{"id":"https://openalex.org/W2262893019","doi":null,"title":"Peptide binding to HLA-DQ2 and development of blocking agents for the treatment of celiac disease","display_name":"Peptide binding to HLA-DQ2 and development of blocking agents for the treatment of celiac disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2262893019","mag":"2262893019"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/28105","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28105","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/28105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009532777","display_name":"Elin Bergseng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elin Bergseng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009532777"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hla-dq2","display_name":"HLA-DQ2","score":1.0},{"id":"https://openalex.org/keywords/peptide-binding","display_name":"peptide binding","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.578000009059906},{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dimeric-peptides","display_name":"dimeric peptides","score":0.9520000219345093},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hla-association","display_name":"HLA association","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.7404557466506958},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6449779272079468},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4451799690723419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3765689432621002},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3390377163887024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2954319715499878},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29525214433670044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25033730268478394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19851186871528625},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1387999951839447},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08657753467559814}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/28105","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28105","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2262893019","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/28105/1/DUO_673_Bergseng.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/28105","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28105","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W74167591","https://openalex.org/W83429383","https://openalex.org/W113162970","https://openalex.org/W211488772","https://openalex.org/W323336631","https://openalex.org/W1531267945","https://openalex.org/W1543556483","https://openalex.org/W1573943305","https://openalex.org/W1592243647","https://openalex.org/W1616319761","https://openalex.org/W1734730736","https://openalex.org/W1815677039","https://openalex.org/W1845975704","https://openalex.org/W1893651774","https://openalex.org/W1912150790","https://openalex.org/W1922747558","https://openalex.org/W1934799579","https://openalex.org/W1948784018","https://openalex.org/W1963584953","https://openalex.org/W1964044302","https://openalex.org/W1966581484","https://openalex.org/W1968747919","https://openalex.org/W1970654655","https://openalex.org/W1971109432","https://openalex.org/W1973445893","https://openalex.org/W1973783918","https://openalex.org/W1975126199","https://openalex.org/W1976083764","https://openalex.org/W1977604079","https://openalex.org/W1980325666","https://openalex.org/W1982034991","https://openalex.org/W1985046231","https://openalex.org/W1986366555","https://openalex.org/W1988749499","https://openalex.org/W1989553533","https://openalex.org/W1990569913","https://openalex.org/W1991443138","https://openalex.org/W1992369970","https://openalex.org/W1997334797","https://openalex.org/W1999436383","https://openalex.org/W2000018152","https://openalex.org/W2005034078","https://openalex.org/W2007678011","https://openalex.org/W2009963809","https://openalex.org/W2012382241","https://openalex.org/W2012952808","https://openalex.org/W2013134683","https://openalex.org/W2015326650","https://openalex.org/W2016779929","https://openalex.org/W2018256463","https://openalex.org/W2018620812","https://openalex.org/W2022356764","https://openalex.org/W2023696892","https://openalex.org/W2023837593","https://openalex.org/W2025476985","https://openalex.org/W2028663182","https://openalex.org/W2028772457","https://openalex.org/W2028797913","https://openalex.org/W2030749217","https://openalex.org/W2034060373","https://openalex.org/W2034141008","https://openalex.org/W2035575908","https://openalex.org/W2035683776","https://openalex.org/W2036052530","https://openalex.org/W2038998186","https://openalex.org/W2040741541","https://openalex.org/W2040866634","https://openalex.org/W2042313682","https://openalex.org/W2042837428","https://openalex.org/W2043745393","https://openalex.org/W2044063726","https://openalex.org/W2044833878","https://openalex.org/W2046171806","https://openalex.org/W2046563727","https://openalex.org/W2047139729","https://openalex.org/W2048796508","https://openalex.org/W2048908755","https://openalex.org/W2050924395","https://openalex.org/W2053396500","https://openalex.org/W2055593452","https://openalex.org/W2059226357","https://openalex.org/W2059633299","https://openalex.org/W2059761425","https://openalex.org/W2059935861","https://openalex.org/W2060232155","https://openalex.org/W2062619192","https://openalex.org/W2063044744","https://openalex.org/W2065057152","https://openalex.org/W2066647807","https://openalex.org/W2066844508","https://openalex.org/W2069634988","https://openalex.org/W2074222872","https://openalex.org/W2077232429","https://openalex.org/W2078710292","https://openalex.org/W2078759091","https://openalex.org/W2079683856","https://openalex.org/W2080891856","https://openalex.org/W2080956086","https://openalex.org/W2082108597","https://openalex.org/W2082280734","https://openalex.org/W2085831528","https://openalex.org/W2086217304","https://openalex.org/W2086404169","https://openalex.org/W2086796885","https://openalex.org/W2087526889","https://openalex.org/W2088243030","https://openalex.org/W2090080655","https://openalex.org/W2093288045","https://openalex.org/W2093817232","https://openalex.org/W2095352046","https://openalex.org/W2095398980","https://openalex.org/W2097319034","https://openalex.org/W2097419199","https://openalex.org/W2097430118","https://openalex.org/W2097723680","https://openalex.org/W2101819134","https://openalex.org/W2102938736","https://openalex.org/W2107555364","https://openalex.org/W2109877208","https://openalex.org/W2112318391","https://openalex.org/W2112357661","https://openalex.org/W2112724457","https://openalex.org/W2113819336","https://openalex.org/W2114957284","https://openalex.org/W2115847623","https://openalex.org/W2118600639","https://openalex.org/W2119520032","https://openalex.org/W2126972494","https://openalex.org/W2128261350","https://openalex.org/W2128452798","https://openalex.org/W2131132948","https://openalex.org/W2133942458","https://openalex.org/W2134783591","https://openalex.org/W2135292334","https://openalex.org/W2140559444","https://openalex.org/W2141820146","https://openalex.org/W2145314352","https://openalex.org/W2148511724","https://openalex.org/W2150575210","https://openalex.org/W2151499881","https://openalex.org/W2151987441","https://openalex.org/W2152465823","https://openalex.org/W2152723368","https://openalex.org/W2154128794","https://openalex.org/W2158393733","https://openalex.org/W2159233913","https://openalex.org/W2159404298","https://openalex.org/W2162143225","https://openalex.org/W2162546929","https://openalex.org/W2163677425","https://openalex.org/W2165249443","https://openalex.org/W2165547934","https://openalex.org/W2168800337","https://openalex.org/W2169302366","https://openalex.org/W2171181902","https://openalex.org/W2171899699","https://openalex.org/W2171974798","https://openalex.org/W2171980652","https://openalex.org/W3035715270","https://openalex.org/W4313333826"],"related_works":["https://openalex.org/W1976706979","https://openalex.org/W1966082986","https://openalex.org/W2151499881","https://openalex.org/W1505668954","https://openalex.org/W2094306125","https://openalex.org/W2007678011","https://openalex.org/W2011968114","https://openalex.org/W1954115773","https://openalex.org/W2123617144","https://openalex.org/W2053969257"],"abstract_inverted_index":{"Celiac":[0],"disease":[1],"is":[2],"a":[3,12,81,135,147],"chronic":[4],"inflammatory":[5],"disorder":[6],"of":[7,28,34,43,80,91,101,125,129],"the":[8,26,32,40,49,99,105,151,162],"small":[9],"intestine":[10],"with":[11],"strong":[13,152],"association":[14,154],"to":[15,23,107,139,149,169,173],"HLA-DQ2.":[16],"This":[17],"thesis":[18],"focused":[19],"on":[20,98],"peptide":[21,29,50,74,116,141],"binding":[22,106],"HLA-DQ2":[24,145,170],"and":[25,53,58,68,110,118,171],"development":[27],"blockers":[30],"for":[31,73,104,123],"treatment":[33],"celiac":[35,156],"disease.":[36,157],"We":[37],"have":[38],"investigated":[39,114],"relative":[41],"contribution":[42],"each":[44],"hydrogen":[45,63,82],"bond":[46,83],"interaction":[47],"between":[48],"main":[51],"chain":[52],"MHC":[54],"residues":[55],"in":[56,84,155],"DQ2":[57,126],"our":[59],"results":[60,159],"demonstrated":[61,120,160],"that":[62,161],"bonds":[64],"at":[65],"positions":[66],"P4":[67],"P2":[69],"are":[70],"most":[71],"important":[72],"binding.":[75],"In":[76],"addition,":[77],"no":[78],"evidence":[79],"position":[85],"P1":[86],"was":[87,137],"found.":[88],"Detailed":[89],"characterization":[90],"gluten":[92,130,163],"T":[93,131,164],"cell":[94,132,165],"epitopes":[95,166],"gave":[96],"knowledge":[97],"importance":[100],"proline":[102],"spacing":[103],"DQ2.":[108],"Cyclic":[109],"dimeric":[111],"peptides":[112],"were":[113],"as":[115,146],"blockers,":[117],"we":[119],"proof-of":[121],"principle":[122],"inhibition":[124],"mediated":[127],"presentation":[128],"epitopes.":[133],"Finally,":[134],"study":[136],"performed":[138],"elucidate":[140],"determinant":[142],"selection":[143],"by":[144],"factor":[148],"explain":[150],"HLA":[153,175],"The":[158],"mainly":[167],"bind":[168],"not":[172],"other":[174],"class":[176],"II":[177],"molecules.":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
