{"id":"https://openalex.org/W2264728367","doi":"https://doi.org/10.1021/acsami.5b07621","title":"Surface Modification of PMMA to Improve Adhesion to Corneal Substitutes in a Synthetic Core\u2013Skirt Keratoprosthesis","display_name":"Surface Modification of PMMA to Improve Adhesion to Corneal Substitutes in a Synthetic Core\u2013Skirt Keratoprosthesis","publication_year":2015,"publication_date":"2015-09-21","ids":{"openalex":"https://openalex.org/W2264728367","doi":"https://doi.org/10.1021/acsami.5b07621","mag":"2264728367","pmid":"https://pubmed.ncbi.nlm.nih.gov/26389670"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.5b07621","doi":"https://doi.org/10.1021/acsami.5b07621","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.5b07621","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsami.5b07621","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039713061","display_name":"Andri K. Riau","orcid":"https://orcid.org/0000-0002-5105-0484","observed_orcids":["https://orcid.org/0000-0002-5105-0484"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Andri K. Riau","raw_affiliation_strings":["Nanyang Technological University , , ,","Singapore Eye Research Institute , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanyang Technological University , , ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore Eye Research Institute , , ,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101523035","display_name":"Debasish Mondal","orcid":"https://orcid.org/0000-0001-9849-5475","observed_orcids":["https://orcid.org/0000-0001-9849-5475"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Debasish Mondal","raw_affiliation_strings":["Singapore Eye Research Institute , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute , , ,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025602559","display_name":"Gary Hin\u2010Fai Yam","orcid":"https://orcid.org/0000-0002-8445-3669","observed_orcids":["https://orcid.org/0000-0002-8445-3669"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gary H. F. Yam","raw_affiliation_strings":["Singapore Eye Research Institute , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute , , ,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071707026","display_name":"Melina Setiawan","orcid":"https://orcid.org/0000-0003-3977-5391","observed_orcids":["https://orcid.org/0000-0003-3977-5391"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Melina Setiawan","raw_affiliation_strings":["Singapore Eye Research Institute , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute , , ,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090004184","display_name":"Bo Liedberg","orcid":"https://orcid.org/0000-0003-2883-6953","observed_orcids":["https://orcid.org/0000-0003-2883-6953"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bo Liedberg","raw_affiliation_strings":["Nanyang Technological University , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanyang Technological University , , ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043812397","display_name":"Subbu S. Venkatraman","orcid":"https://orcid.org/0000-0002-8693-1070","observed_orcids":["https://orcid.org/0000-0002-8693-1070"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Subbu S. Venkatraman","raw_affiliation_strings":["Nanyang Technological University , , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanyang Technological University , , ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050145910","display_name":"Jodhbir Singh Mehta","orcid":"https://orcid.org/0000-0001-6362-4898","observed_orcids":["https://orcid.org/0000-0001-6362-4898"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Jodhbir S. Mehta","raw_affiliation_strings":["Duke-NUS Graduate Medical School , , ,","Nanyang Technological University , , ,","Singapore Eye Research Institute , , ,","Singapore National Eye Center , ,","Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","Singapore National Eye Center, Singapore 168751, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke-NUS Graduate Medical School , , ,","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Nanyang Technological University , , ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore Eye Research Institute , , ,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore National Eye Center , ,","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore 637553, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 168751, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043812397","https://openalex.org/A5050145910"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I2799299286","https://openalex.org/I4210116917","https://openalex.org/I4210126319"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.928,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.94940745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"7","issue":"39","first_page":"21690","last_page":"21702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratoprosthesis","display_name":"keratoprosthesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/corneal-substitutes","display_name":"corneal substitutes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/interfacial-adhesion","display_name":"interfacial adhesion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/oxygen-plasma-treatment","display_name":"oxygen plasma treatment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/calcium-phosphate-coatings","display_name":"calcium phosphate coatings","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dopamine-coating","display_name":"dopamine coating","score":0.8109999895095825},{"id":"https://openalex.org/keywords/3-aminopropyltriethoxysilane","display_name":"3-aminopropyltriethoxysilane","score":0.9480000138282776},{"id":"https://openalex.org/keywords/type-i-collagen-gel","display_name":"type I collagen gel","score":0.9729999899864197},{"id":"https://openalex.org/keywords/corneal-stromal-fibroblasts","display_name":"corneal stromal fibroblasts","score":0.8949999809265137},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8360000252723694},{"id":"https://openalex.org/keywords/device-extrusion","display_name":"device extrusion","score":0.6620000004768372},{"id":"https://openalex.org/keywords/corneal-disease","display_name":"corneal disease","score":0.6499999761581421},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2776053893","wikidata":"https://www.wikidata.org/wiki/Q6393649","display_name":"Keratoprosthesis","level":3,"score":0.9095266461372375},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.8504804968833923},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6397668123245239},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.5692564249038696},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.5253188610076904},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39731118083000183},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.34635430574417114},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.30288058519363403},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.28577494621276855},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.27980005741119385},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.19787883758544922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07396551966667175},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019904","descriptor_name":"Polymethyl Methacrylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.5b07621","doi":"https://doi.org/10.1021/acsami.5b07621","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.5b07621","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},{"id":"pmid:26389670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26389670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsami.5b07621","doi":"https://doi.org/10.1021/acsami.5b07621","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.5b07621","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5402150547","display_name":null,"funder_award_id":"NMRC/TCR/008-SERI/2013","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W147102784","https://openalex.org/W395980133","https://openalex.org/W1926284833","https://openalex.org/W1937407245","https://openalex.org/W1963816790","https://openalex.org/W1978450925","https://openalex.org/W1979811693","https://openalex.org/W1985507853","https://openalex.org/W1986298749","https://openalex.org/W1996156679","https://openalex.org/W2001566575","https://openalex.org/W2006473410","https://openalex.org/W2009416595","https://openalex.org/W2016496198","https://openalex.org/W2019381875","https://openalex.org/W2019842452","https://openalex.org/W2037520688","https://openalex.org/W2042343633","https://openalex.org/W2044334748","https://openalex.org/W2045636658","https://openalex.org/W2045880909","https://openalex.org/W2054152044","https://openalex.org/W2060524088","https://openalex.org/W2063261010","https://openalex.org/W2071482010","https://openalex.org/W2073826009","https://openalex.org/W2086700602","https://openalex.org/W2090099489","https://openalex.org/W2096912978","https://openalex.org/W2099108227","https://openalex.org/W2100696739","https://openalex.org/W2103272211","https://openalex.org/W2122104511","https://openalex.org/W2123215356","https://openalex.org/W2138431756","https://openalex.org/W2147222910","https://openalex.org/W2152635187","https://openalex.org/W2153289002","https://openalex.org/W2313939158","https://openalex.org/W4238452231"],"related_works":["https://openalex.org/W2624649181","https://openalex.org/W2761473298","https://openalex.org/W3002614969","https://openalex.org/W2988294803","https://openalex.org/W2999028350","https://openalex.org/W1997683161","https://openalex.org/W2412566271","https://openalex.org/W4408330845","https://openalex.org/W2923856412","https://openalex.org/W2908356591"],"abstract_inverted_index":{"Patients":[0],"with":[1,7,113,161],"advanced":[2],"corneal":[3,9,53,254],"disease":[4],"do":[5],"poorly":[6],"conventional":[8],"transplantation":[10],"and":[11,35,50,60,69,78,124,180,198,221,290,292,303],"require":[12],"a":[13,36,118],"keratoprosthesis":[14],"(KPro)":[15],"for":[16,57,258],"visual":[17],"rehabilitation.":[18],"The":[19,63,153],"most":[20],"widely":[21],"used":[22],"KPro":[23,120],"is":[24,55],"constructed":[25,123],"using":[26,89],"poly(methyl":[27],"methacrylate)":[28],"(PMMA)":[29],"in":[30,203,239],"the":[31,48,51,67,70,86,134,157,162,189,259,283,307,313],"central":[32],"optical":[33],"core":[34],"donor":[37],"cornea":[38],"as":[39],"skirt":[40],"material.":[41],"In":[42,81,230,272,296],"many":[43],"cases,":[44],"poor":[45],"adherence":[46],"between":[47,66],"PMMA":[49,71,87,136,149,314],"soft":[52],"tissue":[54,68],"responsible":[56],"device":[58,79],"\"extrusion\"":[59],"bacterial":[61],"infiltration.":[62],"interfacial":[64,143,159],"adhesion":[65,144,160,190,217,235,287,308],"was":[72,191,237],"therefore":[73],"critical":[74],"to":[75,147,216,252,306],"successful":[76],"implantation":[77],"longevity.":[80],"our":[82],"approach,":[83],"we":[84,122],"modified":[85,135],"surface":[88,248,277,315],"oxygen":[90],"plasma":[91,94,109,181],"(plasma":[92],"group);":[93],"followed":[95,103,110,168],"by":[96,104,111,169,193,282],"calcium":[97],"phosphate":[98,204],"(CaP)":[99],"coating":[100,106,112],"(p-CaP);":[101],"dopamine":[102],"CaP":[105],"(d-CaP);":[107],"or":[108],"(3-aminopropyl)triethoxysilane":[114],"(3-APTES).":[115],"To":[116],"create":[117],"synthetic":[119],"model,":[121],"attached":[125],"500":[126],"\u03bcm":[127],"thick":[128],"collagen":[129,310],"type":[130],"I":[131],"hydrogel":[132,163,311],"on":[133,275,312],"surfaces.":[137],"Surface":[138],"modifications":[139],"produced":[140],"significantly":[141],"improved":[142],"strength":[145,236],"compared":[146,215],"untreated":[148],"(p":[150,212,226,244],"<":[151,245],"0.001).":[152,246],"p-CaP":[154,240],"group":[155,241],"yielded":[156,207],"best":[158],"(177":[164],"\u00b1":[165,172,177,183,209,223],"27":[166],"mN/cm(2))":[167],"d-CaP":[170,276,298],"(168":[171],"31":[173],"mN/cm(2)),":[174,179],"3-APTES":[175,260],"(145":[176],"12":[178],"(119":[182],"10":[184],"mN/cm(2)).":[185],"Longer-term":[186],"stability":[187,305],"of":[188,201,234,270,285,309],"achieved":[192],"d-CaP,":[194],"which,":[195],"after":[196],"14":[197],"28":[199],"days":[200],"incubation":[202],"buffered":[205],"saline,":[206],"164":[208],"25":[210],"mN/cm(2)":[211,225],"=":[213,227],"0.906":[214],"at":[218,267],"day":[219],"1)":[220],"131":[222],"20":[224],"0.053),":[228],"respectively.":[229],"contrast,":[231,273],"significant":[232],"reduction":[233],"observed":[238],"over":[242],"time":[243],"All":[247],"coatings":[249],"were":[250],"biocompatible":[251],"human":[253],"stromal":[255],"fibroblasts,":[256],"except":[257],"group,":[261],"which":[262],"showed":[263,278],"no":[264],"live":[265],"cells":[266,274],"72":[268],"h":[269],"culture.":[271],"good":[279],"anchorage,":[280],"evidenced":[281],"expression":[284],"focal":[286],"complex":[288],"(paxillin":[289],"vinculin),":[291],"prominent":[293],"filopodia":[294],"protrusions.":[295],"conclusion,":[297],"can":[299],"not":[300],"only":[301],"enhance":[302],"provide":[304],"but":[316],"also":[317],"promote":[318],"biointegration.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}