{"id":"https://openalex.org/W2264451972","doi":"https://doi.org/10.1038/tp.2015.210","title":"Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function","display_name":"Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function","publication_year":2016,"publication_date":"2016-01-19","ids":{"openalex":"https://openalex.org/W2264451972","doi":"https://doi.org/10.1038/tp.2015.210","mag":"2264451972","pmid":"https://pubmed.ncbi.nlm.nih.gov/26784970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5068883"},"language":"en","primary_location":{"id":"doi:10.1038/tp.2015.210","doi":"https://doi.org/10.1038/tp.2015.210","is_oa":true,"landing_page_url":"https://doi.org/10.1038/tp.2015.210","pdf_url":"https://www.nature.com/articles/tp2015210.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/tp2015210.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070303969","display_name":"Sarah A. Sparrow","orcid":"https://orcid.org/0000-0002-5017-5429","observed_orcids":["https://orcid.org/0000-0002-5017-5429"]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Sparrow","raw_affiliation_strings":["MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016442507","display_name":"Jonathan R. Manning","orcid":"https://orcid.org/0000-0002-3483-8456","observed_orcids":["https://orcid.org/0000-0002-3483-8456"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J R Manning","raw_affiliation_strings":["MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210108209","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011517077","display_name":"Jessy Cartier","orcid":"https://orcid.org/0000-0002-0366-8546","observed_orcids":["https://orcid.org/0000-0002-0366-8546"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Cartier","raw_affiliation_strings":["University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022450579","display_name":"Devasuda Anblagan","orcid":"https://orcid.org/0000-0003-3123-4638","observed_orcids":["https://orcid.org/0000-0003-3123-4638"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Anblagan","raw_affiliation_strings":["Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034776089","display_name":"Mark E. Bastin","orcid":"https://orcid.org/0000-0002-0490-0845","observed_orcids":["https://orcid.org/0000-0002-0490-0845"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M E Bastin","raw_affiliation_strings":["Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044795879","display_name":"Chinthika Piyasena","orcid":"https://orcid.org/0000-0001-6286-0629","observed_orcids":["https://orcid.org/0000-0001-6286-0629"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Piyasena","raw_affiliation_strings":["University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108233453","display_name":"Rozalia Pataky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Pataky","raw_affiliation_strings":["MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011937060","display_name":"Emma J. Moore","orcid":"https://orcid.org/0000-0003-0868-6804","observed_orcids":["https://orcid.org/0000-0003-0868-6804"]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E J Moore","raw_affiliation_strings":["MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037866505","display_name":"S I Semple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S I Semple","raw_affiliation_strings":["Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042105047","display_name":"A. Graham Wilkinson","orcid":"https://orcid.org/0000-0001-8518-3704","observed_orcids":["https://orcid.org/0000-0001-8518-3704"]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A G Wilkinson","raw_affiliation_strings":["Department of Radiology, NHS Lothian, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, NHS Lothian, Edinburgh, UK","institution_ids":["https://openalex.org/I1324252669"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Evans","raw_affiliation_strings":["Department of Pathology, NHS Lothian, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, NHS Lothian, Edinburgh, UK","institution_ids":["https://openalex.org/I1324252669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046495186","display_name":"Amanda Jane Drake","orcid":"https://orcid.org/0000-0001-8633-333X","observed_orcids":["https://orcid.org/0000-0001-8633-333X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A J Drake","raw_affiliation_strings":["University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055721719","display_name":"James P. Boardman","orcid":"https://orcid.org/0000-0003-3904-8960","observed_orcids":["https://orcid.org/0000-0003-3904-8960"]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J P Boardman","raw_affiliation_strings":["Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055721719"],"corresponding_institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":4.097,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.95144185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"e716","last_page":"e716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.1738000065088272,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.05570000037550926,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/epigenome","display_name":"epigenome","score":0.6510000228881836},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7559999823570251},{"id":"https://openalex.org/keywords/neural-development","display_name":"neural development","score":0.6129999756813049},{"id":"https://openalex.org/keywords/corticospinal-tract","display_name":"corticospinal tract","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/white-matter-tracts","display_name":"white matter tracts","score":0.6119999885559082},{"id":"https://openalex.org/keywords/differential-methylation","display_name":"differential methylation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/early-life-stress","display_name":"early life stress","score":0.6899999976158142},{"id":"https://openalex.org/keywords/preterm-brain-injury","display_name":"preterm brain injury","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5580000281333923},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2775921022","wikidata":"https://www.wikidata.org/wiki/Q25104749","display_name":"dNaM","level":5,"score":0.9328622221946716},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7346175312995911},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.5123168230056763},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5096468925476074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.462799996137619},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.45127007365226746},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.415755033493042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.370805948972702},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3422958254814148},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.3096298575401306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2712573707103729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23313093185424805},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.16755878925323486},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09114408493041992},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/tp.2015.210","doi":"https://doi.org/10.1038/tp.2015.210","is_oa":true,"landing_page_url":"https://doi.org/10.1038/tp.2015.210","pdf_url":"https://www.nature.com/articles/tp2015210.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4023396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5068883","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5068883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5068883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:26784970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26784970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:publications/55c7a72e-2e29-43d9-80fb-ef4d6140e966","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11820/55c7a72e-2e29-43d9-80fb-ef4d6140e966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sparrow, S, Manning, J, Cartier, J, Anblagan, D, Bastin, M, Piyasena, C, Pataky, R, Moore, E J, Semple, S I, Wilkinson, A, Evans, M, Drake, A J & Boardman, J P 2016, 'Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function', Translational Psychiatry. https://doi.org/10.1038/tp.2015.210","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"mag:2626880719","doi":null,"is_oa":false,"landing_page_url":"https://www.research.ed.ac.uk/portal/files/23712809/tp2015210a.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1038/tp.2015.210","doi":"https://doi.org/10.1038/tp.2015.210","is_oa":true,"landing_page_url":"https://doi.org/10.1038/tp.2015.210","pdf_url":"https://www.nature.com/articles/tp2015210.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1394528540","display_name":"Centre for Cognitive Ageing &amp; Cognitive Epidemiology","funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7149438675","display_name":"MRC Centre for Reproductive Health at the University of Edinburgh","funder_award_id":"MR/N022556/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7570783540","display_name":null,"funder_award_id":"SCD/09","funder_id":"https://openalex.org/F4320320064","funder_display_name":"Scottish Funding Council"}],"funders":[{"id":"https://openalex.org/F4320320064","display_name":"Scottish Funding Council","ror":"https://ror.org/056bwcz71"},{"id":"https://openalex.org/F4320320332","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2264451972.pdf","grobid_xml":"https://content.openalex.org/works/W2264451972.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W66934669","https://openalex.org/W1506411903","https://openalex.org/W1512446190","https://openalex.org/W1546952499","https://openalex.org/W1556848471","https://openalex.org/W1965155154","https://openalex.org/W1969409842","https://openalex.org/W1975446567","https://openalex.org/W1975528145","https://openalex.org/W1981396719","https://openalex.org/W1982232439","https://openalex.org/W1982301384","https://openalex.org/W1982825561","https://openalex.org/W1987180785","https://openalex.org/W1991090438","https://openalex.org/W1991793211","https://openalex.org/W1997796525","https://openalex.org/W2000547934","https://openalex.org/W2010390756","https://openalex.org/W2019347164","https://openalex.org/W2027053612","https://openalex.org/W2028303382","https://openalex.org/W2035317753","https://openalex.org/W2039214507","https://openalex.org/W2039341072","https://openalex.org/W2046155613","https://openalex.org/W2051201617","https://openalex.org/W2052689749","https://openalex.org/W2054485625","https://openalex.org/W2057562617","https://openalex.org/W2065700236","https://openalex.org/W2065834493","https://openalex.org/W2066696364","https://openalex.org/W2067136906","https://openalex.org/W2076644905","https://openalex.org/W2079141380","https://openalex.org/W2081502106","https://openalex.org/W2082145187","https://openalex.org/W2085926540","https://openalex.org/W2092363037","https://openalex.org/W2094005621","https://openalex.org/W2105009603","https://openalex.org/W2105365140","https://openalex.org/W2105787734","https://openalex.org/W2106685029","https://openalex.org/W2106976893","https://openalex.org/W2107466646","https://openalex.org/W2107665951","https://openalex.org/W2108596329","https://openalex.org/W2111554792","https://openalex.org/W2111606353","https://openalex.org/W2112280040","https://openalex.org/W2113996138","https://openalex.org/W2114101267","https://openalex.org/W2118382560","https://openalex.org/W2118802114","https://openalex.org/W2119290186","https://openalex.org/W2121297038","https://openalex.org/W2121734518","https://openalex.org/W2122363306","https://openalex.org/W2123497401","https://openalex.org/W2127431419","https://openalex.org/W2130178715","https://openalex.org/W2134083124","https://openalex.org/W2141267676","https://openalex.org/W2148044501","https://openalex.org/W2148747955","https://openalex.org/W2151085630","https://openalex.org/W2164748311","https://openalex.org/W2169516812","https://openalex.org/W2170861221","https://openalex.org/W2171251197","https://openalex.org/W2171808656","https://openalex.org/W2324335241"],"related_works":["https://openalex.org/W2626880719","https://openalex.org/W4214930963","https://openalex.org/W3093039530","https://openalex.org/W6925316086","https://openalex.org/W3197968099","https://openalex.org/W2887779421","https://openalex.org/W4281761809","https://openalex.org/W7163786163","https://openalex.org/W3112910447","https://openalex.org/W2564990978"],"abstract_inverted_index":{"DNA":[0,69],"methylation":[1,139,224],"(DNAm)":[2],"plays":[3],"a":[4,13,25,84],"determining":[5],"role":[6],"in":[7,35,67,136,152,166,178,180,212],"neural":[8,38,162,219],"cell":[9],"fate":[10],"and":[11,19,40,57,59,78,83,108,113,131,146,195,197,221],"provides":[12],"molecular":[14],"link":[15],"between":[16,54],"early-life":[17],"stress":[18],"neuropsychiatric":[20,42],"disease.":[21],"Preterm":[22,206],"birth":[23,56,207],"is":[24,30,208],"profound":[26],"environmental":[27],"stressor":[28],"that":[29,63,217],"closely":[31],"associated":[32,191,201,209],"with":[33,156,171,192,202,210],"alterations":[34,211],"connectivity":[36],"of":[37,46,87,128,149,159,175,237],"systems":[39],"long-term":[41],"impairment.":[43],"The":[44,103],"aims":[45],"this":[47],"study":[48],"were":[49,97,106,116,169],"to":[50,60,65,124,134],"examine":[51],"the":[52,100,126,167,176,203,213,234],"relationship":[53],"preterm":[55,73,101,153,181,238],"DNAm,":[58],"investigate":[61,125],"factors":[62],"contribute":[64],"variance":[66,135,177],"DNAm.":[68,137],"was":[70,89,122,140,183],"collected":[71],"from":[72,99],"infants":[74,154,182],"(birth<33":[75],"weeks":[76],"gestation)":[77],"healthy":[79],"controls":[80],"(birth>37":[81],"weeks),":[82],"genome-wide":[85],"analysis":[86,121,225],"DNAm":[88,179],"performed;":[90],"diffusion":[91],"magnetic":[92],"resonance":[93],"imaging":[94],"(dMRI)":[95],"data":[96],"acquired":[98],"group.":[102],"major":[104],"fasciculi":[105],"segmented,":[107],"fractional":[109],"anisotropy,":[110],"mean":[111],"diffusivity":[112],"tract":[114,189],"shape":[115,190],"calculated.":[117],"Principal":[118],"components":[119],"(PC)":[120],"used":[123],"contribution":[127],"MRI":[129],"features":[130],"clinical":[132],"variables":[133],"Differential":[138,223],"found":[141],"within":[142],"25":[143],"gene":[144],"bodies":[145],"58":[147],"promoters":[148],"protein-coding":[150],"genes":[151,231],"compared":[155],"controls;":[157],"10":[158],"these":[160],"have":[161],"functions.":[163],"Differences":[164],"detected":[165],"array":[168],"validated":[170],"pyrosequencing.":[172],"Ninety-five":[173],"percent":[174],"explained":[184],"by":[185],"23":[186],"PCs;":[187],"corticospinal":[188],"6th":[193],"PC,":[194],"gender":[196],"early":[198],"nutritional":[199],"exposure":[200],"7th":[204],"PC.":[205],"methylome":[214],"at":[215],"sites":[216],"influence":[218],"development":[220],"function.":[222],"has":[226],"identified":[227],"several":[228],"promising":[229],"candidate":[230],"for":[232],"understanding":[233],"genetic/epigenetic":[235],"basis":[236],"brain":[239],"injury.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}