{"id":"https://openalex.org/W2264831747","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","title":"High fat feeding causes insulin resistance and stimulates an increase in mitochondrial content and function in rat skeletal muscle","display_name":"High fat feeding causes insulin resistance and stimulates an increase in mitochondrial content and function in rat skeletal muscle","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2264831747","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","mag":"2264831747"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.1164.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040214380","display_name":"Chad R. Hancock","orcid":"https://orcid.org/0000-0002-1578-5301","observed_orcids":["https://orcid.org/0000-0002-1578-5301"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad R. Hancock","raw_affiliation_strings":["Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047445286","display_name":"Dong\u2010Ho Han","orcid":"https://orcid.org/0009-0009-3860-6757","observed_orcids":["https://orcid.org/0009-0009-3860-6757"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong\u2010Ho Han","raw_affiliation_strings":["Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041791973","display_name":"May W. Chen","orcid":"https://orcid.org/0000-0003-2644-1667","observed_orcids":["https://orcid.org/0000-0003-2644-1667","https://orcid.org/0000-0002-6814-9819"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May Chen","raw_affiliation_strings":["Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110123538","display_name":"John O. Holloszy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John O. Holloszy","raw_affiliation_strings":["Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Division of Applied Physiology, Washington University in St. Louis, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26680388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.2824999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9850000143051147},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7360000014305115},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-transport","display_name":"insulin-stimulated glucose transport","score":0.9229999780654907},{"id":"https://openalex.org/keywords/palmitate-oxidation","display_name":"palmitate oxidation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.6840000152587891},{"id":"https://openalex.org/keywords/epitrochlearis-muscle","display_name":"epitrochlearis muscle","score":0.9810000061988831},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8841730356216431},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.86760413646698},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.8593437671661377},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8348846435546875},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7883329391479492},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6208465695381165},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6177893877029419},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.4606165587902069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4240008592605591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4099239706993103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25325149297714233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12031194567680359}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.1164.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1164.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9185000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.7900000214576721,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2191510853","display_name":"Dietary Fat Mitochondria and Insulin Signaling","funder_award_id":"F32DK076410","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8100243051","display_name":"Carbohydrate and Fat Metabolism During Exercise","funder_award_id":"R01DK018986","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897669432","https://openalex.org/W2905127295","https://openalex.org/W2048484995","https://openalex.org/W2734604959","https://openalex.org/W2738599413","https://openalex.org/W2164141315","https://openalex.org/W1966567930","https://openalex.org/W1984105528","https://openalex.org/W1977486949","https://openalex.org/W1985904788"],"abstract_inverted_index":{"Recent":[0],"work":[1,196],"has":[2,23],"suggested":[3],"that":[4,27,42,177],"mitochondrial":[5,72,127,139,190],"deficiency":[6,191],"and":[7,18,74,98,103,106,112,118,163,169,202],"dysfunction":[8],"in":[9,16,35,38,93,126,135,144,153,167,192],"skeletal":[10,193],"muscle":[11,39,71,158,166],"causes":[12,51],"the":[13,45,62,154,178],"insulin":[14,52,75,86,179],"resistance":[15,180],"obesity":[17],"type":[19],"2":[20],"diabetes.":[21],"It":[22],"also":[24],"been":[25],"reported":[26],"feeding":[28,50,65,185],"high":[29,67,82,183],"fat":[30,49,68,83,184],"diets":[31,69],"to":[32,60,159],"rodents":[33],"results":[34],"a":[36,81,123,131,136,150],"decrease":[37],"mitochondria,":[40],"suggesting":[41],"this":[43,57],"is":[44,147,186,197],"mechanism":[46],"by":[47,95,108,130,149,182,189,199],"which":[48],"resistance.":[53],"The":[54],"objective":[55],"of":[56,64,80,138,156],"study":[58],"was":[59,91],"determine":[61],"effects":[63],"rats":[66],"on":[70],"biogenesis":[73,128],"responsiveness.":[76],"After":[77],"4":[78],"wk":[79],"diet,":[84],"maximal":[85],"stimulated":[87],"glucose":[88],"transport":[89],"activity":[90],"decreased":[92],"soleus":[94],"~40%":[96],"(5.9\u00b10.63":[97],"3.4\u00b10.32":[99],"\u03bcmol/ml/30min":[100],"for":[101,116],"CH":[102,117,168],"HFD,":[104,119,170],"p<0.05)":[105],"epitrochlearis":[107],"about":[109],"30%":[110],"(2.5\u00b10.20":[111],"1.8\u00b10.14":[113],"\u03bc":[114],"mol/ml/30min":[115],"p<0.05),":[120],"concomitant":[121],"with":[122],"significant":[124],"increase":[125,134,143,152],"evidenced":[129,148],"~2":[132],"fold":[133],"range":[137],"marker":[140],"proteins.":[141],"An":[142],"functional":[145],"mitochondria":[146],"~75%":[151],"capacity":[155],"triceps":[157],"oxidize":[160],"palmitate":[161],"(10.3\u00b11.8":[162],"17.8\u00b12.5":[164],"nmol/min/g":[165],"respectively,":[171],"p<0.05).":[172],"These":[173],"findings":[174],"clearly":[175],"demonstrate":[176],"induced":[181],"not":[187],"caused":[188],"muscle.":[194],"This":[195],"supported":[198],"NIH":[200],"5R01DK018986":[201],"5F32DK076410.":[203]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
