495514},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4854298233985901},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.446845680475235},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4378601312637329},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.41586482524871826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33232247829437256}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jyx.jyu.fi:123456789/47543","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2265489082","doi":null,"is_oa":false,"landing_page_url":"https://jyx.jyu.fi/handle/123456789/47543","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/47543","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-201511023577","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2265489082.pdf","grobid_xml":"https://content.openalex.org/works/W2265489082.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W41870505","https://openalex.org/W157721590","https://openalex.org/W163212441","https://openalex.org/W1480400711","https://openalex.org/W1522588191","https://openalex.org/W1545425202","https://openalex.org/W1561591381","https://openalex.org/W1564217413","https://openalex.org/W1567420244","https://openalex.org/W1594649446","https://openalex.org/W1661544713","https://openalex.org/W1667816862","https://openalex.org/W1934162206","https://openalex.org/W1964003691","https://openalex.org/W1966388921","https://openalex.org/W1968961493","https://openalex.org/W1969137358","https://openalex.org/W1971505293","https://openalex.org/W1973608410","https://openalex.org/W1975310925","https://openalex.org/W1977945339","https://openalex.org/W1981411821","https://openalex.org/W1992031335","https://openalex.org/W1993946895","https://openalex.org/W1997708871","https://openalex.org/W1998356774","https://openalex.org/W2009166328","https://openalex.org/W2014732115","https://openalex.org/W2015687577","https://openalex.org/W2020522359","https://openalex.org/W2021507425","https://openalex.org/W2021522648","https://openalex.org/W2021677937","https://openalex.org/W2022303626","https://openalex.org/W2028092080","https://openalex.org/W2028801154","https://openalex.org/W2028973331","https://openalex.org/W2030279593","https://openalex.org/W2031501484","https://openalex.org/W2031848223","https://openalex.org/W2031866250","https://openalex.org/W2040336985","https://openalex.org/W2042471713","https://openalex.org/W2047973049","https://openalex.org/W2048339949","https://openalex.org/W2049927826","https://openalex.org/W2049946738","https://openalex.org/W2052853635","https://openalex.org/W2053900043","https://openalex.org/W2055869501","https://openalex.org/W2063375243","https://openalex.org/W2064346335","https://openalex.org/W2065183912","https://openalex.org/W2074660641","https://openalex.org/W2077005332","https://openalex.org/W2084146385","https://openalex.org/W2086539844","https://openalex.org/W2086928551","https://openalex.org/W2099295104","https://openalex.org/W2100446366","https://openalex.org/W2101771134","https://openalex.org/W2102096947","https://openalex.org/W2102689053","https://openalex.org/W2103600875","https://openalex.org/W2111409974","https://openalex.org/W2118111782","https://openalex.org/W2121057258","https://openalex.org/W2121134067","https://openalex.org/W2123572224","https://openalex.org/W2129009660","https://openalex.org/W2129333754","https://openalex.org/W2132403618","https://openalex.org/W2142258560","https://openalex.org/W2145049340","https://openalex.org/W2145164170","https://openalex.org/W2146037857","https://openalex.org/W2146674711","https://openalex.org/W2148226248","https://openalex.org/W2150334056","https://openalex.org/W2151566115","https://openalex.org/W2152014155","https://openalex.org/W2157837362","https://openalex.org/W2161767894","https://openalex.org/W2166584906","https://openalex.org/W2167279371","https://openalex.org/W2170819733","https://openalex.org/W2172173997","https://openalex.org/W2177327503","https://openalex.org/W2181908191","https://openalex.org/W2186651573","https://openalex.org/W2253358092","https://openalex.org/W2595920264"],"related_works":["https://openalex.org/W2288814451","https://openalex.org/W2284901724","https://openalex.org/W2086928551","https://openalex.org/W1554163095","https://openalex.org/W2020098764","https://openalex.org/W2018131642","https://openalex.org/W1997303313","https://openalex.org/W1673101132","https://openalex.org/W2897105275","https://openalex.org/W2626983889"],"abstract_inverted_index":{"Uutta":[0],"tietoa":[1],"ihmisen":[2,195],"immuunij\u00e4rjestelm\u00e4st\u00e4":[3],"ja":[4,10,22,28,41,50,60,106,116,140,157,183,197,218,223,269,283,315,325,333,340,359,398,403],"sen":[5],"toiminnasta":[6],"ker\u00e4t\u00e4\u00e4n":[7],"jatkuvasti.":[8],"Synnynn\u00e4inen":[9],"hankittu":[11],"immunij\u00e4rjestelm\u00e4":[12],"toimivat":[13,19],"yhteisty\u00f6ss\u00e4":[14],"erilaisia":[15,80],"patogeeneja":[16],"vastaan.":[17,82],"Dendriittisolut":[18],"siltana":[20],"synnynn\u00e4isen":[21],"hankitun":[23],"vastustuskyvyn":[24],"v\u00e4lill\u00e4":[25],"stimuloimalla":[26],"T":[27,42,57,64,68,155,211,235,250,255,271,275,296,302,365,387],"B":[29],"lymfosyyttej\u00e4.":[30],"Antigeenin":[31],"esittely":[32],"luokan":[33],"II":[34],"MHC":[35],"molekyylin":[36],"(eng.":[37],"major":[38],"histocompatibility":[39],"complex)":[40],"solun":[43],"reseptorin":[44,49],"(TCR)":[45],"v\u00e4lill\u00e4,":[46],"sek\u00e4":[47],"erillisen":[48],"ligandin":[51],"tai":[52,96],"sytokiini":[53],"-signaalin":[54],"v\u00e4lityksell\u00e4,":[55],"CD4+":[56,63],"solut":[58,185,297,327,342],"stimuloituvat":[59],"erilaistuvat.":[61,186],"Erilaistuneita":[62],"auttajasoluja":[65],"(Th,":[66],"eng.":[67,274],"helper":[69],"cell)":[70],"on":[71,110,415],"eri":[72,238,408],"alalajeja,":[73],"jotka":[74],"osallistuvat":[75],"vaihtelevasti":[76],"immuunipuolustukseen,":[77],"esimerkiksi":[78],"suojana":[79],"viruksia":[81],"Ihmisen":[83],"parvovirus":[84],"B19":[85],"(B19V)":[86],"infektoi":[87],"niin":[88,229],"lapsia":[89],"kuin":[90,233,310],"aikuisiakin.":[91],"Tartunta":[92],"voi":[93],"olla":[94],"oireeton":[95],"oireet":[97],"voivat":[98],"vaihdella":[99],"flunssankaltaisesta":[100],"vakavampiin":[101],"tauteihin":[102],"kuten":[103,114],"parvorokkoon,":[104],"nivelsairauksiin":[105],"siki\u00f6n":[107],"vesip\u00f6h\u00f6\u00f6n.":[108],"B19V":[109,160],"my\u00f6s":[111],"yhdistetty":[112],"autoimmuunisairauksiin":[113],"nivelreumaan":[115],"perhosreumaan":[117],"(lupus).":[118],"Patogeenisyyden":[119],"mekanismeja":[120],"B19V:een":[121,420],"liittyviss\u00e4":[122],"autoimmuunisairauksissa":[123],"ei":[124,370],"ole":[125],"kuitenkaan":[126],"viel\u00e4":[127],"selvitetty.":[128],"Kuitenkin":[129],"tiedet\u00e4\u00e4n,":[130],"ett\u00e4":[131,171,378],"viruksen":[132],"ei-rakenteellinen":[133],"proteiini":[134],"1":[135],"(NS1)":[136],"aiheuttaa":[137],"is\u00e4nt\u00e4solussa":[138],"tuhoa":[139],"jopa":[141],"apoptoosia.":[142],"NS1":[143,161,379,411],"proteiinin":[144,162,412],"kyky\u00e4":[145],"laukaista":[146],"immuunireaktio":[147],"tarkkailtiin":[148],"t\u00e4ss\u00e4":[149],"ty\u00f6ss\u00e4.":[150],"Tutkimuksen":[151,373],"tavoitteena":[152],"oli":[153,307,401],"kartoittaa":[154],"solujen":[156,212,251,256,366,388,404],"dendriittisolujen":[158,243],"kanssak\u00e4ymist\u00e4":[159],"aiheuttamien":[163],"apoptoottisilla":[164],"kappaleilla":[165],"(ApoBodit)":[166],"stimuloinnin":[167],"j\u00e4lkeen.":[168],"Hypoteesina":[169],"oletettiin,":[170],"NS1:n":[172],"synnytt\u00e4m\u00e4t":[173],"ApoBodit":[174,381],"saavat":[175],"aikaan":[176],"immuunireaktion,":[177],"jossa":[178,384],"erityisesti":[179],"autoimmuniteettiin":[180],"viittaavat":[181],"Th1":[182,261,324,397],"Th17":[184,267,314,326,399],"Seitsenp\u00e4iv\u00e4inen":[187],"kypsymisprotokolla":[188],"perustettiin":[189],"kaupalliselle":[190],"dendriittisolulinjalle":[191],"(MUTZ-3,":[192],"sytokiini-":[193],"riippuvainen":[194],"solulinja)":[196],"kypsyminen":[198],"viimeisteltiin":[199],"48":[200],"h":[201,282,285,318,345],"kest\u00e4v\u00e4ll\u00e4":[202],"stimuloinnilla.":[203],"T\u00e4m\u00e4n":[204,293,390],"j\u00e4lkeen":[205],"stimuloituja":[206],"MUTZ-3":[207,231],"soluja":[208,306,400],"kasvatettiin":[209],"yhdess\u00e4":[210],"kanssa":[213],"24":[214,281],"h,":[215,217],"72":[216,284,317,344],"7":[219,321,350],"pv:n":[220,351],"ajan.":[221],"Virtaussytometriaa":[222],"konfokaalimikroskopiaa":[224],"k\u00e4ytettiin":[225,254],"solunulkoisten":[226],"merkkien":[227],"tutkimiseen":[228],"kypsytetyilt\u00e4":[230],"soluilta":[232,236],"yhteiskasvatetuilta":[234],"kolmesta":[237],"aikapisteest\u00e4.":[239],"CD83":[240],"toimi":[241],"kypsien":[242],"solunulkoisena":[244],"leimana,":[245],"kun":[246,337],"taas":[247,338],"kuutta":[248],"erilaista":[249],"alalajien":[252],"merkki\u00e4":[253],"v\u00e4rj\u00e4yksess\u00e4:":[257],"CD8a,":[258],"CD4,":[259],"CD183":[260],"soluille,":[262,265],"CD194":[263],"Th2":[264,305,339],"CD196":[266],"soluille":[268],"CD25":[270],"s\u00e4\u00e4telij\u00e4soluille":[272],"(Treg,":[273],"regulatory":[276],"cell).":[277],"My\u00f6s":[278],"sytokiinituotantoa":[279],"tutkittiin":[280],"aikapisteilt\u00e4.":[286],"Dendriittisolujen":[287],"kypsymistulokset":[288],"osoittivat":[289,298],">10":[290],"%":[291,332,335],"kypsymist\u00e4.":[292],"lis\u00e4ksi":[294,354,391],"yhteiskasvatetut":[295],"erilaistumista":[299],"kaikista":[300],"tutkituista":[301],"alalajityypeist\u00e4,":[303],"vaikkakin":[304],"erilaistunut":[308,402],"enemm\u00e4n":[309],"muita":[311],"alalajeja":[312],"(Th1,":[313],"Treg)":[316],"aikapisteest\u00e4":[319],"eteenp\u00e4in.":[320],"pv:\u00e4\u00e4n":[322],"menness\u00e4":[323],"olivat":[328],"tasaisesti":[329],"kasvaneet":[330],"2.5":[331],"1.5":[334],"vastaavasti,":[336],"Treg":[341],"lis\u00e4\u00e4ntyiv\u00e4t":[343],"aikapisteeseen":[346],"asti":[347],"mutta":[348],"hupenivat":[349],"menness\u00e4.":[352],"N\u00e4iden":[353],"sytokiinianalyysi":[355],"ilmensi":[356],"tulehdusta":[357],"edist\u00e4vien":[358],"hillitsevien":[360],"sytokiinien":[361],"tuotannon.":[362],"Kuitenkaan":[363],"kullekin":[364],"alalajille":[367],"tyypillisi\u00e4":[368],"sytokiinej\u00e4":[369],"tutkimuksessa":[371],"havaittu.":[372],"tuloksena":[374],"voitiin":[375],"kuitenkin":[376,416],"todeta,":[377],"indusoimat":[380],"stimuloivat":[382],"tulehdusreaktion,":[383],"erilaistui":[385],"variaatio":[386],"alalajeja.":[389],"hypoteesi":[392],"todettiin":[393],"paikkansa":[394],"pit\u00e4v\u00e4ksi,":[395],"sill\u00e4":[396],"m\u00e4\u00e4r\u00e4":[405],"kasvanut":[406],"kokeen":[407],"aikapisteiden":[409],"v\u00e4lill\u00e4.":[410],"aiheuttamia":[413],"immuunireaktioita":[414],"tutkittava":[417],"lis\u00e4\u00e4,":[418],"jotta":[419],"liittyvien":[421],"autoimmuunisairauksien":[422],"syntymisen":[423],"mekanismit":[424],"voidaan":[425],"tunnistaa.":[426]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}