{"id":"https://openalex.org/W2263666855","doi":"https://doi.org/10.1093/clinchem/34.12.2589","title":"Escape from blockade of interfering heterophile antibodies in a two-site immunoradiometric assay for thyrotropin.","display_name":"Escape from blockade of interfering heterophile antibodies in a two-site immunoradiometric assay for thyrotropin.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2263666855","doi":"https://doi.org/10.1093/clinchem/34.12.2589","mag":"2263666855","pmid":"https://pubmed.ncbi.nlm.nih.gov/3197318"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/34.12.2589","doi":"https://doi.org/10.1093/clinchem/34.12.2589","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/34.12.2589","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046689484","display_name":"MARK H. ZWEIG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Zweig","raw_affiliation_strings":["Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Csako","raw_affiliation_strings":["Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"M Spero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Spero","raw_affiliation_strings":["Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":1.218,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83263978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"12","first_page":"2589","last_page":"2591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8629999756813049},{"id":"https://openalex.org/keywords/heterophile-antibodies","display_name":"heterophile antibodies","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunoradiometric-assay","display_name":"immunoradiometric assay","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sandwich-immunoassay","display_name":"sandwich immunoassay","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mouse-monoclonal-antibodies","display_name":"mouse monoclonal antibodies","score":0.8069999814033508},{"id":"https://openalex.org/keywords/assay-interference","display_name":"assay interference","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mouse-immunoglobulin","display_name":"mouse immunoglobulin","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777774473","wikidata":"https://www.wikidata.org/wiki/Q5747444","display_name":"Heterophile","level":3,"score":0.9275068044662476},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.8090813159942627},{"id":"https://openalex.org/C2778758028","wikidata":"https://www.wikidata.org/wiki/Q19597582","display_name":"Immunoradiometric assay","level":3,"score":0.7609203457832336},{"id":"https://openalex.org/C2776194381","wikidata":"https://www.wikidata.org/wiki/Q3965271","display_name":"Subclass","level":3,"score":0.558673620223999},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.518559992313385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46049240231513977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41797778010368347},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4091606140136719},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.40267401933670044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3756047189235687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2750146985054016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15919530391693115}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000910","descriptor_name":"Antibodies, Heterophile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/34.12.2589","doi":"https://doi.org/10.1093/clinchem/34.12.2589","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/34.12.2589","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:3197318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3197318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1953719837","https://openalex.org/W7098120482","https://openalex.org/W2412275458","https://openalex.org/W1982051540","https://openalex.org/W2268824383","https://openalex.org/W7096582915","https://openalex.org/W2315237592","https://openalex.org/W2049781720","https://openalex.org/W2406811770","https://openalex.org/W2160503070"],"abstract_inverted_index":{"Sandwich-type":[0],"immunoassays":[1],"in":[2,18,48,51,60,66,81,101],"which":[3],"mouse":[4,26,57,91],"monoclonal":[5],"antibodies":[6,16,32],"are":[7,9],"used":[8],"subject":[10],"to":[11,28],"positive":[12],"interference":[13],"by":[14,86],"heterophile":[15,31],"present":[17],"human":[19],"serum.":[20],"Manufacturers":[21],"now":[22],"customarily":[23],"add":[24],"nonspecific":[25],"immunoglobulins":[27,58,92],"absorb":[29],"the":[30,39,56,61,78,94,102],"and":[33,73,98],"eliminate":[34],"such":[35],"interference.":[36],"We":[37,75],"describe":[38],"case":[40],"of":[41,55,90,93],"a":[42,67,71],"patient":[43],"who":[44],"had":[45],"spurious":[46],"increases":[47,80],"thyrotropin":[49,82],"concentration":[50],"serum":[52],"despite":[53],"use":[54],"included":[59],"assay":[62,103],"kit.":[63],"This":[64],"resulted":[65],"puzzling":[68],"clinical":[69],"picture,":[70],"workup,":[72],"treatment.":[74],"demonstrate":[76],"that":[77],"observed":[79],"were":[83],"markedly":[84],"reduced":[85],"including":[87],"additional":[88],"amounts":[89],"appropriate":[95],"class,":[96],"subclass,":[97],"fragment":[99],"type":[100],"mixture.":[104]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}