{"id":"https://openalex.org/W2265056599","doi":"https://doi.org/10.1186/s12868-016-0240-4","title":"Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers","display_name":"Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2265056599","doi":"https://doi.org/10.1186/s12868-016-0240-4","mag":"2265056599","pmid":"https://pubmed.ncbi.nlm.nih.gov/26831335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4736184"},"language":"en","primary_location":{"id":"doi:10.1186/s12868-016-0240-4","doi":"https://doi.org/10.1186/s12868-016-0240-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12868-016-0240-4","pdf_url":"https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/s12868-016-0240-4","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/s12868-016-0240-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060584025","display_name":"Massiva Sayad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]},{"id":"https://openalex.org/I83332908","display_name":"University of Blida","ror":"https://ror.org/03g41pw14","country_code":"DZ","type":"education","lineage":["https://openalex.org/I83332908"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Massiva Sayad","raw_affiliation_strings":["Department of BPO, Faculty of SNV, Blida 1 University, BP 270, 09000, Blida, Algeria. sayad_massiva@yahoo.fr","Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. sayad_massiva@yahoo.fr","Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of BPO, Faculty of SNV, Blida 1 University, BP 270, 09000, Blida, Algeria. sayad_massiva@yahoo.fr","institution_ids":["https://openalex.org/I83332908"]},{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. sayad_massiva@yahoo.fr","institution_ids":["https://openalex.org/I157169809"]},{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072829369","display_name":"Mohamed Zouambia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Mohamed Zouambia","raw_affiliation_strings":["Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. zouambia26@gmail.com","Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. zouambia26@gmail.com","institution_ids":["https://openalex.org/I157169809"]},{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112259168","display_name":"Malika Chaouch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malika Chaouch","raw_affiliation_strings":["Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria. chaouch_malika@hotmail.com","Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria. chaouch_malika@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038872474","display_name":"Farida Ferrat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farida Ferrat","raw_affiliation_strings":["Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria. ferratfarida@yahoo.fr","Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria. ferratfarida@yahoo.fr","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, CHU Ben Aknoun, 16000, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109034878","display_name":"Mustapha Nebbal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustapha Nebbal","raw_affiliation_strings":["Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria. mus.neuro@gmail.com","Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria. mus.neuro@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072741189","display_name":"Mohamed Bendini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Bendini","raw_affiliation_strings":["Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria. m-bendini@hotmail.fr","Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria. m-bendini@hotmail.fr","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072972205","display_name":"Suzanne Lesage","orcid":"https://orcid.org/0000-0003-4158-2601","observed_orcids":["https://orcid.org/0000-0003-4158-2601"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Suzanne Lesage","raw_affiliation_strings":["CNRS UMR 7225, Paris, France. suzanne.lesage@upmc.fr","The Brain and Spinal Cord Institute, 75013, Paris, France. suzanne.lesage@upmc.fr","UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France. suzanne.lesage@upmc.fr","UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 7225, Paris, France. suzanne.lesage@upmc.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"The Brain and Spinal Cord Institute, 75013, Paris, France. suzanne.lesage@upmc.fr","institution_ids":["https://openalex.org/I4210152724"]},{"raw_affiliation_string":"UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France. suzanne.lesage@upmc.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027489586","display_name":"Alexis Brice","orcid":"https://orcid.org/0000-0002-0941-3990","observed_orcids":["https://orcid.org/0000-0002-0941-3990"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexis Brice","raw_affiliation_strings":["CNRS UMR 7225, Paris, France. alexis.brice@upmc.fr","The Brain and Spinal Cord Institute, 75013, Paris, France. alexis.brice@upmc.fr","UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France. alexis.brice@upmc.fr","UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 7225, Paris, France. alexis.brice@upmc.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"The Brain and Spinal Cord Institute, 75013, Paris, France. alexis.brice@upmc.fr","institution_ids":["https://openalex.org/I4210152724"]},{"raw_affiliation_string":"UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France. alexis.brice@upmc.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290130","display_name":"Mohamed Brahim Errahmani","orcid":"https://orcid.org/0000-0003-4273-7994","observed_orcids":["https://orcid.org/0000-0003-4273-7994"]},"institutions":[{"id":"https://openalex.org/I83332908","display_name":"University of Blida","ror":"https://ror.org/03g41pw14","country_code":"DZ","type":"education","lineage":["https://openalex.org/I83332908"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Mohamed Brahim Errahmani","raw_affiliation_strings":["Department of Chemistry, Blida 1 University, BP 270, 09000, Blida, Algeria. m.brahim.errahmani@univ-blida.dz","Department of Chemistry, Blida 1 University, BP 270, 09000, Blida, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Blida 1 University, BP 270, 09000, Blida, Algeria. m.brahim.errahmani@univ-blida.dz","institution_ids":["https://openalex.org/I83332908"]},{"raw_affiliation_string":"Department of Chemistry, Blida 1 University, BP 270, 09000, Blida, Algeria","institution_ids":["https://openalex.org/I83332908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041697100","display_name":"Boualem Asselah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Boualem Asselah","raw_affiliation_strings":["Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. asselah.boualem@gmail.com","Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria. asselah.boualem@gmail.com","institution_ids":["https://openalex.org/I157169809"]},{"raw_affiliation_string":"Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5072829369"],"corresponding_institution_ids":["https://openalex.org/I157169809"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.7572,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88947661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2-g2019s-mutation","display_name":"LRRK2 G2019S mutation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/subthalamic-nucleus-deep-brain-stimulation","display_name":"subthalamic nucleus deep brain stimulation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/parkin-mutations","display_name":"parkin mutations","score":0.6349999904632568},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hoehn-and-yahr-stage","display_name":"Hoehn and Yahr stage","score":0.6370000243186951},{"id":"https://openalex.org/keywords/algerian-patients","display_name":"Algerian patients","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.8821467161178589},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.7553654909133911},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.6994184255599976},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.6675319075584412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5446265935897827},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5342504382133484},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.4880038797855377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4795891344547272},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.46055662631988525},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38052964210510254},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35354524850845337},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35077032446861267},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2246210277080536},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.09260725975036621},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020531","descriptor_name":"Subthalamic Nucleus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12868-016-0240-4","doi":"https://doi.org/10.1186/s12868-016-0240-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12868-016-0240-4","pdf_url":"https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/s12868-016-0240-4","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4736184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4736184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neurosci","raw_type":"Text"},{"id":"pmid:26831335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26831335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01281654v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-01281654","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Neuroscience, 2016, 17 (1), pp.6. ⟨10.1186/s12868-016-0240-4⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/n6gsm-5y725","doi":"https://doi.org/10.60692/n6gsm-5y725","is_oa":true,"landing_page_url":"https://doi.org/10.60692/n6gsm-5y725","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/vjcww-qdj12","doi":"https://doi.org/10.60692/vjcww-qdj12","is_oa":true,"landing_page_url":"https://doi.org/10.60692/vjcww-qdj12","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12868-016-0240-4","doi":"https://doi.org/10.1186/s12868-016-0240-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12868-016-0240-4","pdf_url":"https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/s12868-016-0240-4","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2265056599.pdf","grobid_xml":"https://content.openalex.org/works/W2265056599.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1558427337","https://openalex.org/W1562470756","https://openalex.org/W1571436096","https://openalex.org/W1877873625","https://openalex.org/W1966618111","https://openalex.org/W1984530097","https://openalex.org/W1989153256","https://openalex.org/W1996947678","https://openalex.org/W2006851801","https://openalex.org/W2008686569","https://openalex.org/W2008886854","https://openalex.org/W2030594607","https://openalex.org/W2046910164","https://openalex.org/W2053727139","https://openalex.org/W2055159698","https://openalex.org/W2057135238","https://openalex.org/W2060424239","https://openalex.org/W2063127941","https://openalex.org/W2070881103","https://openalex.org/W2078493209","https://openalex.org/W2083040522","https://openalex.org/W2084553926","https://openalex.org/W2087109317","https://openalex.org/W2095270577","https://openalex.org/W2095728095","https://openalex.org/W2098152756","https://openalex.org/W2099251008","https://openalex.org/W2100300726","https://openalex.org/W2103749983","https://openalex.org/W2110028237","https://openalex.org/W2117335809","https://openalex.org/W2123052357","https://openalex.org/W2126201966","https://openalex.org/W2126974680","https://openalex.org/W2127078504","https://openalex.org/W2134886133","https://openalex.org/W2144016274","https://openalex.org/W2148051178","https://openalex.org/W2152069319","https://openalex.org/W2168172814","https://openalex.org/W2171700030","https://openalex.org/W2317804643","https://openalex.org/W2397833141","https://openalex.org/W2401500688","https://openalex.org/W2972597017","https://openalex.org/W4205816194","https://openalex.org/W4244530412"],"related_works":["https://openalex.org/W2070881103","https://openalex.org/W4389441325","https://openalex.org/W2078493209","https://openalex.org/W4315651059","https://openalex.org/W4409839026","https://openalex.org/W3213938024","https://openalex.org/W4416070956","https://openalex.org/W9965294","https://openalex.org/W2913028043","https://openalex.org/W2071853843"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bilateral":[1],"subthalamic":[2],"nucleus":[3],"deep":[4],"brain":[5],"stimulation":[6,225,303],"(STN-DBS)":[7],"of":[8,29,46,54,70,92,122,141,146,212,224,235,262,276,302,316],"parkinson's":[9,215],"disease":[10,216],"(PD)":[11],"patients":[12,73,136,148,178,231,248,280,321],"has":[13,40,338],"demonstrated":[14,272],"to":[15,20,50,114,153,182,245],"improve":[16],"motor":[17,213],"performance":[18],"and":[19,31,89,103,133,168,176,203,259,267,288,292,306],"reduce":[21],"dopa-induced":[22],"dyskinesia.":[23],"An":[24],"association":[25,161],"between":[26,164],"the":[27,52,55,62,67,86,116,154,165,169,229,240,246,257,286,296,313,323],"occurrence":[28],"dyskinesias":[30],"LRRK2":[32,344],"(leucine-rich":[33],"repeat":[34],"kinase":[35],"2)":[36],"G2019S":[37,56,99,166,345],"gene":[38],"mutations":[39,196],"recently":[41],"been":[42],"suggested.":[43],"The":[44,128,144,207,251],"aim":[45],"this":[47,310],"study":[48,84,332],"is":[49],"discover":[51],"impact":[53,342],"mutation":[57,100,167,325],"(with":[58],"high":[59],"incidence":[60],"in":[61,72,221,228,299],"authors'":[63],"native":[64],"Algeria)":[65],"on":[66,158,343,348],"symptom":[68],"response":[69],"PD":[71,95,135],"who":[74,197],"underwent":[75,328],"STN-DBS.":[76],"METHODS:":[77],"We":[78],"carried":[79],"out":[80],"a":[81,199,222,233,273,300,339],"comparative":[82],"statistical":[83],"for":[85,256,278,282,304,320],"clinical":[87,142,155],"evaluation":[88],"neuropsychological":[90],"assessment":[91],"27":[93],"Algerian":[94],"STN-DBS":[96],"patients,":[97,189],"both":[98],"carriers":[101],"(MC)":[102],"non-carriers":[104],"(NC).":[105],"A":[106],"multiple":[107],"correspondence":[108],"analysis":[109],"(MCA)":[110],"was":[111,162,254],"then":[112],"conducted":[113],"compare":[115],"results":[117,208],"with":[118,124,194,232,322],"those":[119],"from":[120],"groups":[121],"individuals":[123],"similar":[125],"modalities.":[126],"RESULTS:":[127],"MCA":[129],"revealed":[130],"that":[131,334],"MC":[132,177,230,279,305,346],"NC":[134,185,188,247,283,307],"showed":[137,149,209,295],"two":[138,192],"different":[139,200,204],"patterns":[140],"evaluations.":[143],"group":[145],"idiopathic":[147,349],"some":[150],"differences":[151],"compared":[152,244],"evaluations,":[156],"depending":[157],"gender.":[159],"No":[160],"found":[163,191],"Mini":[170],"Mental":[171],"State":[172],"Examination":[173],"scores":[174,315],"(MMSE),":[175],"appeared":[179],"more":[180,340],"susceptible":[181],"dyskinesia":[183],"than":[184,281,347],"patients.":[186,284,308,350],"In":[187,309],"we":[190],"cases":[193],"Parkin":[195,324],"had":[198],"\"honeymoon\"":[201],"period":[202],"initial":[205],"symptoms.":[206],"considerable":[210],"improvement":[211,236],"unified":[214],"rating":[217],"scale":[218,265,290],"III":[219],"(UPDRS-III)":[220],"situation":[223,301],"without":[226],"medication":[227],"percentage":[234],"(51.1":[237],"%)":[238],"over":[239],"required":[241],"30":[242],"%":[243],"(25.5":[249],"%).":[250],"same":[252,297],"result":[253],"observed":[255,319],"Schwab":[258],"England's":[260],"activities":[261],"daily":[263],"living":[264],"(S":[266],"E":[268],"scale),":[269],"which":[270],"thus":[271],"greater":[274],"effectiveness":[275],"DBS":[277],"However,":[285],"Hoehn":[287],"Yahr":[289],"(H":[291],"Y":[293],"Scale)":[294],"significance":[298],"later":[311],"group,":[312],"best":[314],"UPDRS-III":[317],"were":[318],"before":[326],"they":[327],"surgery.":[329],"CONCLUSIONS:":[330],"This":[331],"shows":[333],"surgical":[335],"treatment":[336],"probably":[337],"significant":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}