{"id":"https://openalex.org/W2261217543","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","title":"Influence of graft innervation on neovascularization of embryonic heart tissue grafted in oculo","display_name":"Influence of graft innervation on neovascularization of embryonic heart tissue grafted in oculo","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2261217543","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","mag":"2261217543","pmid":"https://pubmed.ncbi.nlm.nih.gov/8769731"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1996.270.1.h33","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059077667","display_name":"Ronald J. Torry","orcid":"https://orcid.org/0000-0001-9875-6671","observed_orcids":["https://orcid.org/0000-0001-9875-6671"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Torry","raw_affiliation_strings":["Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050773060","display_name":"Brenda J. Rongish","orcid":"https://orcid.org/0000-0002-1559-2876","observed_orcids":["https://orcid.org/0000-0002-1559-2876"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. J. Rongish","raw_affiliation_strings":["Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113688419","display_name":"Daniel Tucker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Tucker","raw_affiliation_strings":["Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110279369","display_name":"D. R. Kostreva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. R. Kostreva","raw_affiliation_strings":["Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026800037","display_name":"Robert J. Tomanek","orcid":"https://orcid.org/0000-0002-4767-3734","observed_orcids":["https://orcid.org/0000-0002-4767-3734"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Tomanek","raw_affiliation_strings":["Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Medicine, University of Iowa, IowaCity 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":0.2893,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65321066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"270","issue":"1","first_page":"H33","last_page":"H37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3230000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3230000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sympathetic-innervation","display_name":"sympathetic innervation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/coronary-microcirculation","display_name":"coronary microcirculation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/superior-cervical-ganglionectomy","display_name":"superior cervical ganglionectomy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/sympathetic-denervation","display_name":"sympathetic denervation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/atrial-tissue","display_name":"atrial tissue","score":0.5519999861717224},{"id":"https://openalex.org/keywords/ventricular-tissue","display_name":"ventricular tissue","score":0.9959999918937683},{"id":"https://openalex.org/keywords/graft-perfusion","display_name":"graft perfusion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.7465839982032776},{"id":"https://openalex.org/C2993386320","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic innervation","level":2,"score":0.7311598062515259},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.48791810870170593},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4856668710708618},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.46830761432647705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45861390233039856},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4423271417617798},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.42851901054382324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42758601903915405},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.4232370853424072},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35013335943222046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2543977200984955},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.1883869767189026},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1996.270.1.h33","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.270.1.h33","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:8769731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8769731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1947348129","display_name":"CORONARY ANGIOGENESIS/VASCULOGENESIS REGULATION","funder_award_id":"R01HL048961","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G257460251","display_name":null,"funder_award_id":"HL-32295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4817338713","display_name":"SCOR IN CORONARY AND VASCULAR DISEASES","funder_award_id":"5p50hl032295-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G481891841","display_name":null,"funder_award_id":"HL-08167","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G614034516","display_name":null,"funder_award_id":"HL 48961","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G855834659","display_name":"CORONARY ANGIOGENESIS IN NORMAL &HYPERTROPHIC HEARTS","funder_award_id":"1f32hl008167-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2333210881","https://openalex.org/W1965678559","https://openalex.org/W2134141043","https://openalex.org/W2159098993","https://openalex.org/W2022915923","https://openalex.org/W1981162769","https://openalex.org/W4225947019","https://openalex.org/W1984506335","https://openalex.org/W2009327856","https://openalex.org/W1966722784"],"abstract_inverted_index":{"We":[0,146],"have":[1],"shown":[2],"that":[3,148],"sympathetic":[4,19,149],"denervation":[5],"increases":[6],"subendocardial":[7],"capillarity":[8],"during":[9],"left":[10],"ventricular":[11,40,122],"hypertrophy.":[12],"To":[13],"determine":[14],"the":[15,24,28,43,59,112,155,158],"direct":[16],"effects":[17],"of":[18,23,30,47,77,119,157],"innervation":[20,137,150],"on":[21,90],"development":[22],"coronary":[25],"microvasculature":[26,159],"in":[27,134,163],"absence":[29],"hemodynamic":[31],"load,":[32],"we":[33],"grafted":[34],"avascular":[35],"fetal":[36],"rat":[37],"atrial":[38,120],"or":[39,70,116,121,131,144,160],"tissue":[41,123,127],"into":[42],"anterior":[44],"eye":[45,61],"chamber":[46,62],"host":[48],"rats":[49],"which":[50],"had":[51],"undergone":[52],"unilateral":[53],"superior":[54],"cervical":[55],"gangliectomies.":[56],"Innervation":[57,107],"to":[58],"contralateral":[60],"remained":[63],"intact.":[64],"The":[65],"grafts":[66],"were":[67,84,98],"harvested":[68],"14":[69,130],"35":[71,132],"days":[72,133],"later,":[73],"and":[74,81,96,103],"volume":[75,114],"densities":[76,115],"blood":[78],"vessels,":[79],"myocytes,":[80],"extracellular":[82],"matrix":[83],"determined":[85],"using":[86],"standard":[87],"point-counting":[88],"techniques":[89],"low-power":[91],"electron":[92],"micrographs.":[93],"Graft":[94],"perfusion":[95,143],"metabolism":[97,162],"assessed":[99],"simultaneously":[100],"with":[101,125],"thallium-201":[102],"2-[14C]deoxy-D-glucose":[104],"uptake,":[105],"respectively.":[106],"did":[108,138],"not":[109,139,152],"significantly":[110,140],"alter":[111,141],"vascular":[113],"cellular":[117],"composition":[118],"compared":[124],"noninnervated":[126],"after":[128],"either":[129],"oculo.":[135],"Similarly,":[136],"graft":[142],"metabolism.":[145],"conclude":[147],"does":[151],"directly":[153],"influence":[154],"growth":[156],"myocardial":[161],"hemodynamically":[164],"unloaded,":[165],"developing":[166],"heart":[167],"tissue.":[168]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}