{"id":"https://openalex.org/W2263993883","doi":null,"title":"Melatonin enhances the expression of \u03b2-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice.","display_name":"Melatonin enhances the expression of \u03b2-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice.","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2263993883","mag":"2263993883","pmid":"https://pubmed.ncbi.nlm.nih.gov/19536438"},"language":"en","primary_location":{"id":"pmid:19536438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19536438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053367486","display_name":"\u9b4f\u4e49\u660e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Ming Wei","raw_affiliation_strings":["Department of Pharmacology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081874661","display_name":"\u8bb8\u76c8","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049212149","display_name":"\u4fde\u660c\u559c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang-Xi Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072129670","display_name":"\u97e9\u9759","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"61","issue":"3","first_page":"255","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.20229999721050262,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.925000011920929},{"id":"https://openalex.org/keywords/morphine-dependence","display_name":"morphine dependence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/naloxone-precipitated-withdrawal","display_name":"naloxone-precipitated withdrawal","score":0.9649999737739563},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.7940000295639038},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2732682228088379}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19536438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19536438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:2263993883","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90118X/200903/30810849.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555152","display_name":"\u751f\u7406\u5b66\u62a5","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7406\u5b66\u62a5","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W130689122","https://openalex.org/W1522048223","https://openalex.org/W1541441850","https://openalex.org/W1592304224","https://openalex.org/W1961859882","https://openalex.org/W1964759272","https://openalex.org/W1972531496","https://openalex.org/W1979241736","https://openalex.org/W1981891173","https://openalex.org/W1995409766","https://openalex.org/W2015046028","https://openalex.org/W2027874257","https://openalex.org/W2030926480","https://openalex.org/W2035308328","https://openalex.org/W2044305686","https://openalex.org/W2046090937","https://openalex.org/W2048528776","https://openalex.org/W2049985521","https://openalex.org/W2054271073","https://openalex.org/W2055873275","https://openalex.org/W2070530252","https://openalex.org/W2076120938","https://openalex.org/W2091889937","https://openalex.org/W2130711954","https://openalex.org/W2133712775","https://openalex.org/W2134699121","https://openalex.org/W2169938627","https://openalex.org/W2225426441","https://openalex.org/W2357163967","https://openalex.org/W2360111993","https://openalex.org/W2373818457","https://openalex.org/W2415980510"],"related_works":["https://openalex.org/W2509674057","https://openalex.org/W806747203","https://openalex.org/W303364492","https://openalex.org/W2377758849","https://openalex.org/W976582240","https://openalex.org/W974042133","https://openalex.org/W969854253","https://openalex.org/W1011384626","https://openalex.org/W2415036552","https://openalex.org/W825615676"],"abstract_inverted_index":{"The":[0,87,123],"study":[1],"was":[2,69,92],"conducted":[3],"to":[4,95,178,183],"investigate":[5],"the":[6,12,18,84,96,100,106,132,144,151,165,179,185],"effect":[7],"of":[8,14,23,29,49,89,108,146,153,167,171,181,187],"melatonin":[9],"(MEL)":[10],"on":[11,83],"expression":[13,152,166],"\u03b2-endorphin":[15],"(\u03b2-EP)":[16],"in":[17,114,136,156,169],"hypothalamic":[19],"arcuate":[20],"nucleus":[21],"(ARH)":[22],"morphine-dependent":[24,137,172],"mice.":[25],"For":[26],"a":[27],"period":[28],"8":[30],"consecutive":[31],"days,":[32],"male":[33],"Kunming":[34],"strain":[35],"mice":[36,138],"were":[37,116],"injected":[38],"subcutaneously":[39],"(s.c.)":[40],"with":[41,54],"normal":[42],"saline":[43],"or":[44,58,61],"increasing":[45],"doses":[46],"(10-80":[47],"mg/kg)":[48,60,130],"morphine,":[50],"and":[51,99,110,120,149],"intraperitoneally":[52],"(i.p.)":[53],"MEL":[55,127,142,163,182],"(10,":[56],"20":[57,129],"40":[59],"vehicle":[62],"(5%":[63],"ethanol":[64],"saline)":[65],"simultaneously.":[66],"Withdrawal":[67],"response":[68,91],"induced":[70],"by":[71,118],"naloxone":[72],"(3":[73],"mg/kg,":[74],"s.c.)":[75],"at":[76],"2":[77],"h":[78],"after":[79],"final":[80],"morphine":[81,188],"injection":[82],"8th":[85],"day.":[86],"potency":[88],"withdrawal":[90,134],"evaluated":[93],"according":[94],"jumping":[97],"times":[98],"body":[101],"weight":[102],"loss.":[103],"After":[104],"that,":[105],"expressions":[107],"\u03b2-EP":[109,168],"proopiomelanocortin":[111],"(POMC)":[112],"mRNA":[113,155],"ARH":[115,157,170],"examined":[117],"immunohistochemistry":[119],"RT-PCR,":[121],"respectively.":[122],"results":[124,160],"showed":[125],"that":[126,162],"(i.p.,":[128],"decreased":[131],"naloxone-precipitated":[133],"responses":[135],"significantly":[139],"(P<0.05).":[140,158],"Meanwhile,":[141],"increased":[143],"intensity":[145],"\u03b2-EP-like":[147],"immunoreactivity":[148],"enhanced":[150],"POMC":[154],"These":[159],"suggest":[161],"increases":[164],"mice,":[173],"which":[174],"may":[175],"partly":[176],"contribute":[177],"action":[180],"inhibit":[184],"development":[186],"dependence.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
