{"id":"https://openalex.org/W2265066695","doi":"https://doi.org/10.1182/blood.v72.4.1324.1324","title":"Correction of canine cyclic hematopoiesis with recombinant human granulocyte colony-stimulating factor","display_name":"Correction of canine cyclic hematopoiesis with recombinant human granulocyte colony-stimulating factor","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2265066695","doi":"https://doi.org/10.1182/blood.v72.4.1324.1324","mag":"2265066695","pmid":"https://pubmed.ncbi.nlm.nih.gov/2458781"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v72.4.1324.1324","doi":"https://doi.org/10.1182/blood.v72.4.1324.1324","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v72.4.1324.1324","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"erratum","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078803622","display_name":"Clinton D. Lothrop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CD Jr Lothrop","raw_affiliation_strings":["Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":null,"display_name":"DJ Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DJ Warren","raw_affiliation_strings":["Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113757673","display_name":"LM Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LM Souza","raw_affiliation_strings":["Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109316755","display_name":"Jones Jb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JB Jones","raw_affiliation_strings":["Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":null,"display_name":"MA Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MA Moore","raw_affiliation_strings":["Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"4","first_page":"1324","last_page":"1328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyclic-neutropenia","display_name":"cyclic neutropenia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7950000166893005},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.8518397808074951},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.8147940635681152},{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.7380461692810059},{"id":"https://openalex.org/C2778726489","wikidata":"https://www.wikidata.org/wiki/Q39266","display_name":"Puppy","level":2,"score":0.7044680118560791},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7028904557228088},{"id":"https://openalex.org/C2778527355","wikidata":"https://www.wikidata.org/wiki/Q5198214","display_name":"Cyclic neutropenia","level":4,"score":0.6528347730636597},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6249518394470215},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5199190974235535},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.5111187100410461},{"id":"https://openalex.org/C2779958370","wikidata":"https://www.wikidata.org/wiki/Q5711176","display_name":"Hematopoietic growth factor","level":4,"score":0.4759135842323303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46847739815711975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4646216332912445},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.46167632937431335},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4434923827648163},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4210956394672394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3381780982017517},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.184373676776886},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0977095365524292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05802091956138611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003115","descriptor_name":"Colony-Stimulating Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007964","descriptor_name":"Leukocytosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007964","descriptor_name":"Leukocytosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v72.4.1324.1324","doi":"https://doi.org/10.1182/blood.v72.4.1324.1324","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v72.4.1324.1324","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:2458781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2458781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4836750078","display_name":null,"funder_award_id":"HL15647-15","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G517293375","display_name":null,"funder_award_id":"CA 31780","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7427769988","display_name":"HUMAN HEMATOPOIETIC TUMORS PROGRAM PROJECT","funder_award_id":"P01CA020194","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W113557068","https://openalex.org/W203479425","https://openalex.org/W237607793","https://openalex.org/W1502292151","https://openalex.org/W1520035358","https://openalex.org/W1528849035","https://openalex.org/W1561502282","https://openalex.org/W1562975611","https://openalex.org/W1599937274","https://openalex.org/W1675276494","https://openalex.org/W1968767557","https://openalex.org/W1973312385","https://openalex.org/W1996190265","https://openalex.org/W2005656020","https://openalex.org/W2010837300","https://openalex.org/W2019998523","https://openalex.org/W2020181699","https://openalex.org/W2020794144","https://openalex.org/W2036631709","https://openalex.org/W2037672711","https://openalex.org/W2050149613","https://openalex.org/W2068382284","https://openalex.org/W2092368843","https://openalex.org/W2151286079","https://openalex.org/W2169663330","https://openalex.org/W2282478790","https://openalex.org/W2293912353","https://openalex.org/W2315613377","https://openalex.org/W2317007280","https://openalex.org/W2394764429","https://openalex.org/W2402354259","https://openalex.org/W2405330697","https://openalex.org/W2407183454","https://openalex.org/W2410402585","https://openalex.org/W2419148223","https://openalex.org/W4409136715"],"related_works":["https://openalex.org/W2418560751","https://openalex.org/W2465121773","https://openalex.org/W2404790262","https://openalex.org/W2278145052","https://openalex.org/W2419079587","https://openalex.org/W1996712367","https://openalex.org/W2010837300","https://openalex.org/W107038307","https://openalex.org/W2220218941","https://openalex.org/W2027339718"],"abstract_inverted_index":{"Canine":[0],"cyclic":[1,212],"hematopoiesis":[2],"(CH)":[3],"is":[4,14,27],"an":[5],"autosomal":[6],"recessive":[7],"disease":[8],"of":[9,36,42,48,152,175,210],"gray":[10],"collie":[11],"dogs":[12,123,138],"that":[13,164,172,189],"characterized":[15],"by":[16,179,200],"neutropenic":[17,116],"episodes":[18,117],"at":[19],"14-day":[20],"intervals.":[21],"The":[22,74,98],"biochemical":[23],"basis":[24],"for":[25,104],"CH":[26,57,122,176,184,195],"not":[28],"known":[29],"but":[30,89],"may":[31],"involve":[32],"a":[33,43,63,80],"regulatory":[34,191],"defect":[35,192],"the":[37,130,140,150,156,165,168,190,207],"response":[38],"to":[39,55,79,155,206],"or":[40],"production":[41],"hematopoietic":[44],"growth":[45],"factor.":[46],"Administration":[47],"recombinant":[49],"human":[50,211],"granulocyte":[51],"colony-stimulating":[52],"factor":[53],"(rhG-CSF)":[54],"two":[56,114],"and":[58,113,145,204],"one":[59],"normal":[60],"dog":[61],"caused":[62],"marked":[64],"leukocytosis":[65,75],"(greater":[66],"than":[67,82,106],"50,000":[68],"WBCs)":[69],"in":[70,85,92,109,120,129,135,167,182,193],"all":[71,110,136],"three":[72,111,137],"dogs.":[73,185],"was":[76,102,146],"due":[77],"largely":[78],"greater":[81],"tenfold":[83],"increase":[84],"neutrophils.":[86],"Less":[87],"pronounced":[88],"significant":[90],"elevations":[91],"monocytes":[93],"occurred":[94,133],"during":[95,124,139],"G-CSF":[96],"treatment.":[97,126],"elevated":[99],"WBC":[100,131],"count":[101,132],"maintained":[103],"more":[105],"20":[107],"days":[108,144],"dogs,":[112],"predicted":[115],"were":[118,177],"prevented":[119],"both":[121,183],"rhG-CSF":[125,158,180,203],"A":[127],"decline":[128],"simultaneously":[134],"last":[141],"five":[142],"treatment":[143,181,201,209],"presumably":[147],"associated":[148],"with":[149,202,214],"development":[151],"neutralizing":[153],"antibodies":[154],"heterologous":[157],"protein.":[159],"Bone":[160],"marrow":[161],"evaluation":[162],"indicated":[163],"swings":[166],"myeloid/erythroid":[169],"progenitor":[170],"cells":[171],"are":[173],"characteristic":[174],"eliminated":[178],"These":[186],"results":[187],"suggest":[188],"canine":[194],"can":[196],"be":[197],"temporarily":[198],"alleviated":[199],"point":[205],"potential":[208],"neutropenia":[213],"this":[215],"agent.":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}